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Select item 111485371.

ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin β1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis

Yuxiang Qiu, Xing Wang, Yan Sun, Ting Jin, Rui Tang, Xinyue Zhou, Ming Xu, Yubi Gan, Rui Wang, Haojun Luo, Manran Liu, Xi Tang

Cancer Res. 2024 Jun 4; 84(11): 1856–1871. Published online 2024 Mar 12. doi: 10.1158/0008-5472.CAN-23-2491

PMCID:: PMC11148537

Abstract Article PDF–29M

Select item 110993252.

Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid β-oxidation pathway rather than lipid droplet accumulation

Hongshuo Zhang, Qianyi Sun, Haojie Dong, Zeen Jin, Mengyue Li, Shanyuan Jin, Xiaolan Zeng, Jianhui Fan, Ying Kong

Mol Metab. 2024 Jun; 84: 101953. Published online 2024 May 4. doi: 10.1016/j.molmet.2024.101953

PMCID:: PMC11099325

Abstract Article PDF–5.2M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108664334.

Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4

Qing Ji, Le Zhang, Hui Ye

Aging (Albany NY) 2024 Jan 31; 16(2): 1925–1937. Published online 2024 Jan 29. doi: 10.18632/aging.205469

PMCID:: PMC10866433

Abstract Article PDF–1.2M

Select item 108447645.

Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4‐mediated ferroptosis

Lili Huang, Ling Zhang, Zheng Zhang, Fangyan Tan, Yixin Ma, Xujia Zeng, Dan Cao, Lili Deng, Qi Liu, Hang Sun, Bingbing Shen, Xiaohui Liao

J Cell Mol Med. 2024 Feb; 28(3): e18076. Published online 2023 Dec 13. doi: 10.1111/jcmm.18076

PMCID:: PMC10844764

Abstract Article PDF–28M

Select item 107775726.

Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice

Xue Bai, Bing Wang, Yiduo Cui, Siqi Tian, Yi Zhang, Linhao You, Yan-Zhong Chang, Guofen Gao

J Neuroinflammation. 2024; 21: 15. Published online 2024 Jan 9. doi: 10.1186/s12974-023-03008-0

PMCID:: PMC10777572

Abstract Article PDF–8.2M

Select item 106011567.

ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model

Dianyu Cao, Jina Zheng, Zheng Li, Yong Yu, Zengrui Chen, Qiang Wang

Arthritis Res Ther. 2023; 25: 212. Published online 2023 Oct 26. doi: 10.1186/s13075-023-03190-9

PMCID:: PMC10601156

Abstract Article PDF–10M

Select item 104965078.

microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis

Zhen Qi, Ruhui Liu, Haining Ju, Mengxi Huang, Zhe Li, Wei Li, Yongyi Wang

Int J Biol Sci. 2023; 19(13): 4223–4241. Published online 2023 Aug 15. doi: 10.7150/ijbs.82287

PMCID:: PMC10496507

Abstract Article PDF–10M

Select item 104801789.

Inhibition of ACSL4 ameliorates tubular ferroptotic cell death and protects against fibrotic kidney disease

Yue Dai, Yuting Chen, Dexiameng Mo, Rui Jin, Yi Huang, Le Zhang, Cuntai Zhang, Hongyu Gao, Qi Yan

Commun Biol. 2023; 6: 907. Published online 2023 Sep 5. doi: 10.1038/s42003-023-05272-5

PMCID:: PMC10480178

Abstract Article PDF–9.0M

Select item 1046689410.

Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury

Peizhong Kong, Miaomiao Yang, Ying Wang, K.N. Yu, Lijun Wu, Wei Han

Redox Biol. 2023 Oct; 66: 102857. Published online 2023 Aug 18. doi: 10.1016/j.redox.2023.102857

PMCID:: PMC10466894

Abstract Article PDF–7.5M

Select item 1045727111.

Inhibition of ACSL4 Alleviates Parkinsonism Phenotypes by Reduction of Lipid Reactive Oxygen Species

Fei Tang, Liu-yao Zhou, Ping Li, Ling-ling Jiao, Kang Chen, Yu-jie Guo, Xu-long Ding, Si-yu He, Biao Dong, Ru-xiang Xu, Huan Xiong, Peng Lei

Neurotherapeutics. 2023 Jul; 20(4): 1154–1166. Published online 2023 May 3. doi: 10.1007/s13311-023-01382-4

PMCID:: PMC10457271

Abstract Article PDF–7.4M

Select item 1045097812.

Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation

Yuki Tomitsuka, Hiroki Imaeda, Haruka Ito, Isaki Asou, Masayuki Ohbayashi, Fumihiro Ishikawa, Hiroshi Kuwata, Shuntaro Hara

Redox Biol. 2023 Oct; 66: 102850. Published online 2023 Aug 12. doi: 10.1016/j.redox.2023.102850

PMCID:: PMC10450978

Abstract Article PDF–5.5M

Select item 1011186213.

ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease

Shujuan Song, Zhenyi Su, Ning Kon, Bo Chu, Huan Li, Xuejun Jiang, Jianyuan Luo, Brent R. Stockwell, Wei Gu

Genes Dev. 2023 Mar 1; 37(5-6): 204–217. doi: 10.1101/gad.350211.122

PMCID:: PMC10111862

Abstract Article PDF–5.3M

Select item 1010652114.

HIV-1 Tat-mediated microglial ferroptosis involves the miR-204–ACSL4 signaling axis

Muthukumar Kannan, Susmita Sil, Abiola Oladapo, Annadurai Thangaraj, Palsamy Periyasamy, Shilpa Buch

Redox Biol. 2023 Jun; 62: 102689. Published online 2023 Apr 1. doi: 10.1016/j.redox.2023.102689

PMCID:: PMC10106521

Abstract Article PDF–14M

Select item 993068015.

Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease

Yingxi Wang, Shuyue Xia

Int J Chron Obstruct Pulmon Dis. 2023; 18: 99–111. Published online 2023 Feb 11. doi: 10.2147/COPD.S391129

PMCID:: PMC9930680

Abstract Article PDF–7.7M

Select item 937610916.

ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression

Julia Grube, Marius Maximilian Woitok, Antje Mohs, Stephanie Erschfeld, Celina Lynen, Christian Trautwein, Tobias Otto

Cell Death Dis. 2022 Aug; 13(8): 704. Published online 2022 Aug 13. doi: 10.1038/s41419-022-05137-5

PMCID:: PMC9376109

Abstract Article PDF–4.6M

Select item 917836617.

ACSL4 contributes to ferroptosis‐mediated rhabdomyolysis in exertional heat stroke

Sixiao He, Ru Li, Yanmei Peng, Ziqing Wang, Junhao Huang, Hongen Meng, Junxia Min, Fudi Wang, Qiang Ma

J Cachexia Sarcopenia Muscle. 2022 Jun; 13(3): 1717–1730. Published online 2022 Mar 3. doi: 10.1002/jcsm.12953

PMCID:: PMC9178366

Abstract Article PDF–29M

Select item 897419018.

Depletion of mmu_circ_0001751 (circular RNA Carm1) protects against acute cerebral infarction injuries by binding with microRNA-3098-3p to regulate acyl-CoA synthetase long-chain family member 4

Rui Mao, Hua Liu

Bioengineered. 2022; 13(2): 4063–4075. Published online 2022 Feb 3. doi: 10.1080/21655979.2022.2032971

PMCID:: PMC8974190

Abstract Article PDF–2.5M

Select item 885707919.

ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury

Yue Wang, Menghan Zhang, Ran Bi, Yali Su, Fei Quan, Yanting Lin, Chongxiu Yue, Xinmeng Cui, Qixiang Zhao, Siliang Liu, Yong Yang, Dayong Zhang, Qiuhua Cao, Xinghua Gao

Redox Biol. 2022 May; 51: 102262. Published online 2022 Feb 9. doi: 10.1016/j.redox.2022.102262

PMCID:: PMC8857079

Abstract Article PDF–16M

Select item 880299720.

Myeloid-specific deficiency of long-chain acyl CoA synthetase 4 (Acsl4) reduces inflammation in vitro and in vivo by remodeling phospholipids and reducing production of arachidonic acid-derived proinflammatory lipid mediators

Andrew R. Reeves, Brian E. Sansbury, Meixia Pan, Xianlin Han, Matthew Spite, Andrew S. Greenberg

J Immunol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: J Immunol. 2021 Dec 1; 207(11): 2744–2753. Published online 2021 Nov 1. doi: 10.4049/jimmunol.2100393

Correction in:: J Immunol. 2022 May 16

PMCID:: PMC8802997

Abstract Article PDF–1.7M

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