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Items: 1 to 20 of 57

1.
Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
Helen C. Wang, Ran Chen, Wei Yang, Yanan Li, Rohini Muthukumar, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, Jeffrey A. Magee
Cell Rep. Author manuscript; available in PMC 2024 Sep 25.
Published in final edited form as: Cell Rep. 2024 Aug 27; 43(8): 114542. Published online 2024 Jul 23. doi: 10.1016/j.celrep.2024.114542
PMCID:
PMC11423277
AbstractArticlePDF–3.0M
2.
CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression
Huiqiang Cai, Bin Zhang, Johanne Ahrenfeldt, Justin V. Joseph, Maria Riedel, Zongliang Gao, Sofie K. Thomsen, Ditte S. Christensen, Rasmus O. Bak, Henrik Hager, Mikkel H. Vendelbo, Xin Gao, Nicolai Birkbak, Martin K. Thomsen
Nat Commun. 2024; 15: 2088. Published online 2024 Mar 7. doi: 10.1038/s41467-024-46370-0
PMCID:
PMC10920892
AbstractArticlePDF–6.9M
3.
Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer
Nikiana Simigdala, Anna Chalari, Aimilia D. Sklirou, Evangelia Chavdoula, George Papafotiou, Pelagia Melissa, Aimilia Kafalidou, Nikolaos Paschalidis, Ioannis S. Pateras, Emmanouil Athanasiadis, Dimitris Konstantopoulos, Ioannis P. Trougakos, Apostolos Klinakis
Cell Mol Life Sci. 2023 Apr; 80(4): 100. Published online 2023 Mar 18. doi: 10.1007/s00018-023-04734-7
PMCID:
PMC10024673
AbstractArticlePDF–2.8M
4.
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
Ryan M. Boileau, Kevin X. Chen, Robert Blelloch
Genome Biol. 2023; 24: 41. Published online 2023 Mar 3. doi: 10.1186/s13059-023-02883-3
PMCID:
PMC9983171
AbstractArticlePDF–6.9M
5.
KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming
Feifei Na, Xiangyu Pan, Jingyao Chen, Xuelan Chen, Manli Wang, Pengliang Chi, Liting You, Lanxin Zhang, Ailing Zhong, Lei Zhao, Siqi Dai, Mengsha Zhang, Yiyun Wang, Bo Wang, Jianan Zheng, Yuying Wang, Jing Xu, Jian Wang, Baohong Wu, Mei Chen, Hongyu Liu, Jianxin Xue, Meijuan Huang, Youling Gong, Jiang Zhu, Lin Zhou, Yan Zhang, Min Yu, Panwen Tian, Mingyu Fan, Zhenghao Lu, Zhihong Xue, Yinglan Zhao, Hanshuo Yang, Chengjian Zhao, Yuan Wang, Junhong Han, Shengyong Yang, Dan Xie, Lu Chen, Qian Zhong, Musheng Zeng, Scott W. Lowe, You Lu, Yu Liu, Yuquan Wei, Chong Chen
Nat Cancer. Author manuscript; available in PMC 2023 Feb 27.
Published in final edited form as: Nat Cancer. 2022 Jun; 3(6): 753–767. Published online 2022 Apr 21. doi: 10.1038/s43018-022-00361-6
PMCID:
PMC9969417
AbstractArticlePDF–8.1M
6.
Circadian clock function does not require the histone methyltransferase MLL3
Matthew Baxter, Toryn Poolman, Peter Cunningham, Louise Hunter, Maria Voronkov, Gareth B. Kitchen, Laurence Goosey, Nicola Begley, Danielle Kay, Abby Hespe, Robert Maidstone, Andrew S. I. Loudon, David W. Ray
FASEB J. 2022 Jul; 36(7): e22356. Published online 2022 Jun 15. doi: 10.1096/fj.202200368R
PMCID:
PMC9328146
AbstractArticlePDF–16M
7.
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis
Tanja Limberger, Michaela Schlederer, Karolina Trachtová, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Högler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichý, Margit Schmeidl, Petra Kodajova, Anton Jäger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer, Sarka Pospisilova, Helmut Dolznig, Wolfgang Wadsak, Zoran Culig, Suzanne D. Turner, Gerda Egger, Sabine Lagger, Lukas Kenner
Mol Cancer. 2022; 21: 89. Published online 2022 Mar 30. doi: 10.1186/s12943-022-01542-8
PMCID:
PMC8966196
AbstractArticlePDF–3.3M
8.
Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice
Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao
Front Cell Dev Biol. 2021; 9: 642931. Published online 2021 Jul 21. doi: 10.3389/fcell.2021.642931
PMCID:
PMC8333871
AbstractArticlePDF–1.4M
9.
Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
Ran Chen, Theresa Okeyo-Owuor, Riddhi M. Patel, Emily B. Casey, Andrew S. Cluster, Wei Yang, Jeffrey A. Magee
Cell Rep. Author manuscript; available in PMC 2021 Mar 11.
Published in final edited form as: Cell Rep. 2021 Feb 16; 34(7): 108751. doi: 10.1016/j.celrep.2021.108751
PMCID:
PMC7951951
AbstractArticlePDF–2.8M
10.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
11.
The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
Christian Huisman, Young A. Kim, Shin Jeon, Bongjin Shin, Jeonghoon Choi, Su Jeong Lim, Sung Min Youn, Younjung Park, Medha K. C., Sangsoo Kim, Soo-Kyung Lee, Seunghee Lee, Jae W. Lee
Nat Commun. 2021; 12: 256. Published online 2021 Jan 11. doi: 10.1038/s41467-020-20511-7
PMCID:
PMC7801453
AbstractArticlePDF–5.6M
12.
MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ
Ji-Eun Lee, Young-Wook Cho, Chu-Xia Deng, Kai Ge
Mol Cell Biol. 2020 Sep; 40(17): e00209-20. Prepublished online 2020 Jun 29. Published online 2020 Aug 14. doi: 10.1128/MCB.00209-20
PMCID:
PMC7431048
AbstractArticlePDF–3.8M
13.
H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development
Younghoon Jang, Aaron Broun, Chaochen Wang, Young-Kwon Park, Lenan Zhuang, Ji-Eun Lee, Eugene Froimchuk, Chengyu Liu, Kai Ge
Nucleic Acids Res. 2019 Jan 25; 47(2): 607–620. Published online 2018 Oct 18. doi: 10.1093/nar/gky982
PMCID:
PMC6344897
AbstractArticlePDF–4.7M
14.
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
John Arne Dahl, Inkyung Jung, Håvard Aanes, Gareth D. Greggains, Adeel Manaf, Mads Lerdrup, Guoqiang Li, Samantha Kuan, Bin Li, Ah Young Lee, Sebastian Preissl, Ingunn Jermstad, Mads Haugland Haugen, Rajikala Suganthan, Magnar Bjørås, Klaus Hansen, Knut Tomas Dalen, Peter Fedorcsak, Bing Ren, Arne Klungland
Nature. Author manuscript; available in PMC 2018 Dec 6.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 548–552. Published online 2016 Sep 14. doi: 10.1038/nature19360
PMCID:
PMC6283663
AbstractArticlePDF–4.9M
15.
KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function
Kinisha Gala, Qing Li, Amit Sinha, Pedram Razavi, Madeline Dorso, Francisco Sanchez-Vega, Young Rock Chung, Ronald Hendrickson, James J. Hsieh, Michael Berger, Nikolaus Schultz, Alessandro Pastore, Omar Abdel-Wahab, Sarat Chandarlapaty
Oncogene. 2018; 37(34): 4692–4710. Published online 2018 May 14. doi: 10.1038/s41388-018-0273-5
PMCID:
PMC6107480
AbstractArticlePDF–4.4M
16.
Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability
Ryan Rickels, Hans-Martin Herz, Christie C Sze, Kaixiang Cao, Marc A Morgan, Clayton K Collings, Maria Gause, Yoh-hei Takahashi, Lu Wang, Emily J Rendleman, Stacy A Marshall, Annika Krueger, Elizabeth T Bartom, Andrea Piunti, Edwin Smith, Nebiyu A Abshiru, Neil L Kelleher, Dale Dorsett, Ali Shilatifard
Nat Genet. Author manuscript; available in PMC 2017 Nov 1.
Published in final edited form as: Nat Genet. 2017 Nov; 49(11): 1647–1653. Published online 2017 Oct 2. doi: 10.1038/ng.3965
PMCID:
PMC5663216
AbstractArticlePDF–1.1M
17.
Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation
Kristel M. Dorighi, Tomek Swigut, Telmo Henriques, Natarajan V. Bhanu, Benjamin S. Scruggs, Nataliya Nady, Christopher D. Still, II, Benjamin A. Garcia, Karen Adelman, Joanna Wysocka
Mol Cell. Author manuscript; available in PMC 2018 May 18.
Published in final edited form as: Mol Cell. 2017 May 18; 66(4): 568–576.e4. Published online 2017 May 5. doi: 10.1016/j.molcel.2017.04.018
PMCID:
PMC5662137
AbstractArticlePDF–780K
18.
The Histone Methyltransferase Mixed Lineage Leukemia (MLL) 3 May Play a Potential Role in Clinical Dilated Cardiomyopathy
Ding-Sheng Jiang, Xin Yi, Rui Li, Yun-Shu Su, Jing Wang, Min-Lai Chen, Li-Gang Liu, Min Hu, Cai Cheng, Ping Zheng, Xue-Hai Zhu, Xiang Wei
Mol Med. 2017; 23: 196–203. Published online 2017 Aug 9. doi: 10.2119/molmed.2017.00012
PMCID:
PMC5630473
AbstractArticlePDF–4.8M
19.
MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis
Binbin Lai, Ji-Eun Lee, Younghoon Jang, Lifeng Wang, Weiqun Peng, Kai Ge
Nucleic Acids Res. 2017 Jun 20; 45(11): 6388–6403. Published online 2017 Apr 8. doi: 10.1093/nar/gkx234
PMCID:
PMC5499743
AbstractArticlePDF–11M
20.
Mammary Stem Cell Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation
Zheng Zhang, John R. Christin, Chunhui Wang, Kai Ge, Maja H. Oktay, Wenjun Guo
Cell Rep. Author manuscript; available in PMC 2016 Oct 19.
Published in final edited form as: Cell Rep. 2016 Sep 20; 16(12): 3146–3156. doi: 10.1016/j.celrep.2016.08.048
PMCID:
PMC5069998
AbstractArticlePDF–2.0M

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