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Select item 108940041.

Developmental expression of the Sturge–Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis

Sarah E Wetzel-Strong, Francesca Galeffi, Christian Benavides, Mary Patrucco, Jessica L Bullock, Carol J Gallione, Han Kyu Lee, Douglas A Marchuk

Genetics. 2023 Aug; 224(4): iyad077. Published online 2023 Apr 25. doi: 10.1093/genetics/iyad077

PMCID:: PMC10894004

Abstract Article PDF–6.8M

Select item 108406922.

A regulatory node involving Gα_q, PLCβ, and RGS proteins modulates platelet reactivity to critical agonists

Shuchi Gupta, Matthew Cooper, Xuefei Zhao, Yanki Yarman, Hannah Thomson, Daniel DeHelian, Lawrence F. Brass, Peisong Ma

J Thromb Haemost. Author manuscript; available in PMC 2024 Dec 1.

Published in final edited form as: J Thromb Haemost. 2023 Dec; 21(12): 3633–3639. Published online 2023 Aug 30. doi: 10.1016/j.jtha.2023.08.022

PMCID:: PMC10840692

Abstract Article PDF–754K

Select item 106912443.

The mechanism of Gα_q regulation of PLCβ3-catalyzed PIP2 hydrolysis

Maria E. Falzone, Roderick MacKinnon

Proc Natl Acad Sci U S A. 2023 Nov 28; 120(48): e2315011120. Published online 2023 Nov 22. doi: 10.1073/pnas.2315011120

PMCID:: PMC10691244

Abstract Article PDF–3.6M

Select item 103078524.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 102596615.

Stretch regulates alveologenesis and homeostasis via mesenchymal G_αq/11-mediated TGFβ2 activation

Amanda T. Goodwin, Alison E. John, Chitra Joseph, Anthony Habgood, Amanda L. Tatler, Katalin Susztak, Matthew Palmer, Stefan Offermanns, Neil C. Henderson, R. Gisli Jenkins

Development. 2023 May 1; 150(9): dev201046. Published online 2023 May 12. doi: 10.1242/dev.201046

PMCID:: PMC10259661

Abstract Article

Select item 87117596.

Deletion of Gα_q/11 or Gα_s Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice

George A Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R Thompson, Rona S Carroll, Min Chen, Lee S Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J Bernard, Ursula B Kaiser

Endocrinology. 2022 Feb; 163(2): bqab247. Published online 2021 Dec 5. doi: 10.1210/endocr/bqab247

PMCID:: PMC8711759

Abstract Article

Select item 86093147.

Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways

Ming-Wei Wang, Zhao Yang, Xu Chen, Shu-Hua Zhou, Ge-Lin Huang, Jian-Ning Sun, Hui Jiang, Wen-Ming Xu, Hao-Cheng Lin, Xiao Yu, Jin-Peng Sun

Proc Natl Acad Sci U S A. 2021 Nov 9; 118(45): e2107363118. Published online 2021 Nov 5. doi: 10.1073/pnas.2107363118

PMCID:: PMC8609314

Abstract Article PDF–3.8M

Select item 85775598.

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle

Qian Wang, Wendy Wing Sze Yue, Zheng Jiang, Tian Xue, Shin H. Kang, Dwight E. Bergles, Katsuhiko Mikoshiba, Stefan Offermanns, King-Wai Yau

Curr Biol. Author manuscript; available in PMC 2021 Nov 9.

Published in final edited form as: Curr Biol. 2017 Jun 19; 27(12): 1791–1800.e5. Published online 2017 Jun 1. doi: 10.1016/j.cub.2017.05.022

PMCID:: PMC8577559

Abstract Article PDF–1.7M

Select item 83165529.

Gαq activation modulates autophagy by promoting mTORC1 signaling

Sofía Cabezudo, Maria Sanz-Flores, Alvaro Caballero, Inmaculada Tasset, Elena Rebollo, Antonio Diaz, Anna M. Aragay, Ana María Cuervo, Federico Mayor, Jr, Catalina Ribas

Nat Commun. 2021; 12: 4540. Published online 2021 Jul 27. doi: 10.1038/s41467-021-24811-4

PMCID:: PMC8316552

Abstract Article PDF–3.3M

Select item 831323910.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 826036311.

G_qα/G₁₁α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity

Eric A. Wilson, Hui Sun, Zhenzhong Cui, Marshal T. Jahnke, Mritunjay Pandey, Peter Metzger, Oksana Gavrilova, Min Chen, Lee S. Weinstein

Am J Physiol Endocrinol Metab. 2021 Feb 1; 320(2): E270–E280. Published online 2020 Nov 9. doi: 10.1152/ajpendo.00059.2020

PMCID:: PMC8260363

Abstract Article

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 768575613.

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

Okechi S. Oduori, Naoya Murao, Kenju Shimomura, Harumi Takahashi, Quan Zhang, Haiqiang Dou, Shihomi Sakai, Kohtaro Minami, Belen Chanclon, Claudia Guida, Lakshmi Kothegala, Johan Tolö, Yuko Maejima, Norihide Yokoi, Yasuhiro Minami, Takashi Miki, Patrik Rorsman, Susumu Seino

J Clin Invest. 2020 Dec 1; 130(12): 6639–6655. Published online 2020 Nov 16. doi: 10.1172/JCI140046

PMCID:: PMC7685756

Abstract Article PDF–6.7M

Select item 739711114.

The orphan receptor GPR139 signals via G_q/11 to oppose opioid effects

Hannah M. Stoveken, Stefano Zucca, Ikuo Masuho, Brock Grill, Kirill A. Martemyanov

J Biol Chem. 2020 Jul 31; 295(31): 10822–10830. Published online 2020 Jun 23. doi: 10.1074/jbc.AC120.014770

PMCID:: PMC7397111

Abstract Article PDF–2.3M

Select item 734198515.

Effects of G-protein mutations on skin color

Catherine D Van Raamsdonk, Karen R Fitch, Helmut Fuchs, Martin Hrabé de Angelis, Gregory S Barsh

Nat Genet. Author manuscript; available in PMC 2020 Jul 8.

Published in final edited form as: Nat Genet. 2004 Sep; 36(9): 961–968. Published online 2004 Aug 22. doi: 10.1038/ng1412

PMCID:: PMC7341985

Abstract Article PDF–1.1M

Select item 726179516.

Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor–mediated chemotaxis

Esther van den Bos, Benjamin Ambrosy, Markus Horsthemke, Stefan Walbaum, Anne C. Bachg, Nina Wettschureck, Giulio Innamorati, Thomas M. Wilkie, Peter J. Hanley

J Biol Chem. 2020 May 29; 295(22): 7726–7742. Published online 2020 Apr 24. doi: 10.1074/jbc.RA119.011984

PMCID:: PMC7261795

Abstract Article PDF–5.0M

Select item 698340017.

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

Jan Wenzel, Cathrin E. Hansen, Carla Bettoni, Miriam A. Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C. Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M. König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter Gass, Stefan Offermanns, Cor de Wit, Carsten A. Wagner, Markus Schwaninger

Proc Natl Acad Sci U S A. 2020 Jan 21; 117(3): 1753–1761. Published online 2020 Jan 2. doi: 10.1073/pnas.1907467117

PMCID:: PMC6983400

Abstract Article PDF–3.6M

Select item 692342418.

Helix 8 is the essential structural motif of mechanosensitive GPCRs

Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler

Nat Commun. 2019; 10: 5784. Published online 2019 Dec 19. doi: 10.1038/s41467-019-13722-0

PMCID:: PMC6923424

Abstract Article PDF–1.4M

Select item 677797919.

Myogenic vasoconstriction requires G₁₂/G₁₃ and LARG to maintain local and systemic vascular resistance

Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns

eLife. 2019; 8: e49374. Published online 2019 Sep 24. doi: 10.7554/eLife.49374

PMCID:: PMC6777979

Abstract Article PDF–4.6M

Select item 677264420.

Muscarinic Inhibition of Calcium Current and M Current in Gα_q-Deficient Mice

Jane E. Haley, Patrick Delmas, Stefan Offermanns, Fe C. Abogadie, Melvin I. Simon, Noel J. Buckley, David A. Brown

J Neurosci. 2000 Jun 1; 20(11): 3973–3979. doi: 10.1523/JNEUROSCI.20-11-03973.2000

PMCID:: PMC6772644

Abstract Article PDF–251K

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