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Items: 1 to 20 of 95

1.
Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis
Paloma Ruiz-Blázquez, María Fernández-Fernández, Valeria Pistorio, Celia Martinez-Sanchez, Michele Costanzo, Paula Iruzubieta, Ekaterina Zhuravleva, Júlia Cacho-Pujol, Silvia Ariño, Alejandro Del Castillo-Cruz, Susana Núñez, Jesper B. Andersen, Margherita Ruoppolo, Javier Crespo, Carmen García-Ruiz, Luigi Michele Pavone, Thomas Reinheckel, Pau Sancho-Bru, Mar Coll, José C. Fernández-Checa, Anna Moles
Mol Metab. 2024 Sep; 87: 101989. Published online 2024 Jul 15. doi: 10.1016/j.molmet.2024.101989
PMCID:
PMC11327474
AbstractArticlePDF–5.2M
2.
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Alzheimers Res Ther. 2024; 16: 70. Published online 2024 Apr 4. doi: 10.1186/s13195-024-01443-6
PMCID:
PMC10996108
AbstractArticlePDF–3.7M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
ZFP750 affects the cutaneous barrier through regulating lipid metabolism
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D’Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Sci Adv. 2023 Apr; 9(17): eadg5423. Published online 2023 Apr 28. doi: 10.1126/sciadv.adg5423
PMCID:
PMC10146900
AbstractArticlePDF–2.3M
5.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
6.
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
Kayvon Pedram, Nouf N. Laqtom, D. Judy Shon, Alessandro Di Spiezio, Nicholas M. Riley, Paul Saftig, Monther Abu-Remaileh, Carolyn R. Bertozzi
Proc Natl Acad Sci U S A. 2022 Sep 27; 119(39): e2117105119. Published online 2022 Sep 19. doi: 10.1073/pnas.2117105119
PMCID:
PMC9522329
AbstractArticlePDF–2.3M
7.
Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins
Chigure Suzuki, Junji Yamaguchi, Takahito Sanada, Juan Alejandro Oliva Trejo, Souichirou Kakuta, Masahiro Shibata, Isei Tanida, Yasuo Uchiyama
Sci Rep. 2022; 12: 11662. Published online 2022 Jul 8. doi: 10.1038/s41598-022-15805-3
PMCID:
PMC9270453
AbstractArticlePDF–7.1M
8.
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
Susy Prieto Huarcaya, Alice Drobny, André R. A. Marques, Alessandro Di Spiezio, Jan Philipp Dobert, Denise Balta, Christian Werner, Tania Rizo, Lisa Gallwitz, Simon Bub, Iva Stojkovska, Nandkishore R. Belur, Jens Fogh, Joseph R Mazzulli, Wei Xiang, Amitkumar Fulzele, Mario Dejung, Markus Sauer, Beate Winner, Stefan Rose-John, Philipp Arnold, Paul Saftig, Friederike Zunke
Autophagy. 2022; 18(5): 1127–1151. Published online 2022 Apr 28. doi: 10.1080/15548627.2022.2045534
PMCID:
PMC9196656
AbstractArticlePDF–5.4M
9.
Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling
Adrienn Skopál, Tamás Kéki, Péter Á. Tóth, Balázs Csóka, Balázs Koscsó, Zoltán H. Németh, Luca Antonioli, Andreas Ivessa, Francisco Ciruela, László Virág, György Haskó, Endre Kókai
J Biol Chem. 2022 May; 298(5): 101888. Published online 2022 Mar 31. doi: 10.1016/j.jbc.2022.101888
PMCID:
PMC9065627
AbstractArticlePDF–3.7M
10.
CREG1 promotes lysosomal biogenesis and function
Jie Liu, Yanmei Qi, Joshua Chao, Pranav Sathuvalli, Leonard Y. Lee, Shaohua Li
Autophagy. 2021; 17(12): 4249–4265. Published online 2021 May 8. doi: 10.1080/15548627.2021.1909997
PMCID:
PMC8726608
AbstractArticlePDF–9.2M
11.
Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice
Tulasi Yadati, Tom Houben, Albert Bitorina, Yvonne Oligschlaeger, Marion J. Gijbels, Ronny Mohren, Dieter Lütjohann, Princy Khurana, Sandeep Goyal, Aditya Kulkarni, Jan Theys, Berta Cillero-Pastor, Ronit Shiri-Sverdlov
Front Immunol. 2021; 12: 675535. Published online 2021 Jul 16. doi: 10.3389/fimmu.2021.675535
PMCID:
PMC8323051
AbstractArticlePDF–1.9M
12.
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour
Enrico Castroflorio, Joery den Hoed, Daria Svistunova, Mattéa J. Finelli, Alberto Cebrian-Serrano, Silvia Corrochano, Andrew R. Bassett, Benjamin Davies, Peter L. Oliver
Cell Mol Life Sci. 2021 Apr; 78(7): 3503–3524. Published online 2020 Dec 19. doi: 10.1007/s00018-020-03721-6
PMCID:
PMC8038996
AbstractArticlePDF–6.4M
13.
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease
Mahmoud Bassal, Junling Liu, Wanda Jankowiak, Paul Saftig, Udo Bartsch
Cells. 2021 Mar; 10(3): 696. Published online 2021 Mar 21. doi: 10.3390/cells10030696
PMCID:
PMC8003850
AbstractArticlePDF–5.0M
14.
Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis
Hideaki Iwama, Sally Mehanna, Mai Imasaka, Shinsuke Hashidume, Hiroshi Nishiura, Ken-ichi Yamamura, Chigure Suzuki, Yasuo Uchiyama, Etsuro Hatano, Masaki Ohmuraya
Sci Rep. 2021; 11: 6596. Published online 2021 Mar 23. doi: 10.1038/s41598-021-85898-9
PMCID:
PMC7988038
AbstractArticlePDF–2.6M
15.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
16.
Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D
Yuqing Wu, Cao Li, Huiming Peng, Ashraf Swaidan, Andrea Riehle, Barbara Pollmeier, Yang Zhang, Erich Gulbins, Heike Grassmé
Cells. 2020 Nov; 9(11): 2406. Published online 2020 Nov 3. doi: 10.3390/cells9112406
PMCID:
PMC7693114
AbstractArticlePDF–3.7M
17.
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling
Stephanie Ketterer, Julia Mitschke, Anett Ketscher, Manuel Schlimpert, Wilfried Reichardt, Natascha Baeuerle, Maria Elena Hess, Patrick Metzger, Melanie Boerries, Christoph Peters, Bernd Kammerer, Tilman Brummer, Florian Steinberg, Thomas Reinheckel
Nat Commun. 2020; 11: 5133. Published online 2020 Oct 12. doi: 10.1038/s41467-020-18935-2
PMCID:
PMC7552405
AbstractArticlePDF–2.7M
18.
Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling
Catherine R. Cochrane, Vijesh Vaghjiani, Anette Szczepny, W. Samantha N. Jayasekara, Alvaro Gonzalez-Rajal, Kazu Kikuchi, Geoffrey W. McCaughan, Andrew Burgess, Daniel J. Gough, D. Neil Watkins, Jason E. Cain
J Clin Invest. 2020 Aug 3; 130(8): 4006–4018. Published online 2020 Jun 22. doi: 10.1172/JCI132513
PMCID:
PMC7410056
AbstractArticlePDF–11M
19.
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40
Caitlin N. Suire, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K. Brizuela, Paul Saftig, Dennis W. Dickson, Terrone L. Rosenberry, Malcolm A. Leissring
Alzheimers Res Ther. 2020; 12: 80. Published online 2020 Jul 6. doi: 10.1186/s13195-020-00649-8
PMCID:
PMC7339583
AbstractArticlePDF–1.4M
20.
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
André R. A. Marques, Alessandro Di Spiezio, Niklas Thießen, Lina Schmidt, Joachim Grötzinger, Renate Lüllmann-Rauch, Markus Damme, Steffen E. Storck, Claus U. Pietrzik, Jens Fogh, Julia Bär, Marina Mikhaylova, Markus Glatzel, Mahmoud Bassal, Udo Bartsch, Paul Saftig
Autophagy. 2020; 16(5): 811–825. Published online 2019 Jul 16. doi: 10.1080/15548627.2019.1637200
PMCID:
PMC7158922
AbstractArticlePDF–6.3M

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