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Select item 114057191.

CMG helicase disassembly is essential and driven by two pathways in budding yeast

Cristian Polo Rivera, Tom D Deegan, Karim P M Labib

EMBO J. 2024 Sep; 43(18): 3818–3845. Published online 2024 Jul 22. doi: 10.1038/s44318-024-00161-x

PMCID:: PMC11405719

Abstract Article PDF–6.9M

Select item 113992612.

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex

Yue Wu, Qiongdan Zhang, Yuhan Lin, Wai Hei Lam, Yuanliang Zhai

Nat Commun. 2024; 15: 8039. Published online 2024 Sep 13. doi: 10.1038/s41467-024-52408-0

PMCID:: PMC11399261

Abstract Article PDF–1.5M

Select item 111048493.

Characterization of the dimeric CMG/pre-initiation complex and its transition into DNA replication forks

Lu Liu, Yue Zhang, Jingjing Zhang, Jian-Hua Wang, Qinhong Cao, Zhen Li, Judith L. Campbell, Meng-Qiu Dong, Huiqiang Lou

Cell Mol Life Sci. 2020 Aug; 77(15): 3041–3058. Published online 2019 Nov 15. doi: 10.1007/s00018-019-03333-9

PMCID:: PMC11104849

Abstract Article PDF–9.1M

Select item 108724774.

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle

Michael J. O’Brien, Athar Ansari

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2024 Jan 1; 1872(1): 140968. Published online 2023 Oct 19. doi: 10.1016/j.bbapap.2023.140968

PMCID:: PMC10872477

Abstract Article PDF–1.7M

Select item 107001385.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 105115616.

Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Zhichun Xu, Jianrong Feng, Daqi Yu, Yunjing Huo, Xiaohui Ma, Wai Hei Lam, Zheng Liu, Xiang David Li, Toyotaka Ishibashi, Shangyu Dang, Yuanliang Zhai

Nat Commun. 2023; 14: 5849. Published online 2023 Sep 20. doi: 10.1038/s41467-023-41506-0

PMCID:: PMC10511561

Abstract Article PDF–5.3M

Select item 105019927.

How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication

Morgan L. Jones, Valentina Aria, Yasemin Baris, Joseph T.P. Yeeles

Mol Cell. 2023 Aug 17; 83(16): 2911–2924.e16. doi: 10.1016/j.molcel.2023.06.035

PMCID:: PMC10501992

Abstract Article

Select item 98133928.

An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing

Aftab Amin, Rentian Wu, Muhammad Ajmal Khan, Man Hei Cheung, Yanting Liang, Changdong Liu, Guang Zhu, Zhi-Ling Yu, Chun Liang

Life Sci Alliance. 2023 Mar; 6(3): e202201594. Published online 2023 Jan 4. doi: 10.26508/lsa.202201594

PMCID:: PMC9813392

Abstract Article PDF–4.3M

Select item 92098119.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 913311210.

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer

Almutasem Saleh, Yasunori Noguchi, Ricardo Aramayo, Marina E. Ivanova, Kathryn M. Stevens, Alex Montoya, S. Sunidhi, Nicolas Lopez Carranza, Marcin J. Skwark, Christian Speck

Nat Commun. 2022; 13: 2915. Published online 2022 May 25. doi: 10.1038/s41467-022-30576-1

PMCID:: PMC9133112

Abstract Article PDF–7.2M

Select item 892711711.

Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase

Jiaxuan Cheng, Ningning Li, Yunjing Huo, Shangyu Dang, Bik-Kwoon Tye, Ning Gao, Yuanliang Zhai

Nat Commun. 2022; 13: 1396. Published online 2022 Mar 16. doi: 10.1038/s41467-022-29070-5

Correction in:: Nat Commun. 2022; 13: 2411.

PMCID:: PMC8927117

Abstract Article PDF–6.6M

Select item 851195012.

The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions

Rajaraman Gopalakrishnan, Fred Winston

J Biol Chem. 2021 Oct; 297(4): 101205. Published online 2021 Sep 17. doi: 10.1016/j.jbc.2021.101205

PMCID:: PMC8511950

Abstract Article PDF–3.1M

Select item 809624413.

The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length

Dipti Vinayak Vernekar, Giordano Reginato, Céline Adam, Lepakshi Ranjha, Florent Dingli, Marie-Claude Marsolier, Damarys Loew, Raphaël Guérois, Bertrand Llorente, Petr Cejka, Valérie Borde

Nucleic Acids Res. 2021 May 7; 49(8): 4522–4533. Published online 2021 Apr 6. doi: 10.1093/nar/gkab232

PMCID:: PMC8096244

Abstract Article PDF–4.1M

Select item 797972614.

Stabilisation of half MCM ring by Cdt1 during DNA insertion

Marina Guerrero-Puigdevall, Narcis Fernandez-Fuentes, Jordi Frigola

Nat Commun. 2021; 12: 1746. Published online 2021 Mar 19. doi: 10.1038/s41467-021-21932-8

PMCID:: PMC7979726

Abstract Article PDF–1.8M

Select item 794844815.

14-3-3 Protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2

Neha Jain, Petra Janning, Heinz Neumann

J Biol Chem. 2021 Jan-Jun; 296: 100078. Published online 2020 Nov 23. doi: 10.1074/jbc.AC120.014758

PMCID:: PMC7948448

Abstract Article PDF–1.3M

Select item 782259416.

Cross-compartment signal propagation in the mitotic exit network

Xiaoxue Zhou, Wenxue Li, Yansheng Liu, Angelika Amon

eLife. 2021; 10: e63645. Published online 2021 Jan 22. doi: 10.7554/eLife.63645

PMCID:: PMC7822594

Abstract Article PDF–4.3M

Select item 764133117.

Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication

Katy Stokes, Alicja Winczura, Boyuan Song, Giacomo De Piccoli, Daniel B Grabarczyk

Nucleic Acids Res. 2020 Aug 20; 48(14): 8128–8145. Published online 2020 Jun 25. doi: 10.1093/nar/gkaa541

PMCID:: PMC7641331

Abstract Article PDF–9.1M

Select item 746261118.

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

Tom D Deegan, Progya P Mukherjee, Ryo Fujisawa, Cristian Polo Rivera, Karim Labib

eLife. 2020; 9: e60371. Published online 2020 Aug 17. doi: 10.7554/eLife.60371

PMCID:: PMC7462611

Abstract Article PDF–4.9M

Select item 739869819.

Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

Syafiq Abd Wahab, Dirk Remus

eLife. 2020; 9: e58571. Published online 2020 Jul 23. doi: 10.7554/eLife.58571

PMCID:: PMC7398698

Abstract Article PDF–2.5M

Select item 739546020.

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

Zuanning Yuan, Sarah Schneider, Thomas Dodd, Alberto Riera, Lin Bai, Chunli Yan, Indiana Magdalou, Ivaylo Ivanov, Bruce Stillman, Huilin Li, Christian Speck

Proc Natl Acad Sci U S A. 2020 Jul 28; 117(30): 17747–17756. Published online 2020 Jul 15. doi: 10.1073/pnas.2006231117