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Items: 1 to 20 of 128

1.
Overexpression of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth
James Drury, Mariah E. Geisen, Josiane Weber Tessmann, Piotr G. Rychahou, Courtney O. Kelson, Daheng He, Chi Wang, B. Mark Evers, Yekaterina Y. Zaytseva
Int J Mol Sci. 2024 May; 25(9): 4883. Published online 2024 Apr 30. doi: 10.3390/ijms25094883
PMCID:
PMC11084459
AbstractArticlePDF–3.3M
2.
TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase
Suowen Xu, Xiumei Wu, Sichen Wang, Mengyun Xu, Tingyu Fang, Xiaoxuan Ma, Meijie Chen, Jiajun Fu, Juan Guo, Song Tian, Tian Tian, Xu Cheng, Hailong Yang, Junjie Zhou, Zhenya Wang, Yanjun Yin, Wen Xu, Fen Xu, Jinhua Yan, Zhihua Wang, Sihui Luo, Xiao-Jing Zhang, Yan-Xiao Ji, Jianping Weng
J Clin Invest. 2024 Mar 1; 134(5): e166149. Published online 2024 Jan 11. doi: 10.1172/JCI166149
PMCID:
PMC10904058
AbstractArticlePDF–21M
3.
Proteolytic activation of fatty acid synthase signals pan-stress resolution
Hai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner, Matthew Sieber, Ralph J. DeBerardinis, Benjamin P. Weaver
Nat Metab. 2024; 6(1): 113–126. Published online 2024 Jan 2. doi: 10.1038/s42255-023-00939-z
PMCID:
PMC10822777
AbstractArticlePDF–22M
4.
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein
Nat Commun. 2024; 15: 45. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44364-y
PMCID:
PMC10762034
AbstractArticlePDF–1.0M
5.
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion
Chun-Guang Guo, Rui Sun, Xiao Wang, Ye Yuan, Yan Xu, Shihan Li, Xueting Sun, Jue Wang, Xinli Hu, Tiannan Guo, Xiao-Wei Chen, Rui-Ping Xiao, Xiuqin Zhang
Mol Metab. 2024 Jan; 79: 101847. Published online 2023 Nov 30. doi: 10.1016/j.molmet.2023.101847
PMCID:
PMC10755498
AbstractArticlePDF–3.6M
6.
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto
JCI Insight. 2023 Sep 8; 8(17): e161282. Published online 2023 Sep 8. doi: 10.1172/jci.insight.161282
PMCID:
PMC10544238
AbstractArticlePDF–3.8M
7.
Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD
Li-Chao Fan, Keith McConn, Maria Plataki, Sarah Kenny, Niamh C. Williams, Kihwan Kim, Jennifer A. Quirke, Yan Chen, Maor Sauler, Matthias E. Möbius, Kuei-Pin Chung, Estela Area Gomez, Augustine M.K. Choi, Jin-Fu Xu, Suzanne M. Cloonan
JCI Insight. 2023 Aug 22; 8(16): e163403. Published online 2023 Aug 22. doi: 10.1172/jci.insight.163403
PMCID:
PMC10543729
AbstractArticlePDF–11M
8.
High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
Xuefei Chen, Wenhua Huang, Jingbo Zhang, Yanjun Li, Zheng Xing, Lanlan Guo, Hongfeng Jiang, Jing Zhang
BMC Biol. 2023; 21: 196. Published online 2023 Sep 19. doi: 10.1186/s12915-023-01698-9
PMCID:
PMC10510295
AbstractArticlePDF–7.9M
9.
CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications
Zhe Gong, Jinjin Zhu, Junxin Chen, Fan Feng, Haitao Zhang, Zheyuan Zhang, Chenxin Song, Kaiyu Liang, Shuhui Yang, Shunwu Fan, Xiangqian Fang, Shuying Shen
Nat Commun. 2023; 14: 5242. Published online 2023 Aug 28. doi: 10.1038/s41467-023-40975-7
PMCID:
PMC10462713
AbstractArticlePDF–9.7M
10.
Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth
Kanako Kobayashi, Kazuko Iwasa, Rika Azuma-Suzuki, Takeshi Kawauchi, Yo-ichi Nabeshima
Life Sci Alliance. 2023 Oct; 6(10): e202301916. Published online 2023 Aug 4. doi: 10.26508/lsa.202301916
PMCID:
PMC10403640
AbstractArticlePDF–2.1M
11.
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech
Cell Rep. Author manuscript; available in PMC 2023 Jun 22.
Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112488. Published online 2023 May 8. doi: 10.1016/j.celrep.2023.112488
PMCID:
PMC10286105
AbstractArticlePDF–3.3M
12.
Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice
Hyesun Shin, Shinhee Park, Jisu Hong, Ae-Rin Baek, Junehyuk Lee, Do-Jin Kim, An-Soo Jang, Su Sie Chin, Sung Hwan Jeong, Sung-Woo Park
Sci Rep. 2023; 13: 9044. Published online 2023 Jun 3. doi: 10.1038/s41598-023-36009-3
PMCID:
PMC10239437
AbstractArticlePDF–5.2M
13.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN
Kaini Zhang, Chen Yang, Xin Zhou, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen, Xiubin Liang, Dongming Su
Cell Mol Life Sci. 2023 Jun; 80(6): 168. Published online 2023 May 30. doi: 10.1007/s00018-023-04820-w
PMCID:
PMC10229743
AbstractArticlePDF–2.9M
14.
De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics
Leslie A. Rowland, Adilson Guilherme, Felipe Henriques, Chloe DiMarzio, Sean Munroe, Nicole Wetoska, Mark Kelly, Keith Reddig, Gregory Hendricks, Meixia Pan, Xianlin Han, Olga R. Ilkayeva, Christopher B. Newgard, Michael P. Czech
Nat Commun. 2023; 14: 1362. Published online 2023 Mar 13. doi: 10.1038/s41467-023-37016-8
PMCID:
PMC10011520
AbstractArticlePDF–5.3M
15.
Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2
George I. Habeos, Fotini Filippopoulou, Evagelia E. Habeos, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, George Lagoumintzis, Athanasios Niarchos, Christos D. Georgiou, Dionysios V. Chartoumpekis
Antioxidants (Basel) 2022 Nov; 11(11): 2274. Published online 2022 Nov 17. doi: 10.3390/antiox11112274
PMCID:
PMC9687455
AbstractArticlePDF–2.0M
16.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
17.
The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation
Ziyi Song, Alus M. Xiaoli, Youlei Li, Gerile Siqin, Tian Wu, Randy Strich, Jeffrey E. Pessin, Fajun Yang
Mol Metab. 2022 Oct; 64: 101548. Published online 2022 Jul 19. doi: 10.1016/j.molmet.2022.101548
PMCID:
PMC9386464
AbstractArticlePDF–6.6M
18.
Therapeutic efficacy of FASN inhibition in preclinical models of HCC
Haichuan Wang, Yi Zhou, Hongwei Xu, Xue Wang, Yi Zhang, Runze Shang, Marie O'Farrell, Stephanie Roessler, Carsten Sticht, Andreas Stahl, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen
Hepatology. Author manuscript; available in PMC 2023 Oct 1.
Published in final edited form as: Hepatology. 2022 Oct; 76(4): 951–966. Published online 2022 Feb 16. doi: 10.1002/hep.32359
PMCID:
PMC9309180
AbstractArticlePDF–3.8M
19.
Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer
James Drury, Lyndsay E. A. Young, Timothy L. Scott, Courtney O. Kelson, Daheng He, Jinpeng Liu, Yuanyan Wu, Chi Wang, Heidi L. Weiss, Teresa Fan, Matthew S. Gentry, Ramon Sun, Yekaterina Y. Zaytseva
Int J Mol Sci. 2022 Jun; 23(12): 6510. Published online 2022 Jun 10. doi: 10.3390/ijms23126510
PMCID:
PMC9245602
AbstractArticlePDF–4.5M
20.
The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring’s Muscle Development and Energy Homeostasis
Saeed Ghnaimawi, Shilei Zhang, Jamie I. Baum, Yan Huang
Front Physiol. 2022; 13: 881624. Published online 2022 Jun 6. doi: 10.3389/fphys.2022.881624
PMCID:
PMC9207413
AbstractArticlePDF–6.0M

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