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Select item 114062481.

Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing

Yoshika Hayakawa-Yano, Takako Furukawa, Tsuyoshi Matsuo, Takahisa Ogasawara, Masahiro Nogami, Kazumasa Yokoyama, Masato Yugami, Munehisa Shinozaki, Chihiro Nakamoto, Kenji Sakimura, Akihide Koyama, Kazuhiro Ogi, Osamu Onodera, Hirohide Takebayashi, Hideyuki Okano, Masato Yano

Proc Natl Acad Sci U S A. 2024 Sep 10; 121(37): e2401531121. Published online 2024 Sep 3. doi: 10.1073/pnas.2401531121

PMCID:: PMC11406248

Abstract Article PDF–5.2M

Select item 112648852.

USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1

Min Tang, Han Cao, Yunqin Ma, Shuangshuang Yao, Xiaohui Wei, Yijiong Tan, Fang liu, Yongde Peng, Nengguang Fan

J Transl Med. 2024; 22: 671. Published online 2024 Jul 20. doi: 10.1186/s12967-024-05465-4

PMCID:: PMC11264885

Abstract Article PDF–15M

Select item 112643823.

Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis

Yuling Sun, Lei Ji, Wei Liu, Jing Sun, Penggang Liu, Xiaoquan Wang, Xiufan Liu, Xiulong Xu

Cell Commun Signal. 2024; 22: 372. Published online 2024 Jul 23. doi: 10.1186/s12964-024-01727-2

PMCID:: PMC11264382

Abstract Article PDF–11M

Select item 110146574.

A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis

Jingwen Yang, Lingxin Zhu, Haichun Pan, Hiroki Ueharu, Masako Toda, Qian Yang, Shawn A. Hallett, Lorin E. Olson, Yuji Mishina

J Clin Invest. 2024 Apr 15; 134(8): e165787. Published online 2024 Mar 11. doi: 10.1172/JCI165787

PMCID:: PMC11014657

Abstract Article PDF–16M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103943316.

Tripartite motif 38 alleviates the pathological process of NAFLD–NASH by promoting TAB2 degradation

Xinxin Yao, Ruixiang Dong, Sha Hu, Zhen Liu, Jie Cui, Fengjiao Hu, Xu Cheng, Xiaoming Wang, Tengfei Ma, Song Tian, Xiao-Jing Zhang, Yufeng Hu, Lan Bai, Hongliang Li, Peng Zhang

J Lipid Res. 2023 Jul; 64(7): 100382. Published online 2023 Apr 26. doi: 10.1016/j.jlr.2023.100382

PMCID:: PMC10394331

Abstract Article PDF–3.1M

Select item 103226787.

Targeted regulation of TAK1 counteracts dystrophinopathy in a DMD mouse model

Anirban Roy, Tatiana E. Koike, Aniket S. Joshi, Meiricris Tomaz da Silva, Kavya Mathukumalli, Mingfu Wu, Ashok Kumar

JCI Insight. 2023 May 22; 8(10): e164768. Published online 2023 May 22. doi: 10.1172/jci.insight.164768

PMCID:: PMC10322678

Abstract Article PDF–24M

Select item 101229128.

SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1‐Dependent Manner

Qiaofeng Qian, Fengjiao Hu, Wenjun Yu, Dewen Leng, Yang Li, Hongjie Shi, Dawei Deng, Kehan Ding, Chuan Liang, Jinping Liu

J Am Heart Assoc. 2023 Apr 4; 12(7): e028628. Published online 2023 Mar 28. doi: 10.1161/JAHA.122.028628

PMCID:: PMC10122912

Abstract Article PDF–25M

Select item 101226199.

TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis

Dilaware Khan, Peter Bedner, Julia Müller, Fabienne Lülsberg, Lukas Henning, Marco Prinz, Christian Steinhäuser, Sajjad Muhammad

Mol Neurobiol. 2023; 60(6): 3413–3422. Published online 2023 Mar 2. doi: 10.1007/s12035-023-03290-2

PMCID:: PMC10122619

Abstract Article PDF–12M

Select item 1011298210.

Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer's disease mouse models

Kazuhito Sai, Aoi Nakanishi, Kimberly M. Scofield, Debra A. Tokarz, Keith E. Linder, Todd J. Cohen, Jun Ninomiya-Tsuji

J Cell Sci. 2023 Mar 15; 136(6): jcs260102. Published online 2023 Mar 13. doi: 10.1242/jcs.260102

PMCID:: PMC10112982

Abstract Article

Select item 1007043811.

E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2

Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren, Liwen Yu, Qian Li, Yapeng Liu, Wenqian Qi, Yonghao Hou, Wenhai Sui, Guohai Su, Yun Zhang, Cheng Zhang, Meng Zhang

Cell Death Differ. 2023 Apr; 30(4): 966–978. Published online 2023 Jan 21. doi: 10.1038/s41418-023-01115-2

PMCID:: PMC10070438

Abstract Article PDF–11M

Select item 967182612.

MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure

Vijay Saxena, Samuel Arregui, Malgorzata Maria Kamocka, David S. Hains, Andrew Schwaderer

J Cell Biochem. 2022 Nov; 123(11): 1817–1826. Published online 2022 Aug 12. doi: 10.1002/jcb.30318

PMCID:: PMC9671826

Abstract Article PDF–1.0M

Select item 955579713.

TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells

Melissa Rodrigues, Tsvetana Petrova, Brendan Tibbs, J. Simon C. Arthur, Philip Cohen

Biochem J. 2022 Sep 16; 479(17): 1891–1907. Prepublished online 2022 Sep 5. Published online 2022 Sep 16. doi: 10.1042/BCJ20220314

PMCID:: PMC9555797

Abstract Article PDF–6.9M

Select item 928853614.

Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1

Yonggang Zou, Qi Zheng, Bin Jiang, Yuning Liu, Yanhua Xu, Liang Ma, Zonghao Hu, Ming Wu, Hai Song

Cell Death Dis. 2022 Jul; 13(7): 618. Published online 2022 Jul 16. doi: 10.1038/s41419-022-05076-1

PMCID:: PMC9288536

Abstract Article PDF–5.1M

Select item 921140615.

TNF-α/Fas-RIP-1–induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations

Yechen Xiao, Hongling Li, Jun Zhang, Andrew Volk, Shubin Zhang, Wei Wei, Shanshan Zhang, Peter Breslin, Jiwang Zhang

Blood. 2011 Dec 1; 118(23): 6057–6067. Prepublished online 2011 Oct 11. doi: 10.1182/blood-2011-06-359448

PMCID:: PMC9211406

Abstract Article

Select item 838263116.

The inflammatory signalling mediator TAK1 mediates lymphocyte recruitment to lipopolysaccharide-activated murine mesenchymal stem cells through interleukin-6

Beatrice Oelze, Kirsten Elger, Patrik Schadzek, Laura Burmeister, Anika Hamm, Sandra Laggies, Virginia Seiffart, Gerhard Gross, Andrea Hoffmann

Mol Cell Biochem. 2021; 476(10): 3655–3670. Published online 2021 May 29. doi: 10.1007/s11010-021-04180-8

PMCID:: PMC8382631

Abstract Article PDF–1.9M

Select item 831323917.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 823759418.

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization

Wilfred López-Pérez, Kazuhito Sai, Yosuke Sakamachi, Cameron Parsons, Sophia Kathariou, Jun Ninomiya-Tsuji

Proc Natl Acad Sci U S A. 2021 Jun 22; 118(25): e2023647118. Published online 2021 Jun 14. doi: 10.1073/pnas.2023647118

PMCID:: PMC8237594

Abstract Article PDF–1.4M

Select item 819248019.

Microbiota Regulate Innate Immune Signaling and Protective Immunity against Cancer

Changsheng Xing, Mingjun Wang, Adebusola A. Ajibade, Peng Tan, Chuntang Fu, Lang Chen, Motao Zhu, Zhao-Zhe Hao, Junjun Chu, Xiao Yu, Bingnan Yin, Jiahui Zhu, Wan-Jou Shen, Tianhao Duan, Helen Y. Wang, Rong-Fu Wang

Cell Host Microbe. Author manuscript; available in PMC 2022 Jun 9.

Published in final edited form as: Cell Host Microbe. 2021 Jun 9; 29(6): 959–974.e7. Published online 2021 Apr 23. doi: 10.1016/j.chom.2021.03.016

PMCID:: PMC8192480

Abstract Article PDF–3.7M

Select item 809881420.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

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