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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 105030422.

Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2

Huimin Huang, Wufei Zhu, Zongwei Huang, Dengze Zhao, Lu Cao, Xian Gao

J Orthop Surg Res. 2023; 18: 687. Published online 2023 Sep 14. doi: 10.1186/s13018-023-04165-x

PMCID:: PMC10503042

Abstract Article PDF–9.3M

Select item 102362033.

HIPK2 in the physiology of nervous system and its implications in neurological disorders

F. Sardina, A. Conte, S. Paladino, G.M. Pierantoni, C. Rinaldo

Biochim Biophys Acta Mol Cell Res. 2023 Jun; 1870(5): 119465. doi: 10.1016/j.bbamcr.2023.119465

PMCID:: PMC10236203

Abstract Article

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 96062805.

miR-4653-3p overexpression is associated with a poor prognosis of pancreatic ductal adenocarcinoma via HIPK2 downregulation

Kenichi Hirabayashi, Masaki Miyazawa, Yumi Takanashi, Masashi Morimachi, Aya Kawanishi, Tsubasa Saika, Toshio Nakagohri, Naoya Nakamura

Sci Rep. 2022; 12: 17927. Published online 2022 Oct 26. doi: 10.1038/s41598-022-22950-2

PMCID:: PMC9606280

Abstract Article PDF–2.4M

Select item 95261396.

Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling

Qiulian Zhou, Danni Meng, Feng Li, Xiao Zhang, Li Liu, Yujiao Zhu, Shuqin Liu, Minjun Xu, Jiali Deng, Zhiyong Lei, Joost P.G. Sluijter, Junjie Xiao

eBioMedicine. 2022 Nov; 85: 104274. Published online 2022 Sep 28. doi: 10.1016/j.ebiom.2022.104274

PMCID:: PMC9526139

Abstract Article PDF–4.1M

Select item 93464717.

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation

Mi Chen, Shreyas Lingadahalli, Nitin Narwade, Kate Man Kei Lei, Shanshan Liu, Zuxianglan Zhao, Yimin Zheng, Qian Lu, Alexander Hin Ning Tang, Terence Chuen Wai Poon, Edwin Cheung

EMBO Rep. 2022 Aug; 23(8): e53468. Published online 2022 Jul 4. doi: 10.15252/embr.202153468

PMCID:: PMC9346471

Abstract Article PDF–5.2M

Select item 88288958.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 86932829.

Exercise and cardioprotection: A “HIP” side of HIPK2 in the heart

Arintaya Phrommintikul, Siriporn C Chattipakorn, Nipon Chattipakorn

EBioMedicine. 2022 Jan; 75: 103766. Published online 2021 Dec 17. doi: 10.1016/j.ebiom.2021.103766

PMCID:: PMC8693282

Article PDF–100K

Select item 859537210.

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

Ines H. Kaltheuner, Kanchan Anand, Jonas Moecking, Robert Düster, Jinhua Wang, Nathanael S. Gray, Matthias Geyer

Nat Commun. 2021; 12: 6607. Published online 2021 Nov 16. doi: 10.1038/s41467-021-26935-z

PMCID:: PMC8595372

Abstract Article PDF–3.6M

Select item 831916811.

Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2

Dong Ha Kim, Hyojeong Park, Yun Jung Choi, Myoung-Hee Kang, Tae-Keun Kim, Chan-Gi Pack, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho

Cell Death Dis. 2021 Aug; 12(8): 747. Published online 2021 Jul 28. doi: 10.1038/s41419-021-04024-9

PMCID:: PMC8319168

Abstract Article PDF–4.0M

Select item 826665812.

Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP–HIPK2 axis

Xiaofeng Jin, Shi Qing, Qian Li, Hui Zhuang, Liliang Shen, Jinhui Li, Honggang Qi, Ting Lin, Zihan Lin, Jian Wang, Xinyi Cao, Jianye Yang, Qi Ma, Linghua Cong, Yang Xi, Shuai Fang, Xiaodan Meng, Zhaohui Gong, Meng Ye, Shuyun Wang, Chenji Wang, Kun Gao

Nucleic Acids Res. 2021 Jul 9; 49(12): 6788–6803. Published online 2021 Jun 16. doi: 10.1093/nar/gkab489

PMCID:: PMC8266658

Abstract Article PDF–5.9M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810612714.

CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis

Xia Li, Meiting Qu, Jie Zhang, Kuanyin Chen, Xianghui Ma

J Orthop Surg Res. 2021; 16: 302. Published online 2021 May 8. doi: 10.1186/s13018-021-02432-3

PMCID:: PMC8106127

Abstract Article PDF–5.1M

Select item 796902315.

DAZAP2 acts as specifier of the p53 response to DNA damage

Magdalena C Liebl, Jutta Moehlenbrink, Huong Becker, Günter Raddatz, Suhaib K Abdeen, Rami I Aqeilan, Frank Lyko, Thomas G Hofmann

Nucleic Acids Res. 2021 Mar 18; 49(5): 2759–2776. Published online 2021 Feb 16. doi: 10.1093/nar/gkab084

PMCID:: PMC7969023

Abstract Article PDF–3.5M

Select item 778001816.

Inactivation of homeodomain‐interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53‐dependent E‐cadherin expression

Xueqing Zheng, Yuemei Pan, Xinming Chen, Shu Xia, Yaying Hu, Yi Zhou, Jiali Zhang

Cancer Sci. 2021 Jan; 112(1): 117–132. Published online 2020 Nov 9. doi: 10.1111/cas.14691

PMCID:: PMC7780018

Abstract Article PDF–3.5M

Select item 753658017.

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations

Dervla M. Connaughton, Rufeng Dai, Danielle J. Owen, Jonathan Marquez, Nina Mann, Adda L. Graham-Paquin, Makiko Nakayama, Etienne Coyaud, Estelle M.N. Laurent, Jonathan R. St-Germain, Lot Snijders Blok, Arianna Vino, Verena Klämbt, Konstantin Deutsch, Chen-Han Wilfred Wu, Caroline M. Kolvenbach, Franziska Kause, Isabel Ottlewski, Ronen Schneider, Thomas M. Kitzler, Amar J. Majmundar, Florian Buerger, Ana C. Onuchic-Whitford, Mao Youying, Amy Kolb, Daanya Salmanullah, Evan Chen, Amelie T. van der Ven, Jia Rao, Hadas Ityel, Steve Seltzsam, Johanna M. Rieke, Jing Chen, Asaf Vivante, Daw-Yang Hwang, Stefan Kohl, Gabriel C. Dworschak, Tobias Hermle, Mariëlle Alders, Tobias Bartolomaeus, Stuart B. Bauer, Michelle A. Baum, Eva H. Brilstra, Thomas D. Challman, Jacob Zyskind, Carrie E. Costin, Katrina M. Dipple, Floor A. Duijkers, Marcia Ferguson, David R. Fitzpatrick, Roger Fick, Ian A. Glass, Peter J. Hulick, Antonie D. Kline, Ilona Krey, Selvin Kumar, Weining Lu, Elysa J. Marco, Ingrid M. Wentzensen, Heather C. Mefford, Konrad Platzer, Inna S. Povolotskaya, Juliann M. Savatt, Natalia V. Shcherbakova, Prabha Senguttuvan, Audrey E. Squire, Deborah R. Stein, Isabelle Thiffault, Victoria Y. Voinova, Michael J.G. Somers, Michael A. Ferguson, Avram Z. Traum, Ghaleb H. Daouk, Ankana Daga, Nancy M. Rodig, Paulien A. Terhal, Ellen van Binsbergen, Loai A. Eid, Velibor Tasic, Hila Milo Rasouly, Tze Y. Lim, Dina F. Ahram, Ali G. Gharavi, Heiko M. Reutter, Heidi L. Rehm, Daniel G. MacArthur, Monkol Lek, Kristen M. Laricchia, Richard P. Lifton, Hong Xu, Shrikant M. Mane, Simone Sanna-Cherchi, Andrew D. Sharrocks, Brian Raught, Simon E. Fisher, Maxime Bouchard, Mustafa K. Khokha, Shirlee Shril, Friedhelm Hildebrandt

Am J Hum Genet. 2020 Oct 1; 107(4): 727–742. Published online 2020 Sep 4. doi: 10.1016/j.ajhg.2020.08.013

PMCID:: PMC7536580

Abstract Article PDF–2.3M

Select item 734377718.

SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma

Yang Li, Yumin Lv, Chao Cheng, Yan Huang, Liu Yang, Jingjing He, Xingyu Tao, Yingying Hu, Yuting Ma, Yun Su, Liyang Wu, Guifang Yu, Qingping Jiang, Shu Liu, Xiong Liu, Zhen Liu

Cell Death Dis. 2020 Jul; 11(7): 509. Published online 2020 Jul 2. doi: 10.1038/s41419-020-2699-2

PMCID:: PMC7343777

Abstract Article PDF–2.3M

Select item 707272719.

An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis

Veronica Gatti, Manuela Ferrara, Ilaria Virdia, Silvia Matteoni, Laura Monteonofrio, Simona di Martino, Maria Grazia Diodoro, Giuliana Di Rocco, Cinzia Rinaldo, Silvia Soddu

Cells. 2020 Feb; 9(2): 484. Published online 2020 Feb 20. doi: 10.3390/cells9020484

PMCID:: PMC7072727

Abstract Article PDF–3.4M

Select item 695080920.

Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy

Yang Tang, Li Yang, Wan Qin, Min’ Xiao Yi, Bo Liu, Xiang’Lin Yuan

Radiat Oncol. 2020; 15: 9. Published online 2020 Jan 8. doi: 10.1186/s13014-019-1456-0

PMCID:: PMC6950809

Abstract Article PDF–689K

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