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Select item 112958841.

Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway

Taiyang Liao, Lei Shi, Chenglong He, Deren Liu, Yibao Wei, Zhenyuan Ma, Peimin Wang, Jun Mao, Peng Wu

J Transl Med. 2024; 22: 715. Published online 2024 Aug 1. doi: 10.1186/s12967-024-05540-w

PMCID:: PMC11295884

Abstract Article PDF–9.2M

Select item 109406502.

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras^G12D-driven tumors

Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna

EMBO Mol Med. 2024 Mar; 16(3): 475–505. Published online 2024 Feb 15. doi: 10.1038/s44321-024-00032-2

PMCID:: PMC10940650

Abstract Article PDF–33M

Select item 99513493.

Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta‐Gonad‐Mesonephros Region

Haizhen Wang, Di Liu, Haifeng Chen, Yuqing Jiao, Haixin Zhao, Zongcheng Li, Siyuan Hou, Yanli Ni, Rong Zhang, Jinyong Wang, Jie Zhou, Bing Liu, Yu Lan

Adv Sci (Weinh) 2023 Feb; 10(6): 2203813. Published online 2023 Jan 13. doi: 10.1002/advs.202203813

PMCID:: PMC9951349

Abstract Article PDF–4.3M

Select item 95618704.

ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts

Laura Gorrell, Elena Makareeva, Shakib Omari, Satoru Otsuru, Sergey Leikin

Adv Sci (Weinh) 2022 Oct; 9(29): 2201273. Published online 2022 Aug 21. doi: 10.1002/advs.202201273

PMCID:: PMC9561870

Abstract Article PDF–4.8M

Select item 87191035.

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway

Tongjie Wang, Chengxiang Xia, Qitong Weng, Kaitao Wang, Yong Dong, Sha Hao, Fang Dong, Xiaofei Liu, Lijuan Liu, Yang Geng, Yuxian Guan, Juan Du, Tao Cheng, Hui Cheng, Jinyong Wang

Haematologica. 2022 Jan 1; 107(1): 154–166. Published online 2020 Dec 10. doi: 10.3324/haematol.2019.239186

PMCID:: PMC8719103

Abstract Article PDF–2.4M

Select item 83132396.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 78436527.

NUPR1 is a critical repressor of ferroptosis

Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer, Daolin Tang

Nat Commun. 2021; 12: 647. Published online 2021 Jan 28. doi: 10.1038/s41467-021-20904-2

PMCID:: PMC7843652

Abstract Article PDF–1.2M

Select item 76631238.

Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality

Rajiv Kumar Sah, Jun Ma, Fatoumata Binta Bah, Zhenkai Xing, Salah Adlat, Zin Ma Oo, Yajun Wang, Noor Bahadar, Ameer Ali Bohio, Farooq Hayel Nagi, Xuechao Feng, Luqing Zhang, Yaowu Zheng

Int J Mol Sci. 2020 Nov; 21(21): 8223. Published online 2020 Nov 3. doi: 10.3390/ijms21218223

PMCID:: PMC7663123

Abstract Article PDF–4.7M

Select item 74739169.

NUPR1 preserves insulin secretion of pancreatic β-cells during inflammatory stress by multiple low-dose streptozotocin and high-fat diet

Günter Päth, Amir E. Mehana, Ingo H. Pilz, Marcus Alt, Johannes Baumann, Ines Sommerer, Albrecht Hoffmeister, Jochen Seufert

Am J Physiol Endocrinol Metab. 2020 Aug 1; 319(2): E338–E344. Published online 2020 Jun 23. doi: 10.1152/ajpendo.00088.2020

PMCID:: PMC7473916

Abstract Article

Select item 624293510.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

Patricia Santofimia-Castaño, Wenjun Lan, Jennifer Bintz, Odile Gayet, Alice Carrier, Gwen Lomberk, José Luis Neira, Antonio González, Raul Urrutia, Philippe Soubeyran, Juan Iovanna

Sci Rep. 2018; 8: 16999. Published online 2018 Nov 19. doi: 10.1038/s41598-018-35020-3

PMCID:: PMC6242935

Abstract Article PDF–2.1M

Select item 605766411.

p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet

Marcus Hollenbach, Nora Klöting, Ines Sommerer, Jana Lorenz, Mario Heindl, Matthias Kern, Joachim Mössner, Matthias Blüher, Albrecht Hoffmeister

PLoS One. 2018; 13(7): e0201159. Published online 2018 Jul 24. doi: 10.1371/journal.pone.0201159

PMCID:: PMC6057664

Abstract Article PDF–1.5M

Select item 599176812.

Nuclear m⁶A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

Seth D. Kasowitz, Jun Ma, Stephen J. Anderson, N. Adrian Leu, Yang Xu, Brian D. Gregory, Richard M. Schultz, P. Jeremy Wang

PLoS Genet. 2018 May; 14(5): e1007412. Published online 2018 May 25. doi: 10.1371/journal.pgen.1007412

PMCID:: PMC5991768

Abstract Article PDF–19M

Select item 528000613.

Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo

Pierre Galichon, Aurélien Bataille, Sophie Vandermeersch, Morgane Wetzstein, Yi-Chun Xu-Dubois, David Legouis, Alexandre Hertig, David Buob, Sandrine Placier, Naïke Bigé, Guillaume Lefevre, Chantal Jouanneau, Caroline Martin, Juan Lucio Iovanna, Eric Rondeau

J Am Soc Nephrol. 2017 Feb; 28(2): 545–556. Published online 2016 Jul 22. doi: 10.1681/ASN.2015080936

PMCID:: PMC5280006

Abstract Article

Select item 513489314.

Variants of Rab GTPase-effector binding protein-2 cause variation in the collateral circulation and severity of stroke

Jennifer L. Lucitti, Robert Sealock, Brian K. Buckley, Hua Zhang, Lin Xiao, Andrew C. Dudley, James E. Faber

Stroke. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Stroke. 2016 Dec; 47(12): 3022–3031. Published online 2016 Nov 3. doi: 10.1161/STROKEAHA.116.014160

PMCID:: PMC5134893

Abstract Article PDF–1.0M

Select item 503941415.

Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1

Naihong Yan, Lin Cheng, Kinsang Cho, Muhammad Taimur A. Malik, Lirong Xiao, Chenying Guo, Honghua Yu, Ruilin Zhu, Rajesh C. Rao, Dong Feng Chen

Sci Rep. 2016; 6: 33887. Published online 2016 Sep 28. doi: 10.1038/srep33887

PMCID:: PMC5039414

Abstract Article PDF–1.8M

Select item 500493916.

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

Adriano Maida, Annika Zota, Kim A. Sjøberg, Jonas Schumacher, Tjeerd P. Sijmonsma, Anja Pfenninger, Marie M. Christensen, Thomas Gantert, Jessica Fuhrmeister, Ulrike Rothermel, Dieter Schmoll, Mathias Heikenwälder, Juan L. Iovanna, Kerstin Stemmer, Bente Kiens, Stephan Herzig, Adam J. Rose

J Clin Invest. 2016 Sep 1; 126(9): 3263–3278. Published online 2016 Aug 22. doi: 10.1172/JCI85946