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Items: 1 to 20 of 134

1.
The plasminogen activator system: biology and regulation
J. P. Irigoyen, P. Muñoz-Cánoves, L. Montero, M. Koziczak, Y. Nagamine
Cell Mol Life Sci. 1999 Oct; 56(1-2): 104–132. doi: 10.1007/PL00000615
PMCID:
PMC11146966
AbstractArticlePDF–222K
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice
Yoshifumi Kida, Toshiya Okahisa, Yasushi Sato, Masahiro Bando, Shota Fujimoto, Beibei Ma, Tadahiko Nakagawa, Tomoyuki Kawaguchi, Fumika Nakamura, Koichi Okamoto, Hiroshi Miyamoto, Masahiro Sogabe, Koichi Tsuneyama, Tetsuji Takayama
Sci Rep. 2023; 13: 2899. Published online 2023 Feb 18. doi: 10.1038/s41598-023-29824-1
PMCID:
PMC9938860
AbstractArticlePDF–2.0M
4.
Urokinase System in Pathogenesis of Pulmonary Fibrosis: A Hidden Threat of COVID-19
Anna A. Shmakova, Vladimir S. Popov, Iliya P. Romanov, Nikita R. Khabibullin, Nailya R. Sabitova, Anna A. Karpukhina, Yana A. Kozhevnikova, Ella V. Kurilina, Zoya I. Tsokolaeva, Polina S. Klimovich, Kseniya A. Rubina, Yegor S. Vassetzky, Ekaterina V. Semina
Int J Mol Sci. 2023 Jan; 24(2): 1382. Published online 2023 Jan 10. doi: 10.3390/ijms24021382
PMCID:
PMC9867169
AbstractArticlePDF–3.8M
5.
The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
Vera Vorstandlechner, Maria Laggner, Dragan Copic, Katharina Klas, Martin Direder, Yiyan Chen, Bahar Golabi, Werner Haslik, Christine Radtke, Erwin Tschachler, Konrad Hötzenecker, Hendrik Jan Ankersmit, Michael Mildner
Nat Commun. 2021; 12: 6242. Published online 2021 Oct 29. doi: 10.1038/s41467-021-26495-2
PMCID:
PMC8556235
AbstractArticlePDF–6.7M
6.
GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling
Wenjun Peng, Yuanyuan Wu, Ge Zhang, Wensi Zhu, Meijia Chang, Ainiwaer Rouzi, Weipeng Jiang, Lin Tong, Qin Wang, Jie Liu, Yuanlin Song, Huayin Li, Ka Li, Jian Zhou
Int J Chron Obstruct Pulmon Dis. 2021; 16: 2817–2832. Published online 2021 Oct 8. doi: 10.2147/COPD.S328313
PMCID:
PMC8517531
AbstractArticlePDF–11M
7.
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice
Yu-Wen Cheng, Ze-Bei Zhang, Bei-Di Lan, Jing-Rong Lin, Xiao-Hui Chen, Ling-Ran Kong, Lian Xu, Cheng-Chao Ruan, Ping-Jin Gao
J Exp Med. 2021 Sep 6; 218(9): e20210252. Published online 2021 Jul 8. doi: 10.1084/jem.20210252
PMCID:
PMC8273546
AbstractArticlePDF–5.6M
8.
Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade
Gibran Ali, Mo Zhang, Runzhen Zhao, Krishan G. Jain, Jianjun Chang, Satoshi Komatsu, Beiyun Zhou, Jiurong Liang, Michael A. Matthay, Hong-Long Ji
Signal Transduct Target Ther. 2021; 6: 97. Published online 2021 Feb 27. doi: 10.1038/s41392-021-00511-9
PMCID:
PMC7910758
ArticlePDF–1002K
9.
Urokinase-Type Plasminogen Activator Protects Cerebral Cortical Neurons from Soluble Aβ-Induced Synaptic Damage
Ariel Diaz, Paola Merino, Ji-Dong Guo, Manuel A. Yepes, Patrick McCann, Tapasya Katta, Elise M. Tong, Enrique Torre, Srikant Rangaraju, Manuel Yepes
J Neurosci. 2020 May 20; 40(21): 4251–4263. doi: 10.1523/JNEUROSCI.2804-19.2020
PMCID:
PMC7244203
AbstractArticlePDF–3.1M
10.
Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis
Jeffrey C. Horowitz, Daniel J. Tschumperlin, Kevin K. Kim, John J. Osterholzer, Natalya Subbotina, Iyabode O. Ajayi, Seagal Teitz-Tennenbaum, Ammara Virk, Megan Dotson, Fei Liu, Delphine Sicard, Shijing Jia, Thomas H. Sisson
Thromb Haemost. Author manuscript; available in PMC 2020 Feb 11.
Published in final edited form as: Thromb Haemost. 2019 Dec; 119(12): 1968–1980. Published online 2019 Nov 8. doi: 10.1055/s-0039-1697953
PMCID:
PMC7011401
AbstractArticlePDF–1.6M
11.
Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse
Paola Merino, Ariel Diaz, Enrique R. Torre, Manuel Yepes
J Biol Chem. 2020 Jan 10; 295(2): 619–630. Published online 2019 Dec 9. doi: 10.1074/jbc.RA119.010644
PMCID:
PMC6956544
AbstractArticlePDF–1.9M
12.
Deficiency of Urokinase Plasminogen Activator May Impair β Cells Regeneration and Insulin Secretion in Type 2 Diabetes Mellitus
Chung-Ze Wu, Shih-Hsiang Ou, Li-Chien Chang, Yuh-Feng Lin, Dee Pei, Jin-Shuen Chen
Molecules. 2019 Dec; 24(23): 4208. Published online 2019 Nov 20. doi: 10.3390/molecules24234208
PMCID:
PMC6930534
AbstractArticlePDF–3.6M
13.
Mice Lacking tPA, uPA, or Plasminogen Genes Showed Delayed Functional Recovery after Sciatic Nerve Crush
Lisa B. Siconolfi, Nicholas W. Seeds
J Neurosci. 2001 Jun 15; 21(12): 4348–4355. doi: 10.1523/JNEUROSCI.21-12-04348.2001
PMCID:
PMC6762762
AbstractArticlePDF–567K
14.
The urokinase‐type plasminogen activator system as drug target in retinitis pigmentosa: New pre‐clinical evidence in the rd10 mouse model
Maurizio Cammalleri, Massimo Dal Monte, Filippo Locri, Valeria Pecci, Mario De Rosa, Vincenzo Pavone, Paola Bagnoli
J Cell Mol Med. 2019 Aug; 23(8): 5176–5192. Published online 2019 Jun 28. doi: 10.1111/jcmm.14391
PMCID:
PMC6653070
AbstractArticlePDF–1.9M
15.
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta
Evangelia Koutelou, Li Wang, Andria C. Schibler, Hsueh-Ping Chao, Xianghong Kuang, Kevin Lin, Yue Lu, Jianjun Shen, Collene R. Jeter, Andrew Salinger, Marenda Wilson, Yi Chun Chen, Boyko S. Atanassov, Dean G. Tang, Sharon Y. R. Dent
Development. 2019 Feb 15; 146(4): dev174037. Published online 2019 Feb 22. doi: 10.1242/dev.174037
PMCID:
PMC6398448
AbstractArticle
16.
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy
Terry R. Medler, Dhaarini Murugan, Wesley Horton, Sushil Kumar, Tiziana Cotechini, Alexandra M. Forsyth, Patrick Leyshock, Justin J. Leitenberger, Molly Kulesz-Martin, Adam A. Margolin, Zena Werb, Lisa M. Coussens
Cancer Cell. Author manuscript; available in PMC 2019 Oct 8.
Published in final edited form as: Cancer Cell. 2018 Oct 8; 34(4): 561–578.e6. doi: 10.1016/j.ccell.2018.09.003
PMCID:
PMC6246036
ArticlePDF–1.9M
17.
Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation
Susan M. Corley, Veronica Mendoza-Reinoso, Nichole Giles, Emma Suwanun Singer, John E. Common, Marc R. Wilkins, Annemiek Beverdam
Cell Death Dis. 2018 Nov; 9(11): 1106. Published online 2018 Oct 31. doi: 10.1038/s41419-018-1141-5
PMCID:
PMC6208416
AbstractArticlePDF–2.7M
18.
Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain
Paola Merino, Ariel Diaz, Luis Guillermo Manrique, Lihong Cheng, Manuel Yepes
J Biol Chem. 2018 Jun 15; 293(24): 9234–9247. Published online 2018 May 2. doi: 10.1074/jbc.RA118.002534
PMCID:
PMC6005443
AbstractArticlePDF–3.5M
19.
Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation
Tobias Kromann-Hansen, Eva Louise Lange, Ida K. Lund, Gunilla Høyer-Hansen, Peter A. Andreasen, Elizabeth A. Komives
PLoS One. 2018; 13(2): e0192661. Published online 2018 Feb 8. doi: 10.1371/journal.pone.0192661
PMCID:
PMC5805342
AbstractArticlePDF–7.5M
20.
Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors
Victoria Stepanova, Konstantin V. Dergilev, Kelci R. Holman, Yelena V. Parfyonova, Zoya I. Tsokolaeva, Mimi Teter, Elena N. Atochina-Vasserman, Alla Volgina, Sergei V. Zaitsev, Shane P. Lewis, Fedor G. Zabozlaev, Kseniya Obraztsova, Vera P. Krymskaya, Douglas B. Cines
J Biol Chem. 2017 Dec 15; 292(50): 20528–20543. Published online 2017 Sep 27. doi: 10.1074/jbc.M117.799593
PMCID:
PMC5733590
AbstractArticlePDF–2.9M

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