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Select item 109836671.

CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1

Guiyong Jiang, Yu Cai, Duo Cheng, Hao Wang, Geyang Deng, Dayong Xiang

J Orthop Surg Res. 2024; 19: 212. Published online 2024 Apr 1. doi: 10.1186/s13018-024-04675-2

PMCID:: PMC10983667

Abstract Article PDF–9.0M

Select item 109386052.

Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s disease

Sheila K. Pirooznia, Hu Wang, Nikhil Panicker, Manoj Kumar, Stewart Neifert, Mohamad Aasif Dar, Evan Lau, Bong Gu Kang, Javier Redding-Ochoa, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson

Sci Adv. 2022 Apr; 8(13): eabh1824. Published online 2022 Apr 1. doi: 10.1126/sciadv.abh1824

PMCID:: PMC10938605

Abstract Article PDF–8.9M

Select item 99455423.

Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum

Shu-yi Tan, Jin-xiang Jiang, Hui-xian Huang, Xiu-ping Mo, Jing-ru Feng, Yu Chen, Li Yang, Cheng Long

Front Mol Neurosci. 2023; 16: 1107355. Published online 2023 Feb 8. doi: 10.3389/fnmol.2023.1107355

Correction in:: Front Mol Neurosci. 2023; 16: 1162275.

PMCID:: PMC9945542

Abstract Article PDF–12M

Select item 89739574.

Impact of CYLD on chromatin structure and histone methylation in malignant melanoma

Mandy Schott, Melanie Kappelmann-Fenzl, Stefan Fischer, Maite G. Fernandez-Barrena, Antonio Pineda-Lucena, Matías A. Ávila, Silke Kuphal, Anja-Katrin Bosserhoff

Int J Mol Med. 2022 May; 49(5): 66. Published online 2022 Mar 15. doi: 10.3892/ijmm.2022.5122

PMCID:: PMC8973957

Abstract Article PDF–3.7M

Select item 88324615.

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun

Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247

PMCID:: PMC8832461

Abstract Article

Select item 87292346.

The deubiquitinase CYLD controls protective immunity against helminth infection by regulation of Treg plasticity

Jee H. Lee, Le Zou, Runqing Yang, Jihye Han, Qingqing Wan, Xian Zhang, Sarah El Baghdady, Andrea Roman, Chris Elly, Hyung-seung Jin, Yoon Park, Michael Croft, Yun-Cai Liu

J Allergy Clin Immunol. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: J Allergy Clin Immunol. 2021 Jul; 148(1): 209–224.e9. Published online 2020 Dec 10. doi: 10.1016/j.jaci.2020.10.042

PMCID:: PMC8729234

Abstract Article PDF–3.3M

Select item 86857177.

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death

Rosalind L. Ang, Mark Chan, Diana Legarda, John P. Sundberg, Shao-Cong Sun, Virginia L. Gillespie, Nicholas Chun, Peter S. Heeger, Huabao Xiong, Sergio A. Lira, Adrian T. Ting

Proc Natl Acad Sci U S A. 2021 Dec 14; 118(50): e2001602118. Published online 2021 Dec 9. doi: 10.1073/pnas.2001602118

PMCID:: PMC8685717

Abstract Article PDF–2.2M

Select item 84850668.

Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala

Hui-dong Li, Dan-ni Li, Li Yang, Cheng Long

Front Cell Neurosci. 2021; 15: 740165. Published online 2021 Sep 17. doi: 10.3389/fncel.2021.740165

PMCID:: PMC8485066

Abstract Article PDF–3.9M

Select item 84066829.

Vinpocetine suppresses Streptococcus pneumoniae-induced inflammation via inhibition of ERK1 by CYLD

Kensei Komatsu, Dae-Hwan Nam, Ji-Yun Lee, Go Yoneda, Chen Yan, Jian-Dong Li

J Immunol. Author manuscript; available in PMC 2021 Aug 31.

Published in final edited form as: J Immunol. 2020 Feb 15; 204(4): 933–942. Published online 2020 Jan 3. doi: 10.4049/jimmunol.1901299

PMCID:: PMC8406682

Abstract Article PDF–1.9M

Select item 831323910.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 826844311.

CYLD Inhibits the Development of Skin Squamous Cell Tumors in Immunocompetent Mice

Josefa P. Alameda, Verónica A. García-García, Silvia López, Ana Hernando, Angustias Page, Manuel Navarro, Rodolfo Moreno-Maldonado, Jesús M. Paramio, Ángel Ramírez, Rosa A. García-Fernández, María Llanos Casanova

Int J Mol Sci. 2021 Jul; 22(13): 6736. Published online 2021 Jun 23. doi: 10.3390/ijms22136736

PMCID:: PMC8268443

Abstract Article PDF–4.2M

Select item 818390812.

CYLD deficiency causes auditory neuropathy due to reduced neurite outgrowth

Song Yang, Nan Ma, Xuemei Wu, Hua Ni, Siqi Gao, Lei Sun, Peng Zhou, Tala, Jie Ran, Jun Zhou, Min Liu, Dengwen Li

J Clin Lab Anal. 2021 Jun; 35(6): e23783. Published online 2021 May 2. doi: 10.1002/jcla.23783

PMCID:: PMC8183908

Abstract Article PDF–946K

Select item 809881413.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

Select item 793877014.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 788144315.

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

Sandip Mukherjee, Ritesh Kumar, Elviche Tsakem Lenou, Venkatesha Basrur, Dimitris L. Kontoyiannis, Fotis Ioakeimidis, George Mosialos, Arianne L. Theiss, Richard A. Flavell, K. Venuprasad

Nat Immunol. Author manuscript; available in PMC 2021 Feb 13.

Published in final edited form as: Nat Immunol. 2020 Jun; 21(6): 626–635. Published online 2020 May 18. doi: 10.1038/s41590-020-0681-x

PMCID:: PMC7881443

Abstract Article PDF–3.3M

Select item 748335916.

CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

Lei Qi, Huimei Zang, Weiwei Wu, Prakash Nagarkatti, Mitzi Nagarkatti, Qinghang Liu, Jeffrey Robbins, Xuejun Wang, Taixing Cui

J Mol Cell Cardiol. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: J Mol Cell Cardiol. 2020 Aug; 145: 59–73. Published online 2020 Jun 14. doi: 10.1016/j.yjmcc.2020.06.004

PMCID:: PMC7483359

Abstract Article PDF–2.7M

Select item 746602417.

The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling

Athanasios Pseftogas, Konstantinos Xanthopoulos, Theofilos Poutahidis, Chrysanthi Ainali, Dimitra Dafou, Emmanuel Panteris, Joseph G. Kern, Xaralabos Varelas, Alexander Hardas, Christos Gonidas, Anastasia Tsingotjidou, Eudoxia Hatzivassiliou, George Mosialos

Cancers (Basel) 2020 Aug; 12(8): 2047. Published online 2020 Jul 24. doi: 10.3390/cancers12082047

PMCID:: PMC7466024

Abstract Article PDF–12M

Select item 741599118.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 703254819.

CYLD, a Mechanosensitive Deubiquitinase, Regulates TGFβ Signaling in Load-Induced Bone Formation

Jacqueline Nguyen, Ramin Massoumi, Tamara Alliston

Bone. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Bone. 2020 Feb; 131: 115148. Published online 2019 Nov 9. doi: 10.1016/j.bone.2019.115148

PMCID:: PMC7032548

Abstract Article PDF–1.1M

Select item 677991320.

Loss of CYLD accelerates melanoma development and progression in the Tg(Grm1) melanoma mouse model

Miriam Martha de Jel, Mandy Schott, Susanne Lamm, Winfried Neuhuber, Silke Kuphal, Anja-Katrin Bosserhoff

Oncogenesis. 2019 Oct; 8(10): 56. Published online 2019 Oct 7. doi: 10.1038/s41389-019-0169-4

PMCID:: PMC6779913

Abstract Article PDF–1.3M

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