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Items: 1 to 20 of 120

1.
Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy
Badih Salman, Emeline Bon, Perrine Delers, Steve Cottin, Elena Pasho, Sorana Ciura, Delphine Sapaly, Suzie Lefebvre
Int J Mol Sci. 2024 Sep; 25(18): 10039. Published online 2024 Sep 18. doi: 10.3390/ijms251810039
PMCID:
PMC11431868
AbstractArticlePDF–3.2M
2.
Impact of KDM6B mosaic brain knockout on synaptic function and behavior
Bastian Brauer, Carlos Ancatén-González, Constanza Ahumada-Marchant, Rodrigo C. Meza, Nicolas Merino-Veliz, Gino Nardocci, Lorena Varela-Nallar, Gloria Arriagada, Andrés E. Chávez, Fernando J. Bustos
Sci Rep. 2024; 14: 20416. Published online 2024 Sep 2. doi: 10.1038/s41598-024-70728-5
PMCID:
PMC11369245
AbstractArticlePDF–3.1M
3.
Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling
Sonya J. Wolf, Christopher O. Audu, Jadie Y. Moon, Amrita D. Joshi, William J. Melvin, Emily C. Barrett, Kevin Mangum, Gabriela Saldana de Jimenez, Sabrina Rocco, Sam Buckley, Zara Ahmed, Rachael Wasikowski, J. Michelle Kahlenberg, Lam C. Tsoi, Johann E. Gudjonsson, Katherine A. Gallagher
Diabetes. 2024 Sep; 73(9): 1462–1472. Published online 2024 Jun 13. doi: 10.2337/db23-0968
PMCID:
PMC11333374
AbstractArticlePDF–52M
4.
Kdm6b Regulates the Generation of Effector CD8+ T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes
Tianhao Xu, Alexander Schutte, Leandro Jimenez, Andre N. A. Gonçalves, Ashleigh Keller, Matthew E. Pipkin, Helder I. Nakaya, Renata M. Pereira, Gustavo J. Martinez
J Immunol. Author manuscript; available in PMC 2024 May 30.
Published in final edited form as: J Immunol. 2021 May 1; 206(9): 2170–2183. Published online 2021 Apr 16. doi: 10.4049/jimmunol.2001459
PMCID:
PMC11139061
AbstractArticlePDF–2.8M
5.
YAP represses intestinal inflammation through epigenetic silencing of JMJD3
Hua Zhu, Jiali Lu, MingYue Fu, Ping Chen, Yali Yu, Min Chen, Qiu Zhao, Min Wu, Mei Ye
Clin Epigenetics. 2024; 16: 14. Published online 2024 Jan 20. doi: 10.1186/s13148-024-01626-w
PMCID:
PMC10800074
AbstractArticlePDF–2.2M
6.
Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical models
Guo Ge, Peng Zhang, Pinpin Sui, Shi Chen, Hui Yang, Ying Guo, Ivan P. Rubalcava, Asra Noor, Caroline R. Delma, Joel Agosto-Peña, Hui Geng, Edward A. Medina, Ying Liang, Stephen D. Nimer, Ruben Mesa, Omar Abdel-Wahab, Mingjiang Xu, Feng-Chun Yang
J Clin Invest. 2024 Jan 2; 134(1): e163964. Published online 2024 Jan 2. doi: 10.1172/JCI163964
PMCID:
PMC10760961
AbstractArticlePDF–12M
7.
KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties
Marvin Sylvestre, Nicolas Barbier, Vonick Sibut, Saba Nayar, Céline Monvoisin, Simon Leonard, Julien Saint-Vanne, Ansie Martin, Marion Guirriec, Maëlle Latour, Florence Jouan, Sylvain Baulande, Mylène Bohec, Léa Verdière, Fatima Mechta-Grigoriou, Frédéric Mourcin, Nicolas Bertheuil, Francesca Barone, Karin Tarte, David Roulois
Sci Adv. 2023 Dec 1; 9(48): eadh2708. Published online 2023 Nov 29. doi: 10.1126/sciadv.adh2708
PMCID:
PMC10686565
AbstractArticlePDF–1.7M
8.
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation
Quan M Phan, Lucia Salz, Sam S Kindl, Jayden S Lopez, Sean M Thompson, Jasson Makkar, Iwona M Driskell, Ryan R Driskell
EMBO J. 2023 Oct; 42(19): e113880. Published online 2023 Aug 21. doi: 10.15252/embj.2023113880
PMCID:
PMC10548174
AbstractArticlePDF–4.5M
9.
The histone demethylase Utx controls CD8+ T‐cell‐dependent antitumor immunity via epigenetic regulation of the effector function
Haruna Noda, Junpei Suzuki, Yuko Matsuoka, Akira Matsumoto, Makoto Kuwahara, Yoshiaki Kamei, Yasutsugu Takada, Masakatsu Yamashita
Cancer Sci. 2023 Jul; 114(7): 2787–2797. Published online 2023 Apr 17. doi: 10.1111/cas.15814
PMCID:
PMC10323087
AbstractArticlePDF–6.8M
10.
Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis
Anning Chen, Zhun Sun, Donglin Sun, Meiying Huang, Hongwei Fang, Jinyuan Zhang, Guojun Qian
Front Immunol. 2023; 14: 1183871. Published online 2023 May 19. doi: 10.3389/fimmu.2023.1183871
PMCID:
PMC10235501
AbstractArticlePDF–7.4M
11.
Inhibition of H3K27me3 demethylases promotes plasmablast formation
Anna K. Kania, Muyao Guo, Christopher D. Scharer, Jeremy M. Boss
Immunohorizons. Author manuscript; available in PMC 2023 May 19.
Published in final edited form as: Immunohorizons. 2021 Dec 8; 5(12): 918–930. Published online 2021 Dec 8. doi: 10.4049/immunohorizons.2000087
PMCID:
PMC10197425
AbstractArticlePDF–1.7M
12.
Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics
Vijyendra Ramesh, Fang Liu, Melyssa S Minto, Urann Chan, Anne E West
eLife. 2023; 12: e86273. Published online 2023 Apr 24. doi: 10.7554/eLife.86273
PMCID:
PMC10181825
AbstractArticlePDF–9.1M
13.
Epigenetic dosage identifies two major and functionally distinct β-cell subtypes
Erez Dror, Luca Fagnocchi, Vanessa Wegert, Stefanos Apostle, Brooke Grimaldi, Tim Gruber, Ilaria Panzeri, Steffen Heyne, Kira Daniela Höffler, Victor Kreiner, Reagan Ching, Tess Tsai-Hsiu Lu, Ayush Semwal, Ben Johnson, Parijat Senapati, Adelheid Lempradl, Dustin Schones, Axel Imhof, Hui Shen, John Andrew Pospisilik
Cell Metab. Author manuscript; available in PMC 2024 May 2.
Published in final edited form as: Cell Metab. 2023 May 2; 35(5): 821–836.e7. Published online 2023 Mar 21. doi: 10.1016/j.cmet.2023.03.008
PMCID:
PMC10160009
AbstractArticlePDF–3.2M
14.
KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2
Yanan Wang, Nitin Khandelwal, Shuiqiao Liu, Mi Zhou, Lei Bao, Jennifer E Wang, Ashwani Kumar, Chao Xing, Jay Gibson, Yingfei Wang
Mol Psychiatry. Author manuscript; available in PMC 2023 Apr 17.
Published in final edited form as: Mol Psychiatry. 2022 Dec; 27(12): 5213–5226. Published online 2022 Aug 26. doi: 10.1038/s41380-022-01750-0
PMCID:
PMC10108576
AbstractArticlePDF–3.0M
15.
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
Nancy Issa, Hassan Bjeije, Elisabeth R. Wilson, Aishwarya Krishnan, Wangisa M.B. Dunuwille, Tyler M. Parsons, Christine R. Zhang, Wentao Han, Andrew L. Young, Zhizhong Ren, Kai Ge, Eunice S. Wang, Andrew P. Weng, Amanda Cashen, David H. Spencer, Grant A. Challen
Leukemia. Author manuscript; available in PMC 2023 Apr 8.
Published in final edited form as: Leukemia. 2023 Apr; 37(4): 728–740. Published online 2023 Feb 17. doi: 10.1038/s41375-023-01853-9
PMCID:
PMC10081958
AbstractArticlePDF–2.9M
16.
JMJD3 Is Required for Acute Pancreatitis and Pancreatitis-Associated Lung Injury
Li Chen, Xiangxian Zhang, Yu Liu, Li Liu, Xiao Liang, Shengqun Yang, Qing Xia, Tao Jin, Yun Ma, Yonghua Chen, Xia Yuan, Yan Tie, Yangzhuo Gu, Chunju Fang, Siyuan Chen, Fei Mo, Ting Yu, Yuzhu Hu, Zhiyong Qian, Yong Peng, Jia Geng, Zongguang Zhou, Min Wu, Jiansheng Ding, Daoke Yang, Xiawei Wei
J Immunol. 2023 Jan 15; 210(2): 180–190. Published online 2023 Jan 15. doi: 10.4049/jimmunol.2200484
PMCID:
PMC9772398
AbstractArticlePDF–3.0M
17.
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment
Bertille Montibus, Jil Cercy, Tristan Bouschet, Amandine Charras, Stéphanie Maupetit-Méhouas, David Nury, Céline Gonthier-Guéret, Sabine Chauveau, Nicolas Allegre, Caroline Chariau, Charles C. Hong, Isabelle Vaillant, C. Joana Marques, Franck Court, Philippe Arnaud
Cell Mol Life Sci. 2021 Jan; 78(2): 757–768. Published online 2020 May 14. doi: 10.1007/s00018-020-03541-8
PMCID:
PMC9644380
AbstractArticlePDF–3.2M
18.
Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair
Christopher O. Audu, William J. Melvin, Amrita D. Joshi, Sonya J. Wolf, Jadie Y. Moon, Frank M. Davis, Emily C. Barrett, Kevin D. Mangum, Hongping Deng, Xianying Xing, Rachel Wasikowski, Lam C. Tsoi, Sriganesh B. Sharma, Tyler M. Bauer, James Shadiow, Matthew A. Corriere, Andrea T. Obi, Steven L. Kunkel, Benjamin Levi, Bethany B. Moore, Johann E. Gudjonsson, Andrew M. Smith, Katherine A. Gallagher
Cell Mol Immunol. 2022 Nov; 19(11): 1251–1262. Published online 2022 Sep 20. doi: 10.1038/s41423-022-00919-5
PMCID:
PMC9622909
AbstractArticlePDF–4.6M
19.
Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis
Hua Liang, Benquan Liu, Ying Gao, Jiayi Nie, Shuyun Feng, Wenqiang Yu, Shihong Wen, Xi Su
Front Immunol. 2022; 13: 978262. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.978262
PMCID:
PMC9494509
AbstractArticlePDF–7.4M
20.
The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes
Haohao Zhang, Yiming Hu, Dandan Liu, Zhi Liu, Ningxia Xie, Sanhong Liu, Jie Zhang, Yuhang Jiang, Cuifeng Li, Qi Wang, Xi Chen, Deji Ye, Donglin Sun, Yujia Zhai, Xinhui Yan, Yongzhong Liu, Charlie Degui Chen, Xingxu Huang, Y. Eugene Chin, Yufang Shi, Baojin Wu, Xiaoren Zhang
Cell Death Differ. 2022 Jul; 29(7): 1349–1363. Published online 2022 Jan 9. doi: 10.1038/s41418-021-00921-w
PMCID:
PMC9287323
AbstractArticlePDF–7.4M

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