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Items: 1 to 20 of 28

1.
Primordial germ cell DNA demethylation and development require DNA translesion synthesis
Pranay Shah, Ross Hill, Camille Dion, Stephen J. Clark, Abdulkadir Abakir, Jeroen Willems, Mark J. Arends, Juan I. Garaycoechea, Harry G. Leitch, Wolf Reik, Gerry P. Crossan
Nat Commun. 2024; 15: 3734. Published online 2024 May 3. doi: 10.1038/s41467-024-47219-2
PMCID:
PMC11068800
AbstractArticlePDF–5.6M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
DNA polymerase θ protects leukemia cells from metabolically induced DNA damage
Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N. Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M. Paietta, Ross L. Levine, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Gaorav P. Gupta, Jean-Yves Masson, Tomasz Skorski
Blood. 2023 May 11; 141(19): 2372–2389. Published online 2022 Dec 30. doi: 10.1182/blood.2022018428
PMCID:
PMC10273171
AbstractArticle
4.
DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis
Agnieszka Smolinska, Kerstin Singer, Janine Golchert, Urszula Smyczynska, Wojciech Fendler, Matthias Sendler, Jens van den Brandt, Stephan Singer, Georg Homuth, Markus M. Lerch, Patryk Moskwa
Cancers (Basel) 2022 Sep; 14(17): 4077. Published online 2022 Aug 23. doi: 10.3390/cancers14174077
PMCID:
PMC9454495
AbstractArticlePDF–8.9M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Mechanistic basis for microhomology identification and genome scarring by polymerase theta
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia, Wanjuan Feng, Richard D. Wood, Jeff Sekelsky, Gaorav P. Gupta, Steven A. Roberts, Dale A. Ramsden
Proc Natl Acad Sci U S A. 2020 Apr 14; 117(15): 8476–8485. Published online 2020 Mar 31. doi: 10.1073/pnas.1921791117
PMCID:
PMC7165422
AbstractArticlePDF–1.0M
7.
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Pedro A. Mateos-Gomez, Tatiana Kent, Sarah K. Deng, Shane McDevitt, Ekaterina Kashkina, Trung M. Hoang, Richard T Pomerantz, Agnel Sfeir
Nat Struct Mol Biol. Author manuscript; available in PMC 2018 Jul 16.
Published in final edited form as: Nat Struct Mol Biol. 2017 Dec; 24(12): 1116–1123. Published online 2017 Oct 23. doi: 10.1038/nsmb.3494
PMCID:
PMC6047744
AbstractArticlePDF–1.3M
8.
Mutational signatures of non‐homologous and polymerase theta‐mediated end‐joining in embryonic stem cells
Joost Schimmel, Hanneke Kool, Robin van Schendel, Marcel Tijsterman
EMBO J. 2017 Dec 15; 36(24): 3634–3649. Published online 2017 Oct 27. doi: 10.15252/embj.201796948
PMCID:
PMC5730883
AbstractArticlePDF–764K
9.
Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
Alex N. Zelensky, Joost Schimmel, Hanneke Kool, Roland Kanaar, Marcel Tijsterman
Nat Commun. 2017; 8: 66. Published online 2017 Jul 7. doi: 10.1038/s41467-017-00124-3
PMCID:
PMC5501794
AbstractArticlePDF–887K
10.
Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance
Kei-ichi Takata, Shelley Reh, Matthew J. Yousefzadeh, Maciej J. Zelazowski, Sarita Bhetawal, David Trono, Megan G. Lowery, Maria Sandoval, Yoko Takata, Yue Lu, Kevin Lin, Jianjun Shen, Donna F. Kusewitt, Kevin M. McBride, Francesca Cole, Richard D. Wood
PLoS Genet. 2017 Jun; 13(6): e1006818. Published online 2017 Jun 1. doi: 10.1371/journal.pgen.1006818
PMCID:
PMC5472330
AbstractArticlePDF–12M
11.
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
Hong Zan, Connie Tat, Zhifang Qiu, Julia R. Taylor, Justin A. Guerrero, Tian Shen, Paolo Casali
Nat Commun. 2017; 8: 14244. Published online 2017 Feb 8. doi: 10.1038/ncomms14244
PMCID:
PMC5309807
AbstractArticlePDF–5.2M
12.
Essential roles for Polymerase θ mediated end-joining in repair of chromosome breaks
David W. Wyatt, Wanjuan Feng, Michael P. Conlin, Matthew J. Yousefzadeh, Steven A. Roberts, Piotr Mieczkowski, Richard D. Wood, Gaorav P. Gupta, Dale A. Ramsden
Mol Cell. Author manuscript; available in PMC 2017 Aug 18.
Published in final edited form as: Mol Cell. 2016 Aug 18; 63(4): 662–673. Published online 2016 Jul 21. doi: 10.1016/j.molcel.2016.06.020
PMCID:
PMC4992412
AbstractArticlePDF–669K
13.
Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining
Tatiana Kent, Pedro A Mateos-Gomez, Agnel Sfeir, Richard T Pomerantz
eLife. 2016; 5: e13740. Published online 2016 Jun 17. doi: 10.7554/eLife.13740
PMCID:
PMC4912351
AbstractArticlePDF–4.7M
14.
Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination
Pedro A. Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M. Miller, Eros Lazzerini-Denchi, Agnel Sfeir
Nature. Author manuscript; available in PMC 2016 Jan 19.
Published in final edited form as: Nature. 2015 Feb 12; 518(7538): 254–257. Published online 2015 Feb 2. doi: 10.1038/nature14157
PMCID:
PMC4718306
AbstractArticlePDF–6.2M
15.
Homologous recombination-deficient tumors are hyper-dependent on POLQ-mediated repair
Raphael Ceccaldi, Jessica C. Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I.R. Petalcorin, Kevin W. O'Connor, Panagiotis A. Konstantinopoulos, Stephen J. Elledge, Simon J. Boulton, Timur Yusufzai, Alan D. D'Andrea
Nature. Author manuscript; available in PMC 2015 Aug 12.
Published in final edited form as: Nature. 2015 Feb 12; 518(7538): 258–262. Published online 2015 Feb 2. doi: 10.1038/nature14184
PMCID:
PMC4415602
ArticlePDF–1.3M
16.
Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ
Matthew J. Yousefzadeh, David W. Wyatt, Kei-ichi Takata, Yunxiang Mu, Sean C. Hensley, Junya Tomida, Göran O. Bylund, Sylvie Doublié, Erik Johansson, Dale A. Ramsden, Kevin M. McBride, Richard D. Wood
PLoS Genet. 2014 Oct; 10(10): e1004654. Published online 2014 Oct 2. doi: 10.1371/journal.pgen.1004654
PMCID:
PMC4183433
AbstractArticlePDF–4.5M
17.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
18.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
19.
Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal Cells In Vitro and Increases Reticulocyte Micronuclei after Total-Body Irradiation
Julie P. Goff, Donna S. Shields, Mineaki Seki, Serah Choi, Michael W. Epperly, Tracy Dixon, Hong Wang, Christopher J. Bakkenist, Stephen D. Dertinger, Dorothea K. Torous, John Wittschieben, Richard D. Wood, Joel S. Greenberger
Radiat Res. Author manuscript; available in PMC 2010 Aug 1.
Published in final edited form as: Radiat Res. 2009 Aug; 172(2): 165–174. doi: 10.1667/RR1598.1
PMCID:
PMC2742993
AbstractArticlePDF–652K
20.
Reevaluation of the role of DNA polymerase ? in somatic hypermutation of immunoglobulin genes
Stella A. Martomo, Huseyin Saribasak, Masayuki Yokoi, Fumio Hanaoka, Patricia J. Gearhart
DNA Repair (Amst) Author manuscript; available in PMC 2009 Sep 1.
Published in final edited form as: DNA Repair (Amst). 2008 Sep 1; 7(9): 1603–1608. Published online 2008 May 16. doi: 10.1016/j.dnarep.2008.04.002
PMCID:
PMC2561943
AbstractArticlePDF–344K

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