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Items: 1 to 20 of 49

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury
Surawee Chuaiphichai, Sandy M. Chu, Ricardo Carnicer, Matthew Kelly, Jenifer K. Bendall, Jillian N. Simon, Gillian Douglas, Mark J. Crabtree, Barbara Casadei, Keith M. Channon
Am J Physiol Heart Circ Physiol. 2023 Apr 1; 324(4): H430–H442. Published online 2023 Feb 3. doi: 10.1152/ajpheart.00562.2022
PMCID:
PMC9988535
AbstractArticle
3.
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1
Di Wang, Weiwei Liang, Di Huo, Hongyong Wang, Ying Wang, Chaohua Cong, Chunting Zhang, Shi Yan, Ming Gao, Xiaoli Su, Xingli Tan, Wenmo Zhang, Ling Han, Dongmei Zhang, Honglin Feng
Cell Death Differ. 2023 Feb; 30(2): 369–382. Published online 2022 Nov 28. doi: 10.1038/s41418-022-01089-7
PMCID:
PMC9950139
AbstractArticlePDF–5.2M
4.
Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo
Ya-Ling Yin, Yuan Chen, Feng Ren, Lu Wang, Mo-Li Zhu, Jun-Xiu Lu, Qian-Qian Wang, Cheng-Biao Lu, Chao Liu, Yong-Ping Bai, Shuang-Xi Wang, Jian-Zhi Wang, Peng Li
Redox Biol. 2022 Dec; 58: 102540. Published online 2022 Nov 13. doi: 10.1016/j.redox.2022.102540
PMCID:
PMC9673109
AbstractArticlePDF–9.8M
5.
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth
Surawee Chuaiphichai, Grace Z. Yu, Cheryl M.J. Tan, Christopher Whiteman, Gillian Douglas, Yasmin Dickinson, Edward N. Drydale, Mahesh Appari, Wei Zhang, Mark J. Crabtree, Eileen McNeill, Ashley B. Hale, Adam J. Lewandowski, Nicholas J. Alp, Manu Vatish, Paul Leeson, Keith M. Channon
Hypertension. 2021 Dec; 78(6): 1871–1884. Published online 2021 Oct 25. doi: 10.1161/HYPERTENSIONAHA.120.17646
PMCID:
PMC8577301
AbstractArticlePDF–2.2M
6.
GCH1-regulated miRNAs are potential targets for microglial activation in neuropathic pain
Shu Jia, Guowu Chen, Yanhu Liang, Xiao Liang, Chunyang Meng
Biosci Rep. 2021 Sep 30; 41(9): BSR20210051. Published online 2021 Sep 10. doi: 10.1042/BSR20210051
PMCID:
PMC8433481
AbstractArticlePDF–1.5M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation
Jade D. Bailey, Marina Diotallevi, Thomas Nicol, Eileen McNeill, Andrew Shaw, Surawee Chuaiphichai, Ashley Hale, Anna Starr, Manasi Nandi, Elena Stylianou, Helen McShane, Simon Davis, Roman Fischer, Benedikt M. Kessler, James McCullagh, Keith M. Channon, Mark J. Crabtree
Cell Rep. 2019 Jul 2; 28(1): 218–230.e7. Published online 2019 Jul 2. doi: 10.1016/j.celrep.2019.06.018
PMCID:
PMC6616861
AbstractArticlePDF–4.1M
9.
The metabolite BH4 controls T–cell proliferation in autoimmunity and cancer
Shane J. F. Cronin, Corey Seehus, Adelheid Weidinger, Sebastien Talbot, Sonja Reissig, Markus Seifert, Yann Pierson, Eileen McNeill, Maria Serena Longhi, Bruna Lenfers Turnes, Taras Kreslavsky, Melanie Kogler, David Hoffmann, Melita Ticevic, Débora da Luz Scheffer, Luigi Tortola, Domagoj Cikes, Alexander Jais, Manu Rangachari, Shuan Rao, Magdalena Paolino, Maria Novatchkova, Martin Aichinger, Lee Barrett, Alban Latremoliere, Gerald Wirnsberger, Guenther Lametschwandtner, Meinrad Busslinger, Stephen Zicha, Alexandra Latini, Simon C. Robson, Ari Waisman, Nick Andrews, Michael Costigan, Keith M. Channon, Guenter Weiss, Andrey V. Kozlov, Mark Tebbe, Kai Johnsson, Clifford J. Woolf, Josef M. Penninger
Nature. Author manuscript; available in PMC 2019 Mar 28.
Published in final edited form as: Nature. 2018 Nov; 563(7732): 564–568. Published online 2018 Nov 7. doi: 10.1038/s41586-018-0701-2
PMCID:
PMC6438708
AbstractArticlePDF–2.3M
10.
Mast cell tetrahydrobiopterin contributes to itch in mice
Katja Zschiebsch, Caroline Fischer, Annett Wilken‐Schmitz, Gerd Geisslinger, Keith Channon, Katrin Watschinger, Irmgard Tegeder
J Cell Mol Med. 2019 Feb; 23(2): 985–1000. Published online 2018 Nov 18. doi: 10.1111/jcmm.13999
PMCID:
PMC6349351
AbstractArticlePDF–5.1M
11.
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon
Nat Commun. 2018; 9: 5409. Published online 2018 Dec 20. doi: 10.1038/s41467-018-07714-9
PMCID:
PMC6302098
AbstractArticlePDF–2.9M
12.
Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
Marissa A. Scavuzzo, Matthew C. Hill, Jolanta Chmielowiec, Diane Yang, Jessica Teaw, Kuanwei Sheng, Yuelin Kong, Maria Bettini, Chenghang Zong, James F. Martin, Malgorzata Borowiak
Nat Commun. 2018; 9: 3356. Published online 2018 Aug 22. doi: 10.1038/s41467-018-05740-1
PMCID:
PMC6105717
AbstractArticlePDF–14M
13.
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
Gillian Douglas, Ashley B Hale, Jyoti Patel, Surawee Chuaiphichai, Ayman Al Haj Zen, Victoria S Rashbrook, Lucy Trelfa, Mark J Crabtree, Eileen McNeill, Keith M Channon
Cardiovasc Res. 2018 Aug 1; 114(10): 1385–1399. Published online 2018 Mar 27. doi: 10.1093/cvr/cvy078
PMCID:
PMC6054219
AbstractArticlePDF–1.3M
14.
Increasing Tetrahydrobiopterin in Cardiomyocytes Adversely Affects Cardiac Redox State and Mitochondrial Function Independently of Changes in NO Production
Savitha Sethumadhavan, Jennifer Whitsett, Brian Bennett, Irina A. Ionova, Galen M. Pieper, Jeannette Vasquez-Vivar
Free Radic Biol Med. Author manuscript; available in PMC 2017 Jul 6.
Published in final edited form as: Free Radic Biol Med. 2016 Apr; 93: 1–11. Published online 2016 Jan 27. doi: 10.1016/j.freeradbiomed.2016.01.019
PMCID:
PMC5498285
AbstractArticlePDF–812K
15.
Cell-Autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation
Surawee Chuaiphichai, Eileen McNeill, Gillian Douglas, Mark J. Crabtree, Jennifer K. Bendall, Ashley B. Hale, Nicholas J. Alp, Keith M. Channon
Hypertension. Author manuscript; available in PMC 2017 Jan 16.
Published in final edited form as: Hypertension. 2014 Sep; 64(3): 530–540. Published online 2014 Apr 28. doi: 10.1161/HYPERTENSIONAHA.114.03089
PMCID:
PMC5238938
AbstractArticlePDF–1.7M
16.
Pulmonary Hypertension in the Newborn GTP-Cyclohydrolase 1-Deficient Mouse
Jaques Belik, Brendan A.S. McIntyre, Masahiro Enomoto, Jingyi Pan, Hartmut Grasemann, Jeannette Vasquez-Vivar
Free Radic Biol Med. Author manuscript; available in PMC 2016 Oct 5.
Published in final edited form as: Free Radic Biol Med. 2011 Dec 15; 51(12): 2227–2233. Published online 2011 Sep 29. doi: 10.1016/j.freeradbiomed.2011.09.012
PMCID:
PMC5050525
AbstractArticlePDF–656K
17.
Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
Hsiang-En Wu, Shelley L. Baumgardt, Juan Fang, Mark Paterson, Yanan Liu, Jianhai Du, Yang Shi, Shigang Qiao, Zeljko J. Bosnjak, David C. Warltier, Judy R. Kersten, Zhi-Dong Ge
Sci Rep. 2016; 6: 27925. Published online 2016 Jun 13. doi: 10.1038/srep27925
PMCID:
PMC4904741
AbstractArticlePDF–2.4M
18.
Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons
Dong-Youn Hwang, Sunghoi Hong, Joo-Won Jeong, Sangdun Choi, Hansoo Kim, Jangwoo Kim, Kwang-Soo Kim
J Neurochem. Author manuscript; available in PMC 2016 Jun 7.
Published in final edited form as: J Neurochem. 2009 Dec; 111(5): 1202–1212. Published online 2009 Sep 24. doi: 10.1111/j.1471-4159.2009.06404.x
PMCID:
PMC4896488
AbstractArticlePDF–732K
19.
Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I
Anantha Vijay R. Santhanam, Livius V. d’Uscio, Zvonimir S. Katusic
Brain Res. Author manuscript; available in PMC 2016 Nov 2.
Published in final edited form as: Brain Res. 2015 Nov 2; 1625: 198–205. Published online 2015 Sep 3. doi: 10.1016/j.brainres.2015.08.034
PMCID:
PMC4637228
AbstractArticlePDF–1.0M
20.
Pet-1 controls tetrahydrobiopterin pathway and Slc22a3 transporter genes in serotonin neurons
Steven C. Wyler, Lauren J. Donovan, Mia Yeager, Evan Deneris
ACS Chem Neurosci. Author manuscript; available in PMC 2015 Jul 16.
Published in final edited form as: ACS Chem Neurosci. 2015 Jul 15; 6(7): 1198–1205. Published online 2015 Feb 18. doi: 10.1021/cn500331z
PMCID:
PMC4504805
AbstractArticlePDF–1.3M

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