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Select item 111316981.

Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1

R. Azar, S. Najib, H. Lahlou, C. Susini, S. Pyronnet

Cell Mol Life Sci. 2008 Oct; 65(19): 3110–3117. Published online 2008 Sep 23. doi: 10.1007/s00018-008-8418-2

PMCID:: PMC11131698

Abstract Article PDF–755K

Select item 110941362.

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier

Nat Commun. 2024; 15: 4083. Published online 2024 May 14. doi: 10.1038/s41467-024-48386-y

PMCID:: PMC11094136

Abstract Article PDF–2.0M

Select item 108791983.

miR-483-5p orchestrates the initiation of protein synthesis by facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1 levels

Siranjeevi Nagaraj, Anna Stankiewicz-Drogon, Edward Darzynkiewicz, Urszula Wojda, Renata Grzela

Sci Rep. 2024; 14: 4237. Published online 2024 Feb 20. doi: 10.1038/s41598-024-54154-1

PMCID:: PMC10879198

Abstract Article PDF–1.8M

Select item 100980394.

4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis

Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin, Yiyuan Zhang, Sheng Zhang, Xiaoqian Liu, Weiqi Zhang, Guang-Hui Liu, Si Wang, Moshi Song, Jing Qu

Protein Cell. 2023 Mar; 14(3): 202–216. Published online 2022 Aug 23. doi: 10.1093/procel/pwac037

PMCID:: PMC10098039

Abstract Article PDF–5.5M

Select item 100609395.

SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions

Nadejda Korneeva, Md Imtiaz Khalil, Ishita Ghosh, Ruping Fan, Thomas Arnold, Arrigo De Benedetti

Virol J. 2023; 20: 55. Published online 2023 Mar 30. doi: 10.1186/s12985-023-02021-2

PMCID:: PMC10060939

Abstract Article PDF–2.7M

Select item 97947146.

4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer

Yanan Wang, Jiapeng Lei, Song Zhang, Xiaomei Wang, Jiangbo Jin, Yufeng Liu, Mingxi Gan, Yi Yuan, Longhua Sun, Xiaolei Li, Tianyu Han, Jian-Bin Wang

Cell Death Dis. 2022 Dec; 13(12): 1075. Published online 2022 Dec 27. doi: 10.1038/s41419-022-05466-5

PMCID:: PMC9794714

Abstract Article PDF–5.7M

Select item 93378527.

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

Raffaele Nicastro, Hélène Gaillard, Laura Zarzuela, Marie-Pierre Péli-Gulli, Elisabet Fernández-García, Mercedes Tomé, Néstor García-Rodríguez, Raúl V Durán, Claudio De Virgilio, Ralf Erik Wellinger

eLife. 2022; 11: e80497. Published online 2022 Jul 29. doi: 10.7554/eLife.80497

PMCID:: PMC9337852

Abstract Article PDF–3.8M

Select item 92233698.

Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection

Yaoxiang Tang, Jiadi Luo, Yang Yang, Sile Liu, Hongmei Zheng, Yuting Zhan, Songqing Fan, Qiuyuan Wen

PLoS One. 2022; 17(6): e0265465. Published online 2022 Jun 23. doi: 10.1371/journal.pone.0265465

PMCID:: PMC9223369

Abstract Article PDF–1.3M

Select item 91875419.

Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m⁶A demethylation of EIF4EBP1 and MLST8 mRNA

Le Zhang, Xiulan Su

Cell Oncol (Dordr) 2022; 45(3): 355–365. Published online 2022 May 17. doi: 10.1007/s13402-022-00666-9

PMCID:: PMC9187541

Abstract Article PDF–2.6M

Select item 917141110.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 876907211.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 868410812.

circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis

Cheng-Peng Gui, Bing Liao, Cheng-Gong Luo, Yu-Hang Chen, Lei Tan, Yi-Ming Tang, Jia-Ying Li, Yi Hou, Hong-De Song, Hai-Shan Lin, Quan-Hui Xu, Gao-Sheng Yao, Hao-Hua Yao, Xi-Liu, Jun-Hang Luo, Jia-Zheng Cao, Jin-Huan Wei

Mol Cancer. 2021; 20: 169. Published online 2021 Dec 18. doi: 10.1186/s12943-021-01449-w

PMCID:: PMC8684108

Abstract Article PDF–7.5M

Select item 857279713.

Targeting of EIF4EBP1 by miR‐99a‐3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression

Meng Yang, Binbin Yang, Danqi Deng

J Cell Mol Med. 2021 Nov; 25(21): 10291–10305. Published online 2021 Oct 20. doi: 10.1111/jcmm.16991

PMCID:: PMC8572797

Abstract Article PDF–2.5M

Select item 851385314.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813450416.

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping

Nat Commun. 2021; 12: 2939. Published online 2021 May 19. doi: 10.1038/s41467-021-23269-8