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Select item 114057191.

CMG helicase disassembly is essential and driven by two pathways in budding yeast

Cristian Polo Rivera, Tom D Deegan, Karim P M Labib

EMBO J. 2024 Sep; 43(18): 3818–3845. Published online 2024 Jul 22. doi: 10.1038/s44318-024-00161-x

PMCID:: PMC11405719

Abstract Article PDF–6.9M

Select item 111048492.

Characterization of the dimeric CMG/pre-initiation complex and its transition into DNA replication forks

Lu Liu, Yue Zhang, Jingjing Zhang, Jian-Hua Wang, Qinhong Cao, Zhen Li, Judith L. Campbell, Meng-Qiu Dong, Huiqiang Lou

Cell Mol Life Sci. 2020 Aug; 77(15): 3041–3058. Published online 2019 Nov 15. doi: 10.1007/s00018-019-03333-9

PMCID:: PMC11104849

Abstract Article PDF–9.1M

Select item 107001383.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 105211374.

Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress

Andreas Hadjicharalambous, Alex J. Whale, Geylani Can, J. Mark Skehel, Jonathan M. Houseley, Philip Zegerman

Version 1. Wellcome Open Res. 2023; 8: 327. Published online 2023 Jul 26. doi: 10.12688/wellcomeopenres.19617.1

PMCID:: PMC10521137

Abstract Article PDF–4.0M

Select item 105115615.

Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Zhichun Xu, Jianrong Feng, Daqi Yu, Yunjing Huo, Xiaohui Ma, Wai Hei Lam, Zheng Liu, Xiang David Li, Toyotaka Ishibashi, Shangyu Dang, Yuanliang Zhai

Nat Commun. 2023; 14: 5849. Published online 2023 Sep 20. doi: 10.1038/s41467-023-41506-0

PMCID:: PMC10511561

Abstract Article PDF–5.3M

Select item 92098116.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 77629747.

Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase—Pol ε Interaction

Milena Denkiewicz-Kruk, Malgorzata Jedrychowska, Shizuko Endo, Hiroyuki Araki, Piotr Jonczyk, Michal Dmowski, Iwona J. Fijalkowska

Int J Mol Sci. 2020 Dec; 21(24): 9484. Published online 2020 Dec 13. doi: 10.3390/ijms21249484

PMCID:: PMC7762974

Abstract Article PDF–2.8M

Select item 77187518.

Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1

Elsbeth Sanders, Phoebe A. Nguyen, Cody M. Rogers, Matthew L. Bochman

G3 (Bethesda) 2020 Dec; 10(12): 4359–4368. Published online 2020 Oct 28. doi: 10.1534/g3.120.401709

PMCID:: PMC7718751

Abstract Article PDF–1.2M

Select item 74626119.

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

Tom D Deegan, Progya P Mukherjee, Ryo Fujisawa, Cristian Polo Rivera, Karim Labib

eLife. 2020; 9: e60371. Published online 2020 Aug 17. doi: 10.7554/eLife.60371

PMCID:: PMC7462611

Abstract Article PDF–4.9M

Select item 721087910.

Budding yeast complete DNA synthesis after chromosome segregation begins

Tsvetomira Ivanova, Michael Maier, Alsu Missarova, Céline Ziegler-Birling, Monica Dam, Mercè Gomar-Alba, Lucas B. Carey, Manuel Mendoza

Nat Commun. 2020; 11: 2267. Published online 2020 May 8. doi: 10.1038/s41467-020-16100-3

PMCID:: PMC7210879

Abstract Article PDF–4.4M

Select item 689951811.

In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast

Progya P. Mukherjee, Karim P.M. Labib

Cell Rep. 2019 Sep 10; 28(11): 2777–2783.e4. Published online 2019 Sep 10. doi: 10.1016/j.celrep.2019.08.026

PMCID:: PMC6899518

Abstract Article

Select item 680000512.

Ctf4 organizes sister replisomes and Pol α into a replication factory

Zuanning Yuan, Roxana Georgescu, Ruda de Luna Almeida Santos, Daniel Zhang, Lin Bai, Nina Y Yao, Gongpu Zhao, Michael E O'Donnell, Huilin Li

eLife. 2019; 8: e47405. Published online 2019 Oct 7. doi: 10.7554/eLife.47405

PMCID:: PMC6800005

Abstract Article PDF–7.0M

Select item 670561413.

Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase

Michael R. Wasserman, Grant D. Schauer, Michael E. O’Donnell, Shixin Liu

Cell. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Cell. 2019 Jul 25; 178(3): 600–611.e16. doi: 10.1016/j.cell.2019.06.032

PMCID:: PMC6705614

Abstract Article PDF–1.6M

Select item 633883414.

Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression

Ryan Mayle, Lance Langston, Kelly R. Molloy, Dan Zhang, Brian T. Chait, Michael E. O’Donnell

Proc Natl Acad Sci U S A. 2019 Jan 15; 116(3): 798–803. Published online 2018 Dec 31. doi: 10.1073/pnas.1819107116

PMCID:: PMC6338834

Abstract Article PDF–1.3M

Select item 616983515.

DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier

Kohji Hizume, Shizuko Endo, Sachiko Muramatsu, Takehiko Kobayashi, Hiroyuki Araki

Genes Dev. 2018 Oct 1; 32(19-20): 1315–1320. doi: 10.1101/gad.317073.118

PMCID:: PMC6169835

Abstract Article PDF–1.3M

Select item 616612816.

Histone H2A‐H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

Cecile Evrin, Joseph D Maman, Aurora Diamante, Luca Pellegrini, Karim Labib

EMBO J. 2018 Oct 1; 37(19): e99021. Published online 2018 Aug 13. doi: 10.15252/embj.201899021

PMCID:: PMC6166128

Abstract Article PDF–1.5M

Select item 576535917.

Genome-Wide Mapping of Decay Factor–mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4

Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese

G3 (Bethesda) 2018 Jan; 8(1): 315–330. Published online 2017 Nov 20. doi: 10.1534/g3.117.300415

PMCID:: PMC5765359

Abstract Article PDF–2.2M

Select item 566188518.

A global interaction network maps a wiring diagram of cellular function

Michael Costanzo, Benjamin VanderSluis, Elizabeth N. Koch, Anastasia Baryshnikova, Carles Pons, Guihong Tan, Wen Wang, Matej Usaj, Julia Hanchard, Susan D. Lee, Vicent Pelechano, Erin B. Styles, Maximilian Billmann, Jolanda van Leeuwen, Nydia van Dyk, Zhen-Yuan Lin, Elena Kuzmin, Justin Nelson, Jeff S. Piotrowski, Tharan Srikumar, Sondra Bahr, Yiqun Chen, Raamesh Deshpande, Christoph F. Kurat, Sheena C. Li, Zhijian Li, Mojca Mattiazzi Usaj, Hiroki Okada, Natasha Pascoe, Bryan-Joseph San Luis, Sara Sharifpoor, Emira Shuteriqi, Scott W. Simpkins, Jamie Snider, Harsha Garadi Suresh, Yizhao Tan, Hongwei Zhu, Noel Malod-Dognin, Vuk Janjic, Natasa Przulj, Olga G. Troyanskaya, Igor Stagljar, Tian Xia, Yoshikazu Ohya, Anne-Claude Gingras, Brian Raught, Michael Boutros, Lars M. Steinmetz, Claire L. Moore, Adam P. Rosebrock, Amy A. Caudy, Chad L. Myers, Brenda Andrews, Charles Boone

Science. Author manuscript; available in PMC 2017 Oct 30.

Published in final edited form as: Science. 2016 Sep 23; 353(6306): aaf1420. doi: 10.1126/science.aaf1420

PMCID:: PMC5661885

Abstract Article PDF–2.6M

Select item 562383519.

Pre‐initiation complex assembly functions as a molecular switch that splits the Mcm2‐7 double hexamer

Mayumi Miyazawa‐Onami, Hiroyuki Araki, Seiji Tanaka

EMBO Rep. 2017 Oct; 18(10): 1752–1761. Published online 2017 Aug 17. doi: 10.15252/embr.201744206

PMCID:: PMC5623835

Abstract Article PDF–944K

Select item 559923920.

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

Lance D Langston, Ryan Mayle, Grant D Schauer, Olga Yurieva, Daniel Zhang, Nina Y Yao, Roxana E Georgescu, Mike E O'Donnell

eLife. 2017; 6: e29118. Published online 2017 Sep 4. doi: 10.7554/eLife.29118

PMCID:: PMC5599239

Abstract Article PDF–3.8M

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