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Items: 1 to 20 of 76

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis
Weidi Ye, Qi Miao, Guangxin Xu, Kai Jin, Xue Li, Weidong Wu, Lina Yu, Min Yan
Ren Fail. 2023; 45(2): 2261552. Published online 2023 Oct 2. doi: 10.1080/0886022X.2023.2261552
PMCID:
PMC10547449
AbstractArticlePDF–14M
3.
The ubiquitin ligase Itch skews light zone selection in germinal centers
Lindsay Renshaw, Peter Kim, Macaul Crici, Hossein Fazelinia, Lynn Spruce, Paula Oliver, Emily Moser
J Immunol. Author manuscript; available in PMC 2024 May 15.
Published in final edited form as: J Immunol. 2023 May 15; 210(10): 1473–1481. doi: 10.4049/jimmunol.2200824
PMCID:
PMC10159933
AbstractArticlePDF–1.8M
4.
PRMT5 epigenetically regulates the E3 ubiquitin ligase ITCH to influence lipid accumulation during mycobacterial infection
Salik Miskat Borbora, Raju S. Rajmani, Kithiganahalli Narayanaswamy Balaji
PLoS Pathog. 2022 Jun; 18(6): e1010095. Published online 2022 Jun 3. doi: 10.1371/journal.ppat.1010095
PMCID:
PMC9200362
AbstractArticlePDF–1.5M
5.
ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids
Rossella Menghini, Lesley Hoyles, Marina Cardellini, Viviana Casagrande, Arianna Marino, Paolo Gentileschi, Francesca Davato, Maria Mavilio, Ivan Arisi, Alessandro Mauriello, Manuela Montanaro, Manuel Scimeca, Richard H. Barton, Francesca Rappa, Francesco Cappello, Manlio Vinciguerra, José Maria Moreno-Navarrete, Wifredo Ricart, Ottavia Porzio, José-Manuel Fernández-Real, Rémy Burcelin, Marc-Emmanuel Dumas, Massimo Federici
Mol Metab. 2022 May; 59: 101454. Published online 2022 Feb 9. doi: 10.1016/j.molmet.2022.101454
PMCID:
PMC8886057
AbstractArticlePDF–2.5M
6.
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells
Chozhavendan Rathinam, Lydia E Matesic, Richard A Flavell
Nat Immunol. Author manuscript; available in PMC 2021 Aug 17.
Published in final edited form as: Nat Immunol. 2011 May; 12(5): 399–407. Published online 2011 Apr 10. doi: 10.1038/ni.2021
PMCID:
PMC8369725
ArticlePDF–1.4M
7.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Gut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice
Mahesh Kathania, Elviche L. Tsakem, Arianne L. Theiss, K. Venuprasad
J Immunol. Author manuscript; available in PMC 2021 Jan 16.
Published in final edited form as: J Immunol. 2020 Apr 15; 204(8): 2277–2284. Published online 2020 Mar 13. doi: 10.4049/jimmunol.1701478
PMCID:
PMC7811274
AbstractArticlePDF–1.7M
10.
Itch attenuates CD4 T-cell proliferation in mice by limiting WBP2 protein stability
Natania S. Field, Omar A. Elbulok, Joseph M. Dybas, Emily K. Moser, Asif A. Dar, Lynn A. Spruce, Hossein Fazelinia, Steven H. Seeholzer, Paula M. Oliver
Eur J Immunol. Author manuscript; available in PMC 2021 Aug 1.
Published in final edited form as: Eur J Immunol. 2020 Oct; 50(10): 1468–1483. Published online 2020 Jun 9. doi: 10.1002/eji.201948323
PMCID:
PMC7541725
AbstractArticlePDF–1.0M
11.
Ubiquitination of interleukin-1α is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH
Xi Lin, Hengwei Zhang, Brendan F. Boyce, Lianping Xing
J Biol Chem. 2020 Aug 14; 295(33): 11764–11775. Published online 2020 Jun 25. doi: 10.1074/jbc.RA120.014298
PMCID:
PMC7450106
AbstractArticlePDF–2.1M
12.
Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis
Simon Borna, Ales Drobek, Jarmila Kralova, Daniela Glatzova, Iva Splichalova, Matej Fabisik, Jana Pokorna, Tereza Skopcova, Pavla Angelisova, Veronika Kanderova, Julia Starkova, Petr Stanek, Orest V. Matveichuk, Nataliia Pavliuchenko, Katarzyna Kwiatkowska, Majd B. Protty, Michael G. Tomlinson, Meritxell Alberich‐Jorda, Vladimir Korinek, Tomas Brdicka
J Cell Mol Med. 2020 Jan; 24(2): 1980–1992. Published online 2019 Dec 17. doi: 10.1111/jcmm.14895
PMCID:
PMC6991692
AbstractArticlePDF–1.8M
13.
miR-34b/c regulates doxorubicin-induced myocardial cell injury through ITCH
Wen-Cai Zhang, Jin-Hua Yang, Guang-Hui Liu, Fan Yang, Jun-Long Gong, Meng-Ge Jia, Meng-Juan Zhang, Luo-Sha Zhao
Cell Cycle. 2019; 18(23): 3263–3274. Published online 2019 Oct 18. doi: 10.1080/15384101.2019.1673618
PMCID:
PMC6927715
AbstractArticlePDF–4.1M
14.
The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses
Emily K. Moser, Jennifer Roof, Joseph M. Dybas, Lynn A. Spruce, Steven H. Seeholzer, Michael P. Cancro, Paula M. Oliver
J Exp Med. 2019 Sep 2; 216(9): 2170–2183. Published online 2019 Jul 16. doi: 10.1084/jem.20181953
PMCID:
PMC6719427
AbstractArticlePDF–2.4M
15.
The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR
Daisuke Aki, Hui Li, Wen Zhang, Mingke Zheng, Chris Elly, Jee H. Lee, Weiguo Zou, Yun-Cai Liu
Nat Immunol. Author manuscript; available in PMC 2019 Jan 28.
Published in final edited form as: Nat Immunol. 2018 Jul; 19(7): 766–775. Published online 2018 Jun 20. doi: 10.1038/s41590-018-0137-8
PMCID:
PMC6348860
AbstractArticlePDF–2.0M
16.
The E3 ubiquitin ligase Itch is required for B-cell development
Xiaoling Liu, Yu Zhang, Yinxiang Wei, Zhiding Wang, Gaizhi Zhu, Ying Fang, Bing Zhai, Ruonan Xu, Gencheng Han, Guojiang Chen, He Xiao, Chunmei Hou, Beifen Shen, Yan Li, Ning Ma, Renxi Wang
Sci Rep. 2019; 9: 421. Published online 2019 Jan 23. doi: 10.1038/s41598-018-36844-9
PMCID:
PMC6344599
AbstractArticlePDF–4.3M
17.
MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex
Yoshinori Abe, Yosuke Suzuki, Kenji Kawamura, Nobuyuki Tanaka
Commun Biol. 2019; 2: 23. Published online 2019 Jan 18. doi: 10.1038/s42003-018-0275-4
PMCID:
PMC6338668
AbstractArticlePDF–1.2M
18.
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
Paola Infante, Roberta Faedda, Flavia Bernardi, Francesca Bufalieri, Ludovica Lospinoso Severini, Romina Alfonsi, Daniela Mazzà, Mariangela Siler, Sonia Coni, Agnese Po, Marialaura Petroni, Elisabetta Ferretti, Mattia Mori, Enrico De Smaele, Gianluca Canettieri, Carlo Capalbo, Marella Maroder, Isabella Screpanti, Marcel Kool, Stefan M. Pfister, Daniele Guardavaccaro, Alberto Gulino, Lucia Di Marcotullio
Nat Commun. 2018; 9: 976. Published online 2018 Mar 7. doi: 10.1038/s41467-018-03339-0
PMCID:
PMC5841288
AbstractArticlePDF–4.9M
19.
Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders
Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba
Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594
PMCID:
PMC5645082
AbstractArticlePDF–2.3M
20.
Allosteric auto‐inhibition and activation of the Nedd4 family E3 ligase Itch
Kang Zhu, Zelin Shan, Xing Chen, Yuqun Cai, Lei Cui, Weiyi Yao, Zhen Wang, Pan Shi, Changlin Tian, Jizhong Lou, Yunli Xie, Wenyu Wen
EMBO Rep. 2017 Sep; 18(9): 1618–1630. Published online 2017 Jul 26. doi: 10.15252/embr.201744454
PMCID:
PMC5579370
AbstractArticlePDF–2.7M

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