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Items: 1 to 20 of 51

1.
PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1
Yuichiro Nakata, Shion Nagasawa, Yasuyuki Sera, Norimasa Yamasaki, Akinori Kanai, Kohei Kobatake, Takeshi Ueda, Miho Koizumi, Ichiro Manabe, Osamu Kaminuma, Hiroaki Honda
Sci Rep. 2024; 14: 17987. Published online 2024 Aug 3. doi: 10.1038/s41598-024-68295-w
PMCID:
PMC11297997
AbstractArticlePDF–1.9M
2.
Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity
Tong Zhang, Manman Cui, Yashu Li, Ying Cheng, Zhuying Gao, Jing Wang, Tiantian Zhang, Guoqiang Han, Rong Yin, Peipei Wang, Wen Tian, Weidong Liu, Jin Hu, Yuhua Wang, Zheming Liu, Haojian Zhang
Haematologica. 2023 Sep 1; 108(9): 2410–2421. Published online 2023 Mar 16. doi: 10.3324/haematol.2022.282224
PMCID:
PMC10483346
AbstractArticlePDF–1.8M
3.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
4.
DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity
Aili Cao, Jianhua Li, Morad Asadi, John M. Basgen, Bingbing Zhu, Zhengzi Yi, Song Jiang, Tomohito Doke, Osama El Shamy, Niralee Patel, Paolo Cravedi, Evren U. Azeloglu, Kirk N. Campbell, Madhav Menon, Steve Coca, Weijia Zhang, Hao Wang, Ke Zen, Zhihong Liu, Barbara Murphy, John C. He, Vivette D. D’Agati, Katalin Susztak, Lewis Kaufman
J Clin Invest. 2021 May 17; 131(10): e141279. Published online 2021 May 17. doi: 10.1172/JCI141279
PMCID:
PMC8121508
AbstractArticlePDF–17M
5.
Regeneration after acute kidney injury requires PTIP-mediated epigenetic modifications
Abdul Soofi, Ana P. Kutschat, Mohammad Azam, Ann M. Laszczyk, Gregory R. Dressler
JCI Insight. 2020 Feb 13; 5(3): e130204. Published online 2020 Feb 13. doi: 10.1172/jci.insight.130204
PMCID:
PMC7098790
AbstractArticlePDF–18M
6.
Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches
Prosun Das, Kylee J. Veazey, Hieu T. Van, Saakshi Kaushik, Kevin Lin, Yue Lu, Masaru Ishii, Junichi Kikuta, Kai Ge, Andre Nussenzweig, Margarida A. Santos
Proc Natl Acad Sci U S A. 2018 Oct 23; 115(43): E10137–E10146. Published online 2018 Oct 8. doi: 10.1073/pnas.1806019115
PMCID:
PMC6205459
AbstractArticlePDF–1.3M
7.
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis
Yuqing Sun, Bo Zhou, Fengbiao Mao, Jing Xu, Hongzhi Miao, Zhenhua Zou, Le Tran Phuc Khoa, Younghoon Jang, Sheng Cai, Matthew Witkin, Richard Koche, Kai Ge, Gregory Dressler, Ross L. Levine, Scott A. Armstrong, Yali Dou, Jay L. Hess
Cancer Cell. Author manuscript; available in PMC 2019 Oct 8.
Published in final edited form as: Cancer Cell. 2018 Oct 8; 34(4): 643–658.e5. Published online 2018 Sep 27. doi: 10.1016/j.ccell.2018.08.018
PMCID:
PMC6179449
AbstractArticlePDF–2.9M
8.
PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice
Dan Su, Stijn Vanhee, Rebeca Soria, Elin Jaensson Gyllenbäck, Linda M. Starnes, Martina Kubec Højfeldt, Gabriel K. Pedersen, Joan Yuan, Jeremy A. Daniel
Proc Natl Acad Sci U S A. 2017 Oct 31; 114(44): E9328–E9337. Published online 2017 Oct 16. doi: 10.1073/pnas.1707938114
PMCID:
PMC5676899
AbstractArticlePDF–3.3M
9.
A PTIP–PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex
Linda M. Starnes, Dan Su, Laura M. Pikkupeura, Brian T. Weinert, Margarida A. Santos, Andreas Mund, Rebeca Soria, Young-Wook Cho, Irina Pozdnyakova, Martina Kubec Højfeldt, Andrea Vala, Wenjing Yang, Blanca López-Méndez, Ji-Eun Lee, Weiqun Peng, Joan Yuan, Kai Ge, Guillermo Montoya, André Nussenzweig, Chunaram Choudhary, Jeremy A. Daniel
Genes Dev. 2016 Jan 15; 30(2): 149–163. doi: 10.1101/gad.268797.115
PMCID:
PMC4719306
AbstractArticlePDF–1.6M
10.
MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
David W. Scoville, Holly A. Cyphert, Lan Liao, Jianming Xu, Al Reynolds, Shuangli Guo, Roland Stein
Diabetes. 2015 Nov; 64(11): 3772–3783. Published online 2015 Jul 15. doi: 10.2337/db15-0281
PMCID:
PMC4613979
AbstractArticlePDF–1.5M
11.
The PTIP-Associated Histone Methyltransferase Complex Prevents Stress-Induced Maladaptive Cardiac Remodeling
Adam B. Stein, Sascha N. Goonewardena, Thomas A. Jones, Parker J. Prusick, Ahmad A. Bazzi, Jane M. Belyavskaya, Makayla M. McCoskey, Rachel A. Dandar
PLoS One. 2015; 10(5): e0127839. Published online 2015 May 22. doi: 10.1371/journal.pone.0127839
PMCID:
PMC4441468
AbstractArticlePDF–3.7M
12.
Evidence for Intermediate Mesoderm and Kidney Progenitor Cell Specification by Pax2 and PTIP Dependent Mechanisms
Egon J. Ranghini, Gregory R. Dressler
Dev Biol. Author manuscript; available in PMC 2016 Mar 15.
Published in final edited form as: Dev Biol. 2015 Mar 15; 399(2): 296–305. Published online 2015 Jan 21. doi: 10.1016/j.ydbio.2015.01.005
PMCID:
PMC4352407
AbstractArticlePDF–1.4M
13.
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors
M Böhringer, K Obermeier, N Griner, D Waldraff, E Dickinson, K Eirich, D Schindler, M Hagen, D J Jerry, L Wiesmüller
Oncogene. 2013 Nov 28; 32(48): 5458–5470. Published online 2013 Feb 25. doi: 10.1038/onc.2013.38
PMCID:
PMC3898496
AbstractArticlePDF–1.6M
14.
H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
Ji-Eun Lee, Chaochen Wang, Shiliyang Xu, Young-Wook Cho, Lifeng Wang, Xuesong Feng, Anne Baldridge, Vittorio Sartorelli, Lenan Zhuang, Weiqun Peng, Kai Ge
eLife. 2013; 2: e01503. Published online 2013 Dec 24. doi: 10.7554/eLife.01503
PMCID:
PMC3869375
AbstractArticlePDF–5.8M
15.
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
Elsa Callen, Michela Di Virgilio, Michael J. Kruhlak, Maria Nieto-Soler, Nancy Wong, Hua-Tang Chen, Robert B. Faryabi, Federica Polato, Margarida Santos, Linda M. Starnes, Duane R. Wesemann, Ji-Eun Lee, Anthony Tubbs, Barry P. Sleckman, Jeremy A. Daniel, Kai Ge, Frederick W. Alt, Oscar Fernandez-Capetillo, Michel C. Nussenzweig, André Nussenzweig
Cell. Author manuscript; available in PMC 2013 Dec 6.
Published in final edited form as: Cell. 2013 Jun 6; 153(6): 1266–1280. Published online 2013 May 30. doi: 10.1016/j.cell.2013.05.023
PMCID:
PMC3713552
AbstractArticlePDF–3.6M
16.
Quantitative Dissection and Stoichiometry Determination of the Human SET1/MLL Histone Methyltransferase Complexes
Rick van Nuland, Arne H. Smits, Paschalina Pallaki, Pascal W. T. C. Jansen, Michiel Vermeulen, H. T. Marc Timmers
Mol Cell Biol. 2013 May; 33(10): 2067–2077. doi: 10.1128/MCB.01742-12
PMCID:
PMC3647974
AbstractArticlePDF–1.8M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
The DNA damage- and transcription- associated protein Paxip1 controls thymocyte development and emigration
Elsa Callen, Robert B. Faryabi, Megan Luckey, Bingtao Hao, Jeremy A. Daniel, Wenjing Yang, Hong-Wei Sun, Greg Dressler, Weiqun Peng, Hongbo Chi, Kai Ge, Michael S. Krangel, Jung-Hyun Park, André Nussenzweig
Immunity. Author manuscript; available in PMC 2013 Dec 14.
Published in final edited form as: Immunity. 2012 Dec 14; 37(6): 971–985. Published online 2012 Nov 15. doi: 10.1016/j.immuni.2012.10.007
PMCID:
PMC3525809
AbstractArticlePDF–4.4M
19.
Arrested Spermatogenesis and Evidence for DNA Damage in PTIP Mutant Testes
Kristopher R. Schwab, Gary D. Smith, Gregory R. Dressler
Dev Biol. Author manuscript; available in PMC 2014 Jan 1.
Published in final edited form as: Dev Biol. 2013 Jan 1; 373(1): 64–71. Published online 2012 Oct 12. doi: 10.1016/j.ydbio.2012.10.006
PMCID:
PMC3508389
AbstractArticlePDF–2.2M
20.
A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability
Hong Xiao, Zhigang Yu, Yipin Wu, John Nan, Diane E. Merry, JoAnn M. Sekiguchi, David O. Ferguson, Andrew P. Lieberman, Gregory R. Dressler
Hum Mol Genet. 2012 Oct 1; 21(19): 4225–4236. Published online 2012 Jun 26. doi: 10.1093/hmg/dds246
PMCID:
PMC3441122
AbstractArticlePDF–615K

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