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Select item 106045351.

CRTC2 activates the epithelial–mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway

Yujie Li, Yufeng Zhang, Hongshuo Shi, Xuemei Liu, Zifa Li, Jiayi Zhang, Xiuge Wang, Wenbo Wang, Xiaolin Tong

Mol Med. 2023; 29: 146. Published online 2023 Oct 26. doi: 10.1186/s10020-023-00744-0

PMCID:: PMC10604535

Abstract Article PDF–4.3M

Select item 105509952.

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Wenjun Wang, Junyang Tan, Xiaomin Liu, Wenqi Guo, Mengmeng Li, Xinjie Liu, Yanyan Liu, Wenyu Dai, Liubing Hu, Yimin Wang, Qiuxia Lu, Wen Xing Lee, Hong-Wen Tang, Qinghua Zhou

Nat Commun. 2023; 14: 6201. Published online 2023 Oct 4. doi: 10.1038/s41467-023-41757-x

Correction in:: Nat Commun. 2024; 15: 7167.

PMCID:: PMC10550995

Abstract Article PDF–3.0M

Select item 90120213.

Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2

Marta Montori-Grau, David Aguilar-Recarte, Mohammad Zarei, Javier Pizarro-Delgado, Xavier Palomer, Manuel Vázquez-Carrera

Cell Commun Signal. 2022; 20: 53. Published online 2022 Apr 15. doi: 10.1186/s12964-022-00865-9

PMCID:: PMC9012021

Abstract Article PDF–2.3M

Select item 89814274.

cAMP‐Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease

Zeyun Mi, Yandong Song, Jiuchen Wang, Zhiheng Liu, Xinyi Cao, Lin Dang, Yumei Lu, Yongzhan Sun, Hui Xiong, Lirong Zhang, Yupeng Chen

Adv Sci (Weinh) 2022 Apr; 9(10): 2104578. Published online 2022 Jan 17. doi: 10.1002/advs.202104578

PMCID:: PMC8981427

Abstract Article PDF–5.9M

Select item 89714105.

IL-1β-activated mTORC2 promotes accumulation of IFN-γ⁺ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis

Qihui Liu, Quanli Yang, Zengfeng Wu, Yanfang Chen, Miaomiao Xu, Hua Zhang, Jiliang Zhao, Zonghua Liu, Zerong Guan, Jing Luo, Zhi-yong Li, Guodong Sun, Qiong Wen, Yan Xu, Zhenhua Li, Kebing Chen, Xiaosong Ben, Wanchun He, Xueshi Li, Zhinan Yin, Jianlei Hao, Ligong Lu

Cell Death Dis. 2022 Apr; 13(4): 289. Published online 2022 Apr 1. doi: 10.1038/s41419-022-04739-3

PMCID:: PMC8971410

Abstract Article PDF–7.0M

Select item 87543336.

Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice

Jin Tanaka, Fuka Ishikawa, Tomoki Jinno, Motoki Miyakita, Haruka Miyamori, Tsutomu Sasaki, Takumi Yokokawa, Tsuyoshi Goto, Kazuo Inoue, Shigenobu Matsumura

PLoS One. 2022; 17(1): e0262577. Published online 2022 Jan 12. doi: 10.1371/journal.pone.0262577

PMCID:: PMC8754333

Abstract Article PDF–4.0M

Select item 87527387.

A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex

Yaqiong Chen, Jiang Wang, Yibing Wang, Pengfei Wang, Zan Zhou, Rong Wu, Qian Xu, Hanyun You, Yaxin Liu, Lei Wang, Lingqin Zhou, Yuting Wu, Lihong Hu, Hong Liu, Yi Liu

Nat Commun. 2022; 13: 246. Published online 2022 Jan 11. doi: 10.1038/s41467-021-27533-9

PMCID:: PMC8752738

Abstract Article PDF–1.7M

Select item 86892478.

A novel role of CRTC2 in promoting nonalcoholic fatty liver disease

Hye-Sook Han, Sang Gyune Kim, Young Seok Kim, Si-Hyong Jang, Yongmin Kwon, Dahee Choi, Tom Huh, Eunyoung Moon, Eunyong Ahn, Je Kyung Seong, Hee-Seok Kweon, Geum-Sook Hwang, Dae Ho Lee, Kae Won Cho, Seung-Hoi Koo

Mol Metab. 2022 Jan; 55: 101402. Published online 2021 Nov 24. doi: 10.1016/j.molmet.2021.101402

PMCID:: PMC8689247

Abstract Article PDF–4.2M

Select item 85367339.

Activation of the adipocyte CREB/CRTC pathway in obesity

Young-Sil Yoon, Weiyi Liu, Sam Van de Velde, Shigenobu Matsumura, Ezra Wiater, Ling Huang, Marc Montminy

Commun Biol. 2021; 4: 1214. Published online 2021 Oct 22. doi: 10.1038/s42003-021-02735-5

PMCID:: PMC8536733

Abstract Article PDF–2.5M

Select item 818508410.

Sam68 promotes hepatic gluconeogenesis via CRTC2

Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk M. Habegger, Jianyi Zhang, Gangjian Qin

Nat Commun. 2021; 12: 3340. Published online 2021 Jun 7. doi: 10.1038/s41467-021-23624-9

PMCID:: PMC8185084

Abstract Article PDF–3.0M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 772413012.

CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function

Hideaki Kanki, Tsutomu Sasaki, Shigenobu Matsumura, Tomohiro Kawano, Kenichi Todo, Shuhei Okazaki, Kumiko Nishiyama, Hiroshi Takemori, Hideki Mochizuki

J Neurosci. 2020 Dec 2; 40(49): 9533–9546. doi: 10.1523/JNEUROSCI.0407-20.2020

PMCID:: PMC7724130

Abstract Article PDF–4.8M

Select item 669212413.

CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers

Sam Van de Velde, Ezra Wiater, Melissa Tran, Yousang Hwang, Philip A. Cole, Marc Montminy

Mol Cell Biol. 2019 Sep 1; 39(17): e00200-19. Prepublished online 2019 Jun 10. Published online 2019 Aug 12. doi: 10.1128/MCB.00200-19

PMCID:: PMC6692124

Abstract Article PDF–4.8M

Select item 631727914.

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment

Tim Sonntag, Jelena Ostojić, Joan M. Vaughan, James J. Moresco, Young-Sil Yoon, John R. Yates, III, Marc Montminy

iScience. 2019 Jan 25; 11: 134–145. Published online 2018 Dec 19. doi: 10.1016/j.isci.2018.12.012

PMCID:: PMC6317279

Abstract Article PDF–6.2M

Select item 605334715.

CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting

Yuanyuan Zhang, Yi Liu, Liqun Chen, Yiguo Wang, Jinbo Han

Protein Cell. 2018 Aug; 9(8): 729–732. Published online 2018 Apr 20. doi: 10.1007/s13238-018-0538-3

PMCID:: PMC6053347

Article PDF–556K

Select item 570939316.

Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis

Hye-Sook Han, Byeong Hun Choi, Jun Seok Kim, Geon Kang, Seung-Hoi Koo

Nat Commun. 2017; 8: 1878. Published online 2017 Nov 30. doi: 10.1038/s41467-017-01878-6

PMCID:: PMC5709393

Abstract Article PDF–2.1M

Select item 567692817.

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis

Jeong-Ho Kim, Susan Hedrick, Wen-Wei Tsai, Ezra Wiater, John Le Lay, Klaus H. Kaestner, Mathias Leblanc, Andrew Loar, Marc Montminy

Proc Natl Acad Sci U S A. 2017 Oct 31; 114(44): 11739–11744. Published online 2017 Oct 16. doi: 10.1073/pnas.1712616114

PMCID:: PMC5676928

Abstract Article PDF–1.0M

Select item 557548218.

A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP‐2

Yujie Li, Yongfeng Song, Meng Zhao, Yanjing Guo, Chunxiao Yu, Wenbin Chen, Shanshan Shao, Chao Xu, Xinli Zhou, Lifang Zhao, Zhenhai Zhang, Tao Bo, Yu Xia, Christopher G. Proud, Xuemin Wang, Li Wang, Jiajun Zhao, Ling Gao

Hepatology. 2017 Aug; 66(2): 481–497. Published online 2017 Jun 27. doi: 10.1002/hep.29206

Correction in:: Hepatology. 2018 Mar; 67(3): 1188.

PMCID:: PMC5575482

Abstract Article PDF–1.5M

Select item 532561419.

Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members

Tim Sonntag, James J. Moresco, Joan M. Vaughan, Shigenobu Matsumura, John R. Yates, III, Marc Montminy

PLoS One. 2017; 12(2): e0173013. Published online 2017 Feb 24. doi: 10.1371/journal.pone.0173013

PMCID:: PMC5325614

Abstract Article PDF–3.2M

Select item 510833920.

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

P Hallenborg, M Siersbæk, I Barrio-Hernandez, R Nielsen, K Kristiansen, S Mandrup, L Grøntved, B Blagoev

Cell Death Dis. 2016 Jun; 7(6): e2289. Published online 2016 Jun 30. doi: 10.1038/cddis.2016.188

PMCID:: PMC5108339

Abstract Article PDF–2.7M

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