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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107037262.

Contribution of Nischarin/IRAS in CNS development, injury and diseases

Peijie Zheng, Chenshu Pan, Chuntao Zhou, Bin Liu, Linlin Wang, Shiwei Duan, Yuemin Ding

J Adv Res. 2023 Dec; 54: 43–57. Published online 2023 Jan 27. doi: 10.1016/j.jare.2023.01.020

PMCID:: PMC10703726

Abstract Article PDF–4.0M

Select item 103477243.

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao

BMC Med. 2023; 21: 254. Published online 2023 Jul 13. doi: 10.1186/s12916-023-02931-6

PMCID:: PMC10347724

Abstract Article PDF–2.3M

Select item 103078524.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 90106405.

The non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake

Swati Gupta, Narges Bazargani, James Drew, Jack H. Howden, Souvik Modi, Sana Al Awabdh, Hélène Marie, David Attwell, Josef T. Kittler

iScience. 2022 Apr 15; 25(4): 104127. Published online 2022 Mar 21. doi: 10.1016/j.isci.2022.104127

PMCID:: PMC9010640

Abstract Article PDF–3.0M

Select item 88357206.

Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH^Δ5-6 Knockout Mouse Model

Tina H. Nguyen, Hassan Yousefi, Samuel C. Okpechi, Lothar Lauterboeck, Shengli Dong, Qinglin Yang, Suresh K. Alahari

Int J Mol Sci. 2022 Feb; 23(3): 1374. Published online 2022 Jan 25. doi: 10.3390/ijms23031374

PMCID:: PMC8835720

Abstract Article PDF–2.3M

Select item 74159917.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 58970538.

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans

Thomas Gstrein, Andrew Edwards, Anna Pristoupilová, Ines Leca, Martin Breuss, Sandra Pilat-Carotta, Andi H. Hansen, Ratna Tripathy, Anna K. Traunbauer, Tobias Hochstoeger, Gavril Rosoklija, Marco Repic, Lukas Landler, Viktor Stránecký, Gerhard Dürnberger, Thomas M. Keane, Johannes Zuber, David J. Adams, Jonathan Flint, Tomas Honzik, Marta Gut, Sergi Beltran, Karl Mechtler, Elliott Sherr, Stanislav Kmoch, Ivo Gut, David A. Keays

Nat Neurosci. Author manuscript; available in PMC 2018 Apr 12.

Published in final edited form as: Nat Neurosci. 2018 Feb; 21(2): 207–217. Published online 2018 Jan 8. doi: 10.1038/s41593-017-0053-5

Correction in:: Nat Neurosci. 2018 Jun 6

PMCID:: PMC5897053

Abstract Article PDF–1.2M

Select item 56450829.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 564186710.

Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase

Shengli Dong, Somesh Baranwal, Anapatricia Garcia, Silvia J. Serrano-Gomez, Steven Eastlack, Tomoo Iwakuma, Donald Mercante, Franck Mauvais-Jarvis, Suresh K. Alahari

J Biol Chem. 2017 Oct 13; 292(41): 16833–16846. Published online 2017 Aug 24. doi: 10.1074/jbc.M117.784256

PMCID:: PMC5641867

Abstract Article PDF–2.9M

Select item 557050711.

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways

Michael Crompton, Tom Purnell, Hayley E. Tyrer, Andrew Parker, Greg Ball, Rachel E. Hardisty-Hughes, Richard Gale, Debbie Williams, Charlotte H. Dean, Michelle M. Simon, Ann-Marie Mallon, Sara Wells, Mahmood F. Bhutta, Martin J. Burton, Hilda Tateossian, Steve D. M. Brown

PLoS Genet. 2017 Aug; 13(8): e1006969. Published online 2017 Aug 14. doi: 10.1371/journal.pgen.1006969

PMCID:: PMC5570507

Abstract Article PDF–34M

Select item 468292412.

Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity

Yuemin Ding, Yuying Li, Lingchao Lu, Ruyi Zhang, Linghui Zeng, Linlin Wang, Xiong Zhang

PLoS One. 2015; 10(12): e0144948. Published online 2015 Dec 15. doi: 10.1371/journal.pone.0144948

PMCID:: PMC4682924

Abstract Article PDF–1.1M

Select item 396495513.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 338306514.

Mapping the Nephronophthisis-Joubert-Meckel-Gruber Protein Network Reveals Ciliopathy Disease Genes and Pathways

Liyun Sang, Julie J. Miller, Kevin C. Corbit, Rachel H. Giles, Matthew J. Brauer, Edgar A. Otto, Lisa M. Baye, Xiaohui Wen, Suzie J. Scales, Mandy Kwong, Erik G. Huntzicker, Mindan K. Sfakianos, Wendy Sandoval, J. Fernando Bazan, Priya Kulkarni, Francesc R. Garcia-Gonzalo, Allen D. Seol, John F. O'Toole, Susanne Held, Heiko M. Reutter, William S. Lane, Muhammad Arshad Rafiq, Abdul Noor, Muhammad Ansar, Akella Radha Rama Devi, Val C. Sheffield, Diane C. Slusarski, John B. Vincent, Daniel A. Doherty, Friedhelm Hildebrandt, Jeremy F. Reiter, Peter K. Jackson

Cell. Author manuscript; available in PMC 2012 Jun 26.

Published in final edited form as: Cell. 2011 May 13; 145(4): 513–528. doi: 10.1016/j.cell.2011.04.019

PMCID:: PMC3383065

Abstract Article PDF–2.0M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 313648216.

Genetic Variations Strongly Influence Phenotypic Outcome in the Mouse Retina

Austin S. Jelcick, Yang Yuan, Barrett D. Leehy, Lakeisha C. Cox, Alexandra C. Silveira, Fang Qiu, Sarah Schenk, Andrew J. Sachs, Margaux A. Morrison, Arne M. Nystuen, Margaret M. DeAngelis, Neena B. Haider

PLoS One. 2011; 6(7): e21858. Published online 2011 Jul 14. doi: 10.1371/journal.pone.0021858

Correction in:: PLoS One. 2011; 6(10): 10.1371/annotation/f375292d-9fc7-4e3c-9dc7-af0aee76fa15.

PMCID:: PMC3136482

Abstract Article PDF–1.4M

Select item 302253417.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 255627018.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 242329319.

Nischarin Inhibits LIM Kinase To Regulate Cofilin Phosphorylation and Cell Invasion

Yuemin Ding, Tanja Milosavljevic, Suresh K. Alahari

Mol Cell Biol. 2008 Jun; 28(11): 3742–3756. Published online 2008 Mar 10. doi: 10.1128/MCB.01832-07

PMCID:: PMC2423293

Abstract Article PDF–1.0M

Select item 219059320.

Nischarin, a Novel Protein That Interacts with the Integrin α5 Subunit and Inhibits Cell Migration

Suresh K. Alahari, Jung Weon Lee, Rudy L. Juliano

J Cell Biol. 2000 Dec 11; 151(6): 1141–1154. doi: 10.1083/jcb.151.6.1141

PMCID:: PMC2190593

Abstract Article PDF–557K

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