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Items: 1 to 20 of 87

1.
The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues
Encan Li, Marcel A. G. van der Heyden
Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(9): 6369–6389. Published online 2024 Apr 29. doi: 10.1007/s00210-024-03116-5
PMCID:
PMC11422472
AbstractArticlePDF–1.9M
2.
The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3
Ana I Moreno-Manuel, Álvaro Macías, Francisco M Cruz, Lilian K Gutiérrez, Fernando Martínez, Andrés González-Guerra, Isabel Martínez Carrascoso, Francisco José Bermúdez-Jimenez, Patricia Sánchez-Pérez, María Linarejos Vera-Pedrosa, Juan Manuel Ruiz-Robles, Juan A Bernal, José Jalife
Cardiovasc Res. 2024 Apr; 120(5): 490–505. Published online 2024 Jan 23. doi: 10.1093/cvr/cvae019
PMCID:
PMC11060485
AbstractArticlePDF–1.5M
3.
Phenotypic Variability of Andersen–Tawil Syndrome Due to Allelic Mutation c.652C>T in the KCNJ2 Gene—A New Family Case Report
Maria Elena Onore, Esther Picillo, Paola D’Ambrosio, Salvatore Morra, Vincenzo Nigro, Luisa Politano
Biomolecules. 2024 Apr; 14(4): 507. Published online 2024 Apr 22. doi: 10.3390/biom14040507
PMCID:
PMC11048520
AbstractArticlePDF–3.1M
4.
Activation of Kir2.1 improves myocardial fibrosis by inhibiting Ca 2+ overload and the TGF-β1/Smad signaling pathway : Activation of Kir2.1 improves myocardial fibrosis
Yi Rong, Xin Zhou, Zhenli Guo, Yingying Zhang, Wenjuan Qin, Li Li, Junqiang Si, Rui Yang, Xinzhi Li, Ketao Ma
Acta Biochim Biophys Sin (Shanghai) 2023 May; 55(5): 749–757. Published online 2023 May 15. doi: 10.3724/abbs.2023083
PMCID:
PMC10281881
AbstractArticlePDF–2.4M
5.
Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes
Jingjun Zhou, Baiping Cui, Xiaochen Wang, Hongkun Wang, Junnan Zheng, Fengfeng Guo, Yaxun Sun, Hangping Fan, Jiaxi Shen, Jun Su, Jue Wang, Haige Zhao, Yiquan Tang, Tingyu Gong, Ning Sun, Ping Liang
Stem Cell Res Ther. 2023; 14: 92. Published online 2023 Apr 15. doi: 10.1186/s13287-023-03312-9
PMCID:
PMC10105952
AbstractArticlePDF–7.7M
6.
Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel
Carlos A. H. Fernandes, Dania Zuniga, Charline Fagnen, Valérie Kugler, Rosa Scala, Gérard Péhau-Arnaudet, Renaud Wagner, David Perahia, Saïd Bendahhou, Catherine Vénien-Bryan
Sci Adv. 2022 Sep; 8(38): eabq8489. Published online 2022 Sep 23. doi: 10.1126/sciadv.abq8489
PMCID:
PMC9506730
AbstractArticlePDF–7.3M
7.
Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters
Weiwei Yu, Zhen Wang, Xiafei Yu, Yonghui Zhao, Zili Xie, Kailian Zhang, Zhexu Chi, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Yuxian Guo, Xuyan Yang, Xue Zhang, Yingliang Wu, Wei Yang, Di Wang
Nat Commun. 2022; 13: 3544. Published online 2022 Jun 21. doi: 10.1038/s41467-022-31149-y
PMCID:
PMC9213538
AbstractArticlePDF–4.2M
8.
Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas
Yan-Xia Wang, Haibo Wu, Yong Ren, Shengqing Lv, Chengdong Ji, Dongfang Xiang, Mengsi Zhang, Huimin Lu, Wenjuan Fu, Qing Liu, Zexuan Yan, Qinghua Ma, Jingya Miao, Ruili Cai, Xi Lan, Bin Wu, Wenying Wang, Yinhua Liu, Dai-Zhong Wang, Mianfu Cao, Zhicheng He, Yu Shi, Yifang Ping, Xiaohong Yao, Xia Zhang, Peng Zhang, Ji Ming Wang, Yan Wang, Youhong Cui, Xiu-Wu Bian
Signal Transduct Target Ther. 2022; 7: 72. Published online 2022 Mar 11. doi: 10.1038/s41392-022-00890-7
PMCID:
PMC8913686
AbstractArticlePDF–6.4M
9.
Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx
Sang Joon Ahn, Elizabeth Le Master, James C. Lee, Shane A. Phillips, Irena Levitan, Ibra S. Fancher
Am J Physiol Heart Circ Physiol. 2022 Feb 1; 322(2): H156–H166. Published online 2021 Dec 10. doi: 10.1152/ajpheart.00399.2021
PMCID:
PMC8742723
AbstractArticle
10.
Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators
Philipp Rühl, Johanna M. Langner, Jasmin Reidel, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
Commun Biol. 2021; 4: 1164. Published online 2021 Oct 7. doi: 10.1038/s42003-021-02675-0
PMCID:
PMC8497494
AbstractArticlePDF–3.1M
11.
Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression
Siyuan Chen, Miaoming Huang, Xiarong Hu
Mol Med Rep. 2021 Sep; 24(3): 622. Published online 2021 Jun 30. doi: 10.3892/mmr.2021.12261
PMCID:
PMC8261621
AbstractArticlePDF–11M
12.
Electrophysiology of hiPSC-Cardiomyocytes Co-Cultured with HEK Cells Expressing the Inward Rectifier Channel
Ana Da Silva Costa, Peter Mortensen, Maria P. Hortigon-Vinagre, Marcel A. G. van der Heyden, Francis L. Burton, Hao Gao, Radostin D. Simitev, Godfrey L. Smith
Int J Mol Sci. 2021 Jun; 22(12): 6621. Published online 2021 Jun 21. doi: 10.3390/ijms22126621
PMCID:
PMC8235371
AbstractArticlePDF–5.8M
13.
Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents
Sung-Soo Park, Daniela Ponce-Balbuena, Rork Kuick, Guadalupe Guerrero-Serna, Justin Yoon, Dattatreya Mellacheruvu, Kevin P. Conlon, Venkatesha Basrur, Alexey I. Nesvizhskii, José Jalife, Jean-François Rual
Mol Cell Proteomics. 2020 Sep; 19(9): 1436–1449. Published online 2020 Nov 25. doi: 10.1074/mcp.RA120.002071
PMCID:
PMC8143648
AbstractArticlePDF–3.9M
14.
Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2–MEK1/2–ERK1/2 Signaling
Cheng-Dong Ji, Yan-Xia Wang, Dong-Fang Xiang, Qiang Liu, Zhi-Hua Zhou, Feng Qian, Lang Yang, Yong Ren, Wei Cui, Sen-Lin Xu, Xi-Long Zhao, Xia Zhang, Yan Wang, Peng Zhang, Ji-Ming Wang, You-Hong Cui, Xiu-Wu Bian
Cancer Res. Author manuscript; available in PMC 2021 May 11.
Published in final edited form as: Cancer Res. 2018 Jun 1; 78(11): 3041–3053. Published online 2018 Mar 16. doi: 10.1158/0008-5472.CAN-17-3776
PMCID:
PMC8111788
AbstractArticlePDF–2.1M
15.
Association between Sour Taste SNP KCNJ2-rs236514, Diet Quality and Mild Cognitive Impairment in an Elderly Cohort
Celeste Ferraris, Alexandria Turner, Christopher Scarlett, Martin Veysey, Mark Lucock, Tamara Bucher, Emma L. Beckett
Nutrients. 2021 Mar; 13(3): 719. Published online 2021 Feb 24. doi: 10.3390/nu13030719
PMCID:
PMC7996326
AbstractArticlePDF–311K
16.
Syncytium cell growth increases Kir2.1 contribution in human iPSC-cardiomyocytes
Weizhen Li, Julie L. Han, Emilia Entcheva
Am J Physiol Heart Circ Physiol. 2020 Nov 1; 319(5): H1112–H1122. Published online 2020 Sep 28. doi: 10.1152/ajpheart.00148.2020
PMCID:
PMC7789971
AbstractArticle
17.
Impairment of flow-sensitive inwardly rectifying K+ channels via disruption of glycocalyx mediates obesity-induced endothelial dysfunction
Ibra S. Fancher, Elizabeth Le Master, Sang Joon Ahn, Crystal Adamos, James C. Lee, Evgeny Berdyshev, Randal O. Dull, Shane A. Phillips, Irena Levitan
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Sep; 40(9): e240–e255. Published online 2020 Jul 23. doi: 10.1161/ATVBAHA.120.314935
PMCID:
PMC7503211
AbstractArticlePDF–2.2M
18.
Multivariate analysis of TU wave complex on electrocardiogram in Andersen–Tawil syndrome with KCNJ2 mutations
Hitoshi Horigome, Yasuhiro Ishikawa, Norito Kokubun, Masao Yoshinaga, Naokata Sumitomo, Lisheng Lin, Yoshiaki Kato, Yuri Tanabe‐Kameda, Seiko Ohno, Masami Nagashima, Minoru Horie
Ann Noninvasive Electrocardiol. 2020 May; 25(3): e12721. Published online 2019 Nov 14. doi: 10.1111/anec.12721
PMCID:
PMC7358888
AbstractArticlePDF–1.1M
19.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
20.
Computational Study to Identify the Effects of the KCNJ2 E299V Mutation in Cardiac Pumping Capacity
Da Un Jeong, Jiyeong Lee, Ki Moo Lim
Comput Math Methods Med. 2020; 2020: 7194275. Published online 2020 Mar 31. doi: 10.1155/2020/7194275
PMCID:
PMC7150720
AbstractArticlePDF–2.4M

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