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Select item 109017401.

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Marian Hruska-Plochan, Vera I. Wiersma, Katharina M. Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D. Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann, Magdalini Polymenidou

Nature. 2024; 626(8001): 1073–1083. Published online 2024 Feb 14. doi: 10.1038/s41586-024-07042-7

PMCID:: PMC10901740

Abstract Article PDF–107M

Select item 105435702.

NPTX2 in cerebrospinal fluid predicts the progression from normal cognition to Mild Cognitive Impairment

Anja Soldan, Sungtaek Oh, Taekyung Ryu, Corinne Pettigrew, Yuxin Zhu, Abhay Moghekar, Mei-Fang Xiao, Gregory M. Pontone, Marilyn Albert, Chan-Hyun Na, Paul Worley

Ann Neurol. Author manuscript; available in PMC 2024 Oct 1.

Published in final edited form as: Ann Neurol. 2023 Oct; 94(4): 620–631. Published online 2023 Jul 25. doi: 10.1002/ana.26725

PMCID:: PMC10543570

Abstract Article PDF–838K

Select item 96613383.

A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias

Katharina Bolsewig, Yanaika S. Hok-A-Hin, Federica N. Sepe, Lynn Boonkamp, Dirk Jacobs, Giovanni Bellomo, Federico Paolini Paoletti, Eugeen Vanmechelen, Charlotte E. Teunissen, Lucilla Parnetti, Eline A. J. Willemse

J Alzheimers Dis. 2022; 90(1): 363–380. Prepublished online 2022 Sep 15. Published online 2022 Oct 25. doi: 10.3233/JAD-220318

PMCID:: PMC9661338

Abstract Article PDF–1.3M

Select item 88069774.

Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2)

Long Pei, Xianqiang Lv, Gaopei Jia, Xiaoliang Tan, Ming Li, Aili Zhang

Bioengineered. 2021; 12(1): 8279–8295. Published online 2021 Oct 21. doi: 10.1080/21655979.2021.1984002

PMCID:: PMC8806977

Abstract Article PDF–4.7M

Select item 88062175.

Neuronal pentraxin II (NPTX2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway

Guofeng Xu, Linfeng Fan, Shufeng Zhao, Canhui OuYang

Bioengineered. 2021; 12(1): 1311–1323. Published online 2021 Apr 25. doi: 10.1080/21655979.2021.1915658

PMCID:: PMC8806217

Abstract Article PDF–3.3M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74330537.

Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

Olivia Belbin, Mei-Fang Xiao, Desheng Xu, Maria Carmona-Iragui, Jordi Pegueroles, Bessy Benejam, Laura Videla, Susana Fernández, Isabel Barroeta, Raúl Nuñez-Llaves, Victor Montal, Eduard Vilaplana, Miren Altuna, Jordi Clarimón, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Paul F. Worley, Juan Fortea

Mol Neurodegener. 2020; 15: 46. Published online 2020 Aug 17. doi: 10.1186/s13024-020-00398-0

PMCID:: PMC7433053

Abstract Article PDF–1.4M

Select item 72791978.

Neuronal pentraxin 2: a synapse-derived CSF biomarker in genetic frontotemporal dementia

Emma L van der Ende, Meifang Xiao, Desheng Xu, Jackie M Poos, Jessica L Panman, Lize C Jiskoot, Lieke H Meeter, Elise GP Dopper, Janne M Papma, Carolin Heller, Rhian Convery, Katrina Moore, Martina Bocchetta, Mollie Neason, Georgia Peakman, David M Cash, Charlotte E Teunissen, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sánchez-Valle, Rik Vandenberghe, Robert Laforce Jr, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Christopher R Butler, Simon Ducharme, Alex Gerhard, Adrian Danek, Johannes Levin, Yolande AL Pijnenburg, Markus Otto, Barbara Borroni, Fabrizio Tagliavini, Alexandre de Mendonca, Isabel Santana, Daniela Galimberti, Harro Seelaar, Jonathan D Rohrer, Paul F Worley, John C van Swieten, Genetic Frontotemporal Dementia Initiative (GENFI)

J Neurol Neurosurg Psychiatry. 2020 Jun; 91(6): 612–621. Published online 2020 Apr 9. doi: 10.1136/jnnp-2019-322493

PMCID:: PMC7279197

Abstract Article PDF–1.9M

Select item 70254039.

Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease

Marta Moreno-Rodriguez, Sylvia E. Perez, Muhammad Nadeem, Michael Malek-Ahmadi, Elliott J. Mufson

J Neuroinflammation. 2020; 17: 58. Published online 2020 Feb 17. doi: 10.1186/s12974-020-1723-x

PMCID:: PMC7025403

Abstract Article PDF–5.8M

Select item 639924010.

NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6

Chunjie Xu, Guangang Tian, Chunhui Jiang, Hanbing Xue, Manzila Kuerbanjiang, Longci Sun, Lei Gu, Hong Zhou, Ye Liu, Zhigang Zhang, Qing Xu

Cell Death Dis. 2019 Mar; 10(3): 217. Published online 2019 Mar 4. doi: 10.1038/s41419-019-1467-7

PMCID:: PMC6399240

Abstract Article PDF–4.7M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 540491912.

NPTX2 and cognitive dysfunction in Alzheimer’s Disease

Mei-Fang Xiao, Desheng Xu, Michael T Craig, Kenneth A Pelkey, Chun-Che Chien, Yang Shi, Juhong Zhang, Susan Resnick, Olga Pletnikova, David Salmon, James Brewer, Steven Edland, Jerzy Wegiel, Benjamin Tycko, Alena Savonenko, Roger H Reeves, Juan C Troncoso, Chris J McBain, Douglas Galasko, Paul F Worley

eLife. 2017; 6: e23798. Published online 2017 Mar 23. doi: 10.7554/eLife.23798

PMCID:: PMC5404919

Abstract Article PDF–1.6M

Select item 534932413.

Neuronal Pentraxin 2 Predicts Medial Temporal Atrophy and Memory Decline Across the Alzheimer’s Disease Spectrum

Ashley Swanson, AA Willette

Brain Behav Immun. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: Brain Behav Immun. 2016 Nov; 58: 201–208. Published online 2016 Jul 18. doi: 10.1016/j.bbi.2016.07.148

PMCID:: PMC5349324

Abstract Article PDF–1.3M

Select item 529679114.

Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses

Sung-Jin Lee, Mengping Wei, Chen Zhang, Stephan Maxeiner, ChangHui Pak, Salome Calado Botelho, Justin Trotter, Fredrik H. Sterky, Thomas C. Südhof

J Neurosci. 2017 Feb 1; 37(5): 1062–1080. doi: 10.1523/JNEUROSCI.2768-16.2016

PMCID:: PMC5296791

Abstract Article PDF–9.0M

Select item 415499915.

Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4

Christina A. von Roemeling, Derek C. Radisky, Laura A. Marlow, Simon J. Cooper, Stefan K. Grebe, Panagiotis Z. Anastasiadis, Han W. Tun, John A. Copland

Cancer Res. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Cancer Res. 2014 Sep 1; 74(17): 4796–4810. Published online 2014 Jun 24. doi: 10.1158/0008-5472.CAN-14-0210

PMCID:: PMC4154999

Abstract Article PDF–3.9M

Select item 380402816.

Obligatory role for the immediate early gene NARP in critical period plasticity

Yu Gu, Shiyong Huang, Michael Chang, Paul Worley, Alfredo Kirkwood, Elizabeth M. Quinlan

Neuron. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Neuron. 2013 Jul 24; 79(2): 335–346. doi: 10.1016/j.neuron.2013.05.016

PMCID:: PMC3804028

Abstract Article PDF–3.1M

Select item 337620317.

Association Study of Early-Immediate Genes in Childhood-Onset Mood Disorders and Suicide Attempt

J. Strauss, S. McGregor, N. Freeman, A. Tiwari, C.J. George, M. Kovacs, J.L. Kennedy

Psychiatry Res. Author manuscript; available in PMC 2013 May 15.

Published in final edited form as: Psychiatry Res. 2012 May 15; 197(1-2): 49–54. Published online 2012 Mar 27. doi: 10.1016/j.psychres.2011.11.022

PMCID:: PMC3376203

Article PDF–307K

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 288296119.

Human Chromosome 7: DNA Sequence and Biology

Stephen W. Scherer, Joseph Cheung, Jeffrey R. MacDonald, Lucy R. Osborne, Kazuhiko Nakabayashi, Jo-Anne Herbrick, Andrew R. Carson, Layla Parker-Katiraee, Jennifer Skaug, Razi Khaja, Junjun Zhang, Alexander K. Hudek, Martin Li, May Haddad, Gavin E. Duggan, Bridget A. Fernandez, Emiko Kanematsu, Simone Gentles, Constantine C. Christopoulos, Sanaa Choufani, Dorota Kwasnicka, Xiangqun H. Zheng, Zhongwu Lai, Deborah Nusskern, Qing Zhang, Zhiping Gu, Fu Lu, Susan Zeesman, Malgorzata J. Nowaczyk, Ikuko Teshima, David Chitayat, Cheryl Shuman, Rosanna Weksberg, Elaine H. Zackai, Theresa A. Grebe, Sarah R. Cox, Susan J. Kirkpatrick, Nazneen Rahman, Jan M. Friedman, Henry H. Q. Heng, Pier Giuseppe Pelicci, Francesco Lo-Coco, Elena Belloni, Lisa G. Shaffer, Barbara Pober, Cynthia C. Morton, James F. Gusella, Gail A. P. Bruns, Bruce R. Korf, Bradley J. Quade, Azra H. Ligon, Heather Ferguson, Anne W. Higgins, Natalia T. Leach, Steven R. Herrick, Emmanuelle Lemyre, Chantal G. Farra, Hyung-Goo Kim, Anne M. Summers, Karen W. Gripp, Wendy Roberts, Peter Szatmari, Elizabeth J. T. Winsor, Karl-Heinz Grzeschik, Ahmed Teebi, Berge A. Minassian, Juha Kere, Lluis Armengol, Miguel Angel Pujana, Xavier Estivill, Michael D. Wilson, Ben F. Koop, Sabrina Tosi, Gudrun E. Moore, Andrew P. Boright, Eitan Zlotorynski, Batsheva Kerem, Peter M. Kroisel, Erwin Petek, David G. Oscier, Sarah J. Mould, Hartmut Döhner, Konstanze Döhner, Johanna M. Rommens, John B. Vincent, J. Craig Venter, Peter W. Li, Richard J. Mural, Mark D. Adams, Lap-Chee Tsui

Science. Author manuscript; available in PMC 2010 Jun 9.

Published in final edited form as: Science. 2003 May 2; 300(5620): 767–772. Published online 2003 Apr 10. doi: 10.1126/science.1083423

PMCID:: PMC2882961

Abstract Article PDF–1.2M

Select item 227035320.

Neuronal pentraxin II is highly upregulated in Parkinson’s disease and a novel component of Lewy bodies

Linda B. Moran, Lorraine Hickey, Gregory J. Michael, Maria Derkacs, Lynne M. Christian, Michail E. Kalaitzakis, Ronald K. B. Pearce, Manuel B. Graeber

Acta Neuropathol. 2008 Apr; 115(4): 471–478. Published online 2007 Nov 7. doi: 10.1007/s00401-007-0309-3

PMCID:: PMC2270353

Abstract Article PDF–479K

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