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Select item 101516151.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 98144502.

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2

Hui Zhou, Junru Chen, Mingjie Fan, Huajian Cai, Yufei Dong, Yue Qiu, Qianqian Zhuang, Zhaoying Lei, Mengyao Li, Xue Ding, Peng Yan, Aifu Lin, Shusen Zheng, Qingfeng Yan

J Exp Clin Cancer Res. 2023; 42: 5. Published online 2023 Jan 5. doi: 10.1186/s13046-022-02562-4

PMCID:: PMC9814450

Abstract Article PDF–14M

Select item 97725583.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 94819334.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92759306.

MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2

Hongwei Fan, Rong Ai, Suen Mu, Xuemin Niu, Zhengrong Guo, Lin Liu

Bioengineered. 2022; 13(5): 12021–12029. Published online 2022 May 21. doi: 10.1080/21655979.2022.2054194

PMCID:: PMC9275930

Abstract Article PDF–1.9M

Select item 92152277.

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication

Hainan Liu, Yu Bai, Xun Zhang, Ting Gao, Yue Liu, Entao Li, Xuefeng Wang, Zheng Cao, Lin Zhu, Qincai Dong, Yong Hu, Guangfei Wang, Caiwei Song, Xiayang Niu, Tong Zheng, Di Wang, Zijing Liu, Yanwen Jin, Ping Li, Xiuwu Bian, Cheng Cao, Xuan Liu

J Virol. 2022 Jun; 96(12): e00412-22. Published online 2022 Jun 2. doi: 10.1128/jvi.00412-22

PMCID:: PMC9215227

Abstract Article PDF–4.2M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90565259.

Deubiquitylase OTUD3 prevents Parkinson’s disease through stabilizing iron regulatory protein 2

Fengju Jia, Hongchang Li, Qian Jiao, Chaonan Li, Lin Fu, Chunping Cui, Hong Jiang, Lingqiang Zhang

Cell Death Dis. 2022 Apr; 13(4): 418. Published online 2022 Apr 30. doi: 10.1038/s41419-022-04704-0

PMCID:: PMC9056525

Abstract Article PDF–6.3M

Select item 895155610.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 855290711.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 851385312.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 785743614.

The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity

Jia Song, Tongtong Liu, Yue Yin, Wei Zhao, Zhiqiang Lin, Yuxin Yin, Dan Lu, Fuping You

EMBO Rep. 2021 Feb 3; 22(2): e51162. Published online 2021 Jan 4. doi: 10.15252/embr.202051162

PMCID:: PMC7857436

Abstract Article PDF–3.0M

Select item 774962515.

Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression

Yanhong Zhang, Xiuli Feng, Jin Zhang, Xinbin Chen

Mol Cancer Res. Author manuscript; available in PMC 2020 Dec 19.

Published in final edited form as: Mol Cancer Res. 2020 Jul; 18(7): 1039–1049. Published online 2020 Apr 10. doi: 10.1158/1541-7786.MCR-19-1104

PMCID:: PMC7749625

Abstract Article PDF–1.5M

Select item 715999416.

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

Hui Wang, Hui Shi, Malini Rajan, Elizabeth R. Canarie, Seoyeon Hong, Daniele Simoneschi, Michele Pagano, Matthew F. Bush, Stefan Stoll, Elizabeth A. Leibold, Ning Zheng

Mol Cell. Author manuscript; available in PMC 2021 Apr 2.

Published in final edited form as: Mol Cell. 2020 Apr 2; 78(1): 31–41.e5. Published online 2020 Mar 2. doi: 10.1016/j.molcel.2020.02.011

PMCID:: PMC7159994

Abstract Article PDF–2.4M

Select item 712213117.

Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis

Yanhong Zhang, Xiuli Feng, Jin Zhang, Minyi Chen, Eric Huang, Xinbin Chen

Oncogene. Author manuscript; available in PMC 2020 Apr 3.

Published in final edited form as: Oncogene. 2019 Aug; 38(35): 6256–6269. Published online 2019 Jul 22. doi: 10.1038/s41388-019-0876-5

PMCID:: PMC7122131

Abstract Article PDF–3.8M

Select item 701855318.

Mdm2 is a Target and Mediator of IRP2 in Cell Growth Control

Jin Zhang, Xiangmudong Kong, Yanhong Zhang, Wenqiang Sun, Enshun Xu, Xinbin Chen

FASEB J. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: FASEB J. 2020 Feb; 34(2): 2301–2311. Published online 2019 Dec 12. doi: 10.1096/fj.201902278RR

PMCID:: PMC7018553

Abstract Article PDF–1.8M

Select item 666039219.

Oxygen-dependent interaction between FBXL5 and CIA targeting complex regulates iron homeostasis

Adarsh K. Mayank, Vijaya Pandey, Ajay A. Vashisht, William D. Barshop, Shima Rayatpisheh, Tanu Sharma, Tisha Haque, David N. Powers, James A. Wohlschlegel

Mol Cell. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Mol Cell. 2019 Jul 25; 75(2): 382–393.e5. Published online 2019 Jun 19. doi: 10.1016/j.molcel.2019.05.020

PMCID:: PMC6660392

Abstract Article PDF–2.1M

Select item 648733720.

Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome

Gregory Costain, Manik C Ghosh, Nunziata Maio, Amanda Carnevale, Yue C Si, Tracey A Rouault, Grace Yoon

Brain. 2019 May; 142(5): 1195–1202. Published online 2019 Mar 26. doi: 10.1093/brain/awz072

PMCID:: PMC6487337

Abstract Article PDF–1022K

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