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Select item 114237921.

Novel EWSR1::GFI1B Gene Fusion in Angiofibroma of Soft Tissue

Albert J.H. Suurmeijer, Arjen H.G. Cleven, Cristina R. Antonescu, Lauren A. Duckworth, Karen J. Fritchie, Steven D. Billings, Josephine K. Dermawan

Histopathology. Author manuscript; available in PMC 2024 Dec 1.

Published in final edited form as: Histopathology. 2023 Dec; 83(6): 959–966. Published online 2023 Sep 7. doi: 10.1111/his.15044

PMCID:: PMC11423792

Abstract Article PDF–2.4M

Select item 109789562.

GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation

Jeron Venhuizen, Maaike G. J. M. van Bergen, Saskia M. Bergevoet, Daan Gilissen, Cornelia G. Spruijt, Laura Wingens, Emile van den Akker, Michiel Vermeulen, Joop H. Jansen, Joost H. A. Martens, Bert A. van der Reijden

Commun Biol. 2024; 7: 374. Published online 2024 Mar 28. doi: 10.1038/s42003-024-06090-z

PMCID:: PMC10978956

Abstract Article PDF–3.2M

Select item 94179983.

GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia

Longlong Liu, Pradeep Kumar Patnana, Xiaoqing Xie, Daria Frank, Subbaiah Chary Nimmagadda, Minhua Su, Donghua Zhang, Thorsten Koenig, Frank Rosenbauer, Marie Liebmann, Luisa Klotz, Wendan Xu, Jan Vorwerk, Felix Neumann, Jana Hüve, Andreas Unger, Jürgen Günther Okun, Bertram Opalka, Cyrus Khandanpour

Leukemia. 2022; 36(9): 2196–2207. Published online 2022 Jul 8. doi: 10.1038/s41375-022-01635-9

PMCID:: PMC9417998

Abstract Article PDF–4.6M

Select item 87191024.

Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation

Michela Faleschini, Nicole Papa, Marie-Christine Morel-Kopp, Caterina Marconi, Tania Giangregorio, Federica Melazzini, Valeria Bozzi, Marco Seri, Patrizia Noris, Alessandro Pecci, Anna Savoia, Roberta Bottega

Haematologica. 2022 Jan 1; 107(1): 260–267. Published online 2021 Jan 21. doi: 10.3324/haematol.2020.267328

PMCID:: PMC8719102

Abstract Article PDF–6.0M

Select item 80090485.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 76485996.

Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium

Freya F. Bruveris, Elizabeth S. Ng, Ana Rita Leitoguinho, Ali Motazedian, Katerina Vlahos, Koula Sourris, Robyn Mayberry, Penelope McDonald, Lisa Azzola, Nadia M. Davidson, Alicia Oshlack, Edouard G. Stanley, Andrew G. Elefanty

Development. 2020 Oct 15; 147(20): dev193037. Published online 2020 Oct 29. doi: 10.1242/dev.193037

PMCID:: PMC7648599

Abstract Article

Select item 75566817.

Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice

Hugues Beauchemin, Peiman Shooshtharizadeh, Jordan Pinder, Graham Dellaire, Tarik Möröy

Haematologica. 2020 Oct 1; 105(10): 2457–2470. Published online 2019 Nov 21. doi: 10.3324/haematol.2019.222596

PMCID:: PMC7556681

Abstract Article PDF–5.5M

Select item 72829478.

Loss of myeloid‐specific lamin A/C drives lung metastasis through Gfi‐1 and C/EBPε‐mediated granulocytic differentiation

Hiroki Ishii, Woo‐Yong Park, Jaeyoung So, Skyler Kuhn, Vishal N. Koparde, Yanli Pang, Tim F. Greten, M. Christine Hollander, Li Yang

Mol Carcinog. 2020 Jul; 59(7): 679–690. Published online 2020 Jan 7. doi: 10.1002/mc.23147

PMCID:: PMC7282947

Abstract Article PDF–3.5M

Select item 66460879.

Macrothrombocytopenia associated with a rare GFI1B missense variant confounding the presentation of immune thrombocytopenia

Aaron N. Cheng, Erik L. Bao, Claudia Fiorini, Vijay G. Sankaran

Pediatr Blood Cancer. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Pediatr Blood Cancer. 2019 Sep; 66(9): e27874. Published online 2019 Jun 17. doi: 10.1002/pbc.27874

PMCID:: PMC6646087

Abstract Article PDF–419K

Select item 658070410.

Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex

David McClellan, Mattie J. Casey, Diana Bareyan, Helena Lucente, Christopher Ours, Matthew Velinder, Jason Singer, Mehraju Din Lone, Wenxiang Sun, Yunuen Coria, Clinton C. Mason, Michael E. Engel

Mol Cell Biol. 2019 Jul 1; 39(13): e00020-19. Prepublished online 2019 Apr 15. Published online 2019 Jun 13. doi: 10.1128/MCB.00020-19

PMCID:: PMC6580704

Abstract Article PDF–1.6M

Select item 654582911.

Inherited missense variants that affect GFI1B function do not necessarily cause bleeding diatheses

Rinske van Oorschot, Anna E. Marneth, Saskia M. Bergevoet, Maaike G.J.M. van Bergen, Kathelijne Peerlinck, Claire E. Lentaigne, Carolyn M. Millar, Sarah K. Westbury, Remi Favier, Wendy N. Erber, Ernest Turro, Joop H. Jansen, Willem H. Ouwehand, Harriet L. McKinney, NIHR BioResource Collaborative Group, Kate Downes, Kathleen Freson, Bert A. van der Reijden

Haematologica. 2019 Jun; 104(6): e260–e264. doi: 10.3324/haematol.2018.207712

PMCID:: PMC6545829

Article PDF–880K

Select item 642687012.

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Peiman Shooshtarizadeh, Anne Helness, Charles Vadnais, Nelleke Brouwer, Hugues Beauchemin, Riyan Chen, Halil Bagci, Frank J. T. Staal, Jean-François Coté, Tarik Möröy

Nat Commun. 2019; 10: 1270. Published online 2019 Mar 20. doi: 10.1038/s41467-019-09273-z

PMCID:: PMC6426870

Abstract Article PDF–2.3M

Select item 642645513.

Mapping the genetic landscape of human cells

Max A. Horlbeck, Albert Xu, Min Wang, Neal K. Bennett, Chong Y. Park, Derek Bogdanoff, Britt Adamson, Eric D. Chow, Martin Kampmann, Tim R. Peterson, Ken Nakamura, Michael A. Fischbach, Jonathan S. Weissman, Luke A. Gilbert

Cell. Author manuscript; available in PMC 2019 Aug 9.

Published in final edited form as: Cell. 2018 Aug 9; 174(4): 953–967.e22. Published online 2018 Jul 19. doi: 10.1016/j.cell.2018.06.010

PMCID:: PMC6426455

Abstract Article PDF–3.6M

Select item 629516514.

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression

Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-François Rual, James Douglas Engel

Genes Dev. 2018 Dec 1; 32(23-24): 1537–1549. doi: 10.1101/gad.318436.118

PMCID:: PMC6295165

Abstract Article PDF–3.5M

Select item 586543815.

Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome

Aniththa Thivakaran, Lacramioara Botezatu, Judith M. Hönes, Judith Schütte, Lothar Vassen, Yahya S. Al-Matary, Pradeep Patnana, Amos Zeller, Michael Heuser, Felicitas Thol, Razif Gabdoulline, Nadine Olberding, Daria Frank, Marina Suslo, Renata Köster, Klaus Lennartz, Andre Görgens, Bernd Giebel, Bertram Opalka, Ulrich Dührsen, Cyrus Khandanpour

Haematologica. 2018 Apr; 103(4): 614–625. Prepublished online 2018 Jan 11. doi: 10.3324/haematol.2017.167288

PMCID:: PMC5865438

Abstract Article PDF–2.6M

Select item 534647416.

Combined alpha-delta platelet storage pool deficiency is associated with mutations in GFI1B

Carlos R. Ferreira, Dong Chen, Shirley M. Abraham, David R. Adams, Karen L. Simon, May C. Malicdan, Thomas C. Markello, Meral Gunay-Aygun, William A. Gahl

Mol Genet Metab. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Mol Genet Metab. 2017 Mar; 120(3): 288–294. Published online 2016 Dec 18. doi: 10.1016/j.ymgme.2016.12.006

PMCID:: PMC5346474

Abstract Article PDF–1.0M

Select item 507449617.

Cooperative Stimulation of Megakaryocytic Differentiation by Gfi1b Gene Targets Kindlin3 and Talin1

Divya Singh, Ghanshyam Upadhyay, Ananya Sengupta, Mohammed A. Biplob, Shaleen Chakyayil, Tiji George, Shireen Saleque

PLoS One. 2016; 11(10): e0164506. Published online 2016 Oct 21. doi: 10.1371/journal.pone.0164506

PMCID:: PMC5074496

Abstract Article PDF–2.1M

Select item 497416918.

Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis

Linda M. Polfus, Rajiv K. Khajuria, Ursula M. Schick, Nathan Pankratz, Raha Pazoki, Jennifer A. Brody, Ming-Huei Chen, Paul L. Auer, James S. Floyd, Jie Huang, Leslie Lange, Frank J.A. van Rooij, Richard A. Gibbs, Ginger Metcalf, Donna Muzny, Narayanan Veeraraghavan, Klaudia Walter, Lu Chen, Lisa Yanek, Lewis C. Becker, Gina M. Peloso, Aoi Wakabayashi, Mart Kals, Andres Metspalu, Tõnu Esko, Keolu Fox, Robert Wallace, Nora Franceshini, Nena Matijevic, Kenneth M. Rice, Traci M. Bartz, Leo-Pekka Lyytikäinen, Mika Kähönen, Terho Lehtimäki, Olli T. Raitakari, Ruifang Li-Gao, Dennis O. Mook-Kanamori, Guillaume Lettre, Cornelia M. van Duijn, Oscar H. Franco, Stephen S. Rich, Fernando Rivadeneira, Albert Hofman, André G. Uitterlinden, James G. Wilson, Bruce M. Psaty, Nicole Soranzo, Abbas Dehghan, Eric Boerwinkle, Xiaoling Zhang, Andrew D. Johnson, Christopher J. O’Donnell, Jill M. Johnsen, Alexander P. Reiner, Santhi K. Ganesh, Vijay G. Sankaran

Am J Hum Genet. 2016 Aug 4; 99(2): 481–488. Published online 2016 Aug 2. doi: 10.1016/j.ajhg.2016.06.016

Correction in:: Am J Hum Genet. 2016 Sep 1; 99(3): 785.

PMCID:: PMC4974169

Abstract Article PDF–986K

Select item 467383419.

Control of developmentally primed erythroid genes by combinatorial co-repressor actions

Ralph Stadhouders, Alba Cico, Tharshana Stephen, Supat Thongjuea, Petros Kolovos, H. Irem Baymaz, Xiao Yu, Jeroen Demmers, Karel Bezstarosti, Alex Maas, Vilma Barroca, Christel Kockx, Zeliha Ozgur, Wilfred van Ijcken, Marie-Laure Arcangeli, Charlotte Andrieu-Soler, Boris Lenhard, Frank Grosveld, Eric Soler

Nat Commun. 2015; 6: 8893. Published online 2015 Nov 23. doi: 10.1038/ncomms9893

PMCID:: PMC4673834

Abstract Article PDF–2.7M

Select item 467110620.

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation

Tarik Möröy, Lothar Vassen, Brian Wilkes, Cyrus Khandanpour

Blood. 2015 Dec 10; 126(24): 2561–2569. Prepublished online 2015 Oct 7. doi: 10.1182/blood-2015-06-655043

PMCID:: PMC4671106

Abstract Article

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