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Select item 111146631.

The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1

Paola Grimaldi, Mariangela Pucci, Sara Di Siena, Daniele Di Giacomo, Valentina Pirazzi, Raffaele Geremia, Mauro Maccarrone

Cell Mol Life Sci. 2012 Dec; 69(24): 4177–4190. Published online 2012 Jul 17. doi: 10.1007/s00018-012-1074-6

PMCID:: PMC11114663

Abstract Article PDF–780K

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106242033.

FAAH inhibition ameliorates breast cancer in a murine model

Mallika Tripathy, Amy Bui, Jared Henderson, Jeffrey Sun, Christian Rutan Woods, Soumya Somani, Thao Doan, Anto Sam Crosslee Louis Sam Titus, Chandra Mohan

Oncotarget. 2023; 14: 910–918. Published online 2023 Oct 31. doi: 10.18632/oncotarget.28534

PMCID:: PMC10624203

Abstract Article PDF–1.6M

Select item 106002004.

Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition

Laia Alegre-Zurano, Alba Caceres-Rodriguez, Paula Berbegal-Sáez, Olivier Lassalle, Olivier Manzoni, Olga Valverde

Sci Rep. 2023; 13: 18229. Published online 2023 Oct 25. doi: 10.1038/s41598-023-45476-7

PMCID:: PMC10600200

Abstract Article PDF–2.7M

Select item 100298255.

Genetic Knockout of Fatty Acid Amide Hydrolase Ameliorates Cisplatin-Induced Nephropathy in Mice

Chaoling Chen, Weili Wang, Marissa Raymond, Fereshteh Ahmadinejad, Justin L. Poklis, Brandon Em, David A. Gewirtz, Aron H. Lichtman, Ningjun Li

Mol Pharmacol. 2023 Apr; 103(4): 230–240. Published online 2023 Apr. doi: 10.1124/molpharm.122.000618

PMCID:: PMC10029825

Abstract Article PDF–1.5M

Select item 96723546.

The endocannabinoid anandamide is an airway relaxant in health and disease

Annika Simon, Thomas von Einem, Alexander Seidinger, Michaela Matthey, Laura Bindila, Daniela Wenzel

Nat Commun. 2022; 13: 6941. Published online 2022 Nov 17. doi: 10.1038/s41467-022-34327-0

PMCID:: PMC9672354

Abstract Article PDF–1019K

Select item 91069317.

In situ Identification of Cellular Drug Targets in Mammalian Tissue

Zhengyuan Pang, Michael A. Schafroth, Daisuke Ogasawara, Yu Wang, Victoria Nudell, Neeraj Lal, Dong Yang, Kristina Wang, Dylan M Herbst, Jacquelyn Ha, Carlos Guijas, Jacqueline L Blankman, Benjamin F. Cravatt, Li Ye

Cell. Author manuscript; available in PMC 2023 May 12.

Published in final edited form as: Cell. 2022 May 12; 185(10): 1793–1805.e17. Published online 2022 Apr 27. doi: 10.1016/j.cell.2022.03.040

PMCID:: PMC9106931

Abstract Article PDF–3.0M

Select item 89109118.

Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury

Tiziana Genovese, Andrea Duranti, Ramona D’Amico, Roberta Fusco, Daniela Impellizzeri, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro

Int J Mol Sci. 2022 Mar; 23(5): 2781. Published online 2022 Mar 3. doi: 10.3390/ijms23052781

PMCID:: PMC8910911

Abstract Article PDF–3.6M

Select item 84826149.

Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease

Gonzalo Ruiz-Pérez, Samuel Ruiz de Martín Esteban, Sharai Marqués, Noelia Aparicio, M. Teresa Grande, Irene Benito-Cuesta, Ana M. Martínez-Relimpio, M. Andrea Arnanz, Rosa M. Tolón, María Posada-Ayala, Benjamin F. Cravatt, José A. Esteban, Julián Romero, Rocío Palenzuela

J Neuroinflammation. 2021; 18: 223. Published online 2021 Sep 29. doi: 10.1186/s12974-021-02276-y

PMCID:: PMC8482614

Abstract Article PDF–4.1M

Select item 843570210.

Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice

Claudia Yaghootfam, Bernd Gehrig, Marc Sylvester, Volkmar Gieselmann, Ulrich Matzner

J Biol Chem. 2021 Sep; 297(3): 101064. Published online 2021 Aug 8. doi: 10.1016/j.jbc.2021.101064

PMCID:: PMC8435702

Abstract Article PDF–2.0M

Select item 714542311.

Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH

Joon T Kim, Stephanie M Terrell, Veronica L Li, Wei Wei, Curt R Fischer, Jonathan Z Long

eLife. 2020; 9: e55211. Published online 2020 Apr 9. doi: 10.7554/eLife.55211

PMCID:: PMC7145423

Abstract Article PDF–2.9M

Select item 701569012.

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice

Caitlin E. Burgdorf, Deqiang Jing, Ruirong Yang, Chienchun Huang, Matthew N. Hill, Ken Mackie, Teresa A. Milner, Virginia M. Pickel, Francis S. Lee, Anjali M. Rajadhyaksha

Sci Adv. 2020 Feb; 6(7): eaay1502. Published online 2020 Feb 12. doi: 10.1126/sciadv.aay1502

PMCID:: PMC7015690

Abstract Article PDF–705K

Select item 690053213.

N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis

Trisha J. Grevengoed, Samuel A. J. Trammell, Michele K. McKinney, Natalia Petersen, Rebecca L. Cardone, Jens S. Svenningsen, Daisuke Ogasawara, Christina C. Nexøe-Larsen, Filip K. Knop, Thue W. Schwartz, Richard G. Kibbey, Benjamin F. Cravatt, Matthew P. Gillum

Proc Natl Acad Sci U S A. 2019 Dec 3; 116(49): 24770–24778. Published online 2019 Nov 18. doi: 10.1073/pnas.1916288116

PMCID:: PMC6900532

Abstract Article PDF–1.7M

Select item 678491014.

Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses

Tina Zimmermann, Julia C. Bartsch, Annika Beer, Ermelinda Lomazzo, Stephan Guggenhuber, Maren D. Lange, Laura Bindila, Hans-Christian Pape, Beat Lutz

Neuropsychopharmacology. 2019 Jul; 44(8): 1377–1388. Published online 2018 Nov 15. doi: 10.1038/s41386-018-0274-7

PMCID:: PMC6784910

Abstract Article PDF–3.3M

Select item 674218415.

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase

Angela B. Clement, E. Gregory Hawkins, Aron H. Lichtman, Benjamin F. Cravatt

J Neurosci. 2003 May 1; 23(9): 3916–3923. doi: 10.1523/JNEUROSCI.23-09-03916.2003

PMCID:: PMC6742184

Abstract Article PDF–361K

Select item 673023216.

Circuitry for Associative Plasticity in the Amygdala Involves Endocannabinoid Signaling

Shahnaz C. Azad, Krisztina Monory, Giovanni Marsicano, Benjamin F. Cravatt, Beat Lutz, Walter Zieglgänsberger, Gerhard Rammes

J Neurosci. 2004 Nov 3; 24(44): 9953–9961. doi: 10.1523/JNEUROSCI.2134-04.2004

PMCID:: PMC6730232

Abstract Article PDF–568K

Select item 624877217.

Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels

Xiaofei Sun, Alexandra Tavenier, Wenbo Deng, Emma Leishman, Heather B Bradshaw, Sudhansu K Dey

Biol Reprod. 2018 Feb; 98(2): 208–217. Published online 2017 Dec 5. doi: 10.1093/biolre/iox164

PMCID:: PMC6248772

Abstract Article PDF–2.3M

Select item 623073718.

Modulation of mean arterial pressure and diuresis by renomedullary infusion of a selective inhibitor of fatty acid amide hydrolase

Ashfaq Ahmad, Sara K. Dempsey, Zdravka Daneva, Ningjun Li, Justin L. Poklis, Pin-Lan Li, Joseph K. Ritter

Am J Physiol Renal Physiol. 2018 Oct 1; 315(4): F967–F976. Published online 2018 May 30. doi: 10.1152/ajprenal.00090.2018

PMCID:: PMC6230737

Abstract Article

Select item 605517119.

Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance

Georgia Balsevich, Martin Sticht, Nicole P. Bowles, Arashdeep Singh, Tiffany T. Y. Lee, Zhiying Li, Prasanth K. Chelikani, Francis S. Lee, Stephanie L. Borgland, Cecilia J. Hillard, Bruce S. McEwen, Matthew N. Hill

Proc Natl Acad Sci U S A. 2018 Jul 17; 115(29): 7605–7610. Published online 2018 Jul 2. doi: 10.1073/pnas.1802251115

PMCID:: PMC6055171

Abstract Article PDF–733K

Select item 579215420.

Stimulation of diuresis and natriuresis by renomedullary infusion of a dual inhibitor of fatty acid amide hydrolase and monoacylglycerol lipase

Ashfaq Ahmad, Zdravka Daneva, Guangbi Li, Sara K. Dempsey, Ningjun Li, Justin L. Poklis, Aron Lichtman, Pin-Lan Li, Joseph K. Ritter

Am J Physiol Renal Physiol. 2017 Nov 1; 313(5): F1068–F1076. Published online 2017 Aug 2. doi: 10.1152/ajprenal.00196.2017

PMCID:: PMC5792154

Abstract Article

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