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Select item 113624591.

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation

Lisa Kofler, Lorenz Grundmann, Magdalena Gerhalter, Michael Prattes, Juliane Merl-Pham, Gertrude Zisser, Irina Grishkovskaya, Victor-Valentin Hodirnau, Martin Vareka, Rolf Breinbauer, Stefanie M. Hauck, David Haselbach, Helmut Bergler

Nat Commun. 2024; 15: 7511. Published online 2024 Aug 29. doi: 10.1038/s41467-024-51754-3

PMCID:: PMC11362459

Abstract Article PDF–3.5M

Select item 108997792.

The RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis

Valentin Mitterer, Hussein Hamze, Natalia Kunowska, Ulrich Stelzl, Anthony K Henras, Ed Hurt

Nucleic Acids Res. 2024 Feb 28; 52(4): 1975–1987. Published online 2023 Dec 19. doi: 10.1093/nar/gkad1206

PMCID:: PMC10899779

Abstract Article PDF–1.6M

Select item 108724773.

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle

Michael J. O’Brien, Athar Ansari

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2024 Jan 1; 1872(1): 140968. Published online 2023 Oct 19. doi: 10.1016/j.bbapap.2023.140968

PMCID:: PMC10872477

Abstract Article PDF–1.7M

Select item 107988584.

Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking

Lucas J. Marmorale, Huan Jin, Thomas G. Reidy, Brandon Palomino-Alonso, Christopher J. Zysnarski, Fatima Jordan-Javed, Sagar Lahiri, Mara C. Duncan

J Cell Biol. 2024 Mar 4; 223(3): e202309047. Published online 2024 Jan 19. doi: 10.1083/jcb.202309047

PMCID:: PMC10798858

Abstract Article PDF–6.4M

Select item 107001385.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 106390616.

Yeast ribosome biogenesis factors Puf6 and Nog2 and ribosomal proteins uL2 and eL43 act in concert to facilitate the release of nascent large ribosomal subunits from the nucleolus

Amber J LaPeruta, Stefanie Hedayati, Jelena Micic, Fiona Fitzgerald, David Kim, Grace Oualline, John L Woolford

Nucleic Acids Res. 2023 Nov 10; 51(20): 11277–11290. Published online 2023 Oct 9. doi: 10.1093/nar/gkad794

PMCID:: PMC10639061

Abstract Article PDF–3.7M

Select item 101540287.

Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase

Valentin Mitterer, Matthias Thoms, Robert Buschauer, Otto Berninghausen, Ed Hurt, Roland Beckmann

eLife. 2023; 12: e84877. Published online 2023 Mar 17. doi: 10.7554/eLife.84877

PMCID:: PMC10154028

Abstract Article PDF–9.4M

Select item 95088198.

Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation

Priya Bhutada, Sébastien Favre, Mariam Jaafar, Jutta Hafner, Laura Liesinger, Stefan Unterweger, Karin Bischof, Barbara Darnhofer, Devanarayanan Siva Sankar, Gerald Rechberger, Raghida Abou Merhi, Simon Lebaron, Ruth Birner-Gruenberger, Dieter Kressler, Anthony K Henras, Brigitte Pertschy

Nucleic Acids Res. 2022 Sep 23; 50(17): 10053–10077. Published online 2022 Aug 26. doi: 10.1093/nar/gkac724

PMCID:: PMC9508819

Abstract Article PDF–16M

Select item 95079699.

Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1

Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Christina Hetzmannseder, Gertrude Zisser, Carolin Sailer, Vasileios Kargas, Mathias Loibl, Magdalena Gerhalter, Lisa Kofler, Alan J. Warren, Florian Stengel, David Haselbach, Helmut Bergler

Nat Struct Mol Biol. 2022; 29(9): 942–953. Published online 2022 Sep 12. doi: 10.1038/s41594-022-00832-5

PMCID:: PMC9507969

Abstract Article PDF–9.4M

Select item 920981110.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 883720211.

The MIDAS domain of AAA mechanoenzyme Mdn1 forms catch bonds with two different substrates

Keith J Mickolajczyk, Paul Dominic B Olinares, Brian T Chait, Shixin Liu, Tarun M Kapoor

eLife. 2022; 11: e73534. Published online 2022 Feb 11. doi: 10.7554/eLife.73534

PMCID:: PMC8837202

Abstract Article PDF–1.8M

Select item 851195012.

The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions

Rajaraman Gopalakrishnan, Fred Winston

J Biol Chem. 2021 Oct; 297(4): 101205. Published online 2021 Sep 17. doi: 10.1016/j.jbc.2021.101205

PMCID:: PMC8511950

Abstract Article PDF–3.1M

Select item 773068713.

Mutational Analysis of the Nsa2 N-Terminus Reveals Its Essential Role in Ribosomal 60S Subunit Assembly

Helge Paternoga, Alexander Früh, Ruth Kunze, Bettina Bradatsch, Jochen Baßler, Ed Hurt

Int J Mol Sci. 2020 Dec; 21(23): 9108. Published online 2020 Nov 30. doi: 10.3390/ijms21239108

PMCID:: PMC7730687

Abstract Article PDF–3.1M

Select item 754769014.

Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel

Daniel M. Wilson, Yu Li, Amber LaPeruta, Michael Gamalinda, Ning Gao, John L. Woolford, Jr

Nat Commun. 2020; 11: 5111. Published online 2020 Oct 9. doi: 10.1038/s41467-020-18878-8

PMCID:: PMC7547690

Abstract Article PDF–3.4M

Select item 630060215.

RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes

Lukas Brüning, Philipp Hackert, Roman Martin, Jimena Davila Gallesio, Gerald Ryan R. Aquino, Henning Urlaub, Katherine E. Sloan, Markus T. Bohnsack

Nat Commun. 2018; 9: 5383. Published online 2018 Dec 19. doi: 10.1038/s41467-018-07783-w

PMCID:: PMC6300602

Abstract Article PDF–3.9M

Select item 617370116.

Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation

Matthias Thoms, Valentin Mitterer, Lukas Kater, Laurent Falquet, Roland Beckmann, Dieter Kressler, Ed Hurt

Nat Commun. 2018; 9: 4094. Published online 2018 Oct 5. doi: 10.1038/s41467-018-06660-w

PMCID:: PMC6173701

Abstract Article PDF–6.1M

Select item 602853917.

Hierarchical recruitment of ribosomal proteins and assembly factors remodels nucleolar pre-60S ribosomes

Stephanie Biedka, Jelena Micic, Daniel Wilson, Hailey Brown, Luke Diorio-Toth, John L. Woolford, Jr.

J Cell Biol. 2018 Jul 2; 217(7): 2503–2518. doi: 10.1083/jcb.201711037

PMCID:: PMC6028539

Abstract Article PDF–2.9M

Select item 592252818.

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Harley O’Connor Mount, Nicole M. Revie, Robert T. Todd, Kaitlin Anstett, Cathy Collins, Michael Costanzo, Charles Boone, Nicole Robbins, Anna Selmecki, Leah E. Cowen

PLoS Genet. 2018 Apr; 14(4): e1007319. Published online 2018 Apr 27. doi: 10.1371/journal.pgen.1007319

PMCID:: PMC5922528

Abstract Article PDF–7.1M

Select item 588816019.

Viewing pre-60S maturation at a minute’s timescale

Gertrude Zisser, Uli Ohmayer, Christina Mauerhofer, Valentin Mitterer, Isabella Klein, Gerald N Rechberger, Heimo Wolinski, Michael Prattes, Brigitte Pertschy, Philipp Milkereit, Helmut Bergler

Nucleic Acids Res. 2018 Apr 6; 46(6): 3140–3151. Published online 2017 Dec 27. doi: 10.1093/nar/gkx1293