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Items: 1 to 20 of 27

1.
A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models
Paul R. Stabach, Dominique Sims, Eduardo Gomez-Bañuelos, Sandra Zehentmeier, Kris Dammen-Brower, Andrew Bernhisel, Sophia Kujawski, Sam G. Lopez, Michelle Petri, Daniel W. Goldman, Ethan R. Lester, Quan Le, Tayyaba Ishaq, Hana Kim, Shivani Srivastava, Deepika Kumar, Joao P. Pereira, Kevin J. Yarema, Fotios Koumpouras, Felipe Andrade, Demetrios T. Braddock
JCI Insight. 2024 Jul 22; 9(14): e177003. Published online 2024 Jun 18. doi: 10.1172/jci.insight.177003
PMCID:
PMC11383374
AbstractArticlePDF–14M
2.
Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue
Lucia Montorsi, Michael J. Pitcher, Yuan Zhao, Chiara Dionisi, Alicia Demonti, Thomas J. Tull, Pawan Dhami, Richard J. Ellis, Cynthia Bishop, Jeremy D. Sanderson, Sahil Jain, David D’Cruz, Deena L. Gibbons, Thomas H. Winkler, Mats Bemark, Francesca D. Ciccarelli, Jo Spencer
Nat Commun. 2024; 15: 4051. Published online 2024 May 14. doi: 10.1038/s41467-024-48267-4
PMCID:
PMC11094119
AbstractArticlePDF–13M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice
Minal Engavale, Colton J. Hernandez, Angelica Infante, Tanya LeRoith, Elliott Radovan, Lauryn Evans, Johanna Villarreal, Christopher M. Reilly, R. Bryan Sutton, Peter A. Keyel
J Leukoc Biol. Author manuscript; available in PMC 2024 Nov 24.
Published in final edited form as: J Leukoc Biol. 2023 Nov 24; 114(6): 547–556. doi: 10.1093/jleuko/qiad115
PMCID:
PMC10843819
AbstractArticlePDF–1.7M
5.
Neutrophil extracellular traps and DNases orchestrate formation of peritoneal adhesions
Julia Elrod, Annika Heuer, Jasmin Knopf, Janina Schoen, Lavinia Schönfeld, Magdalena Trochimiuk, Carolin Stiel, Birgit Appl, Laia Pagerols Raluy, Ceren Saygi, Leticija Zlatar, Sami Hosari, Dmytro Royzman, Thomas H. Winkler, Günter Lochnit, Moritz Leppkes, Robert Grützmann, Georg Schett, Christian Tomuschat, Konrad Reinshagen, Martin Herrmann, Tobias A. Fuchs, Michael Boettcher
iScience. 2023 Dec 15; 26(12): 108289. Published online 2023 Oct 27. doi: 10.1016/j.isci.2023.108289
PMCID:
PMC10682263
AbstractArticlePDF–7.0M
6.
DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer
Wenling Li, Hideki Nakano, Wei Fan, Yuanyuan Li, Payel Sil, Keiko Nakano, Fei Zhao, Peer W. Karmaus, Sara A. Grimm, Min Shi, Xin Xu, Ryushin Mizuta, Daisuke Kitamura, Yisong Wan, Michael B. Fessler, Donald N. Cook, Igor Shats, Xiaoling Li, Leping Li
JCI Insight. 2023 Sep 8; 8(17): e168161. Published online 2023 Sep 8. doi: 10.1172/jci.insight.168161
PMCID:
PMC10544201
AbstractArticlePDF–3.6M
7.
Targeting NETs using dual-active DNase1 variants
Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath, Maike Frye, Reiner K. Mailer, Manu Beerens, Julian C. Gerwers, Roger J. S. Preston, Jacob Odeberg, Lynn M. Butler, Coen Maas, Evi X. Stavrou, Tobias A. Fuchs, Thomas Renné
Front Immunol. 2023; 14: 1181761. Published online 2023 May 23. doi: 10.3389/fimmu.2023.1181761
PMCID:
PMC10242134
AbstractArticlePDF–7.6M
8.
Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms
Keenan A. Lacey, Lee Serpas, Sohei Makita, Yueyang Wang, Ali Rashidfarrokhi, Chetna Soni, Sandra Gonzalez, Andre Moreira, Victor J. Torres, Boris Reizis
J Exp Med. 2023 Jun 5; 220(6): e20221086. Published online 2023 Mar 16. doi: 10.1084/jem.20221086
PMCID:
PMC10037111
AbstractArticlePDF–9.4M
9.
Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus
Marina A. Korn, Marie Steffensen, Carolin Brandl, Dmytro Royzman, Christoph Daniel, Thomas H. Winkler, Lars Nitschke
Front Immunol. 2023; 14: 1095830. Published online 2023 Mar 8. doi: 10.3389/fimmu.2023.1095830
PMCID:
PMC10030676
AbstractArticlePDF–5.8M
10.
Effects of nucleases on cell-free extrachromosomal circular DNA
Sarah T.K. Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca W.Y. Chan, Stefano Volpi, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Suk Hang Cheng, Danny K.L. Wong, Kathy O. Lui, Peiyong Jiang, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo
JCI Insight. 2022 Apr 22; 7(8): e156070. Published online 2022 Apr 22. doi: 10.1172/jci.insight.156070
PMCID:
PMC9089787
AbstractArticlePDF–917K
11.
Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris
Lukas Verhülsdonk, Hans Georg Mannherz, Markus Napirei
PLoS One. 2021; 16(7): e0253476. Published online 2021 Jul 30. doi: 10.1371/journal.pone.0253476
PMCID:
PMC8323900
AbstractArticlePDF–4.0M
12.
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
Johannes Hartl, Lee Serpas, Yueyang Wang, Ali Rashidfarrokhi, Oriana A. Perez, Benjamin Sally, Vanja Sisirak, Chetna Soni, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Ivan Caiello, Claudia Bracaglia, Stefano Volpi, Gian Marco Ghiggeri, Asiya Seema Chida, Ignacio Sanz, Mimi Y. Kim, H. Michael Belmont, Gregg J. Silverman, Robert M. Clancy, Peter M. Izmirly, Jill P. Buyon, Boris Reizis
J Exp Med. 2021 May 3; 218(5): e20201138. Published online 2021 Mar 30. doi: 10.1084/jem.20201138
PMCID:
PMC8020718
AbstractArticlePDF–4.6M
13.
Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction
Rebecca W.Y. Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T. Hiraki, Lai-Shan Tam, Ali Rashidfarrokhi, Priscilla C.H. Wong, Lydia H.P. Tam, Yueyang Wang, Peiyong Jiang, Alice S.H. Cheng, Wenlei Peng, Diana S.C. Han, Patty P.P. Tse, Pik Ki Lau, Wing-Shan Lee, Alberto Magnasco, Elisa Buti, Vanja Sisirak, Nora AlMutairi, K.C. Allen Chan, Rossa W.K. Chiu, Boris Reizis, Y.M. Dennis Lo
Am J Hum Genet. 2020 Nov 5; 107(5): 882–894. Published online 2020 Oct 5. doi: 10.1016/j.ajhg.2020.09.006
PMCID:
PMC7674998
AbstractArticlePDF–2.1M
14.
Plasmacytoid dendritic cells and type I interferon promote extrafollicular B cell responses to extracellular self-DNA
Chetna Soni, Oriana A. Perez, William N. Voss, Joseph N. Pucella, Lee Serpas, Justin Mehl, Krystal L. Ching, Jule Goike, George Georgiou, Gregory C. Ippolito, Vanja Sisirak, Boris Reizis
Immunity. Author manuscript; available in PMC 2021 Jun 16.
Published in final edited form as: Immunity. 2020 Jun 16; 52(6): 1022–1038.e7. Published online 2020 May 25. doi: 10.1016/j.immuni.2020.04.015
PMCID:
PMC7306002
AbstractArticlePDF–3.5M
15.
Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA
Lee Serpas, Rebecca W. Y. Chan, Peiyong Jiang, Meng Ni, Kun Sun, Ali Rashidfarrokhi, Chetna Soni, Vanja Sisirak, Wing-Shan Lee, Suk Hang Cheng, Wenlei Peng, K. C. Allen Chan, Rossa W. K. Chiu, Boris Reizis, Y. M. Dennis Lo
Proc Natl Acad Sci U S A. 2019 Jan 8; 116(2): 641–649. Published online 2018 Dec 28. doi: 10.1073/pnas.1815031116
PMCID:
PMC6329986
AbstractArticlePDF–864K
16.
Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA
Thomas Weisenburger, Bettina von Neubeck, Andrea Schneider, Nadja Ebert, Daniel Schreyer, Andreas Acs, Thomas H. Winkler
Front Immunol. 2018; 9: 1551. Published online 2018 Jul 5. doi: 10.3389/fimmu.2018.01551
PMCID:
PMC6041390
AbstractArticlePDF–3.0M
17.
Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity
Vanja Sisirak, Benjamin Sally, Vivette D’Agati, Wilnelly Martinez-Ortiz, Z. Birsin Özçakar, Joseph David, Ali Rashidfarrokhi, Ada Yeste, Casandra Panea, Asiya Seema Chida, Milena Bogunovic, Ivaylo I. Ivanov, Francisco J. Quintana, Inaki Sanz, Keith B. Elkon, Mustafa Tekin, Fatos Yalçinkaya, Timothy J. Cardozo, Robert M. Clancy, Jill P. Buyon, Boris Reizis
Cell. Author manuscript; available in PMC 2017 Jun 30.
Published in final edited form as: Cell. 2016 Jun 30; 166(1): 88–101. Published online 2016 Jun 9. doi: 10.1016/j.cell.2016.05.034
PMCID:
PMC5030815
AbstractArticlePDF–2.4M
18.
DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis
Ryushin Mizuta, Shinsuke Araki, Makoto Furukawa, Yuki Furukawa, Syota Ebara, Daisuke Shiokawa, Katsuhiko Hayashi, Sei-ichi Tanuma, Daisuke Kitamura
PLoS One. 2013; 8(12): e80223. Published online 2013 Dec 2. doi: 10.1371/journal.pone.0080223
PMCID:
PMC3846476
AbstractArticlePDF–4.5M
19.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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