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Items: 1 to 20 of 90

1.
Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian
Cells. 2023 Oct; 12(19): 2354. Published online 2023 Sep 26. doi: 10.3390/cells12192354
PMCID:
PMC10571910
AbstractArticlePDF–5.7M
2.
A PKA Inhibitor Motif within SMOOTHENED Controls Hedgehog Signal Transduction
John T. Happ, Corvin D. Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B. Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S. Hedeen, Ju-Fen Zhu, Jacob L. Capener, Jan W. Bröckel, Lily Vu, C.C. King, Victor L. Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W. Herberg, Susan S. Taylor, Benjamin R. Myers
Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Apr 6.
Published in final edited form as: Nat Struct Mol Biol. 2022 Oct; 29(10): 990–999. Published online 2022 Oct 6. doi: 10.1038/s41594-022-00838-z
PMCID:
PMC9696579
AbstractArticlePDF–4.9M
3.
SMO Regulates IGF1R levels and AKT Localization and Signaling
Nitin K Agarwal, Chae-Hwa Kim, Kranthi Kunkalla, Amineh Vaghefi, Sandra Sanchez, Samantha Manuel, Daniel Bilbao, Francisco Vega, Ralf Landgraf
Lab Invest. Author manuscript; available in PMC 2022 Jun 10.
Published in final edited form as: Lab Invest. 2022 Apr; 102(4): 401–410. Published online 2021 Dec 10. doi: 10.1038/s41374-021-00702-6
PMCID:
PMC8969180
AbstractArticlePDF–2.0M
4.
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
eLife. 2021; 10: e70504. Published online 2021 Oct 26. doi: 10.7554/eLife.70504
PMCID:
PMC8654371
AbstractArticlePDF–2.0M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits
Corvin D. Arveseth, John T. Happ, Danielle S. Hedeen, Ju-Fen Zhu, Jacob L. Capener, Dana Klatt Shaw, Ishan Deshpande, Jiahao Liang, Jiewei Xu, Sara L. Stubben, Isaac B. Nelson, Madison F. Walker, Kouki Kawakami, Asuka Inoue, Nevan J. Krogan, David J. Grunwald, Ruth Hüttenhain, Aashish Manglik, Benjamin R. Myers
PLoS Biol. 2021 Apr; 19(4): e3001191. Published online 2021 Apr 22. doi: 10.1371/journal.pbio.3001191
PMCID:
PMC8096101
AbstractArticlePDF–4.6M
7.
sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p
Jieun Kim, Chanbin Lee, Yongbo Shin, Sihyung Wang, Jinsol Han, Minju Kim, Ji Min Kim, Sung-Chan Shin, Byung-Joo Lee, Tae-Jin Kim, Youngmi Jung
Mol Ther. 2021 Apr 7; 29(4): 1471–1486. Published online 2020 Dec 19. doi: 10.1016/j.ymthe.2020.12.025
PMCID:
PMC8058446
AbstractArticlePDF–5.4M
8.
MIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway
Yunhong Xia, Lu Zhen, Hongxia Li, Shuomin Wang, Sun Chen, Chongchong Wang, Xiaoyu Yang
Cell Death Dis. 2021 Apr; 12(4): 326. Published online 2021 Mar 26. doi: 10.1038/s41419-021-03494-1
PMCID:
PMC7997896
AbstractArticlePDF–6.5M
9.
Cholesterol access in cellular membranes controls Hedgehog signaling
Arun Radhakrishnan, Rajat Rohatgi, Christian Siebold
Nat Chem Biol. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: Nat Chem Biol. 2020 Dec; 16(12): 1303–1313. Published online 2020 Nov 16. doi: 10.1038/s41589-020-00678-2
PMCID:
PMC7872078
AbstractArticlePDF–1.7M
10.
Targeting Hedgehog Pathway and DNA Methyltransferases in Uterine Leiomyosarcoma Cells
Natalia Garcia, Ayman Al-Hendy, Edmund C. Baracat, Katia Candido Carvalho, Qiwei Yang
Cells. 2021 Jan; 10(1): 53. Published online 2020 Dec 31. doi: 10.3390/cells10010053
PMCID:
PMC7824187
AbstractArticlePDF–2.5M
11.
Silencing of long non-coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA-503
Chuihua Sun, Ting Xiao, Ying Xiao, Yunbao Li
Mol Med Rep. 2021 Mar; 23(3): 168. Published online 2020 Dec 23. doi: 10.3892/mmr.2020.11807
PMCID:
PMC7821340
AbstractArticlePDF–1.6M
12.
A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity
Xujia Wu, Songhua Xiao, Maolei Zhang, Lixuan Yang, Jian Zhong, Bo Li, Fanying Li, Xin Xia, Xixi Li, Huangkai Zhou, Dawei Liu, Nunu Huang, Xuesong Yang, Feizhe Xiao, Nu Zhang
Genome Biol. 2021; 22: 33. Published online 2021 Jan 14. doi: 10.1186/s13059-020-02250-6
PMCID:
PMC7807754
AbstractArticlePDF–3.1M
13.
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Xiaofeng Qi, Lucas Friedberg, Ryan DeBose-Boyd, Tao Long, Xiaochun Li
Nat Chem Biol. Author manuscript; available in PMC 2021 Mar 14.
Published in final edited form as: Nat Chem Biol. 2020 Dec; 16(12): 1368–1375. Published online 2020 Sep 14. doi: 10.1038/s41589-020-0646-2
PMCID:
PMC7669734
AbstractArticlePDF–2.1M
14.
Hedgehog inhibitor decreases chemosensitivity to 5‐fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer
Hideya Onishi, Yoshihiro Morifuji, Masaya Kai, Kumi Suyama, Hironori Iwasaki, Mitsuo Katano
Cancer Sci. 2012 Jul; 103(7): 1272–1279. Published online 2012 May 17. doi: 10.1111/j.1349-7006.2012.02297.x
PMCID:
PMC7659296
AbstractArticlePDF–686K
15.
中国人群Hedgehog通路基因与非综合征型唇腭裂的亲源效应
李 文咏, 王 梦莹, 周 仁, 王 斯悦, 郑 鸿尘, 朱 洪平, 周 治波, 吴 涛, 王 红, 石 冰
Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Oct 18; 52(5): 809–814. Chinese. Published online 2020 Jun 3. doi: 10.19723/j.issn.1671-167X.2020.05.003
PMCID:
PMC7653437
AbstractArticlePDF–913K
16.
The inhibition of microRNA‐326 by SP1/HDAC1 contributes to proliferation and metastasis of osteosarcoma through promoting SMO expression
Jiang‐Hu Huang, Yang Xu, Fei‐Yue Lin
J Cell Mol Med. 2020 Sep; 24(18): 10876–10888. Published online 2020 Aug 3. doi: 10.1111/jcmm.15716
PMCID:
PMC7521251
AbstractArticlePDF–2.5M
17.
Signalling in the primary cilium through the lens of the Hedgehog pathway
Eduardo D. Gigante, Tamara Caspary
Wiley Interdiscip Rev Dev Biol. Author manuscript; available in PMC 2021 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2020 Nov; 9(6): e377. Published online 2020 Feb 21. doi: 10.1002/wdev.377
PMCID:
PMC7444278
AbstractArticlePDF–2.3M
18.
Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population
Augusto Monteiro de Souza, Otávio Sérgio Lopes, Andressa de Lima Liberato, Paulo Junior Ribeiro de Oliveira, Sylvia Satomi Takeno Herrero, Agnaldo Luiz do Nascimento, Carlos Alberto Longui, Ivan Rodrigues de Carvalho Filho, Leonardo Ferreira Soares, Renally Barbosa da Silva, Rommel Rodriguez Burbano, Plínio Delatorre, Eleonidas Moura Lima
Asian Pac J Cancer Prev. 2020; 21(1): 25–29. doi: 10.31557/APJCP.2020.21.1.25
PMCID:
PMC7294008
AbstractArticlePDF–269K
19.
Bi-allelic Variations of SMO in Humans Cause a Broad Spectrum of Developmental Anomalies Due to Abnormal Hedgehog Signaling
Thuy-Linh Le, Yunia Sribudiani, Xiaomin Dong, Céline Huber, Chelsea Kois, Geneviève Baujat, Christopher T. Gordon, Valerie Mayne, Louise Galmiche, Valérie Serre, Nicolas Goudin, Mohammed Zarhrate, Christine Bole-Feysot, Cécile Masson, Patrick Nitschké, Frans W. Verheijen, Lynn Pais, Anna Pelet, Simon Sadedin, John A. Pugh, Natasha Shur, Susan M. White, Salima El Chehadeh, John Christodoulou, Valérie Cormier-Daire, R.M.W. Hofstra, Stanislas Lyonnet, Tiong Yang Tan, Tania Attié-Bitach, Wilhelmina S. Kerstjens-Frederikse, Jeanne Amiel, Sophie Thomas
Am J Hum Genet. 2020 Jun 4; 106(6): 779–792. Published online 2020 May 14. doi: 10.1016/j.ajhg.2020.04.010
PMCID:
PMC7273534
AbstractArticlePDF–2.5M
20.
Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO
Zhiyong Xiong, Chaoyang Zhou, Luyang Wang, Ronglan Zhu, Liangchen Zhong, Dengfeng Wan, Qiangping Wang
Aging (Albany NY) 2019 Dec 31; 11(24): 12345–12360. Published online 2019 Dec 30. doi: 10.18632/aging.102576
PMCID:
PMC6949074
AbstractArticlePDF–3.5M

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