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Select item 105481121.

AGAP1-associated endolysosomal trafficking abnormalities link gene–environment interactions in neurodevelopmental disorders

Sara A. Lewis, Somayeh Bakhtiari, Jacob Forstrom, Allan Bayat, Frédéric Bilan, Gwenaël Le Guyader, Ebba Alkhunaizi, Hilary Vernon, Sergio R. Padilla-Lopez, Michael C. Kruer

Dis Model Mech. 2023 Sep 1; 16(9): dmm049838. Published online 2023 Sep 26. doi: 10.1242/dmm.049838

PMCID:: PMC10548112

Abstract Article

Select item 103411342.

Potent New Targets for Autophagy Enhancement to Delay Neuronal Ageing

Janka Szinyákovics, Fanni Keresztes, Eszter Anna Kiss, Gergő Falcsik, Tibor Vellai, Tibor Kovács

Cells. 2023 Jul; 12(13): 1753. Published online 2023 Jun 30. doi: 10.3390/cells12131753

PMCID:: PMC10341134

Abstract Article PDF–6.8M

Select item 101057363.

Next-generation large-scale binary protein interaction network for Drosophila melanogaster

Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, István A. Kovács, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Coté, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr

Nat Commun. 2023; 14: 2162. Published online 2023 Apr 15. doi: 10.1038/s41467-023-37876-0

PMCID:: PMC10105736

Abstract Article PDF–3.2M

Select item 96729664.

Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila

Tsuyoshi Inoshita, Jun-Yi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba-Fukushima, Nobutaka Hattori, Yuzuru Imai

iScience. 2022 Dec 22; 25(12): 105476. Published online 2022 Nov 2. doi: 10.1016/j.isci.2022.105476

PMCID:: PMC9672966

Abstract Article PDF–5.0M

Select item 92396805.

An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination

Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen

eLife. 2022; 11: e76077. Published online 2022 Jun 20. doi: 10.7554/eLife.76077

PMCID:: PMC9239680

Abstract Article PDF–1.2M

Select item 86644866.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 84688277.

Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders

Stefano Sechi, Angela Karimpour-Ghahnavieh, Anna Frappaolo, Laura Di Francesco, Roberto Piergentili, Eugenia Schininà, Pier Paolo D’Avino, Maria Grazia Giansanti

Cells. 2021 Sep; 10(9): 2336. Published online 2021 Sep 6. doi: 10.3390/cells10092336

PMCID:: PMC8468827

Abstract Article PDF–4.1M

Select item 80252348.

Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi

Torsten W.B. Götz, Dmytro Puchkov, Veronika Lysiuk, Janine Lützkendorf, Alexander G. Nikonenko, Christine Quentin, Martin Lehmann, Stephan J. Sigrist, Astrid G. Petzoldt

J Cell Biol. 2021 May 3; 220(5): e202006040. Published online 2021 Apr 2. doi: 10.1083/jcb.202006040

PMCID:: PMC8025234

Abstract Article PDF–11M

Select item 71824349.

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman

eLife. 2020; 9: e51977. Published online 2020 Apr 14. doi: 10.7554/eLife.51977

PMCID:: PMC7182434

Abstract Article PDF–10M

Select item 696157810.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 691068811.

Changes in endolysosomal organization define a pre-degenerative state in the crumbs mutant Drosophila retina

Rachel S. Kraut, Elisabeth Knust

PLoS One. 2019; 14(12): e0220220. Published online 2019 Dec 13. doi: 10.1371/journal.pone.0220220

PMCID:: PMC6910688

Abstract Article PDF–4.5M

Select item 685580612.

An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

Oguz Kanca, Jonathan Zirin, Jorge Garcia-Marques, Shannon Marie Knight, Donghui Yang-Zhou, Gabriel Amador, Hyunglok Chung, Zhongyuan Zuo, Liwen Ma, Yuchun He, Wen-Wen Lin, Ying Fang, Ming Ge, Shinya Yamamoto, Karen L Schulze, Yanhui Hu, Allan C Spradling, Stephanie E Mohr, Norbert Perrimon, Hugo J Bellen

eLife. 2019; 8: e51539. Published online 2019 Nov 1. doi: 10.7554/eLife.51539

PMCID:: PMC6855806

Abstract Article PDF–1.5M

Select item 659268013.

Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt

Péter Lőrincz, Lili Anna Kenéz, Sarolta Tóth, Viktória Kiss, Ágnes Varga, Tamás Csizmadia, Zsófia Simon-Vecsei, Gábor Juhász

eLife. 2019; 8: e45631. Published online 2019 Jun 13. doi: 10.7554/eLife.45631

PMCID:: PMC6592680

Abstract Article PDF–14M

Select item 650489914.

Homeostatic scaling of active zone scaffolds maintains global synaptic strength

Pragya Goel, Dominique Dufour Bergeron, Mathias A. Böhme, Luke Nunnelly, Martin Lehmann, Christopher Buser, Alexander M. Walter, Stephan J. Sigrist, Dion Dickman

J Cell Biol. 2019 May 6; 218(5): 1706–1724. Published online 2019 Mar 26. doi: 10.1083/jcb.201807165