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Items: 1 to 20 of 506

1.
IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development
Roshana Thambyrajah, Maria Maqueda, Muhammad Zaki Fadlullah, Martin Proffitt, Wen Hao Neo, Yolanda Guillén, Marta Casado-Pelaez, Patricia Herrero-Molinero, Carla Brujas, Noemi Castelluccio, Jessica González, Arnau Iglesias, Laura Marruecos, Cristina Ruiz-Herguido, Manel Esteller, Elisabetta Mereu, Georges Lacaud, Lluis Espinosa, Anna Bigas
Nat Commun. 2024; 15: 4673. Published online 2024 Jun 1. doi: 10.1038/s41467-024-48854-5
PMCID:
PMC11144194
AbstractArticlePDF–3.9M
2.
Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination
Shah Md Toufiqur Rahman, Apeksha Singh, Sarina Lowe, Mohammad Aqdas, Kevin Jiang, Haripriya Vaidehi Narayanan, Alexander Hoffmann, Myong-Hee Sung
Cell Rep. Author manuscript; available in PMC 2024 Apr 13.
Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113940. Published online 2024 Mar 13. doi: 10.1016/j.celrep.2024.113940
PMCID:
PMC11015162
AbstractArticlePDF–2.0M
3.
The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer
Allison Voisin, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Roxane Pommier, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A. Cassier, Yenkel Grinberg-Bleyer
Front Immunol. 2024; 15: 1379777. Published online 2024 Mar 5. doi: 10.3389/fimmu.2024.1379777
PMCID:
PMC10948531
AbstractArticlePDF–5.7M
4.
Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation
Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen
Cell Death Dis. 2024 Mar; 15(3): 180. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06545-5
PMCID:
PMC10907691
AbstractArticlePDF–9.3M
5.
TCR-independent CD137 (4–1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation
Andrea C. Pichler, Nadège Carrié, Marine Cuisinier, Samira Ghazali, Allison Voisin, Pierre-Paul Axisa, Marie Tosolini, Céline Mazzotti, Dominic P. Golec, Sabrina Maheo, Laura do Souto, Rüçhan Ekren, Eve Blanquart, Lea Lemaitre, Virginie Feliu, Marie-Véronique Joubert, Jennifer L. Cannons, Camille Guillerey, Hervé Avet-Loiseau, Tania H. Watts, Benoit L. Salomon, Olivier Joffre, Yenkel Grinberg-Bleyer, Pamela L. Schwartzberg, Liliana E. Lucca, Ludovic Martinet
Immunity. Author manuscript; available in PMC 2023 Nov 15.
Published in final edited form as: Immunity. 2023 Jul 11; 56(7): 1631–1648.e10. Published online 2023 Jun 30. doi: 10.1016/j.immuni.2023.06.007
PMCID:
PMC10649891
AbstractArticlePDF–3.7M
6.
Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling
Libao Liu, Shuai Huang, Yingzhen Du, Hao Zhou, Kai Zhang, Jinyuan He
Int J Biol Sci. 2023; 19(11): 3428–3440. Published online 2023 Jul 3. doi: 10.7150/ijbs.84426
PMCID:
PMC10367568
AbstractArticlePDF–7.2M
7.
RELA governs a network of islet-specific metabolic genes necessary for beta cell function
Nathan W. Zammit, Ying Ying Wong, Stacey N. Walters, Joanna Warren, Simon C. Barry, Shane T. Grey
Diabetologia. 2023; 66(8): 1516–1531. Published online 2023 Jun 14. doi: 10.1007/s00125-023-05931-6
PMCID:
PMC10317895
AbstractArticlePDF–3.0M
8.
Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway
Peng Wang, Cuicui Yang, Jinhong Lu, Yongxin Ren, David Goltzman, Dengshun Miao
J Orthop Translat. 2023 May; 40: 13–26. Published online 2023 May 5. doi: 10.1016/j.jot.2023.04.003
PMCID:
PMC10185703
AbstractArticlePDF–4.9M
9.
Circadian disruption in lung fibroblasts enhances NF‐κB activity to exacerbate neutrophil recruitment
Shannon L. Cox, James R. O'Siorain, Yan He, Ronan Lordan, Amruta Naik, Soon Yew Tang, Shaon Sengupta, Garret A. FitzGerald, Richard G. Carroll, Annie M. Curtis
FASEB J. 2023 Feb; 37(2): e22753. Published online 2023 Jan 9. doi: 10.1096/fj.202201456R
PMCID:
PMC10107448
AbstractArticlePDF–7.7M
10.
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
Lioba Koerner, Marcel Schmiel, Tsun-Po Yang, Martin Peifer, Reinhard Buettner, Manolis Pasparakis
Cell Death Differ. 2023 Apr; 30(4): 938–951. Published online 2023 Jan 18. doi: 10.1038/s41418-023-01112-5
PMCID:
PMC10070460
AbstractArticlePDF–7.1M
11.
Opposing Roles of Hepatic Stellate Cell Subpopulations in Hepatocarcinogenesis
Aveline Filliol, Yoshinobu Saito, Ajay Nair, Dianne H. Dapito, Le-Xing Yu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Silvia Affo, Naoto Fujiwara, Hua Su, Qiuyan Sun, Thomas M Savage, John R Wilson-Kanamori, Jorge M Caviglia, LiKang Chin, Dongning Chen, Xiaobo Wang, Stefano Caruso, Jin Ku Kang, Amit Dipak Amin, Sebastian Wallace, Ross Dobie, Deqi Yin, Oscar M Rodriguez-Fiallos, Chuan Yin, Adam Mehal, Benjamin Izar, Richard A. Friedman, Rebecca G. Wells, Utpal B. Pajvani, Yujin Hoshida, Helen E. Remotti, Nicholas Arpaia, Jessica Zucman-Rossi, Michael Karin, Neil C Henderson, Ira Tabas, Robert F. Schwabe
Nature. Author manuscript; available in PMC 2023 Apr 5.
Published in final edited form as: Nature. 2022 Oct; 610(7931): 356–365. Published online 2022 Oct 5. doi: 10.1038/s41586-022-05289-6
PMCID:
PMC9949942
AbstractArticlePDF–10M
12.
Integration of genome-scale data identifies candidate sleep regulators
Yin Yeng Lee, Mehari Endale, Gang Wu, Marc D Ruben, Lauren J Francey, Andrew R Morris, Natalie Y Choo, Ron C Anafi, David F Smith, Andrew C Liu, John B Hogenesch
Sleep. 2023 Feb; 46(2): zsac279. Published online 2022 Dec 3. doi: 10.1093/sleep/zsac279
PMCID:
PMC9905783
AbstractArticlePDF–2.7M
13.
A Stk4 -Foxp3-P65 Transcriptional Complex Promotes Treg Cell Activation and Homeostasis
Ye Cui, Mehdi Benamar, Klaus Schmitz-Abe, Varsha Poondi-Krishnan, Qian Chen, Bat-Erdene Jugder, Benoit Fatou, Jason Fong, Yuelin Zhong, Stuti Mehta, Altantsetseg Buyanbat, Beray Selver Eklioglu, Esra Karabiber, Safa Baris, Ayca Kiykim, Sevgi Keles, Emmanuel Stephen-Victor, Claudia Angelini, Louis-Marie Charbonnier, Talal A. Chatila
Sci Immunol. Author manuscript; available in PMC 2023 Jan 6.
Published in final edited form as: Sci Immunol. 2022 Sep 23; 7(75): eabl8357. Published online 2022 Sep 23. doi: 10.1126/sciimmunol.abl8357
PMCID:
PMC9816918
AbstractArticlePDF–3.0M
14.
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
Jill E. Hunter, Amy E. Campbell, Nicola L. Hannaway, Scott Kerridge, Saimir Luli, Jacqueline A. Butterworth, Helene Sellier, Reshmi Mukherjee, Nikita Dhillon, Praveen D. Sudhindar, Ruchi Shukla, Philip J. Brownridge, Hayden L. Bell, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Ian Collins, Michelle D. Garrett, Claire E. Eyers, Neil D. Perkins
Biochem J. 2022 Oct 14; 479(19): 2063–2086. Prepublished online 2022 Aug 24. Published online 2022 Oct 14. doi: 10.1042/BCJ20220102
PMCID:
PMC9704646
AbstractArticlePDF–12M
15.
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
Jill E. Hunter, Amy E. Campbell, Jacqueline A. Butterworth, Helene Sellier, Nicola L. Hannaway, Saimir Luli, Achilleas Floudas, Niall S. Kenneth, Adam J. Moore, Philip J. Brownridge, Huw D. Thomas, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Andrew M. Knight, Michelle D. Garrett, Ian Collins, Claire E. Eyers, Neil D. Perkins
Biochem J. 2022 Oct 14; 479(19): 2087–2113. Prepublished online 2022 Aug 19. Published online 2022 Oct 14. doi: 10.1042/BCJ20220089
PMCID:
PMC9704643
ArticlePDF–12M
16.
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
Kelvin Yin, Daniel Patten, Sarah Gough, Susana de Barros Gonçalves, Adelyne Chan, Ioana Olan, Liam Cassidy, Marta Poblocka, Haoran Zhu, Aaron Lun, Martijn Schuijs, Andrew Young, Celia Martinez-Jimenez, Timotheus Y.F. Halim, Shishir Shetty, Masashi Narita, Matthew Hoare
Genes Dev. 2022 May 1; 36(9-10): 533–549. doi: 10.1101/gad.349585.122
PMCID:
PMC9186388
AbstractArticlePDF–15M
17.
SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes
Kyle Jones, Sergio Ramirez-Perez, Sean Niu, Umesh Gangishetti, Hicham Drissi, Pallavi Bhattaram
Front Immunol. 2022; 13: 789349. Published online 2022 Apr 22. doi: 10.3389/fimmu.2022.789349
PMCID:
PMC9074688
AbstractArticlePDF–4.6M
18.
EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice
Zili Lei, Wanwan Liu, Ya Nie, Yanhong Yang, Guibin Chen, Li Huang, Huijuan Wu, Yuting Lei, Lei Chen, Qing Hu, Hedong Rong, Siping Yu, Qi Song, Fengxue Tong, Jiao Guo
Front Immunol. 2022; 13: 843378. Published online 2022 Apr 13. doi: 10.3389/fimmu.2022.843378
PMCID:
PMC9043958
AbstractArticlePDF–8.1M
19.
Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65
Huaji Jiang, Xuemei Lin, Wei Liang, Yiqiang Li, Xiao Yu
Nutrients. 2022 Apr; 14(8): 1673. Published online 2022 Apr 18. doi: 10.3390/nu14081673
PMCID:
PMC9031956
AbstractArticlePDF–4.2M
20.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M

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