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Select item 113045501.

BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma

Yuliang Feng, Liuyang Cai, Martin Pook, Feng Liu, Chao-Hui Chang, Mai Abdel Mouti, Reshma Nibhani, Stefania Militi, James Dunford, Martin Philpott, Yanbo Fan, Guo-Chang Fan, Qi Liu, Jun Qi, Cheng Wang, Wanzi Hong, Hannah Morgan, Mingyang Wang, Sakthivel Sadayappan, Anil G. Jegga, Udo Oppermann, Yigang Wang, Wei Huang, Lei Jiang, Siim Pauklin

Gastroenterology. Author manuscript; available in PMC 2024 Aug 7.

Published in final edited form as: Gastroenterology. 2024 Jan; 166(1): 139–154. Published online 2023 Sep 21. doi: 10.1053/j.gastro.2023.09.021

PMCID:: PMC11304550

Abstract Article PDF–3.2M

Select item 111264512.

Exosomes derived from adipose tissue-derived stem cells alleviated H₂O₂-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway

Yan Li, Yujie Xiao, Yage Shang, Chaolei Xu, Chao Han, Dahai Hu, Juntao Han, Hongtao Wang

Cell Biol Toxicol. 2024; 40(1): 39. Published online 2024 May 25. doi: 10.1007/s10565-024-09881-6

PMCID:: PMC11126451

Abstract Article PDF–6.5M

Select item 110769923.

MAP4K4 and WT1 mediate SOX6‐induced cellular senescence by synergistically activating the ATF2–TGFβ2–Smad2/3 signaling pathway in cervical cancer

Han Zheng, Mingchen Liu, Shu Shi, Hongxin Huang, Xingwen Yang, Ziheng Luo, Yarong Song, Qiang Xu, Tingting Li, Lixiang Xue, Fengmin Lu, Jie Wang

Mol Oncol. 2024 May; 18(5): 1327–1346. Published online 2024 Feb 21. doi: 10.1002/1878-0261.13613

PMCID:: PMC11076992

Abstract Article PDF–3.9M

Select item 109428254.

DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways

Lu Chen, Hongyu Su, Zekai Tao, Cui Liang, Zhongzhao Liu, Yiming Dong, Peipei Zheng, Yuan Liu

Cardiovasc Ther. 2024; 2024: 5583961. Published online 2024 Mar 8. doi: 10.1155/2024/5583961

PMCID:: PMC10942825

Abstract Article PDF–4.1M

Select item 107646955.

Exosomes Derived from Human Adipose Mesenchymal Stem Cells Inhibits Fibrosis and Treats Oral Submucous Fibrosis via the miR-181a-5p/Smad2 Axis

Zifei Shao, Jinhao Xu, Xiaoyang Xu, Xiang Wang, Yuxi Zhou, Yiyang Li, Kun Li

Tissue Eng Regen Med. 2024 Jan; 21(1): 123–135. Published online 2023 Sep 27. doi: 10.1007/s13770-023-00579-0

PMCID:: PMC10764695

Abstract Article PDF–7.6M

Select item 106171236.

Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis

Milena Paw, Agnieszka A. Kusiak, Kinga Nit, Jacek J. Litewka, Marcin Piejko, Dawid Wnuk, Michał Sarna, Kinga Fic, Kinga B. Stopa, Ruba Hammad, Olga Barczyk-Woznicka, Toni Cathomen, Ewa Zuba-Surma, Zbigniew Madeja, Paweł E. Ferdek, Sylwia Bobis-Wozowicz

BMC Med. 2023; 21: 412. Published online 2023 Oct 31. doi: 10.1186/s12916-023-03117-w

PMCID:: PMC10617123

Abstract Article PDF–13M

Select item 105845187.

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans

Narin Osman, K. Jane Grande-Allen, Mandy L. Ballinger, Robel Getachew, Silvana Marasco, Kevin D. O’Brien, Peter J. Little

Cardiovasc Pathol. Author manuscript; available in PMC 2023 Oct 18.

Published in final edited form as: Cardiovasc Pathol. 2013 Mar-Apr; 22(2): 146–155. Published online 2012 Sep 21. doi: 10.1016/j.carpath.2012.07.002

PMCID:: PMC10584518

Abstract Article PDF–876K

Select item 105306868.

The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta

Kei Hashimoto, Yuko Miyagawa, Saya Watanabe, Kazuki Takasaki, Miki Nishizawa, Keita Yatsuki, Yuko Takahashi, Hideo Kamata, Chikara Kihira, Haruko Hiraike, Yukifumi Sasamori, Koichiro Kido, Eiji Ryo, Kazunori Nagasaka

Int J Mol Sci. 2023 Sep; 24(18): 13706. Published online 2023 Sep 5. doi: 10.3390/ijms241813706

PMCID:: PMC10530686

Abstract Article PDF–3.3M

Select item 104109639.

SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis

Xingxing Mao, Weijie Wu, Yunyi Nan, Weiwei Sun, Youhua Wang

Arthritis Res Ther. 2023; 25: 144. Published online 2023 Aug 9. doi: 10.1186/s13075-023-03136-1

PMCID:: PMC10410963

Abstract Article PDF–3.9M

Select item 1036258910.

GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling

Ze Wu, Lingling Zhang, Yuanyuan Jia, Beibei Bi, Lanlan Fang, Jung-Chien Cheng

Cell Commun Signal. 2023; 21: 179. Published online 2023 Jul 21. doi: 10.1186/s12964-023-01201-5

PMCID:: PMC10362589

Abstract Article PDF–3.3M

Select item 1034596311.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 1023742212.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1018294413.

EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling

Yingqing Zhang, Weibo Qi, Yonglei Wu

Environ Sci Pollut Res Int. 2023; 30(24): 65237–65249. Published online 2023 Apr 20. doi: 10.1007/s11356-023-26307-8

PMCID:: PMC10182944

Abstract Article PDF–6.6M

Select item 1014194814.

The β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance

Wei-Juan Huang, Song-Bin Guo, Hui Shi, Xin-Ling Li, Yong Zhu, Mei Li, Li-Yan Song, Rong-Min Yu, Qing-Qing Cai, Xiao-Peng Tian

J Exp Clin Cancer Res. 2023; 42: 105. Published online 2023 Apr 28. doi: 10.1186/s13046-023-02670-9

PMCID:: PMC10141948

Abstract Article PDF–2.4M

Select item 999586715.

CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis

Yan Wu, Fuhua Wang, Jing Shi, Xiangyun Guo, Feng Li

J Gynecol Oncol. 2023 Mar; 34(2): e19. Published online 2023 Jan 2. doi: 10.3802/jgo.2023.34.e19

PMCID:: PMC9995867

Abstract Article PDF–2.3M

Select item 999017816.

Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein

Zhi-yuan Zhang, Cui-yu Ju, Liu-zheng Wu, Han Yan, Wen-bin Hong, Hang-zi Chen, Peng-bo Yang, Bao-Rui Wang, Tong Gou, Xiao-yan Chen, Zhi-hong Jiang, Wei-jia Wang, Tianwei Lin, Fu-nan Li, Qiao Wu

Cell Chem Biol. 2023 Mar 16; 30(3): 261–277.e8. Published online 2023 Mar 7. doi: 10.1016/j.chembiol.2023.02.004

PMCID:: PMC9990178

Abstract Article PDF–6.9M

Select item 988875617.

Expanding the phenotypic spectrum of Mendelian connective tissue disorders to include prominent kidney phenotypes

Alanna Strong, Cara Skraban, Kevin Meyers, Sandra Amaral, Susan Furth, Stacey Drant, Wendy Hsiao, Lauren Galea, Jessica Gold, Nina B. Gold, Jacqueline Leonard, Sonya Lopez, Elaine H. Zackai, Reed E. Pyeritz

Am J Med Genet A. Author manuscript; available in PMC 2023 Jan 31.

Published in final edited form as: Am J Med Genet A. 2021 Dec; 185(12): 3762–3769. Published online 2021 Aug 6. doi: 10.1002/ajmg.a.62449

PMCID:: PMC9888756

Abstract Article PDF–1.0M

Select item 983440518.

Candida albicans-induced activation of the TGF-β/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion

Xingping Zhao, Dan Sun, Aiqian Zhang, Huan Huang, Yueran Li, Dabao Xu

Sci Rep. 2023; 13: 579. Published online 2023 Jan 11. doi: 10.1038/s41598-022-25471-0

PMCID:: PMC9834405

Abstract Article PDF–2.4M

Select item 974488419.

Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling

Huan Hu, Guangyu Mao, Jianghong Zheng, Feng Guo

Drug Des Devel Ther. 2022; 16: 4223–4234. Published online 2022 Dec 8. doi: 10.2147/DDDT.S386786

PMCID:: PMC9744884

Abstract Article PDF–9.9M

Select item 953698620.

A Regulatory Network Analysis of the Importance of USP15 in Breast Cancer Metastasis and Prognosis

Jun Ling, Chenhui Qin, Tao Li, Baozhen Wang, Weiji Cai, Lei Ma, Yanfeng Wang, Jing Chen, Fang Xu

J Oncol. 2022; 2022: 1427726. Published online 2022 Sep 29. doi: 10.1155/2022/1427726

PMCID:: PMC9536986

Abstract Article PDF–2.9M

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