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Select item 113686811.

Ras promotes germline stem cell division in Drosophila ovaries

Qi Zhang, Yanfang Wang, Zhenan Bu, Yang Zhang, Qian Zhang, Le Li, Lizhong Yan, Yuejia Wang, Shaowei Zhao

Stem Cell Reports. 2024 Aug 13; 19(8): 1205–1216. Published online 2024 Jul 18. doi: 10.1016/j.stemcr.2024.06.005

PMCID:: PMC11368681

Abstract Article PDF–5.6M

Select item 111999552.

Modeling neurodegenerative and neurodevelopmental disorders in the Drosophila mushroom body

Aaron Stahl, Seth M. Tomchik

Learn Mem. 2024 May; 31(5): a053816. Published online 2024 May. doi: 10.1101/lm.053816.123

PMCID:: PMC11199955

Abstract Article PDF–937K

Select item 111084043.

Regulatory mechanisms of EGFR signalling during Drosophila eye development

Marianne Malartre

Cell Mol Life Sci. 2016 May; 73(9): 1825–1843. Published online 2016 Mar 2. doi: 10.1007/s00018-016-2153-x

PMCID:: PMC11108404

Abstract Article PDF–1.7M

Select item 110485134.

Non-Mammalian Models for Understanding Neurological Defects in RASopathies

Mario Rodríguez-Martín, Juan Báez-Flores, Vanessa Ribes, María Isidoro-García, Jesus Lacal, Pablo Prieto-Matos

Biomedicines. 2024 Apr; 12(4): 841. Published online 2024 Apr 10. doi: 10.3390/biomedicines12040841

PMCID:: PMC11048513

Abstract Article PDF–1.3M

Select item 110112025.

Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster

Sebastian Deichsel, Bernd M. Gahr, Helena Mastel, Anette Preiss, Anja C. Nagel

Cells. 2024 Apr; 13(7): 576. Published online 2024 Mar 26. doi: 10.3390/cells13070576

PMCID:: PMC11011202

Abstract Article PDF–5.5M

Select item 110070526.

Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma

Junki Fukuda, Shinya Kosuge, Yusuke Satoh, Sho Sekiya, Ryodai Yamamura, Takako Ooshio, Taiga Hirata, Reo Sato, Kanako C. Hatanaka, Tomoko Mitsuhashi, Toru Nakamura, Yoshihiro Matsuno, Yutaka Hatanaka, Satoshi Hirano, Masahiro Sonoshita

Cancer Sci. 2024 Apr; 115(4): 1333–1345. Published online 2024 Feb 6. doi: 10.1111/cas.16100

PMCID:: PMC11007052

Abstract Article PDF–4.5M

Select item 108232327.

Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells

Enric Ureña, Bowen Xu, Jennifer C. Regan, Magda L. Atilano, Lucy J. Minkley, Danny Filer, Yu-Xuan Lu, Ekin Bolukbasi, Mobina Khericha, Nazif Alic, Linda Partridge

Proc Natl Acad Sci U S A. 2024 Jan 23; 121(4): e2311313121. Published online 2024 Jan 19. doi: 10.1073/pnas.2311313121

PMCID:: PMC10823232

Abstract Article PDF–814K

Select item 106476828.

Signaling Pathways Controlling Axonal Wrapping in Drosophila

Marie Baldenius, Steffen Kautzmann, Suchet Nanda, Christian Klämbt

Cells. 2023 Nov; 12(21): 2553. Published online 2023 Oct 31. doi: 10.3390/cells12212553

PMCID:: PMC10647682

Abstract Article PDF–4.3M

Select item 104506729.

Evolutionary history of MEK1 illuminates the nature of deleterious mutations

Ekaterina P. Andrianova, Robert A. Marmion, Stanislav Y. Shvartsman, Igor B. Zhulin

Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34): e2304184120. Published online 2023 Aug 14. doi: 10.1073/pnas.2304184120

PMCID:: PMC10450672

Abstract Article PDF–3.7M

Select item 1028092810.

Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS

Wenkai Yue, Xue Deng, Zhao Wang, Mingsheng Jiang, Rirong Hu, Yongjia Duan, Qiangqiang Wang, Jihong Cui, Yanshan Fang

Immun Ageing. 2023; 20: 27. Published online 2023 Jun 20. doi: 10.1186/s12979-023-00354-8

PMCID:: PMC10280928

Abstract Article PDF–9.0M

Select item 1015140811.

A targeted genetic modifier screen in Drosophila uncovers vulnerabilities in a genetically complex model of colon cancer

Ishwaree Datta, Tajah Vassel, Benjamin Linkous, Tyler Odum, Christian Drew, Andrew Taylor, Erdem Bangi

G3 (Bethesda) 2023 May; 13(5): jkad053. Published online 2023 Mar 6. doi: 10.1093/g3journal/jkad053

PMCID:: PMC10151408

Abstract Article PDF–785K

Select item 1011708012.

EGFR Signaling Activates Intestinal Stem Cells by Promoting Mitochondrial Biogenesis and β-oxidation

Chenge Zhang, Yinhua Jin, Marco Marchetti, Mitchell R. Lewis, Omar T. Hammouda, Bruce A. Edgar

Curr Biol. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Curr Biol. 2022 Sep 12; 32(17): 3704–3719.e7. Published online 2022 Jul 26. doi: 10.1016/j.cub.2022.07.003

PMCID:: PMC10117080

Abstract Article PDF–3.9M

Select item 1011040213.

A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer

John E. La Marca, Robert W. Ely, Sarah T. Diepstraten, Peter Burke, Gemma L. Kelly, Patrick O. Humbert, Helena E. Richardson

Dis Model Mech. 2023 Mar 1; 16(3): dmm049769. Published online 2023 Apr 3. doi: 10.1242/dmm.049769

PMCID:: PMC10110402

Abstract Article

Select item 1002669714.

STOCHASTIC PHENOTYPES IN RAS-DEPENDENT DEVELOPMENTAL DISEASES

Robert A. Marmion, Alison G. Simpkins, Lena A. Barrett, David W. Denberg, Susan Zusman, Jodi Schottenfeld-Roames, Trudi Schüpbach, Stanislav Y. Shvartsman

Curr Biol. Author manuscript; available in PMC 2024 Mar 13.

Published in final edited form as: Curr Biol. 2023 Mar 13; 33(5): 807–816.e4. Published online 2023 Jan 26. doi: 10.1016/j.cub.2023.01.008

PMCID:: PMC10026697

Abstract Article PDF–2.2M

Select item 949265215.

Regulation of oocyte maturation: Role of conserved ERK signaling

Debabrata Das, Swathi Arur

Mol Reprod Dev. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Mol Reprod Dev. 2022 Jul 31 : 10.1002/mrd.23637. Published online 2022 Jul 31. doi: 10.1002/mrd.23637

PMCID:: PMC9492652

Abstract Article PDF–2.5M

Select item 947454516.

Mettl3-dependent m⁶A modification attenuates the brain stress response in Drosophila

Alexandra E. Perlegos, Emily J. Shields, Hui Shen, Kathy Fange Liu, Nancy M. Bonini

Nat Commun. 2022; 13: 5387. Published online 2022 Sep 14. doi: 10.1038/s41467-022-33085-3

PMCID:: PMC9474545

Abstract Article PDF–2.7M

Select item 913365317.

Auxilin regulates intestinal stem cell proliferation through EGFR

Hang Zhao, Xuejing Ren, Ruiyan Kong, Lin Shi, Zhengran Li, Runqi Wang, Rui Ma, Huiqing Zhao, Fuli Liu, Henry C. Chang, Chun-Hong Chen, Zhouhua Li

Stem Cell Reports. 2022 May 10; 17(5): 1120–1137. Published online 2022 Apr 14. doi: 10.1016/j.stemcr.2022.03.010

PMCID:: PMC9133653

Abstract Article PDF–7.1M

Select item 883299718.

The Yun/Prohibitin complex regulates adult Drosophila intestinal stem cell proliferation through the transcription factor E2F1

Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Xuejing Ren, Rui Ma, Lemei Jia, Meifang Ma, Shan Lu, Ran Xu, Richard Binari, Jian-Hua Wang, Meng-qiu Dong, Norbert Perrimon, Zhouhua Li

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2111711119. Published online 2022 Feb 3. doi: 10.1073/pnas.2111711119

PMCID:: PMC8832997

Abstract Article PDF–4.4M

Select item 879554019.

Translational control of E2f1 regulates the Drosophila cell cycle

Jan Inge Øvrebø, Mary-Rose Bradley-Gill, Norman Zielke, Minhee Kim, Marco Marchetti, Jonathan Bohlen, Megan Lewis, Monique van Straaten, Nam-Sung Moon, Bruce A. Edgar

Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2113704119. Published online 2022 Jan 24. doi: 10.1073/pnas.2113704119