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Items: 1 to 20 of 68

1.
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development
Timothy J. Mead, Sumit Bhutada, Simon J. Foulcer, Niccolò Peruzzi, Courtney M. Nelson, Deborah E. Seifert, Jonathan Larkin, Karin Tran-Lundmark, Jorge Filmus, Suneel S. Apte
Matrix Biol. Author manuscript; available in PMC 2024 Oct 31.
Published in final edited form as: Matrix Biol. 2024 Aug; 131: 1–16. Published online 2024 May 13. doi: 10.1016/j.matbio.2024.05.003
PMCID:
PMC11526477
AbstractArticlePDF–5.2M
2.
PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development
Jong Geol Lee, Jung-Min Yon, Globinna Kim, Seul-Gi Lee, C-Yoon Kim, Seung-A Cheong, Hyun-Yi Kim, Jiyoung Yu, Kyunggon Kim, Young Hoon Sung, Hyun Ju Yoo, Dong-Cheol Woo, Jin Kyung Rho, Chang Hoon Ha, Chan-Gi Pack, Seak Hee Oh, Joon Seo Lim, Yu Mi Han, Eui-Ju Hong, Je Kyung Seong, Han-Woong Lee, Sang-Wook Lee, Ki-Up Lee, Chong Jai Kim, Sang-Yoon Nam, You Sook Cho, In-Jeoung Baek
Nat Commun. 2024; 15: 1487. Published online 2024 Feb 19. doi: 10.1038/s41467-024-45647-8
PMCID:
PMC10876648
AbstractArticlePDF–10M
3.
Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity
Angela Ruscitto, Peng Chen, Ikue Tosa, Ziyi Wang, Gan Zhou, Ingrid Safina, Ran Wei, Mallory M Morel, Alia Koch, Michael Forman, Gwendolyn Reeve, Michael K Lecholop, Marshall Wilson, Daniel Bonthius, Mo Chen, Mitsuaki Ono, Timothy C Wang, Hai Yao, Mildred C Embree
Cell Stem Cell. Author manuscript; available in PMC 2024 Sep 7.
Published in final edited form as: Cell Stem Cell. 2023 Sep 7; 30(9): 1179–1198.e7. doi: 10.1016/j.stem.2023.08.004
PMCID:
PMC10790417
AbstractArticlePDF–6.0M
4.
MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting Adamts5 in Skeletal Muscle Regeneration and Myogenesis
Yanwen Liu, Yilong Yao, Yongsheng Zhang, Chao Yan, Mingsha Yang, Zishuai Wang, Wangzhang Li, Fanqinyu Li, Wei Wang, Yalan Yang, Xinyun Li, Zhonglin Tang
Int J Mol Sci. 2023 Mar; 24(5): 4995. Published online 2023 Mar 5. doi: 10.3390/ijms24054995
PMCID:
PMC10003123
AbstractArticlePDF–5.9M
5.
The Adaptive Response of the Mandibular Condyle to Increased Load is Disrupted by ADAMTS5 Deficiency
Sarah C. Porto, Alexandra Rogers-DeCotes, Emmaline Schafer, Christine B. Kern
Connect Tissue Res. Author manuscript; available in PMC 2024 Jan 1.
Published in final edited form as: Connect Tissue Res. 2023 Jan; 64(1): 93–104. Published online 2022 Aug 1. doi: 10.1080/03008207.2022.2102491
PMCID:
PMC9852085
AbstractArticlePDF–1.3M
6.
ADAMTS5 Is Required For Normal Trabeculated Bone Development In The Mandibular Condyle
Alexandra W. Rogers-DeCotes, Sarah C. Porto, Loren E. Dupuis, Christine B. Kern
Osteoarthritis Cartilage. Author manuscript; available in PMC 2022 Apr 1.
Published in final edited form as: Osteoarthritis Cartilage. 2021 Apr; 29(4): 547–557. Published online 2021 Feb 6. doi: 10.1016/j.joca.2021.01.005
PMCID:
PMC8759092
AbstractArticlePDF–4.5M
7.
Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling
Javier Barallobre-Barreiro, Tamás Radovits, Marika Fava, Ursula Mayr, Wen-Yu Lin, Elizaveta Ermolaeva, Diego Martínez-López, Eric L. Lindberg, Elisa Duregotti, László Daróczi, Maria Hasman, Lukas E. Schmidt, Bhawana Singh, Ruifang Lu, Ferheen Baig, Aleksandra Malgorzata Siedlar, Friederike Cuello, Norman Catibog, Konstantinos Theofilatos, Ajay M. Shah, Maria G. Crespo-Leiro, Nieves Doménech, Norbert Hübner, Béla Merkely, Manuel Mayr
Circulation. 2021 Dec 21; 144(25): 2021–2034. Published online 2021 Nov 22. doi: 10.1161/CIRCULATIONAHA.121.055732
PMCID:
PMC8687617
AbstractArticlePDF–2.2M
8.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
9.
Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture
Weihan Wang, Hao Zhang, Changkai Hou, Quanlei Liu, Shuyuan Yang, Zhen Zhang, Weidong Yang, Xinyu Yang
Aging (Albany NY) 2021 May 15; 13(9): 12800–12816. Published online 2021 May 2. doi: 10.18632/aging.202948
PMCID:
PMC8148490
AbstractArticlePDF–1.4M
10.
ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice
Rui Zhu, Yi-Hsuan Pan, Lijie Sun, Tianhao Zhang, Caiyun Wang, Shuai Ye, Ning Yang, Tiantian Lu, Thomas Wisniewski, Suying Dang, Wei Zhang
Neuroscience. Author manuscript; available in PMC 2021 Mar 29.
Published in final edited form as: Neuroscience. 2019 Feb 10; 399: 53–64. Published online 2018 Dec 21. doi: 10.1016/j.neuroscience.2018.12.025
PMCID:
PMC8006808
AbstractArticlePDF–2.1M
11.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican
Courtney C. Hong, Alan T. Tang, Matthew R. Detter, Jaesung P. Choi, Rui Wang, Xi Yang, Andrea A. Guerrero, Carl F. Wittig, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Lauren M. Goddard, Aileen A. Ren, N. Adrian Leu, Stephanie Sterling, Jisheng Yang, Li Li, Mei Chen, Patricia Mericko-Ishizuka, Lukas E. Dow, Hideto Watanabe, Markus Schwaninger, Wang Min, Douglas A. Marchuk, Xiangjian Zheng, Issam A. Awad, Mark L. Kahn
J Exp Med. 2020 Oct 5; 217(10): e20200140. Published online 2020 Jul 10. doi: 10.1084/jem.20200140
PMCID:
PMC7537394
AbstractArticlePDF–7.2M
12.
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth
Sumeda Nandadasa, Jason M Szafron, Vai Pathak, Sae-Il Murtada, Caroline M Kraft, Anna O'Donnell, Christian Norvik, Clare Hughes, Bruce Caterson, Miriam S Domowicz, Nancy B Schwartz, Karin Tran-Lundmark, Martina Veigl, David Sedwick, Elliot H Philipson, Jay D Humphrey, Suneel S Apte
eLife. 2020; 9: e60683. Published online 2020 Sep 10. doi: 10.7554/eLife.60683
PMCID:
PMC7529456
AbstractArticlePDF–18M
13.
Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles
Alex B. Addinsall, Leonard G. Forgan, Natasha L. McRae, Rhys W. Kelly, Penny L. McDonald, Bryony McNeil, Daniel R. McCulloch, Nicole Stupka
Biomolecules. 2020 Mar; 10(3): 416. Published online 2020 Mar 7. doi: 10.3390/biom10030416
Correction in:
Biomolecules. 2020 Jul; 10(7): 1053.
PMCID:
PMC7175239
AbstractArticlePDF–4.3M
14.
Degrading products of chondroitin sulfate can induce hypertrophy-like changes and MMP-13/ADAMTS5 production in chondrocytes
Youn-Kwan Jung, Hye-Ri Park, Hyun-Jung Cho, Ji-Ae Jang, Eun-Ju Lee, Min-Su Han, Gun-Woo Kim, Seungwoo Han
Sci Rep. 2019; 9: 15846. Published online 2019 Nov 1. doi: 10.1038/s41598-019-52358-4
PMCID:
PMC6825126
AbstractArticlePDF–7.2M
15.
Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction
Reddemma Sandireddy, Dasan Mary Cibi, Priyanka Gupta, Anamika Singh, Nicole Tee, Akiyoshi Uemura, Jonathan A. Epstein, Manvendra K. Singh
JCI Insight. 2019 Aug 22; 4(16): e125908. Published online 2019 Aug 22. doi: 10.1172/jci.insight.125908
PMCID:
PMC6777811
AbstractArticlePDF–21M
16.
Adamts5−/− Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate with Ascending Aortic Anomalies
Loren E. Dupuis, E. Lockett Nelson, Brittany Hozik, Sarah C. Porto, Alexandra Rogers-DeCotes, Amanda Fosang, Christine B. Kern
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2020 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Oct; 39(10): 2067–2081. Published online 2019 Aug 1. doi: 10.1161/ATVBAHA.119.313077
PMCID:
PMC6761016
AbstractArticlePDF–8.0M
17.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
18.
GATA6 regulates aortic valve remodeling and its haploinsufficiency leads to RL-type Bicuspid Aortic Valve
Lara Gharibeh, Hiba Komati, Yohan Bossé, Munir Boodhwani, Mahyar Heydarpour, Megan Fortier, Romina Hassanzadeh, Janet Ngu, Patrick Mathieu, Simon Body, Mona Nemer, Bicuspid Aortic Valve Consortium
Circulation. Author manuscript; available in PMC 2019 Sep 4.
Published in final edited form as: Circulation. 2018 Sep 4; 138(10): 1025–1038. doi: 10.1161/CIRCULATIONAHA.117.029506
PMCID:
PMC6151169
AbstractArticlePDF–2.4M
19.
Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling
Marika Fava, Javier Barallobre-Barreiro, Ursula Mayr, Ruifang Lu, Athanasios Didangelos, Ferheen Baig, Marc Lynch, Norman Catibog, Abhishek Joshi, Temo Barwari, Xiaoke Yin, Marjan Jahangiri, Manuel Mayr
Arterioscler Thromb Vasc Biol. 2018 Jul; 38(7): 1537–1548. Published online 2018 Apr 5. doi: 10.1161/ATVBAHA.117.310562
PMCID:
PMC6026471
AbstractArticlePDF–2.0M
20.
Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis
Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett, Michael Stock
Arthritis Res Ther. 2018; 20: 88. Published online 2018 May 2. doi: 10.1186/s13075-018-1583-2
PMCID:
PMC5932879
AbstractArticlePDF–13M

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