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Items: 1 to 20 of 116

1.
Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis
Stefan Tholen, Martin L. Biniossek, Martina Gansz, Theresa D. Ahrens, Manuel Schlimpert, Jayachandran N. Kizhakkedathu, Thomas Reinheckel, Oliver Schilling
Cell Mol Life Sci. 2014 Mar; 71(5): 899–916. Published online 2013 Jun 29. doi: 10.1007/s00018-013-1406-1
PMCID:
PMC11113308
AbstractArticlePDF–1.3M
2.
Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
Myung Jong Kim, Soojin Kim, Thomas Reinheckel, Dimitri Krainc
JCI Insight. 2024 Feb 8; 9(3): e169594. Published online 2024 Feb 8. doi: 10.1172/jci.insight.169594
PMCID:
PMC10967467
AbstractArticlePDF–3.2M
3.
Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure
Ouzna Dali, Shereen D’Cruz, Louis Legoff, Mariam Diba Lahmidi, Celine Heitz, Pierre-Etienne Merret, Pierre-Yves Kernanec, Farzad Pakdel, Fatima Smagulova
Life Sci Alliance. 2024 Feb; 7(2): e202302237. Published online 2023 Nov 16. doi: 10.26508/lsa.202302237
PMCID:
PMC10654101
AbstractArticlePDF–3.1M
4.
Identification of procathepsin L (pCTS-L)–neutralizing monoclonal antibodies to treat potentially lethal sepsis
Cassie Shu Zhu, Xiaoling Qiang, Weiqiang Chen, Jianhua Li, Xiqian Lan, Huan Yang, Jonathan Gong, Lance Becker, Ping Wang, Kevin J. Tracey, Haichao Wang
Sci Adv. 2023 Feb; 9(5): eadf4313. Published online 2023 Feb 3. doi: 10.1126/sciadv.adf4313
PMCID:
PMC9897667
AbstractArticlePDF–2.5M
5.
hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9
Yujiao Wen, Xixiang Ma, Xiaoli Wang, Fengli Wang, Juan Dong, Yanqing Wu, Chunyu Lv, Kuan Liu, Yan Zhang, Zhibing Zhang, Shuiqiao Yuan
Theranostics. 2021; 11(20): 10030–10046. Published online 2021 Oct 25. doi: 10.7150/thno.66819
PMCID:
PMC8581416
AbstractArticlePDF–3.5M
6.
Cathepsin L, a Target of Hypoxia-Inducible Factor-1-α, Is Involved in Melanosome Degradation in Melanocytes
Ji Young Kim, Eun Jung Lee, Yuri Ahn, Sujin Park, Yu Jeong Bae, Tae Gyun Kim, Sang Ho Oh
Int J Mol Sci. 2021 Aug; 22(16): 8596. Published online 2021 Aug 10. doi: 10.3390/ijms22168596
PMCID:
PMC8395286
AbstractArticlePDF–5.8M
7.
Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis
Hideaki Iwama, Sally Mehanna, Mai Imasaka, Shinsuke Hashidume, Hiroshi Nishiura, Ken-ichi Yamamura, Chigure Suzuki, Yasuo Uchiyama, Etsuro Hatano, Masaki Ohmuraya
Sci Rep. 2021; 11: 6596. Published online 2021 Mar 23. doi: 10.1038/s41598-021-85898-9
PMCID:
PMC7988038
AbstractArticlePDF–2.6M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression
María Alejandra Parigiani, Anett Ketscher, Sylvia Timme, Peter Bronsert, Manuel Schlimpert, Bernd Kammerer, Arnaud Jacquel, Paul Chaintreuil, Thomas Reinheckel
Cancers (Basel) 2020 Aug; 12(8): 2004. Published online 2020 Jul 22. doi: 10.3390/cancers12082004
PMCID:
PMC7463523
AbstractArticlePDF–4.9M
10.
Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice
Jihene Klibi, Kamel Benlagha
Front Immunol. 2020; 11: 815. Published online 2020 May 7. doi: 10.3389/fimmu.2020.00815
PMCID:
PMC7221135
AbstractArticlePDF–1.3M
11.
Proteolytic Disassembly Is a Critical Determinant for Reovirus Oncolysis
Tommy Alain, Tom SY Kim, XueQing Lun, Adelhamid Liacini, Leslie A Schiff, Donna L Senger, Peter A Forsyth
Mol Ther. 2007 Aug; 15(8): 1512–1521. Published online 2016 Dec 14. doi: 10.1038/sj.mt.6300207
PMCID:
PMC7185731
AbstractArticlePDF–2.0M
12.
Proteomic analysis of cathepsin B and L-deficient mouse brain lysosomes
Sonja Stahl, Yvonne Reinders, Esther Asan, Walther Mothes, Ernst Conzelmann, Albert Sickmann, Ute Felbor
Biochim Biophys Acta Proteins Proteom. 2007 Oct; 1774(10): 1237–1246. Published online 2007 Jul 19. doi: 10.1016/j.bbapap.2007.07.004
PMCID:
PMC7105221
AbstractArticlePDF–2.0M
13.
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Saara Hämälistö, Jonathan Lucien Stahl, Elena Favaro, Qing Yang, Bin Liu, Line Christoffersen, Ben Loos, Claudia Guasch Boldú, Johanna A. Joyce, Thomas Reinheckel, Marin Barisic, Marja Jäättelä
Nat Commun. 2020; 11: 229. Published online 2020 Jan 13. doi: 10.1038/s41467-019-14009-0
PMCID:
PMC6957743
AbstractArticlePDF–4.3M
14.
Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis
Yan Lin, Bin Bao, Hao Yin, Xin Wang, Airong Feng, Lin Zhao, Xianqi Nie, Nan Yang, Guo-Ping Shi, Jian Liu
BMC Biol. 2019; 17: 93. Published online 2019 Nov 26. doi: 10.1186/s12915-019-0719-4
PMCID:
PMC6880508
AbstractArticlePDF–3.5M
15.
Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia
Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Leonardo Bonilha, Gayenell S. Magwood, Daniel Lackland, Robert J. Adams, Mark S. Kindy
J Neurosci. 2019 Nov 20; 39(47): 9465–9476. doi: 10.1523/JNEUROSCI.0801-19.2019
PMCID:
PMC6867810
AbstractArticlePDF–1.5M
16.
Frontline Science: Multiple cathepsins promote inflammasome‐independent, particle‐induced cell death during NLRP3‐dependent IL‐1β activation
Gregory M. Orlowski, Shruti Sharma, Jeff D. Colbert, Matthew Bogyo, Stephanie A. Robertson, Hiroshi Kataoka, Francis K. Chan, Kenneth L. Rock
J Leukoc Biol. 2017 Jul; 102(1): 7–17. Published online 2017 Jan 13. doi: 10.1189/jlb.3HI0316-152R
PMCID:
PMC6608057
AbstractArticle
17.
Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation
Tommy Weiss-Sadan, Gal Itzhak, Farnusch Kaschani, Zhanru Yu, Mohamed Mahameed, Adi Anaki, Yael Ben-Nun, Emmanuelle Merquiol, Boaz Tirosh, Benedikt Kessler, Markus Kaiser, Galia Blum
Mol Cell Proteomics. 2019 Jul; 18(7): 1330–1344. Published online 2019 Apr 22. doi: 10.1074/mcp.RA119.001392
PMCID:
PMC6601214
AbstractArticlePDF–3.4M
18.
Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model
Yang Liu, Yang Jiao, Yuxiang He, Xiangjiu Ding, Qingbo Su, Yan Zhao, Jianjun Jiang
J Int Med Res. 2019 Jun; 47(6): 2499–2506. Published online 2019 May 17. doi: 10.1177/0300060519847880
PMCID:
PMC6567726
AbstractArticlePDF–571K
19.
Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis
Akia N. Parks, Juhi Nahata, Naomi-Eliana Edouard, Johnna S. Temenoff, Manu O. Platt
Sci Rep. 2019; 9: 5399. Published online 2019 Apr 1. doi: 10.1038/s41598-019-41782-1
PMCID:
PMC6443789
AbstractArticlePDF–1.6M
20.
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
Paul K. Ziegler, Julia Bollrath, Charles K. Pallangyo, Takaji Matsutani, Özge Canli, Tiago De Oliveira, Michaela A. Diamanti, Nina Müller, Jaba Gamrekelashvili, Tracy Putoczki, David Horst, Arun K. Mankan, Meryem G. Öner, Susanna Müller, Josef Müller-Höcker, Thomas Kirchner, Julia Slotta-Huspenina, M. Mark Taketo, Thomas Reinheckel, Stefan Dröse, Andrew C. Larner, Winfried S. Wels, Matthias Ernst, Tim F. Greten, Melek C. Arkan, Thomas Korn, Dagmar Wirth, Florian R. Greten
Cell. Author manuscript; available in PMC 2019 Jun 28.
Published in final edited form as: Cell. 2018 Jun 28; 174(1): 88–101.e16. Published online 2018 Jun 14. doi: 10.1016/j.cell.2018.05.028
PMCID:
PMC6354256
AbstractArticlePDF–3.4M

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