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Select item 112523311.

Rational correction of pathogenic conformational defects in HTRA1

Nathalie Beaufort, Linda Ingendahl, Melisa Merdanovic, Andree Schmidt, David Podlesainski, Tim Richter, Thorben Neumann, Michael Kuszner, Ingrid R. Vetter, Patricia Stege, Steven G. Burston, Anto Filipovic, Yasser B. Ruiz-Blanco, Kenny Bravo-Rodriguez, Joel Mieres-Perez, Christine Beuck, Stephan Uebel, Monika Zobawa, Jasmin Schillinger, Rainer Malik, Katalin Todorov-Völgyi, Juliana Rey, Annabell Roberti, Birte Hagemeier, Benedikt Wefers, Stephan A. Müller, Wolfgang Wurst, Elsa Sanchez-Garcia, Alexander Zimmermann, Xiao-Yu Hu, Tim Clausen, Robert Huber, Stefan F. Lichtenthaler, Carsten Schmuck, Michael Giese, Markus Kaiser, Michael Ehrmann, Martin Dichgans

Nat Commun. 2024; 15: 5944. Published online 2024 Jul 16. doi: 10.1038/s41467-024-49982-8

PMCID:: PMC11252331

Abstract Article PDF–3.5M

Select item 109589332.

HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy

Hongjie Shi, Ming Yuan, Jie Cai, Lan Lan, Yumou Wang, Wei Wang, Jianliang Zhou, Bin Wang, Wenjun Yu, Zhe Dong, Dawei Deng, Qiaofeng Qian, Yang Li, Xianwu Zhou, Jinping Liu

J Transl Med. 2024; 22: 297. Published online 2024 Mar 22. doi: 10.1186/s12967-024-05098-7

PMCID:: PMC10958933

Abstract Article PDF–4.0M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103078524.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 94996405.

HTRA1 Regulates Subclinical Inflammation and Activates Proangiogenic Response in the Retina and Choroid

Waseem Ahamed, Richard Ming Chuan Yu, Yang Pan, Takeshi Iwata, Veluchamy Amutha Barathi, Yeo Sia Wey, Sai Bo Bo Tun, Beiying Qiu, Alison Tan, Xiaomeng Wang, Chui Ming Gemmy Cheung, Tien Yin Wong, Yasuo Yanagi

Int J Mol Sci. 2022 Sep; 23(18): 10206. Published online 2022 Sep 6. doi: 10.3390/ijms231810206

PMCID:: PMC9499640

Abstract Article PDF–8.3M

Select item 93925356.

HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF‐β/Smad signaling pathway in CARASIL model mice

Li Chuanfen, Wang Xiaoling, Jing Wen, Cao Bingzhen, Wang Min

Brain Behav. 2022 Aug; 12(8): e2691. Published online 2022 Jul 15. doi: 10.1002/brb3.2691

PMCID:: PMC9392535

Abstract Article PDF–3.2M

Select item 92758667.

Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL)

Haifeng Guo, Xia Guo, Shiting Jiang

Bioengineered. 2022; 13(5): 12248–12260. Published online 2022 May 13. doi: 10.1080/21655979.2022.2074738

PMCID:: PMC9275866

Abstract Article PDF–8.7M

Select item 90694738.

Placental HTRA1 cleaves α₁-antitrypsin to generate a NET-inhibitory peptide

Robert A. Campbell, Heather D. Campbell, J. Samuel Bircher, Claudia Valeria de Araujo, Frederik Denorme, Jacob L. Crandell, John L. Rustad, Josh Monts, Mark J. Cody, Yasuhiro Kosaka, Christian C. Yost

Blood. 2021 Sep 16; 138(11): 977–988. Prepublished online 2021 Jun 30. doi: 10.1182/blood.2020009021

PMCID:: PMC9069473

Abstract Article

Select item 88954299.

RUNX2 co-operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers

Qian Zhang, Huanyan Zuo, Shuaitong Yu, Yuxiu Lin, Shuo Chen, Huan Liu, Zhi Chen

J Cell Physiol. Author manuscript; available in PMC 2022 Mar 4.

Published in final edited form as: J Cell Physiol. 2020 Nov; 235(11): 8601–8612. Published online 2020 Apr 23. doi: 10.1002/jcp.29704

PMCID:: PMC8895429

Abstract Article PDF–939K

Select item 831323910.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 776905011.

Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

John DeSisto, Rebecca O’Rourke, Hannah E. Jones, Bradley Pawlikowski, Alexandra D. Malek, Stephanie Bonney, Fabien Guimiot, Kenneth L. Jones, Julie A. Siegenthaler

Dev Cell. Author manuscript; available in PMC 2021 Jul 6.

Published in final edited form as: Dev Cell. 2020 Jul 6; 54(1): 43–59.e4. doi: 10.1016/j.devcel.2020.06.009

PMCID:: PMC7769050

Abstract Article PDF–2.6M

Select item 739063912.

A single cell transcriptional atlas of early synovial joint development

Qin Bian, Yu-Hao Cheng, Jordan P. Wilson, Emily Y. Su, Dong Won Kim, Hong Wang, Sooyeon Yoo, Seth Blackshaw, Patrick Cahan

Development. 2020 Jul 15; 147(14): dev185777. Published online 2020 Jul 20. doi: 10.1242/dev.185777

PMCID:: PMC7390639

Abstract Article

Select item 729503313.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 689077714.

Loss of the serine protease HTRA1 impairs smooth muscle cells maturation

Ralph Klose, Alexander Prinz, Fabian Tetzlaff, Eva-Maria Weis, Iris Moll, Juan Rodriguez-Vita, Chio Oka, Thomas Korff, Andreas Fischer

Sci Rep. 2019; 9: 18224. Published online 2019 Dec 3. doi: 10.1038/s41598-019-54807-6

PMCID:: PMC6890777

Abstract Article PDF–2.5M

Select item 652479315.

HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression

Zhigang Lu, Victor Lin, Adam May, Briana Che, Xu Xiao, Daniel H. Shaw, Fei Su, Zhihao Wang, Hongjun Du, Peter X. Shaw

PLoS One. 2019; 14(5): e0216808. Published online 2019 May 17. doi: 10.1371/journal.pone.0216808

PMCID:: PMC6524793

Abstract Article PDF–2.7M

Select item 639718116.

Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment

Nagahiro Ochiai, Yutaka Nakachi, Tomotaka Yokoo, Takahiro Ichihara, Tore Eriksson, Yuki Yonemoto, Takehiko Kato, Hitoshi Ogata, Natsuko Fujimoto, Yasuhiro Kobayashi, Nobuyuki Udagawa, Shinsuke Kaku, Tomokazu Ueki, Yasushi Okazaki, Naoyuki Takahashi, Tatsuo Suda

Commun Biol. 2019; 2: 86. Published online 2019 Mar 1. doi: 10.1038/s42003-019-0334-5