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Select item 111419171.

Gα₁₁ deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia

Birol Ay, Sajin Marcus Cyr, Kaitlin Klovdahl, Wen Zhou, Christina M. Tognoni, Yorihiro Iwasaki, Eugene P Rhee, Alpaslan Dedeoglu, Petra Simic, Murat Bastepe

JCI Insight. 2024 May 8; 9(9): e178993. Published online 2024 Mar 26. doi: 10.1172/jci.insight.178993

PMCID:: PMC11141917

Abstract Article PDF–1.5M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102596613.

Stretch regulates alveologenesis and homeostasis via mesenchymal G_αq/11-mediated TGFβ2 activation

Amanda T. Goodwin, Alison E. John, Chitra Joseph, Anthony Habgood, Amanda L. Tatler, Katalin Susztak, Matthew Palmer, Stefan Offermanns, Neil C. Henderson, R. Gisli Jenkins

Development. 2023 May 1; 150(9): dev201046. Published online 2023 May 12. doi: 10.1242/dev.201046

PMCID:: PMC10259661

Abstract Article

Select item 87117594.

Deletion of Gα_q/11 or Gα_s Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice

George A Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R Thompson, Rona S Carroll, Min Chen, Lee S Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J Bernard, Ursula B Kaiser

Endocrinology. 2022 Feb; 163(2): bqab247. Published online 2021 Dec 5. doi: 10.1210/endocr/bqab247

PMCID:: PMC8711759

Abstract Article

Select item 85775595.

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle

Qian Wang, Wendy Wing Sze Yue, Zheng Jiang, Tian Xue, Shin H. Kang, Dwight E. Bergles, Katsuhiko Mikoshiba, Stefan Offermanns, King-Wai Yau

Curr Biol. Author manuscript; available in PMC 2021 Nov 9.

Published in final edited form as: Curr Biol. 2017 Jun 19; 27(12): 1791–1800.e5. Published online 2017 Jun 1. doi: 10.1016/j.cub.2017.05.022

PMCID:: PMC8577559

Abstract Article PDF–1.7M

Select item 82603636.

G_qα/G₁₁α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity

Eric A. Wilson, Hui Sun, Zhenzhong Cui, Marshal T. Jahnke, Mritunjay Pandey, Peter Metzger, Oksana Gavrilova, Min Chen, Lee S. Weinstein

Am J Physiol Endocrinol Metab. 2021 Feb 1; 320(2): E270–E280. Published online 2020 Nov 9. doi: 10.1152/ajpendo.00059.2020

PMCID:: PMC8260363

Abstract Article

Select item 80988147.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 73971119.

The orphan receptor GPR139 signals via G_q/11 to oppose opioid effects

Hannah M. Stoveken, Stefano Zucca, Ikuo Masuho, Brock Grill, Kirill A. Martemyanov

J Biol Chem. 2020 Jul 31; 295(31): 10822–10830. Published online 2020 Jun 23. doi: 10.1074/jbc.AC120.014770

PMCID:: PMC7397111

Abstract Article PDF–2.3M

Select item 734198510.

Effects of G-protein mutations on skin color

Catherine D Van Raamsdonk, Karen R Fitch, Helmut Fuchs, Martin Hrabé de Angelis, Gregory S Barsh

Nat Genet. Author manuscript; available in PMC 2020 Jul 8.

Published in final edited form as: Nat Genet. 2004 Sep; 36(9): 961–968. Published online 2004 Aug 22. doi: 10.1038/ng1412

PMCID:: PMC7341985

Abstract Article PDF–1.1M

Select item 726179511.

Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor–mediated chemotaxis

Esther van den Bos, Benjamin Ambrosy, Markus Horsthemke, Stefan Walbaum, Anne C. Bachg, Nina Wettschureck, Giulio Innamorati, Thomas M. Wilkie, Peter J. Hanley

J Biol Chem. 2020 May 29; 295(22): 7726–7742. Published online 2020 Apr 24. doi: 10.1074/jbc.RA119.011984

PMCID:: PMC7261795

Abstract Article PDF–5.0M

Select item 698340012.

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

Jan Wenzel, Cathrin E. Hansen, Carla Bettoni, Miriam A. Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C. Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M. König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter Gass, Stefan Offermanns, Cor de Wit, Carsten A. Wagner, Markus Schwaninger

Proc Natl Acad Sci U S A. 2020 Jan 21; 117(3): 1753–1761. Published online 2020 Jan 2. doi: 10.1073/pnas.1907467117

PMCID:: PMC6983400

Abstract Article PDF–3.6M

Select item 692342413.

Helix 8 is the essential structural motif of mechanosensitive GPCRs

Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler

Nat Commun. 2019; 10: 5784. Published online 2019 Dec 19. doi: 10.1038/s41467-019-13722-0

PMCID:: PMC6923424

Abstract Article PDF–1.4M

Select item 677797914.

Myogenic vasoconstriction requires G₁₂/G₁₃ and LARG to maintain local and systemic vascular resistance

Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns

eLife. 2019; 8: e49374. Published online 2019 Sep 24. doi: 10.7554/eLife.49374

PMCID:: PMC6777979

Abstract Article PDF–4.6M

Select item 677264415.

Muscarinic Inhibition of Calcium Current and M Current in Gα_q-Deficient Mice

Jane E. Haley, Patrick Delmas, Stefan Offermanns, Fe C. Abogadie, Melvin I. Simon, Noel J. Buckley, David A. Brown

J Neurosci. 2000 Jun 1; 20(11): 3973–3979. doi: 10.1523/JNEUROSCI.20-11-03973.2000

PMCID:: PMC6772644

Abstract Article PDF–251K

Select item 676286516.

Gα_q-Deficient Mice Lack Metabotropic Glutamate Receptor-Dependent Long-Term Depression But Show Normal Long-Term Potentiation in the Hippocampal CA1 Region

Thomas Kleppisch, Viktor Voigt, Rüdiger Allmann, Stefan Offermanns

J Neurosci. 2001 Jul 15; 21(14): 4943–4948. doi: 10.1523/JNEUROSCI.21-14-04943.2001

PMCID:: PMC6762865

Abstract Article PDF–166K

Select item 675849317.

Functional Specificity of Gα_q and Gα₁₁ in the Cholinergic and Glutamatergic Modulation of Potassium Currents and Excitability in Hippocampal Neurons

Michael Krause, Stefan Offermanns, Martin Stocker, Paola Pedarzani

J Neurosci. 2002 Feb 1; 22(3): 666–673. doi: 10.1523/JNEUROSCI.22-03-00666.2002

PMCID:: PMC6758493

Abstract Article PDF–308K

Select item 675780718.

Group I Metabotropic Glutamate Receptor Signaling via Gαq/Gα11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA1

Masami Miura, Masahiko Watanabe, Stefan Offermanns, Melvin I. Simon, Masanobu Kano

J Neurosci. 2002 Oct 1; 22(19): 8379–8390. doi: 10.1523/JNEUROSCI.22-19-08379.2002

PMCID:: PMC6757807

Abstract Article PDF–393K

Select item 672919519.

Distinct Roles of Gα_q and Gα₁₁ for Purkinje Cell Signaling and Motor Behavior

J. Hartmann, R. Blum, Y. Kovalchuk, H. Adelsberger, R. Kuner, G. M. Durand, M. Miyata, M. Kano, S. Offermanns, A. Konnerth

J Neurosci. 2004 Jun 2; 24(22): 5119–5130. doi: 10.1523/JNEUROSCI.4193-03.2004

PMCID:: PMC6729195

Abstract Article PDF–710K

Select item 672501820.

Gα_o2 Regulates Vesicular Glutamate Transporter Activity by Changing Its Chloride Dependence

Sandra Winter, Irene Brunk, Diego J. Walther, Markus Höltje, Meisheng Jiang, Jens-Uwe Peter, Shigeo Takamori, Reinhard Jahn, Lutz Birnbaumer, Gudrun Ahnert-Hilger

J Neurosci. 2005 May 4; 25(18): 4672–4680. doi: 10.1523/JNEUROSCI.0549-05.2005

PMCID:: PMC6725018

Abstract Article PDF–840K

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