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Select item 114656881.

Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation

Gerry A. Shipman, Reinnier Padilla, Cynthia Horth, Bo Hu, Eric Bareke, Francisca N. Vitorino, Joanna M. Gongora, Benjamin A. Garcia, Chao Lu, Jacek Majewski

Genome Biol. 2024; 25: 263. Published online 2024 Oct 10. doi: 10.1186/s13059-024-03415-3

PMCID:: PMC11465688

Abstract Article PDF–6.0M

Select item 113216372.

Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic Tumorigenesis

Wenxin Feng, Ningning Niu, Ping Lu, Zhuo Chen, Hanyu Rao, Wei Zhang, Chunxiao Ma, Changwei Liu, Yue Xu, Wei‐Qiang Gao, Jing Xue, Li Li

Adv Sci (Weinh) 2024 Aug; 11(30): 2309387. Published online 2024 Jun 18. doi: 10.1002/advs.202309387

PMCID:: PMC11321637

Abstract Article PDF–7.7M

Select item 110768093.

ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin

Naoki Goto, Kazuma Suke, Nao Yonezawa, Hidenori Nishihara, Tetsuya Handa, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Kazuo Yamagata, Hiroshi Kimura

J Cell Biol. 2024 Aug 5; 223(8): e202310084. Published online 2024 May 6. doi: 10.1083/jcb.202310084

PMCID:: PMC11076809

Abstract Article PDF–7.4M

Select item 106583294.

Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway

Guoquan Wei, Chuling Li, Xiaoqian Jia, Jingfang Xie, Zhenquan Tang, Ming Jin, Qiqi Chen, Yili Sun, Sisi He, Xinzhong Li, Yanmei Chen, Hao Zheng, Wangjun Liao, Yulin Liao, Jianping Bin, Senlin Huang

J Adv Res. 2023 Nov; 53: 199–218. Published online 2022 Dec 29. doi: 10.1016/j.jare.2022.12.014

PMCID:: PMC10658329

Abstract Article PDF–9.9M

Select item 106562345.

Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development

Dan Su, Steve Eliason, Zhao Sun, Fan Shao, Brad A. Amendt

J Biol Chem. 2023 Nov; 299(11): 105324. Published online 2023 Oct 6. doi: 10.1016/j.jbc.2023.105324

PMCID:: PMC10656234

Abstract Article PDF–5.0M

Select item 90618426.

Histone methyltransferase Nsd2 ensures maternal–fetal immune tolerance by promoting regulatory T-cell recruitment

Le Zhang, Xuehui Long, Yuye Yin, Jun Wang, Huamin Zhu, Jingjing Chen, Yuliang Wang, Yun Chen, Xiaoming Wang

Cell Mol Immunol. 2022 May; 19(5): 634–643. Published online 2022 Mar 23. doi: 10.1038/s41423-022-00849-2

PMCID:: PMC9061842

Abstract Article PDF–3.9M

Select item 90122827.

Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ–stimulated antitumor immunity

Jiale Ren, Ni Li, Siyu Pei, Yannan Lian, Li Li, Yuchong Peng, Qiuli Liu, Jiacheng Guo, Xuege Wang, Ying Han, Guoying Zhang, Hanling Wang, Yaqi Li, Jun Jiang, Qintong Li, Minjia Tan, Junjie Peng, Guohong Hu, Yichuan Xiao, Xiong Li, Moubin Lin, Jun Qin

J Clin Invest. 2022 Apr 15; 132(8): e153167. Published online 2022 Apr 15. doi: 10.1172/JCI153167

PMCID:: PMC9012282

Abstract Article PDF–4.0M

Select item 89693408.

METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy

Weiming Tang, Yilin Zhao, Hui Zhang, Ying Peng, Zhilian Rui

BMC Nephrol. 2022; 23: 124. Published online 2022 Mar 30. doi: 10.1186/s12882-022-02753-3

PMCID:: PMC8969340

Abstract Article PDF–12M

Select item 87772769.

PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway

Nianyin Lv, Sufeng Jin, Zihao Liang, Xiaohui Wu, Yanhua Kang, Lan Su, Yeping Dong, Bingwei Wang, Tonghui Ma, Liyun Shi

Front Immunol. 2021; 12: 751409. Published online 2022 Jan 7. doi: 10.3389/fimmu.2021.751409

PMCID:: PMC8777276

Abstract Article PDF–10M

Select item 851061310.

A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation

Shusaku Abe, Hiroaki Nagatomo, Hiroyuki Sasaki, Takashi Ishiuchi

Epigenetics. 2021; 16(10): 1123–1134. Published online 2020 Nov 16. doi: 10.1080/15592294.2020.1841873

PMCID:: PMC8510613

Abstract Article PDF–7.2M

Select item 850426611.

Wolf–Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation

Caixia Liu, Benlong Cai, Dan Li, Yuan Yao

Innate Immun. 2021 Aug; 27(6): 437–447. Published online 2021 Aug 25. doi: 10.1177/17534259211035426

PMCID:: PMC8504266

Abstract Article PDF–2.0M

Select item 839594412.

Inhibition of WHSC1 Allows for Reprogramming of the Immune Compartment in Prostate Cancer

Muzamil Y. Want, Ellen Karasik, Bryan Gillard, A. J. Robert McGray, Sebastiano Battaglia

Int J Mol Sci. 2021 Aug; 22(16): 8742. Published online 2021 Aug 14. doi: 10.3390/ijms22168742

PMCID:: PMC8395944

Abstract Article PDF–2.4M

Select item 802048513.

Whsc1 links pluripotency exit with mesendoderm specification

Tian V. Tian, Bruno Di Stefano, Grégoire Stik, Maria Vila-Casadesús, José Luis Sardina, Enrique Vidal, Alessandro Dasti, Carolina Segura Morales, Luisa De Andres Aguayo, Antonio Gomez, Johanna Goldmann, Rudolf Jaenisch, Thomas Graf

Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 5.

Published in final edited form as: Nat Cell Biol. 2019 Jul; 21(7): 824–834. Published online 2019 Jun 24. doi: 10.1038/s41556-019-0342-1

PMCID:: PMC8020485

Abstract Article PDF–2.3M

Select item 796892514.

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam

eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873

PMCID:: PMC7968925

Abstract Article PDF–4.0M

Select item 772205815.

The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice

Marc-Werner Dobenecker, Jonas Marcello, Annette Becker, Eugene Rudensky, Natarajan V. Bhanu, Thomas Carrol, Benjamin A. Garcia, Rabinder Prinjha, Vyacheslav Yurchenko, Alexander Tarakhovsky

FEBS Lett. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: FEBS Lett. 2020 Oct; 594(20): 3324–3337. Published online 2020 Aug 29. doi: 10.1002/1873-3468.13903

PMCID:: PMC7722058

Abstract Article PDF–873K

Select item 729984316.

H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres

Inge de Krijger, Jaco van der Torre, Marieke H. Peuscher, Mathias Eder, Jacqueline J. L. Jacobs

Oncogene. 2020; 39(25): 4814–4827. Published online 2020 May 29. doi: 10.1038/s41388-020-1334-0

PMCID:: PMC7299843

Abstract Article PDF–1.7M

Select item 703724717.

Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation

Xuehui Long, Le Zhang, Yang Zhang, Min Min, Bichun Lin, Jingjing Chen, Xiaojie Ma, Sulan Zhai, Zhenming Cai, Yingxia Liu, Yanlai Lu, Nan Che, Wenfeng Tan, Jun Qin, Xiaoming Wang

J Exp Med. 2020 Jan 6; 217(1): e20190832. Published online 2019 Oct 21. doi: 10.1084/jem.20190832

PMCID:: PMC7037247

Abstract Article PDF–5.9M

Select item 630776118.

NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2

Xue‐liang Zhou, Rong‐rong Zhu, Xia Wu, Hua Xu, Yun‐yun Li, Qi‐rong Xu, Sheng Liu, Huang Huang, Xinping Xu, Li Wan, Qi‐cai Wu, Ji‐chun Liu

J Cell Mol Med. 2019 Jan; 23(1): 568–575. Published online 2018 Oct 18. doi: 10.1111/jcmm.13961

PMCID:: PMC6307761

Abstract Article PDF–1.0M

Select item 628161019.

NSD2 is a conserved driver of metastatic prostate cancer progression

Alvaro Aytes, Arianna Giacobbe, Antonina Mitrofanova, Katia Ruggero, Joanna Cyrta, Juan Arriaga, Luis Palomero, Sonia Farran-Matas, Mark A. Rubin, Michael M. Shen, Andrea Califano, Cory Abate-Shen

Nat Commun. 2018; 9: 5201. Published online 2018 Dec 5. doi: 10.1038/s41467-018-07511-4