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Select item 113393881.

JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms

Ryota Ishibashi, Masahiko Itani, Akitsugu Kawashima, Yoshiki Arakawa, Tomohiro Aoki

Sci Rep. 2024; 14: 19458. Published online 2024 Aug 21. doi: 10.1038/s41598-024-70493-5

PMCID:: PMC11339388

Abstract Article PDF–2.4M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111481843.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 107597314.

Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma

Kunyuan Wang, Qianting Lu, Yufeng Luo, Ganxiang Yu, Zhilei Wang, Jiaen Lin, Zhenlin Tan, Yueqiong Lao, Shiming Liu, Hui Yang

Biol Direct. 2024; 19: 4. Published online 2024 Jan 2. doi: 10.1186/s13062-023-00442-1

PMCID:: PMC10759731

Abstract Article PDF–7.6M

Select item 102809405.

CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability

Feifei Yang, Qiang Ma, Bo Huang, Xiaolin Wang, Xiaojuan Pan, Ting Yu, Lingyu Ran, Shan Jiang, Haiping Li, Ye Chen, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang, Wei Li, Bin Xiao

J Transl Med. 2023; 21: 402. Published online 2023 Jun 20. doi: 10.1186/s12967-023-04235-y

PMCID:: PMC10280940

Abstract Article PDF–11M

Select item 100729066.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 94819337.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88970229.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 876157110.

c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1

Xiaodong Tian, Benno Traub, Jingwei Shi, Nadine Huber, Stefan Schreiner, Guowei Chen, Shaoxia Zhou, Doris Henne-Bruns, Uwe Knippschild, Marko Kornmann

Cancer Gene Ther. 2022; 29(1): 73–86. Published online 2021 Feb 1. doi: 10.1038/s41417-020-00290-5

PMCID:: PMC8761571

Abstract Article PDF–6.5M

Select item 874676411.

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abigail O. Smith, Julie A. Jonassen, Kenley M. Preval, Roger J. Davis, Gregory J. Pazour

PLoS Genet. 2021 Dec; 17(12): e1009711. Published online 2021 Dec 28. doi: 10.1371/journal.pgen.1009711

PMCID:: PMC8746764

Abstract Article PDF–7.1M

Select item 865623512.

miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury

Jing Yang, Hanh Chi Do-Umehara, Qiao Zhang, Huashan Wang, Changchun Hou, Huali Dong, Edith A. Perez, Marc A. Sala, Kishore R. Anekalla, James M. Walter, Shuwen Liu, Richard G. Wunderink, G.R. Scott Budinger, Jing Liu

Front Immunol. 2021; 12: 700933. Published online 2021 Nov 25. doi: 10.3389/fimmu.2021.700933

PMCID:: PMC8656235

Abstract Article PDF–5.8M

Select item 851157913.

F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2

Cheol-Jung Lee, Ga-Eun Lee, Hyun-Jung An, Eun Suh Cho, Weidong Chen, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Yong-Yeon Cho

J Cancer Prev. 2021 Sep 30; 26(3): 174–182. Published online 2021 Sep 30. doi: 10.15430/JCP.2021.26.3.174

PMCID:: PMC8511579

Abstract Article PDF–2.6M

Select item 843179114.

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases

Jing Chen, Chao Ye, Chao Wan, Gang Li, Lianci Peng, Yuanyi Peng, Rendong Fang

Int J Mol Sci. 2021 Sep; 22(17): 9640. Published online 2021 Sep 6. doi: 10.3390/ijms22179640

PMCID:: PMC8431791

Abstract Article PDF–12M

Select item 819175615.

Post-translational modification of RNA m⁶A demethylase ALKBH5 regulates ROS-induced DNA damage response

Fang Yu, Jiangbo Wei, Xiaolong Cui, Chunjie Yu, Wei Ni, Jörg Bungert, Lizi Wu, Chuan He, Zhijian Qian

Nucleic Acids Res. 2021 Jun 4; 49(10): 5779–5797. Published online 2021 May 28. doi: 10.1093/nar/gkab415

PMCID:: PMC8191756

Abstract Article PDF–5.7M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 742732717.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 730149918.

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding, Chengbiao Wu

Transl Neurodegener. 2020; 9: 26. Published online 2020 Jun 18. doi: 10.1186/s40035-020-00206-1

PMCID:: PMC7301499

Abstract Article PDF–14M

Select item 723748619.

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation

Peiyuan Zhang, Yingjie Liu, Cheng Lian, Xuan Cao, Yuan Wang, Xiaoxun Li, Min Cong, Pu Tian, Xue Zhang, Gang Wei, Tong Liu, Guohong Hu

Nat Commun. 2020; 11: 2487. Published online 2020 May 19. doi: 10.1038/s41467-020-16051-9

PMCID:: PMC7237486

Abstract Article PDF–1.7M

Select item 718130320.

JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells

Lili Du, Anna Anderson, Kimberly Nguyen, Sandra S. Ojeda, Ivannie Ortiz-Rivera, Tran Ngoc Nguyen, Tinghu Zhang, Tamer S. Kaoud, Nathanael S. Gray, Kevin N. Dalby, Kenneth Y. Tsai

ACS Chem Biol. Author manuscript; available in PMC 2020 Jul 19.

Published in final edited form as: ACS Chem Biol. 2019 Jul 19; 14(7): 1426–1435. Published online 2019 May 17. doi: 10.1021/acschembio.9b00083

PMCID:: PMC7181303

Abstract Article PDF–1.6M

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