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Select item 112969141.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112232992.

A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis

Lisha Chang, Jie Ding, Juan Pu, Jing Zhu, Xiang Zhou, Qian Luo, Jie Li, Mengsen Qian, Shuhui Lin, Juan Li, Keming Wang

J Exp Clin Cancer Res. 2024; 43: 185. Published online 2024 Jul 4. doi: 10.1186/s13046-024-03095-8

PMCID:: PMC11223299

Abstract Article PDF–14M

Select item 110407613.

Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu

Respir Res. 2024; 25: 176. Published online 2024 Apr 24. doi: 10.1186/s12931-024-02816-z

PMCID:: PMC11040761

Abstract Article PDF–15M

Select item 104801874.

HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth

Huajie Mao, Runzhi Wang, Fengling Shao, Ming Zhao, Dayu Tian, Hua Xia, Ya Zhao

Sci Rep. 2023; 13: 14629. Published online 2023 Sep 5. doi: 10.1038/s41598-023-41343-7

PMCID:: PMC10480187

Abstract Article PDF–12M

Select item 103586235.

HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study

Rongrong Ding, Tianyou Chen, Yuan Zhang, Xiaorong Chen, Liping Zhuang, Zongguo Yang

Sci Prog. 2021 Jul-Sep; 104(3): 00368504211031749. Published online 2021 Jul 14. doi: 10.1177/00368504211031749

PMCID:: PMC10358623

Abstract Article PDF–2.9M

Select item 99064286.

LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease

Mi Bai, Mengqiu Wu, Mingzhu Jiang, Jia He, Xu Deng, Shuang Xu, Jiaojiao Fan, Mengqiu Miao, Ting Wang, Yuting Li, Xiaowen Yu, Lin Wang, Yue Zhang, Songming Huang, Li Yang, Zhanjun Jia, Aihua Zhang

EMBO Mol Med. 2023 Feb; 15(2): e16581. Published online 2023 Jan 11. doi: 10.15252/emmm.202216581

PMCID:: PMC9906428

Abstract Article PDF–14M

Select item 90398707.

Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

Shaza Asif, Ri Youn Kim, Thet Fatica, Jordan Sim, Xiaoling Zhao, Yena Oh, Alix Denoncourt, Angela C. Cheung, Michael Downey, Erin E. Mulvihill, Kyoung-Han Kim

Mol Metab. 2022 Jul; 61: 101494. Published online 2022 Apr 12. doi: 10.1016/j.molmet.2022.101494

PMCID:: PMC9039870

Abstract Article PDF–5.9M

Select item 87003778.

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari

Cells. 2021 Dec; 10(12): 3550. Published online 2021 Dec 16. doi: 10.3390/cells10123550

PMCID:: PMC8700377

Abstract Article PDF–2.5M

Select item 86641299.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 843809010.

SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis

Jie Li, Ming-han Li, Tian-tian Wang, Xiao-ning Liu, Xiao-ting Zhu, Yun-zhang Dai, Ke-chao Zhai, Yong-da Liu, Jia-li Lin, Rui-liang Ge, Shu-han Sun, Fang Wang, Ji-hang Yuan

Br J Cancer. 2021 Sep 14; 125(6): 865–876. Published online 2021 Jul 17. doi: 10.1038/s41416-021-01490-y

PMCID:: PMC8438090

Abstract Article PDF–2.3M

Select item 826679811.

Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation

Lei Fang, Tu-Shuai Li, Jing-Zi Zhang, Zhi-Hong Liu, Jie Yang, Bing-Hao Wang, Yu-Meng Wang, Jie Zhou, Ling-Dong Kong

Signal Transduct Target Ther. 2021; 6: 253. Published online 2021 Jul 9. doi: 10.1038/s41392-021-00570-y

PMCID:: PMC8266798

Article PDF–1.5M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 722681213.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle

Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834

PMCID:: PMC7226812

Abstract Article PDF–2.3M

Select item 711512814.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Abstract Article PDF–1.6M

Select item 694617415.

The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice

Stefan Bagheri-Fam, Huijun Chen, Sean Wilson, Katie Ayers, James Hughes, Frederique Sloan-Bena, Pierre Calvel, Gorjana Robevska, Beatriz Puisac, Kamila Kusz-Zamelczyk, Stefania Gimelli, Anna Spik, Jadwiga Jaruzelska, Alina Warenik-Szymankiewicz, Sultana Faradz, Serge Nef, Juan Pié, Paul Thomas, Andrew Sinclair, Dagmar Wilhelm

PLoS One. 2020; 15(1): e0227411. Published online 2020 Jan 7. doi: 10.1371/journal.pone.0227411

PMCID:: PMC6946174

Abstract Article PDF–4.9M

Select item 677020916.

Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells

Ji Tae Kim, Chang Li, Heidi L. Weiss, Yuning Zhou, Chunming Liu, Qingding Wang, B. Mark Evers

Cells. 2019 Sep; 8(9): 1106. Published online 2019 Sep 19. doi: 10.3390/cells8091106

PMCID:: PMC6770209

Abstract Article PDF–2.3M

Select item 663406817.

Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker

Kejian Zou, Yan Hu, Musheng Li, Hongli Wang, Yuhua Zhang, Ling Huang, Yuanwen Xie, Songyu Li, Xingui Dai, Wanfu Xu, Zhiyong Ke, Sitang Gong, Yaodong Wang

Can J Gastroenterol Hepatol. 2019; 2019: 8348967. Published online 2019 Jul 1. doi: 10.1155/2019/8348967

PMCID:: PMC6634068

Abstract Article PDF–1.6M

Select item 632162518.

Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes

Chih-Yuan Fang, Mien-Cheng Chen, Tzu-Hao Chang, Chia-Chen Wu, Jen-Ping Chang, Hsien-Da Huang, Wan-Chun Ho, Yi-Zhen Wang, Kuo-Li Pan, Yu-Sheng Lin, Yao-Kuang Huang, Chien-Jen Chen, Wei-Chieh Lee

Int J Mol Sci. 2018 Dec; 19(12): 4094. Published online 2018 Dec 18. doi: 10.3390/ijms19124094

PMCID:: PMC6321625

Abstract Article PDF–2.9M

Select item 628329319.

Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies

Christina Schiza, Dimitrios Korbakis, Efstratia Panteleli, Keith Jarvi, Andrei P. Drabovich, Eleftherios P. Diamandis

Mol Cell Proteomics. 2018 Dec; 17(12): 2480–2495. Published online 2018 Aug 10. doi: 10.1074/mcp.RA118.000749

PMCID:: PMC6283293

Abstract Article PDF–1.9M

Select item 616668220.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

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