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Select item 109385211.

Identification of a Novel CYP11B2 Variant in a Family with Varying Degrees of Aldosterone Synthase Deficiency

Mark R. Garrelfs, Tuula Rinne, Jacquelien J. Hillebrand, Peter Lauffer, Merijn W. Bijlsma, Hedi L. Claahsen-van der Grinten, Nicole de Leeuw, Martijn J.J. Finken, Joost Rotteveel, Nitash Zwaveling-Soonawala, Max Nieuwdorp, A.S. Paul van Trotsenburg, Christiaan F. Mooij

J Clin Res Pediatr Endocrinol. 2024 Mar; 16(1): 95–101. Published online 2024 Mar 11. doi: 10.4274/jcrpe.galenos.2022.2022-3-4

PMCID:: PMC10938521

Abstract Article PDF–552K

Select item 102978982.

Association between Aldosterone Synthase (CYP11B2) Gene Polymorphism and Hypertension in Pashtun Ethnic Population of Khyber Pakhtunkwha, Pakistan

Waheed Ali Shah, Asif Jan, Muhammad Asghar Khan, Muhammad Saeed, Naveed Rahman, Zakiullah, Muhammad Sajjad Afridi, Fazli Khuda, Rani Akbar

Genes (Basel) 2023 Jun; 14(6): 1184. Published online 2023 May 29. doi: 10.3390/genes14061184

PMCID:: PMC10297898

Abstract Article PDF–581K

Select item 88226633.

Effect of ACE, ACE2 and CYP11B2 gene polymorphisms and noise on essential hypertension among steelworkers in China: a case–control study

Xiaohong Zhang, Ying Wang, Yao Zheng, Juxiang Yuan, Junwang Tong, Jingya Xu, Qinglin Li, Peishuai Li, Shoufang Jiang, Zhaoyang Wang, Feng Chai, Xiangwen Li

BMC Med Genomics. 2022; 15: 22. Published online 2022 Feb 8. doi: 10.1186/s12920-022-01177-0

PMCID:: PMC8822663

Abstract Article PDF–1.0M

Select item 87508454.

GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism

Yu-Ching Wu, Chia-I Chen, Peng-Ying Chen, Chun-Hung Kuo, Yi-Hsuan Hung, Kang-Yung Peng, Vin-Cent Wu, Jyy-Jih Tsai-Wu, Chia-Lang Hsu, TAIPAI group

BMC Bioinformatics. 2021; 22(Suppl 10): 613. Published online 2022 Jan 10. doi: 10.1186/s12859-022-04561-w

PMCID:: PMC8750845

Abstract Article PDF–1.7M

Select item 86641295.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 86249496.

Molecular recognition in mitochondrial cytochromes P450 that catalyze the terminal steps of corticosteroid biosynthesis

Hwei-Ming Peng, Richard J. Auchus

Biochemistry. Author manuscript; available in PMC 2021 Nov 26.

Published in final edited form as: Biochemistry. 2017 May 2; 56(17): 2282–2293. Published online 2017 Apr 17. doi: 10.1021/acs.biochem.7b00034

PMCID:: PMC8624949

Abstract Article PDF–1.4M

Select item 82152937.

Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin

Simoné Brixius-Anderko, Emily E. Scott

J Biol Chem. 2021 Jan-Jun; 296: 100794. Published online 2021 May 18. doi: 10.1016/j.jbc.2021.100794

PMCID:: PMC8215293

Abstract Article PDF–2.7M

Select item 81863408.

Clinical and Genetic Characteristics of Patients with Corticosterone Methyloxidase Deficiency Type 2: Novel Mutations in CYP11B2

Hande Turan, Aydilek Dağdeviren Çakır, Yavuz Özer, Gürkan Tarçın, Bahar Özcabi, Serdar Ceylaner, Oya Ercan, Saadet Olcay Evliyaoğlu

J Clin Res Pediatr Endocrinol. 2021 Jun; 13(2): 232–238. Published online 2021 Jun 2. doi: 10.4274/jcrpe.galenos.2020.2019.0216

PMCID:: PMC8186340

Abstract Article PDF–736K

Select item 81238559.

DNA Methylation of the Angiotensinogen Gene, AGT, and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases

Yoshimichi Takeda, Masashi Demura, Takashi Yoneda, Yoshiyu Takeda

Int J Mol Sci. 2021 May; 22(9): 4587. Published online 2021 Apr 27. doi: 10.3390/ijms22094587

PMCID:: PMC8123855

Abstract Article PDF–3.2M

Select item 795486910.

Characterization of human adrenal cytochrome P450 11B2 products of progesterone and androstenedione oxidation

Sarah M. Glass, Michael J. Reddish, Stella A. Child, Clayton J. Wilkey, Donald F. Stec, F. Peter Guengerich

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2021 Apr; 208: 105787. Published online 2020 Nov 12. doi: 10.1016/j.jsbmb.2020.105787

PMCID:: PMC7954869

Abstract Article PDF–1.4M

Select item 771023311.

Correlation between CYP11B2 polymorphism and the risk of preeclampsia

Yan Wang, Minhua Zhou, Xun Deng, Yanjiao Ma, Deqi Jiang

Medicine (Baltimore) 2020 Nov 25; 99(48): e23322. Published online 2020 Nov 25. doi: 10.1097/MD.0000000000023322

PMCID:: PMC7710233

Abstract Article PDF–396K

Select item 750301712.

Association of −344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension

Lili Wang, Zhi Zhang, Dongxia Liu, Kexin Yuan, Guohua Zhu, Xiaoyong Qi

J Int Med Res. 2020 Sep; 48(9): 0300060520949409. Published online 2020 Sep 16. doi: 10.1177/0300060520949409

PMCID:: PMC7503017

Abstract Article PDF–226K

Select item 742713213.

Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population

Jia Fan, Yaoliang Shen, Bo Chen, Chunyang Xu, Hongwei Ye, Jian Wang, Wenjun Zhou, Yuefeng Sheng, Feng Xu, Peng Yang

J Int Med Res. 2020 Aug; 48(8): 0300060520947916. Published online 2020 Aug 13. doi: 10.1177/0300060520947916

PMCID:: PMC7427132

Abstract Article PDF–574K

Select item 741597114.

Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice

Brahmaraju Mopidevi, Indu Sivankutty, Shoujin Hao, Nicholas R. Ferreri, Ashok Kumar

J Biol Chem. 2020 Aug 7; 295(32): 11068–11081. Published online 2020 Jun 15. doi: 10.1074/jbc.RA120.013047

PMCID:: PMC7415971

Abstract Article PDF–3.5M

Select item 729974315.

IMMUNOHISTOCHEMISTRY OF THE HUMAN ADRENAL CYP11B2 IN NORMAL INDIVIDUALS AND IN PATIENTS WITH PRIMARY ALDOSTERONISM

Celso E. Gomez-Sanchez, Elise P. Gomez-Sanchez, Koshiro Nishimoto

Horm Metab Res. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Horm Metab Res. 2020 Jun; 52(6): 421–426. Published online 2020 Apr 14. doi: 10.1055/a-1139-2079

PMCID:: PMC7299743

Abstract Article PDF–518K

Select item 678677116.

Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity

Taiki Hayashi, Zhen Zhang, Ghaith Al-Eyd, Atsushi Sasaki, Masanori Yasuda, Masafumi Oyama, Celso E. Gomez-Sanchez, Hirotaka Asakura, Tsugio Seki, Kuniaki Mukai, Koshiro Nishimoto

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2019 Jul; 191: 105361. Published online 2019 Apr 8. doi: 10.1016/j.jsbmb.2019.04.010

PMCID:: PMC6786771

Abstract Article PDF–1.8M

Select item 672195117.

Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone

Michael J. Reddish, F. Peter Guengerich

J Biol Chem. 2019 Aug 30; 294(35): 12975–12991. Published online 2019 Jul 11. doi: 10.1074/jbc.RA119.009830

PMCID:: PMC6721951

Abstract Article PDF–2.1M

Select item 603187718.

MiR‐193a‐3p functions as a tumour suppressor in human aldosterone‐producing adrenocortical adenoma by down‐regulating CYP11B2

Guoxi Zhang, Xiaofeng Zou, Quanliang Liu, Tianpeng Xie, Ruohui Huang, Huan Kang, Changfu Lai, Jiaxing Zhu

Int J Exp Pathol. 2018 Apr; 99(2): 77–86. Published online 2018 Apr 17. doi: 10.1111/iep.12267

PMCID:: PMC6031877

Abstract Article PDF–897K

Select item 601530119.

Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II

Yoshimichi Takeda, Masashi Demura, Fen Wang, Shigehiro Karashima, Takashi Yoneda, Mitsuhiro Kometani, Atsushi Hashimoto, Daisuke Aono, Shin‐ichi Horike, Makiko Meguro‐Horike, Masakazu Yamagishi, Yoshiyu Takeda

J Am Heart Assoc. 2018 May 15; 7(10): e008281. Published online 2018 May 8. doi: 10.1161/JAHA.117.008281

PMCID:: PMC6015301

Abstract Article PDF–1.0M

Select item 584387620.

Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis

Haiyan Xu, Xu Wang, Mingming Liu, Xin Shao, Xueyuan He

J Renin Angiotensin Aldosterone Syst. 2016 Jan-Mar; 17(1): 1470320316633896. Published online 2016 Mar 8. doi: 10.1177/1470320316633896

PMCID:: PMC5843876

Abstract Article PDF–525K

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