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Items: 1 to 20 of 91

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine
Fan Wu, Xiang Li, Mario Looso, Hang Liu, Dong Ding, Stefan Günther, Carsten Kuenne, Shuya Liu, Norbert Weissmann, Thomas Boettger, Ann Atzberger, Saeed Kolahian, Harald Renz, Stefan Offermanns, Ulrich Gärtner, Michael Potente, Yonggang Zhou, Xuejun Yuan, Thomas Braun
Nat Genet. 2023; 55(1): 100–111. Published online 2022 Dec 20. doi: 10.1038/s41588-022-01252-3
PMCID:
PMC9839451
AbstractArticlePDF–24M
3.
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules
Oanh N. Hoang, Anna Ermund, Ana M. Jaramillo, Dalia Fakih, Cory B. French, Jose R. Flores, Harry Karmouty-Quintana, Jesper M. Magnusson, Giorgio Fois, Michael Fauler, Manfred Frick, Peter Braubach, Joshua B. Hales, Richard C. Kurten, Reynold Panettieri, Leoncio Vergara, Camille Ehre, Roberto Adachi, Michael J. Tuvim, Gunnar C. Hansson, Burton F. Dickey
Am J Respir Crit Care Med. 2022 Nov 1; 206(9): 1081–1095. Published online 2022 Jul 1. doi: 10.1164/rccm.202202-0309OC
PMCID:
PMC9704839
AbstractArticlePDF–4.3M
4.
Excess Neuropeptides in Lung Signal through Endothelial Cells to Impair Gas Exchange
Jinhao Xu, Le Xu, Pengfei Sui, Jiyuan Chen, Esteban A. Moya, Patrick Hume, William J. Janssen, Jason M. Duran, Patricia Thistlethwaite, Aaron Carlin, Peter Gulleman, Brandon Banaschewski, Mary Kate Goldy, Jason X.-J. Yuan, Atul Malhotra, Gloria Pryhuber, Laura Crotty-Alexander, Gail Deutsch, Lisa R. Young, Xin Sun
Dev Cell. Author manuscript; available in PMC 2023 Apr 11.
Published in final edited form as: Dev Cell. 2022 Apr 11; 57(7): 839–853.e6. Published online 2022 Mar 17. doi: 10.1016/j.devcel.2022.02.023
PMCID:
PMC9137452
AbstractArticlePDF–2.9M
5.
Mucin 5AC-mediated CD44/ITGB1 clustering mobilizes adipose-derived mesenchymal stem cells to modulate pancreatic cancer stromal heterogeneity
Koelina Ganguly, Jesse L. Cox, Dario Ghersi, Paul M. Grandgenett, Michael A Hollingsworth, Maneesh Jain, Sushil Kumar, Surinder K. Batra
Gastroenterology. Author manuscript; available in PMC 2023 Jun 1.
Published in final edited form as: Gastroenterology. 2022 Jun; 162(7): 2032–2046.e12. Published online 2022 Feb 24. doi: 10.1053/j.gastro.2022.02.032
PMCID:
PMC9117481
AbstractArticlePDF–3.1M
6.
Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease
Aran Singanayagam, Joseph Footitt, Matthias Marczynski, Giorgia Radicioni, Michael T. Cross, Lydia J. Finney, Maria-Belen Trujillo-Torralbo, Maria Calderazzo, Jie Zhu, Julia Aniscenko, Thomas B. Clarke, Philip L. Molyneaux, Nathan W. Bartlett, Miriam F. Moffatt, William O. Cookson, Jadwiga Wedzicha, Christopher M. Evans, Richard C. Boucher, Mehmet Kesimer, Oliver Lieleg, Patrick Mallia, Sebastian L. Johnston
J Clin Invest. 2022 Apr 15; 132(8): e120901. Published online 2022 Apr 15. doi: 10.1172/JCI120901
PMCID:
PMC9012283
AbstractArticlePDF–1.4M
7.
MUC5AC serves as the nexus for β-catenin/c-Myc interplay to promote glutamine dependency during pancreatic cancer chemoresistance
Koelina Ganguly, Rakesh Bhatia, Sanchita Rauth, Andrew Kisling, Pranita Atri, Christopher Thompson, Raghupathy Vengoji, Shiv Ram Krishn, Dhananjay Shinde, Vinai Thomas, Sukhwinder Kaur, Kavita Mallya, Jesse L. Cox, Sushil Kumar, Surinder K. Batra
Gastroenterology. Author manuscript; available in PMC 2023 Jan 1.
Published in final edited form as: Gastroenterology. 2022 Jan; 162(1): 253–268.e13. Published online 2021 Sep 14. doi: 10.1053/j.gastro.2021.09.017
PMCID:
PMC8678212
AbstractArticlePDF–2.9M
8.
GATA4 Controls Epithelial Morphogenesis in the Developing Stomach to Promote Establishment of Glandular Columnar Epithelium
Ann DeLaForest, Bridget M. Kohlnhofer, Olivia D. Franklin, Roman Stavniichuk, Cayla A. Thompson, Kirthi Pulakanti, Sridhar Rao, Michele A. Battle
Cell Mol Gastroenterol Hepatol. 2021; 12(4): 1391–1413. Published online 2021 Jun 7. doi: 10.1016/j.jcmgh.2021.05.021
PMCID:
PMC8479485
AbstractArticlePDF–9.8M
9.
Autophagy of mucin granules contributes to resolution of airway mucous metaplasia
J. M. Sweeter, K. Kudrna, K. Hunt, P. Thomes, B. F. Dickey, S. L. Brody, J. D. Dickinson
Sci Rep. 2021; 11: 13037. Published online 2021 Jun 22. doi: 10.1038/s41598-021-91932-7
PMCID:
PMC8219712
AbstractArticlePDF–17M
10.
Role for mucin-5AC in upper and lower airway pathogenesis in mice
Hye-Youn Cho, Soojung Park, Laura Miller, Huei-Chen Lee, Robert Langenbach, Steven R. Kleeberger
Toxicol Pathol. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Toxicol Pathol. 2021 Jul; 49(5): 1077–1099. Published online 2021 May 3. doi: 10.1177/01926233211004433
PMCID:
PMC8195843
AbstractArticlePDF–2.9M
11.
VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9 dependent pathway
Ming Jiang, Yinshan Fang, Yu Li, Huachao Huang, Zichen Wei, Xia Gao, Hoon-Ki Sung, Jim Hu, Li Qiang, Jian Ruan, Qixuan Chen, Dianhua Jiang, Jeffrey A. Whitsett, Xingbin Ai, Jianwen Que
Dev Cell. Author manuscript; available in PMC 2022 Jun 7.
Published in final edited form as: Dev Cell. 2021 Jun 7; 56(11): 1646–1660.e5. Published online 2021 May 18. doi: 10.1016/j.devcel.2021.04.027
PMCID:
PMC8187331
AbstractArticlePDF–3.5M
12.
Secretory mucin 5AC promotes neoplastic progression by augmenting KLF4-mediated pancreatic cancer cell stemness
Koelina Ganguly, Shiv Ram Krishn, Satyanarayana Rachagani, Rahat Jahan, Ashu Shah, Palanisamy Nallasamy, Sanchita Rauth, Pranita Atri, Jesse L. Cox, Ramesh Pothuraju, Lynette M. Smith, Sudhua Ayala, Christopher Evans, Moorthy P. Ponnusamy, Sushil Kumar, Sukhwinder Kaur, Surinder K. Batra
Cancer Res. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Cancer Res. 2021 Jan 1; 81(1): 91–102. Published online 2020 Oct 30. doi: 10.1158/0008-5472.CAN-20-1293
PMCID:
PMC7990052
AbstractArticlePDF–2.6M
13.
Porphyromonasgingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells
Chihiro Miya, Marni E. Cueno, Ryuta Suzuki, Shuichiro Maruoka, Yasuhiro Gon, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai
FEBS Open Bio. 2021 Feb; 11(2): 446–455. Published online 2020 Dec 30. doi: 10.1002/2211-5463.13066
PMCID:
PMC7876492
AbstractArticlePDF–740K
14.
Disulfide disruption reverses mucus dysfunction in allergic airway disease
Leslie E. Morgan, Ana M. Jaramillo, Siddharth K. Shenoy, Dorota Raclawska, Nkechinyere A. Emezienna, Vanessa L. Richardson, Naoko Hara, Anna Q. Harder, James C. NeeDell, Corinne E. Hennessy, Hassan M. El-Batal, Chelsea M. Magin, Diane E. Grove Villalon, Gregg Duncan, Justin S. Hanes, Jung Soo Suk, David J. Thornton, Fernando Holguin, William J. Janssen, William R. Thelin, Christopher M. Evans
Nat Commun. 2021; 12: 249. Published online 2021 Jan 11. doi: 10.1038/s41467-020-20499-0
PMCID:
PMC7801631
AbstractArticlePDF–1.7M
15.
Ablation of IL33 suppresses Th2 responses, but with sustained mucus obstruction, in the Scnn1b transgenic mouse model
Brandon W Lewis, Thao Vo, Ishita Choudhary, Allison Kidder, Chandra Bathula, Camille Ehre, Nobuko Wakamatsu, Sonika Patial, Yogesh Saini
J Immunol. Author manuscript; available in PMC 2020 Dec 3.
Published in final edited form as: J Immunol. 2020 Mar 15; 204(6): 1650–1660. Published online 2020 Feb 14. doi: 10.4049/jimmunol.1900234
PMCID:
PMC7714586
AbstractArticlePDF–1.5M
16.
MUC1 contributes to goblet cell metaplasia and MUC5AC expression in response to cigarette smoke in vivo
Kosuke Kato, Eugene H. Chang, Yin Chen, Wenju Lu, Marianne M. Kim, Maki Niihori, Louise Hecker, Kwang Chul Kim
Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1; 319(1): L82–L90. Published online 2020 May 13. doi: 10.1152/ajplung.00049.2019
PMCID:
PMC7468848
AbstractArticle
17.
Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development
Hankyu Lee, Hyuk Wan Ko
BMB Rep. 2020 Jul 31; 53(7): 367–372. Published online 2020 Jul 31. doi: 10.5483/BMBRep.2020.53.7.295
PMCID:
PMC7396919
AbstractArticlePDF–23M
18.
Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin
Dalia Fakih, Ana M. Rodriguez-Piñeiro, Sergio Trillo-Muyo, Christopher M. Evans, Anna Ermund, Gunnar C. Hansson
Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1; 318(6): L1270–L1279. Published online 2020 Apr 29. doi: 10.1152/ajplung.00485.2019
PMCID:
PMC7347266
AbstractArticle
19.
Muc5ac null mice are predisposed to spontaneous gastric antro-pyloric hyperplasia and adenomas coupled with attenuated H. pylori induced corpus mucous metaplasia
Sureshkumar Muthupalani, Zhongming Ge, Joanna Joy, Yan Feng, Carrie Dobey, Hye-Youn Cho, Robert Langenbach, Timothy C Wang, Susan J Hagen, James G Fox
Lab Invest. Author manuscript; available in PMC 2020 Feb 9.
Published in final edited form as: Lab Invest. 2019 Dec; 99(12): 1887–1905. Published online 2019 Aug 9. doi: 10.1038/s41374-019-0293-y
PMCID:
PMC6927550
AbstractArticlePDF–5.6M
20.
WNT/RYK signaling restricts goblet cell differentiation during lung development and repair
Hyun-Taek Kim, Wenguang Yin, Yuko Nakamichi, Paolo Panza, Beate Grohmann, Carmen Buettner, Stefan Guenther, Clemens Ruppert, Yasuhiro Kobayashi, Andreas Guenther, Didier Y. R. Stainier
Proc Natl Acad Sci U S A. 2019 Dec 17; 116(51): 25697–25706. Published online 2019 Nov 27. doi: 10.1073/pnas.1911071116
PMCID:
PMC6926051
AbstractArticlePDF–2.9M

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