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Select item 111727721.

Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sjögren’s Sicca Syndrome

Joanna A. Papinska, Justyna Durślewicz, Harini Bagavant, Umesh S. Deshmukh

Int J Mol Sci. 2024 Jun; 25(11): 5983. Published online 2024 May 30. doi: 10.3390/ijms25115983

PMCID:: PMC11172772

Abstract Article PDF–4.7M

Select item 109078542.

SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential

Shota Tamagawa, Daisuke Sakai, Hidetoshi Nojiri, Yoshihiko Nakamura, Takayuki Warita, Erika Matsushita, Jordy Schol, Hazuki Soma, Shota Ogasawara, Daiki Munesada, Masato Koike, Takahiko Shimizu, Masato Sato, Muneaki Ishijima, Masahiko Watanabe

Redox Biol. 2024 May; 71: 103091. Published online 2024 Feb 19. doi: 10.1016/j.redox.2024.103091

PMCID:: PMC10907854

Abstract Article PDF–25M

Select item 107886173.

Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation

Esteban Díaz-Jara, Katherine Pereyra, Sinay Vicencio, Margrethe A. Olesen, Karla G. Schwarz, Camilo Toledo, Hugo S. Díaz, Rodrigo A. Quintanilla, Rodrigo Del Rio

Redox Biol. 2024 Feb; 69: 102992. Published online 2023 Dec 12. doi: 10.1016/j.redox.2023.102992

PMCID:: PMC10788617

Abstract Article PDF–7.3M

Select item 107743624.

miR-195b is required for proper cellular homeostasis in the elderly

Maria del Mar Muñoz-Gallardo, Carlos Garcia-Padilla, Cristina Vicente-Garcia, Jaime Carvajal, Amelia Arenega, Diego Franco

Sci Rep. 2024; 14: 810. Published online 2024 Jan 8. doi: 10.1038/s41598-024-51256-8

PMCID:: PMC10774362

Abstract Article PDF–3.7M

Select item 106376995.

The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model

Hui Zhao, Ronald J. Wong, David K. Stevenson

PLoS One. 2023; 18(11): e0294185. Published online 2023 Nov 10. doi: 10.1371/journal.pone.0294185

PMCID:: PMC10637699

Abstract Article PDF–3.6M

Select item 103623946.

β-secretase 1 overexpression by AAV-mediated gene delivery prevents retina degeneration in a mouse model of age-related macular degeneration

Xiaoping Qi, Carolina Francelin, Sayak Mitter, Sanford L. Boye, Hongmei Gu, Judith Quigley, Maria B. Grant, Michael E. Boulton

Mol Ther. 2023 Jul 5; 31(7): 2042–2055. Published online 2023 Apr 3. doi: 10.1016/j.ymthe.2023.03.029

PMCID:: PMC10362394

Abstract Article PDF–7.7M

Select item 98695357.

Parkin coregulates glutathione metabolism in adult mammalian brain

Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher

Acta Neuropathol Commun. 2023; 11: 19. Published online 2023 Jan 23. doi: 10.1186/s40478-022-01488-4

PMCID:: PMC9869535

Abstract Article PDF–2.6M

Select item 97801788.

Endogenous SOD2 regulates platelet-dependent thrombin generation and thrombosis during aging

Vijay K Sonkar, Alicia S Eustes, Azaj Ahmed, Melissa Jensen, Mitali V Solanki, Jagadish Swamy, Rahul Kumar, Trevor P. Fidler, Jon C.D. Houtman, Bryan G. Allen, Douglas R Spitz, E. Dale Abel, Sanjana Dayal

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Jan; 43(1): 79–91. Published online 2022 Nov 3. doi: 10.1161/ATVBAHA.121.317735

PMCID:: PMC9780178

Abstract Article PDF–1.0M

Select item 97201049.

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis

Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Jr., Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen

Redox Biol. 2023 Feb; 59: 102550. Published online 2022 Nov 26. doi: 10.1016/j.redox.2022.102550

PMCID:: PMC9720104

Abstract Article PDF–9.5M

Select item 960386010.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 935708811.

Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis

Wenjie Bao, Huayue Xing, Shiwei Cao, Xin Long, Haifeng Liu, Junwei Ma, Fan Guo, Zimu Deng, Xiaolong Liu

Nat Commun. 2022; 13: 4583. Published online 2022 Aug 6. doi: 10.1038/s41467-022-32325-w

PMCID:: PMC9357088

Abstract Article PDF–19M

Select item 935164312.

Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis

Matthew P. Baier, Raghavendra Y. Nagaraja, Hannah P. Yarbrough, Daniel B. Owen, Anthony M. Masingale, Rojina Ranjit, Megan A. Stiles, Ashley Murphy, Martin-Paul Agbaga, Mohiuddin Ahmad, David M. Sherry, Michael T. Kinter, Holly Van Remmen, Sreemathi Logan

J Neurosci. 2022 Aug 3; 42(31): 5992–6006. doi: 10.1523/JNEUROSCI.2543-21.2022

PMCID:: PMC9351643

Abstract Article PDF–4.4M

Select item 924939713.

Androglobin, a chimeric mammalian globin, is required for male fertility

Anna Keppner, Miguel Correia, Sara Santambrogio, Teng Wei Koay, Darko Maric, Carina Osterhof, Denise V Winter, Angèle Clerc, Michael Stumpe, Frédéric Chalmel, Sylvia Dewilde, Alex Odermatt, Dieter Kressler, Thomas Hankeln, Roland H Wenger, David Hoogewijs

eLife. 2022; 11: e72374. Published online 2022 Jun 14. doi: 10.7554/eLife.72374

PMCID:: PMC9249397

Abstract Article PDF–22M

Select item 911803714.

Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice

Astrid M. Schoppa, Xiangxu Chen, Jan-Moritz Ramge, Anna Vikman, Verena Fischer, Melanie Haffner-Luntzer, Jana Riegger, Jan Tuckermann, Karin Scharffetter-Kochanek, Anita Ignatius

Dis Model Mech. 2022 May 1; 15(5): dmm049392. Published online 2022 May 13. doi: 10.1242/dmm.049392

PMCID:: PMC9118037

Abstract Article

Select item 911465415.

Heterozygous SOD2 deletion selectively impairs SERCA function in the soleus of female mice

Jessica L. Braun, Holt N. Messner, Riley E. G. Cleverdon, Ryan W. Baranowski, Sophie I. Hamstra, Mia S. Geromella, Jeffrey A. Stuart, Val A. Fajardo

Physiol Rep. 2022 May; 10(10): e15285. Published online 2022 May 17. doi: 10.14814/phy2.15285

PMCID:: PMC9114654

Abstract Article PDF–2.2M

Select item 893928716.

Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response

Ruth E. Fulton, Jennifer N. Pearson-Smith, Christopher Q. Huynh, Timothy Fabisiak, Li-Ping Liang, Stefanos Aivazidis, Brigit A. High, Georgia Buscaglia, Timothy Corrigan, Robert Valdez, Takahiko Shimizu, Manisha N. Patel

Neurobiol Dis. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Neurobiol Dis. 2021 Oct; 158: 105470. Published online 2021 Aug 8. doi: 10.1016/j.nbd.2021.105470

PMCID:: PMC8939287

Abstract Article PDF–635K

Select item 875318617.

Enterocyte superoxide dismutase 2 deletion drives obesity

Oihane Garcia-Irigoyen, Fabiola Bovenga, Marilidia Piglionica, Elena Piccinin, Marica Cariello, Maria Arconzo, Claudia Peres, Paola Antonia Corsetto, Angela Maria Rizzo, Marta Ballanti, Rossella Menghini, Geltrude Mingrone, Philippe Lefebvre, Bart Staels, Takuji Shirasawa, Carlo Sabbà, Gaetano Villani, Massimo Federici, Antonio Moschetta

iScience. 2022 Jan 21; 25(1): 103707. Published online 2021 Dec 27. doi: 10.1016/j.isci.2021.103707

PMCID:: PMC8753186

Abstract Article PDF–3.9M

Select item 865507518.

Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis

Luca Perico, Marina Morigi, Anna Pezzotta, Daniela Corna, Valerio Brizi, Sara Conti, Cristina Zanchi, Fabio Sangalli, Piera Trionfini, Sara Buttò, Christodoulos Xinaris, Susanna Tomasoni, Carlamaria Zoja, Giuseppe Remuzzi, Ariela Benigni, Barbara Imberti

Sci Rep. 2021; 11: 23580. Published online 2021 Dec 8. doi: 10.1038/s41598-021-03039-8

PMCID:: PMC8655075

Abstract Article PDF–9.3M

Select item 848707819.

SOD2 in skeletal muscle: New insights from an inducible deletion model

Aowen Zhuang, Christine Yang, Yingying Liu, Yanie Tan, Simon T. Bond, Shannen Walker, Tim Sikora, Adrienne Laskowski, Arpeeta Sharma, Judy B. de Haan, Peter J. Meikle, Takahiko Shimizu, Melinda T. Coughlan, Anna C. Calkin, Brian G. Drew

Redox Biol. 2021 Nov; 47: 102135. Published online 2021 Sep 14. doi: 10.1016/j.redox.2021.102135

PMCID:: PMC8487078

Abstract Article PDF–8.4M

Select item 803782120.

Pathological Relationship between Intracellular Superoxide Metabolism and p53 Signaling in Mice

Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Takahiko Shimizu

Int J Mol Sci. 2021 Apr; 22(7): 3548. Published online 2021 Mar 29. doi: 10.3390/ijms22073548

PMCID:: PMC8037821

Abstract Article PDF–1.9M

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