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Select item 110787471.

PGE₂ limits effector expansion of tumour-infiltrating stem-like CD8⁺ T cells

Sebastian B. Lacher, Janina Dörr, Gustavo P. de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J. Rudolph, Nadine Spranger, Matteo Morotti, Alizee J. Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H. Busch, Veit R. Buchholz, Percy A. Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan P. Böttcher

Nature. 2024; 629(8011): 417–425. Published online 2024 Apr 24. doi: 10.1038/s41586-024-07254-x

PMCID:: PMC11078747

Abstract Article PDF–17M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 95422243.

Increased COX‐2 after ureter obstruction attenuates fibrosis and is associated with EP₂ receptor upregulation in mouse and human kidney

Signe S. Tofteng, Line Nilsson, Amalie K. Mogensen, Rikke Nørregaard, Rolf Nüsing, Mikhail Diatchikhine, Lars Lund, Claus Bistrup, Boye L. Jensen, Kirsten Madsen

Acta Physiol (Oxf) 2022 Aug; 235(4): e13828. Published online 2022 May 20. doi: 10.1111/apha.13828

PMCID:: PMC9542224

Abstract Article PDF–53M

Select item 91156334.

Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local anti-tumor immunity in the tumor stroma

Maria Khan, Cecilia Engström, Johan Bourghardt Fagman, Ulrika Smedh, Kent Lundholm, Britt-Marie Iresjö

Oncol Rep. 2022 Jun; 47(6): 118. Published online 2022 May 11. doi: 10.3892/or.2022.8329

PMCID:: PMC9115633

Abstract Article PDF–1.1M

Select item 88428505.

Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation

Lei Zhou, Wenqing Zhou, Ann M. Joseph, Coco Chu, Gregory G. Putzel, Beibei Fang, Fei Teng, Mengze Lv, Hiroshi Yano, Katrin I. Andreasson, Eisuke Mekada, Gerard Eberl, Gregory F. Sonnenberg

Nat Immunol. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Nat Immunol. 2022 Feb; 23(2): 251–261. Published online 2022 Jan 31. doi: 10.1038/s41590-021-01110-0

PMCID:: PMC8842850

Abstract Article PDF–5.4M

Select item 82748166.

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson

Nature. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Nature. 2021 Feb; 590(7844): 122–128. Published online 2021 Jan 20. doi: 10.1038/s41586-020-03160-0

PMCID:: PMC8274816

Article PDF–6.0M

Select item 82115407.

Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP₃ Receptors

Anna Eskilsson, Kiseko Shionoya, David Engblom, Anders Blomqvist

J Neurosci. 2021 Jun 16; 41(24): 5206–5218. doi: 10.1523/JNEUROSCI.0313-21.2021

PMCID:: PMC8211540

Abstract Article PDF–5.4M

Select item 81462348.

Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection

Lan Chen, Xiaofang Ji, Manni Wang, Xiaoyan Liao, Cuiying Liang, Juanjuan Tang, Zhencheng Wen, Ferrandon Dominique, Zi Li

Parasit Vectors. 2021; 14: 279. Published online 2021 May 25. doi: 10.1186/s13071-021-04790-7

PMCID:: PMC8146234

Abstract Article PDF–2.1M

Select item 78802949.

Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus

Nicholas H. Varvel, Claudia Espinosa-Garcia, Sarah Hunter-Chang, Di Chen, Ariel Biegel, Allison Hsieh, Lisa Blackmer-Raynolds, Thota Ganesh, Raymond Dingledine

J Neurosci. 2021 Feb 3; 41(5): 1105–1117. doi: 10.1523/JNEUROSCI.2040-20.2020

PMCID:: PMC7880294

Abstract Article PDF–3.6M

Select item 751988710.

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis

Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell

Cardiovasc Res. 2020 Oct 1; 116(12): 1972–1980. Published online 2019 Nov 5. doi: 10.1093/cvr/cvz290

PMCID:: PMC7519887

Abstract Article PDF–928K

Select item 744152111.

PGE₂ accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

Loka R Penke, Jennifer M Speth, Christina Draijer, Zbigniew Zaslona, Judy Chen, Peter Mancuso, Christine M Freeman, Jeffrey L Curtis, Daniel R Goldstein, Marc Peters-Golden

Life Sci Alliance. 2020 Nov; 3(11): e202000800. Published online 2020 Aug 20. doi: 10.26508/lsa.202000800

PMCID:: PMC7441521

Abstract Article PDF–1.7M

Select item 672958212.

Neuroprotective Function of the PGE₂ EP2 Receptor in Cerebral Ischemia

Louise McCullough, Liejun Wu, Norman Haughey, Xibin Liang, Tracey Hand, Qian Wang, Richard M. Breyer, Katrin Andreasson

J Neurosci. 2004 Jan 7; 24(1): 257–268. doi: 10.1523/JNEUROSCI.4485-03.2004

PMCID:: PMC6729582

Abstract Article PDF–536K

Select item 672580313.

Deletion of the Prostaglandin E₂ EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease

Xibin Liang, Qian Wang, Tracey Hand, Liejun Wu, Richard M. Breyer, Thomas J. Montine, Katrin Andreasson

J Neurosci. 2005 Nov 2; 25(44): 10180–10187. doi: 10.1523/JNEUROSCI.3591-05.2005

PMCID:: PMC6725803

Abstract Article PDF–335K

Select item 670545214.

COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex

Alexandre Lacroix, Xavier Toussay, Eitan Anenberg, Clotilde Lecrux, Nerea Ferreirós, Anastassios Karagiannis, Fabrice Plaisier, Patrick Chausson, Frédéric Jarlier, Sean A. Burgess, Elizabeth M. C. Hillman, Irmgard Tegeder, Timothy H. Murphy, Edith Hamel, Bruno Cauli

J Neurosci. 2015 Aug 26; 35(34): 11791–11810. doi: 10.1523/JNEUROSCI.0651-15.2015

PMCID:: PMC6705452

Abstract Article PDF–14M

Select item 667464215.

Bidirectional Trafficking of Prostaglandin E₂ Receptors Involved in Long-Term Potentiation in Visual Cortex

Yukio Akaneya, Tadaharu Tsumoto

J Neurosci. 2006 Oct 4; 26(40): 10209–10221. doi: 10.1523/JNEUROSCI.3028-06.2006

PMCID:: PMC6674642

Abstract Article PDF–913K

Select item 652549816.

PGE₂ signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia

Qingkun Liu, Xibin Liang, Qian Wang, Edward N. Wilson, Rachel Lam, Jing Wang, William Kong, Connie Tsai, Tingting Pan, Paul B. Larkin, Mehrdad Shamloo, Katrin I. Andreasson

Proc Natl Acad Sci U S A. 2019 May 14; 116(20): 10019–10024. Published online 2019 Apr 29. doi: 10.1073/pnas.1818544116