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Select item 104505801.

Milton assembles large mitochondrial clusters, mitoballs, to sustain spermatogenesis

Andy Y. Z. Li, Ying Di, Sumaera Rathore, Ason C.-Y. Chiang, Jan Jezek, Hansong Ma

Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34): e2306073120. Published online 2023 Aug 14. doi: 10.1073/pnas.2306073120

PMCID:: PMC10450580

Abstract Article PDF–8.2M

Select item 99534512.

Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models

Michele Brischigliaro, Erika Fernandez-Vizarra, Carlo Viscomi

Biomolecules. 2023 Feb; 13(2): 378. Published online 2023 Feb 16. doi: 10.3390/biom13020378

PMCID:: PMC9953451

Abstract Article PDF–1.6M

Select item 96530943.

Mitochondrial DNA maintenance in Drosophila melanogaster

Ana P.C. Rodrigues, Audrey C. Novaes, Grzegorz L. Ciesielski, Marcos T. Oliveira

Biosci Rep. 2022 Nov 30; 42(11): BSR20211693. Published online 2022 Nov 10. doi: 10.1042/BSR20211693

PMCID:: PMC9653094

Abstract Article PDF–1.3M

Select item 96527054.

REC drives recombination to repair double-strand breaks in animal mtDNA

Anna Klucnika, Peiqiang Mu, Jan Jezek, Matthew McCormack, Ying Di, Charles R. Bradshaw, Hansong Ma

J Cell Biol. 2023 Jan 2; 222(1): e202201137. Published online 2022 Nov 10. doi: 10.1083/jcb.202201137

PMCID:: PMC9652705

Abstract Article PDF–5.4M

Select item 94057055.

Downregulating Mitochondrial DNA Polymerase γ in the Muscle Stimulated Autophagy, Apoptosis, and Muscle Aging-Related Phenotypes in Drosophila Adults

Mika Ozaki, Tuan Dat Le, Yoshihiro H. Inoue

Biomolecules. 2022 Aug; 12(8): 1105. Published online 2022 Aug 11. doi: 10.3390/biom12081105

PMCID:: PMC9405705

Abstract Article PDF–23M

Select item 93513776.

Mitigation of age-dependent accumulation of defective mitochondrial genomes

Pei-I Tsai, Ekaterina Korotkevich, Patrick H. O’Farrell

Proc Natl Acad Sci U S A. 2022 Aug 2; 119(31): e2119009119. Published online 2022 Jul 26. doi: 10.1073/pnas.2119009119

PMCID:: PMC9351377

Abstract Article PDF–1.2M

Select item 84962777.

A cross-species approach for the identification of Drosophila male sterility genes

Kimihide Ibaraki, Mihoko Nakatsuka, Takashi Ohsako, Masahide Watanabe, Yu Miyazaki, Machi Shirakami, Timothy L Karr, Rikako Sanuki, Masatoshi Tomaru, Toshiyuki Takano-Shimizu-Kouno

G3 (Bethesda) 2021 Aug; 11(8): jkab183. Published online 2021 May 29. doi: 10.1093/g3journal/jkab183

PMCID:: PMC8496277

Abstract Article PDF–421K

Select item 77145298.

The DNA polymerases of Drosophila melanogaster

Steven J. Marygold, Helen Attrill, Elena Speretta, Kate Warner, Michele Magrane, Maria Berloco, Sue Cotterill, Mitch McVey, Yikang Rong, Masamitsu Yamaguchi

Fly (Austin) 2020; 14(1-4): 49–61. Published online 2020 Jan 14. doi: 10.1080/19336934.2019.1710076

PMCID:: PMC7714529

Abstract Article PDF–1.9M

Select item 73375059.

Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation

Zhe Chen, Zong-Heng Wang, Guofeng Zhang, Christopher K.E. Bleck, Dillon J. Chung, Grey P. Madison, Eric Lindberg, Christian Combs, Robert S. Balaban, Hong Xu

J Cell Biol. 2020 Jul 6; 219(7): e201905160. Published online 2020 May 6. doi: 10.1083/jcb.201905160

PMCID:: PMC7337505

Abstract Article PDF–4.3M

Select item 710926310.

Drosophila as a Model System to Investigate the Effects of Mitochondrial Variation on Innate Immunity

Tiina S. Salminen, Pedro F. Vale

Front Immunol. 2020; 11: 521. Published online 2020 Mar 25. doi: 10.3389/fimmu.2020.00521

PMCID:: PMC7109263

Abstract Article PDF–1.0M

Select item 696157811.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 692647612.

A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations

Ason C.-Y. Chiang, Eleanor McCartney, Patrick H. O'Farrell, Hansong Ma

Curr Biol. 2019 Dec 16; 29(24): 4330–4336.e3. doi: 10.1016/j.cub.2019.10.060

PMCID:: PMC6926476

Abstract Article

Select item 665041713.

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth

Nat Commun. 2019; 10: 3280. Published online 2019 Jul 23. doi: 10.1038/s41467-019-10857-y

PMCID:: PMC6650417

Abstract Article PDF–2.6M

Select item 628944914.

Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ

Colby L. Samstag, Jake G. Hoekstra, Chiu-Hui Huang, Mark J. Chaisson, Richard J. Youle, Scott R. Kennedy, Leo J. Pallanck

PLoS Genet. 2018 Nov; 14(11): e1007805. Published online 2018 Nov 19. doi: 10.1371/journal.pgen.1007805

PMCID:: PMC6289449

Abstract Article PDF–2.4M

Select item 618711815.

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

Timo E. S. Kauppila, Ana Bratic, Martin Borch Jensen, Francesca Baggio, Linda Partridge, Heinrich Jasper, Sebastian Grönke, Nils-Göran Larsson

Proc Natl Acad Sci U S A. 2018 Oct 9; 115(41): E9620–E9629. Published online 2018 Sep 24. doi: 10.1073/pnas.1721683115

PMCID:: PMC6187118

Abstract Article PDF–2.0M

Select item 605204316.

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase

Ana Paula C. Rodrigues, André F. Camargo, Ana Andjelković, Howard T. Jacobs, Marcos T. Oliveira

Sci Rep. 2018; 8: 10882. Published online 2018 Jul 18. doi: 10.1038/s41598-018-29150-x

PMCID:: PMC6052043

Abstract Article PDF–1.1M

Select item 603284517.

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency

Marie‐Lune Simard, Arnaud Mourier, Laura C Greaves, Robert W Taylor, James B Stewart

J Pathol. 2018 Jul; 245(3): 311–323. Published online 2018 May 14. doi: 10.1002/path.5084

PMCID:: PMC6032845

Abstract Article PDF–11M

Select item 588611518.

A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma

Triinu Siibak, Paula Clemente, Ana Bratic, Helene Bruhn, Timo E.S. Kauppila, Bertil Macao, Florian A. Rosenberger, Nicole Lesko, Rolf Wibom, Karin Naess, Inger Nennesmo, Anna Wedell, Bradley Peter, Christoph Freyer, Maria Falkenberg, Anna Wredenberg

Hum Mol Genet. 2017 Jul 1; 26(13): 2515–2525. Published online 2017 Apr 17. doi: 10.1093/hmg/ddx146