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Select item 111999551.

Modeling neurodegenerative and neurodevelopmental disorders in the Drosophila mushroom body

Aaron Stahl, Seth M. Tomchik

Learn Mem. 2024 May; 31(5): a053816. Published online 2024 May. doi: 10.1101/lm.053816.123

PMCID:: PMC11199955

Article PDF–937K

Select item 111244572.

Box–Behnken Design-Based Optimization of Phytochemical Extraction from Diplazium esculentum (Retz.) Sw. Associated with Its Antioxidant and Anti-Alzheimer’s Properties

Sirawit Kongsung, Woorawee Inthachat, Boonrat Chantong, Uthaiwan Suttisansanee, Nattira On-Nom, Chaowanee Chupeerach, Sirinapa Thangsiri, Pornsiri Pitchakarn, Piya Temviriyanukul

Molecules. 2024 May; 29(10): 2204. Published online 2024 May 8. doi: 10.3390/molecules29102204

PMCID:: PMC11124457

Article PDF–3.8M

Select item 109071663.

RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer’s disease

Yu Li, Dongyue Liu, Xuejing Zhang, Suman Rimal, Bingwei Lu, Shuangxi Li

J Biol Chem. 2024 Mar; 300(3): 105719. Published online 2024 Feb 2. doi: 10.1016/j.jbc.2024.105719

PMCID:: PMC10907166

Article PDF–4.0M

Select item 103940044.

Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model

Jung-Eun Park, Jiyoun Lee, Soonhyuck Ok, Seunghee Byun, Eun-Ju Chang, Sung-Eun Yoon, Young-Joon Kim, Min-Ji Kang

Exp Mol Med. 2023 Jul; 55(7): 1544–1555. Published online 2023 Jul 18. doi: 10.1038/s12276-023-01044-7

PMCID:: PMC10394004

Article PDF–3.8M

Select item 101464925.

c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD

Talanjeri Gopalakrishna Sahana, Katherine Johnson Chase, Feilin Liu, Thomas E. Lloyd, Wilfried Rossoll, Ke Zhang

J Neurosci. 2023 Apr 26; 43(17): 3186–3197. doi: 10.1523/JNEUROSCI.1799-22.2023

PMCID:: PMC10146492

Article PDF–3.9M

Select item 100908786.

The small compound Icerguastat reduces muscle defects in oculopharyngeal muscular dystrophy through the PERK pathway of the unfolded protein response

Rima Naït-Saïdi, Aymeric Chartier, Emmanuelle Abgueguen, Philippe Guédat, Martine Simonelig

Open Biol. 2023 Apr; 13(4): 230008. Published online April 12, 2023. doi: 10.1098/rsob.230008

PMCID:: PMC10090878

Article PDF–1.6M

Select item 100823677.

PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy

Ning Zhao, Ning Li, Tao Wang

J Cell Biol. 2023 May 1; 222(5): e202208147. Published online 2023 Apr 6. doi: 10.1083/jcb.202208147

PMCID:: PMC10082367

Article PDF–8.9M

Select item 99017448.

Mitochondrial remodelling is essential for female germ cell differentiation and survival

Vernon Leander Monteiro, Darya Safavian, Deepika Vasudevan, Thomas Ryan Hurd

PLoS Genet. 2023 Jan; 19(1): e1010610. Published online 2023 Jan 25. doi: 10.1371/journal.pgen.1010610

PMCID:: PMC9901744

Article PDF–4.3M

Select item 97134319.

Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila

Kate Ding, Elizabeth C Barretto, Michael Johnston, Byoungchun Lee, Marco Gallo, Savraj S Grewal

G3 (Bethesda) 2022 Dec; 12(12): jkac263. Published online 2022 Oct 6. doi: 10.1093/g3journal/jkac263

PMCID:: PMC9713431

Article PDF–1.0M

Select item 958632110.

Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation

Shuai Yang, Hua Jiang, Weixiang Bian, Wenyan Xu, Yifan Guo, Sha Song, Jiadong Zheng, Xiaoyu Kuang, Chenxi Wu, Xiang Ding, Xiaowei Guo, Lei Xue, Zijing Yu, Yongdeng Zhang, Hyung Don Ryoo, Xu Li, Xianjue Ma

Proc Natl Acad Sci U S A. 2022 Oct 18; 119(42): e2202133119. Published online 2022 Oct 10. doi: 10.1073/pnas.2202133119

PMCID:: PMC9586321

Article PDF–4.4M

Select item 935702211.

The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila

Youjie Yin, Peng Ma, Saifei Wang, Yao Zhang, Ruolei Han, Chunyu Huo, Meixian Wu, Hansong Deng

Cell Death Dis. 2022 Aug; 13(8): 688. Published online 2022 Aug 6. doi: 10.1038/s41419-022-05122-y

PMCID:: PMC9357022

Article PDF–4.5M

Select item 927386812.

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform

Frank W. Pun, Bonnie Hei Man Liu, Xi Long, Hoi Wing Leung, Geoffrey Ho Duen Leung, Quinlan T. Mewborne, Junli Gao, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evelyne Bischof, Evgeny Izumchenko, Xiaoming Guan, Ke Zhang, Bai Lu, Jeffrey D. Rothstein, Merit E. Cudkowicz, Alex Zhavoronkov

Front Aging Neurosci. 2022; 14: 914017. Published online 2022 Jun 28. doi: 10.3389/fnagi.2022.914017

PMCID:: PMC9273868

Article PDF–3.6M

Select item 912493513.

Hsian-Tsao (Mesona chinensis Benth.) Extract Improves the Thermal Tolerance of Drosophila melanogaster

Yan Huang, Pumo Cai, Xinxin Su, Mingjing Zheng, Wenwen Chi, Shaoling Lin, Zhiwei Huang, Si Qin, Shaoxiao Zeng

Front Nutr. 2022; 9: 819319. Published online 2022 May 9. doi: 10.3389/fnut.2022.819319

Correction in:: Front Nutr. 2022; 9: 953463.

PMCID:: PMC9124935

Article PDF–15M

Select item 909303914.

New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein

Ryan R. Myers, Jonatan Sanchez-Garcia, Daniel C. Leving, Richard G. Melvin, Pedro Fernandez-Funez

Dis Model Mech. 2022 Apr 1; 15(4): dmm049184. Published online 2022 May 4. doi: 10.1242/dmm.049184

PMCID:: PMC9093039

Article

Select item 894824415.

Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay

Fátima Cairrão, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi, Pedro M. Domingos

Nat Commun. 2022; 13: 1587. Published online 2022 Mar 24. doi: 10.1038/s41467-022-29105-x

PMCID:: PMC8948244

Article PDF–3.0M

Select item 858458116.

Expression of Human Mutant Preproinsulins Induced Unfolded Protein Response, Gadd45 Expression, JAK-STAT Activation, and Growth Inhibition in Drosophila

Tatsuki Yamazoe, Yasuyuki Nakahara, Hiroka Katsube, Yoshihiro H. Inoue

Int J Mol Sci. 2021 Nov; 22(21): 12038. Published online 2021 Nov 7. doi: 10.3390/ijms222112038

PMCID:: PMC8584581

Article PDF–2.8M

Select item 851424117.

The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila

Brian Brown, Sahana Mitra, Finnegan D Roach, Deepika Vasudevan, Hyung Don Ryoo

eLife. 2021; 10: e74047. Published online 2021 Oct 4. doi: 10.7554/eLife.74047

PMCID:: PMC8514241

Article PDF–13M

Select item 844560218.

Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells

Chujun Zhang, Wessel van Leeuwen, Marloes Blotenburg, Angelica Aguilera-Gomez, Sem Brussee, Rianne Grond, Harm H. Kampinga, Catherine Rabouille

J Cell Sci. 2021 Sep 1; 134(17): jcs258685. Published online 2021 Sep 6. doi: 10.1242/jcs.258685

PMCID:: PMC8445602

Article

Select item 836451019.

The Role of Ire1 in Drosophila Eye pigmentation Revealed by an RNase Dead Allele

Sahana Mitra, Hyung Don Ryoo

Dev Biol. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Dev Biol. 2021 Oct; 478: 205–211. Published online 2021 Jul 13. doi: 10.1016/j.ydbio.2021.07.008

PMCID:: PMC8364510

Article PDF–1.3M

Select item 833318520.

Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila

Peng Zhao, Ping Huang, Tongfu Xu, Xiaoxiang Xiang, Ying Sun, Jingqi Liu, Cheng Yan, Lei Wang, Jiamei Gao, Shang Cui, Xiangdong Wang, Lixing Zhan, Haiyun Song, Jingnan Liu, Wei Song, Yong Liu

iScience. 2021 Aug 20; 24(8): 102819. Published online 2021 Jul 7. doi: 10.1016/j.isci.2021.102819