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Select item 95256791.

Inositol hexakisphosphate is required for Integrator function

Min-Han Lin, Madeline K. Jensen, Nathan D. Elrod, Kai-Lieh Huang, Kevin A. Welle, Eric J. Wagner, Liang Tong

Nat Commun. 2022; 13: 5742. Published online 2022 Sep 30. doi: 10.1038/s41467-022-33506-3

PMCID:: PMC9525679

Abstract Article PDF–2.7M

Select item 86644862.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 76609703.

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

Kai-Lieh Huang, David Jee, Chad B. Stein, Nathan D. Elrod, Telmo Henriques, Lauren G. Mascibroda, David Baillat, William K. Russell, Karen Adelman, Eric J. Wagner

Mol Cell. Author manuscript; available in PMC 2021 Oct 15.

Published in final edited form as: Mol Cell. 2020 Oct 15; 80(2): 345–358.e9. Published online 2020 Sep 22. doi: 10.1016/j.molcel.2020.08.016

PMCID:: PMC7660970

Abstract Article PDF–3.3M

Select item 69615784.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 69526395.

The Integrator complex attenuates promoter-proximal transcription at protein-coding genes

Nathan D. Elrod, Telmo Henriques, Kai-Lieh Huang, Deirdre C. Tatomer, Jeremy E. Wilusz, Eric J. Wagner, Karen Adelman

Mol Cell. Author manuscript; available in PMC 2020 Dec 5.

Published in final edited form as: Mol Cell. 2019 Dec 5; 76(5): 738–752.e7. doi: 10.1016/j.molcel.2019.10.034

PMCID:: PMC6952639

Abstract Article PDF–3.2M

Select item 68244656.

The Integrator complex cleaves nascent mRNAs to attenuate transcription

Deirdre C. Tatomer, Nathan D. Elrod, Dongming Liang, Mei-Sheng Xiao, Jeffrey Z. Jiang, Michael Jonathan, Kai-Lieh Huang, Eric J. Wagner, Sara Cherry, Jeremy E. Wilusz

Genes Dev. 2019 Nov 1; 33(21-22): 1525–1538. doi: 10.1101/gad.330167.119

PMCID:: PMC6824465

Abstract Article PDF–4.0M

Select item 59346447.

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

Todd R Albrecht, Sergey P Shevtsov, Yixuan Wu, Lauren G Mascibroda, Natoya J Peart, Kai-Lieh Huang, Iain A Sawyer, Liang Tong, Miroslav Dundr, Eric J Wagner

Nucleic Acids Res. 2018 May 4; 46(8): 4241–4255. Published online 2018 Feb 20. doi: 10.1093/nar/gky100

PMCID:: PMC5934644

Abstract Article PDF–9.0M

Select item 57078058.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 56890029.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 488965810.

mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster

Gildas Lepennetier, Francesco Catania

G3 (Bethesda) 2016 Jun; 6(6): 1617–1626. Published online 2016 Mar 28. doi: 10.1534/g3.116.029231

PMCID:: PMC4889658

Abstract Article PDF–1.5M

Select item 478811611.

Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet

Ibrahim Ömer Çiçek, Samir Karaca, Marko Brankatschk, Suzanne Eaton, Henning Urlaub, Halyna R. Shcherbata

Genetics. 2016 Mar; 202(3): 1167–1183. Published online 2016 Jan 22. doi: 10.1534/genetics.115.185371

PMCID:: PMC4788116

Abstract Article PDF–4.7M

Select item 473800512.

Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Sadhna Phanse, Cuihong Wan, Blake Borgeson, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Bezginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, W. Brent Derry, Elisabeth R. Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Data Brief. 2016 Mar; 6: 715–721. Published online 2015 Dec 12. doi: 10.1016/j.dib.2015.11.062

PMCID:: PMC4738005

Abstract Article PDF–205K

Select item 469182813.

Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination

Paul Brewer-Jensen, Carrie B. Wilson, John Abernethy, Lonna Mollison, Samantha Card, Lillie L. Searles

RNA. 2016 Jan; 22(1): 139–154. doi: 10.1261/rna.048819.114

PMCID:: PMC4691828

Abstract Article PDF–586K

Select item 452833014.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders

Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937

PMCID:: PMC4528330

Abstract Article PDF–2.2M

Select item 452832915.

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data

Beverley B. Matthews, Gilberto dos Santos, Madeline A. Crosby, David B. Emmert, Susan E. St. Pierre, L. Sian Gramates, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, Victor Strelets, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1721–1736. Published online 2015 Jun 24. doi: 10.1534/g3.115.018929

PMCID:: PMC4528329

Abstract Article PDF–4.9M

Select item 435288716.

The Release 6 reference sequence of the Drosophila melanogaster genome

Roger A. Hoskins, Joseph W. Carlson, Kenneth H. Wan, Soo Park, Ivonne Mendez, Samuel E. Galle, Benjamin W. Booth, Barret D. Pfeiffer, Reed A. George, Robert Svirskas, Martin Krzywinski, Jacqueline Schein, Maria Carmela Accardo, Elisabetta Damia, Giovanni Messina, María Méndez-Lago, Beatriz de Pablos, Olga V. Demakova, Evgeniya N. Andreyeva, Lidiya V. Boldyreva, Marco Marra, A. Bernardo Carvalho, Patrizio Dimitri, Alfredo Villasante, Igor F. Zhimulev, Gerald M. Rubin, Gary H. Karpen, Susan E. Celniker

Genome Res. 2015 Mar; 25(3): 445–458. doi: 10.1101/gr.185579.114