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Select item 112161681.

Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues

Ambre J. Sala, Rogan A. Grant, Ghania Imran, Claire Morton, Renee M. Brielmann, Szymon Gorgoń, Jennifer Watts, Laura C. Bott, Richard I. Morimoto

Genes Dev. 2024 May 1; 38(9-10): 380–392. doi: 10.1101/gad.351829.124

PMCID:: PMC11216168

Abstract Article PDF–4.5M

Select item 108029522.

Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly

Marcos Schaan Profes, Araven Tiroumalechetty, Neel Patel, Stephanie S. Lauar, Simone Sidoli, Peri T. Kurshan

PLoS Biol. 2024 Jan; 22(1): e3002466. Published online 2024 Jan 22. doi: 10.1371/journal.pbio.3002466

PMCID:: PMC10802952

Abstract Article PDF–2.7M

Select item 107446243.

Dissecting the Neuronal Contributions of the Lipid Regulator NHR-49 Function in Lifespan and Behavior in C. elegans

Saebom Kwon, Kyu-Sang Park, Kyoung-hye Yoon

Life (Basel) 2023 Dec; 13(12): 2346. Published online 2023 Dec 15. doi: 10.3390/life13122346

PMCID:: PMC10744624

Abstract Article PDF–1.4M

Select item 107442774.

Maackiain Mimics Caloric Restriction through aak-2-Mediated Lipid Reduction in Caenorhabditis elegans

Saveta G. Mladenova, Monika N. Todorova, Martina S. Savova, Milen I. Georgiev, Liliya V. Mihaylova

Int J Mol Sci. 2023 Dec; 24(24): 17442. Published online 2023 Dec 13. doi: 10.3390/ijms242417442

PMCID:: PMC10744277

Abstract Article PDF–2.6M

Select item 105019375.

Eicosapentaenoic acid influences the pathogenesis of Candidaalbicans in Caenorhabditiselegans via inhibition of hyphal formation and stimulation of the host immune response

N. Z. Mokoena, H. Steyn, A. Hugo, T. Dix-Peek, C. Dickens, O. M. N. Gcilitshana, O. Sebolai, J. Albertyn, C. H. Pohl

Med Microbiol Immunol. 2023; 212(5): 349–368. Published online 2023 Sep 6. doi: 10.1007/s00430-023-00777-6

PMCID:: PMC10501937

Abstract Article PDF–3.9M

Select item 104614806.

Nuclear hormone receptor NHR-49 is an essential regulator of stress resilience and healthy aging in Caenorhabditis elegans

Kelsie R. S. Doering, Glafira Ermakova, Stefan Taubert

Front Physiol. 2023; 14: 1241591. Published online 2023 Aug 14. doi: 10.3389/fphys.2023.1241591

PMCID:: PMC10461480

Abstract Article PDF–1.3M

Select item 104482127.

Preparation of low molecular weight polysaccharides from Tremella fuciformis by ultrasonic-assisted H₂O₂-Vc method: Structural characteristics, in vivo antioxidant activity and stress resistance

Quancen Lee, Xianjing Han, Mingfeng Zheng, Feng Lv, Bin Liu, Feng Zeng

Ultrason Sonochem. 2023 Oct; 99: 106555. Published online 2023 Aug 9. doi: 10.1016/j.ultsonch.2023.106555

PMCID:: PMC10448212

Abstract Article PDF–3.2M

Select item 102343988.

Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans

Grace Ying Shyen Goh, Arshia Beigi, Junran Yan, Kelsie R S Doering, Stefan Taubert

G3 (Bethesda) 2023 Jun; 13(6): jkad087. Published online 2023 Apr 19. doi: 10.1093/g3journal/jkad087

PMCID:: PMC10234398

Abstract Article PDF–639K

Select item 101918619.

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

Hyun Ju Lee, Hafiza Alirzayeva, Seda Koyuncu, Amirabbas Rueber, Alireza Noormohammadi, David Vilchez

Nat Aging. 2023; 3(5): 546–566. Published online 2023 Apr 3. doi: 10.1038/s43587-023-00383-4

PMCID:: PMC10191861

Abstract Article PDF–9.4M

Select item 988544010.

Intracellular lipid surveillance by small G protein geranylgeranylation

Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald, Peter M. Douglas

Nature. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Nature. 2022 May; 605(7911): 736–740. Published online 2022 May 18. doi: 10.1038/s41586-022-04729-7

PMCID:: PMC9885440

Abstract Article PDF–4.2M

Select item 984940211.

A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity

Jin-Hyuck Jeong, Jun-Seok Han, Youngae Jung, Seung-Min Lee, So-Hyun Park, Mooncheol Park, Min-Gi Shin, Nami Kim, Mi Sun Kang, Seokho Kim, Kwang-Pyo Lee, Ki-Sun Kwon, Chun-A. Kim, Yong Ryoul Yang, Geum-Sook Hwang, Eun-Soo Kwon

Nat Commun. 2023; 14: 288. Published online 2023 Jan 18. doi: 10.1038/s41467-023-35952-z

PMCID:: PMC9849402

Abstract Article PDF–2.5M

Select item 974990612.

2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans

Emily Schifano, Giorgia Conta, Adele Preziosi, Carino Ferrante, Giovanni Batignani, Patrizia Mancini, Alberta Tomassini, Fabio Sciubba, Tullio Scopigno, Daniela Uccelletti, Alfredo Miccheli

Front Mol Biosci. 2022; 9: 986022. Published online 2022 Nov 23. doi: 10.3389/fmolb.2022.986022

PMCID:: PMC9749906

Abstract Article PDF–3.1M

Select item 968444113.

Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis

Mario Ruiz, Ranjan Devkota, Dimitra Panagaki, Per-Olof Bergh, Delaney Kaper, Marcus Henricsson, Ali Nik, Kasparas Petkevicius, Johanna L. Höög, Mohammad Bohlooly-Y, Peter Carlsson, Jan Borén, Marc Pilon

Nat Commun. 2022; 13: 7162. Published online 2022 Nov 22. doi: 10.1038/s41467-022-34931-0

PMCID:: PMC9684441

Abstract Article PDF–3.2M

Select item 964207614.

Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization

Abigail Watterson, Sonja L.B. Arneaud, Naureen Wajahat, Jordan M. Wall, Lexus Tatge, Shaghayegh T. Beheshti, Melina Mihelakis, Nicholas Y. Cheatwood, Jacob McClendon, Atossa Ghorashi, Ishmael Dehghan, Chase D. Corley, Jeffrey G. McDonald, Peter M. Douglas

Cell Rep. Author manuscript; available in PMC 2022 Nov 8.

Published in final edited form as: Cell Rep. 2022 Oct 18; 41(3): 111493. doi: 10.1016/j.celrep.2022.111493

PMCID:: PMC9642076

Abstract Article PDF–1.6M

Select item 957220615.

Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49-Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans

Zhongqin Wu, Yu Xiao, Fang Zhou, Jiaxu Chen, Xinming Chen, Aixiang Hou, Yuanliang Wang, Zongjun Li

Molecules. 2022 Oct; 27(19): 6159. Published online 2022 Sep 20. doi: 10.3390/molecules27196159

PMCID:: PMC9572206

Abstract Article PDF–3.1M

Select item 948099016.

Nutrient sensing pathways regulating adult reproductive diapause in C. elegans

Moriah Eustice, Daniel Konzman, Jeff M. Reece, Salil Ghosh, Jhullian Alston, Tyler Hansen, Andy Golden, Michelle R. Bond, Lara K. Abramowitz, John A. Hanover

PLoS One. 2022; 17(9): e0274076. Published online 2022 Sep 16. doi: 10.1371/journal.pone.0274076

PMCID:: PMC9480990

Abstract Article PDF–2.1M

Select item 933594017.

A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological traits

Ranjan Devkota, Delaney Kaper, Rakesh Bodhicharla, Marcus Henricsson, Jan Borén, Marc Pilon

Genetics. 2021 Sep; 219(1): iyab093. Published online 2021 Jun 14. doi: 10.1093/genetics/iyab093

PMCID:: PMC9335940

Abstract Article PDF–1.6M

Select item 924087018.

SKN-1 regulates stress resistance downstream of amino catabolism pathways

Phillip A. Frankino, Talha F. Siddiqi, Theodore Bolas, Raz Bar-Ziv, Holly K. Gildea, Hanlin Zhang, Ryo Higuchi-Sanabria, Andrew Dillin

iScience. 2022 Jul 15; 25(7): 104571. Published online 2022 Jun 9. doi: 10.1016/j.isci.2022.104571

PMCID:: PMC9240870

Abstract Article PDF–3.8M

Select item 920327519.

Lysosome lipid signalling from the periphery to neurons regulates longevity

Marzia Savini, Andrew Folick, Yi-Tang Lee, Feng Jin, André Cuevas, Matthew C. Tillman, Jonathon D. Duffy, Qian Zhao, Isaiah A. Neve, Pei-Wen Hu, Yong Yu, Qinghao Zhang, Youqiong Ye, William B. Mair, Jin Wang, Leng Han, Eric A. Ortlund, Meng C. Wang

Nat Cell Biol. 2022; 24(6): 906–916. Published online 2022 Jun 9. doi: 10.1038/s41556-022-00926-8