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Items: 1 to 20 of 48

1.
OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824
Shiu Yeung Lam, Ruben van der Lugt, Aurora Cerutti, Zeliha Yalçin, Alexander M. Thouin, Marco Simonetta, Jacqueline J. L. Jacobs
Nat Commun. 2024; 15: 8960. Published online 2024 Oct 17. doi: 10.1038/s41467-024-53404-0
PMCID:
PMC11486905
AbstractArticlePDF–1.9M
2.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
3.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
4.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
5.
The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining
Fangzhou Li, Qianqian Sun, Kun Liu, Haichao Han, Ning Lin, Zhongyi Cheng, Yueming Cai, Feng Tian, Zebin Mao, Tanjun Tong, Wenhui Zhao
Cell Mol Life Sci. 2019 Oct; 76(19): 3861–3873. Published online 2019 Apr 12. doi: 10.1007/s00018-019-03094-5
PMCID:
PMC11105630
AbstractArticlePDF–2.0M
6.
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo, Qiuran Xu
Biol Direct. 2024; 19: 31. Published online 2024 Apr 24. doi: 10.1186/s13062-024-00475-0
PMCID:
PMC11041014
AbstractArticlePDF–8.9M
7.
Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency Is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis
Jingjing Dai, Liren Zhang, Ruizhi Zhang, Jing Ge, Feifan Yao, Suiqing Zhou, Jiali Xu, Kai Yu, Jing Xu, Longfeng Jiang, Ke Jin, Xinzheng Dai, Jun Li, Qing Li
Cell Mol Gastroenterol Hepatol. 2024; 17(3): 399–421. Published online 2023 Nov 29. doi: 10.1016/j.jcmgh.2023.11.014
PMCID:
PMC10827517
AbstractArticlePDF–11M
8.
Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury
Li-Kai Chu, Xu Cao, Lin Wan, Qiang Diao, Yu Zhu, Yu Kan, Li-Li Ye, Yi-Ming Mao, Xing-Qiang Dong, Qian-Wei Xiong, Ming-Cui Fu, Ting Zhang, Hui-Ting Zhou, Shi-Zhong Cai, Zhou-Rui Ma, Ssu-Wei Hsu, Reen Wu, Ching-Hsien Chen, Xiang-Ming Yan, Jun Liu
Nat Commun. 2023; 14: 8393. Published online 2023 Dec 18. doi: 10.1038/s41467-023-44228-5
PMCID:
PMC10728081
AbstractArticlePDF–9.6M
9.
The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5
Lin Fu, Kun Lu, Qian Jiao, Xi Chen, Fengju Jia
Cells. 2023 Apr; 12(8): 1161. Published online 2023 Apr 14. doi: 10.3390/cells12081161
PMCID:
PMC10136533
AbstractArticlePDF–2.5M
10.
Mechanism of OTUD5 in non-small cell lung cancer cell proliferation, invasion, and migration
Xuebing Li, Baohua Lu, Lina Zhang, Jing Yang, Yurong Cheng, Dong Yan
Bosn J Basic Med Sci. 2022 Dec; 22(6): 901–911. Published online 2022 Jun 27. doi: 10.17305/bjbms.2022.7206
PMCID:
PMC9589305
AbstractArticlePDF–4.1M
11.
Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function
Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner
Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1
PMCID:
PMC9481602
AbstractArticlePDF–3.7M
12.
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression
Tao Hou, Weichao Dan, Tianjie Liu, Bo Liu, Yi Wei, Chenyang Yue, Taotao Que, Bohan Ma, Yuzeshi Lei, Zixi Wang, Jin Zeng, Yizeng Fan, Lei Li
Cell Death Dis. 2022 Sep; 13(9): 778. Published online 2022 Sep 9. doi: 10.1038/s41419-022-05128-6
PMCID:
PMC9463452
AbstractArticlePDF–5.7M
13.
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
Qiangqiang Liu, Qian Luo, Jianyu Feng, Yanping Zhao, Biao Ma, Hongcheng Cheng, Tian Zhao, Hong Lei, Chenglong Mu, Linbo Chen, Yuanyuan Meng, Jiaojiao Zhang, Yijia Long, Jingyi Su, Guo Chen, Yanjun Li, Gang Hu, Xudong Liao, Quan Chen, Yushan Zhu
eLife. 2022; 11: e81247. Published online 2022 Aug 1. doi: 10.7554/eLife.81247
PMCID:
PMC9377797
AbstractArticlePDF–4.9M
14.
Structural and functional consequences of NEDD8 phosphorylation
Katrin Stuber, Tobias Schneider, Jill Werner, Michael Kovermann, Andreas Marx, Martin Scheffner
Nat Commun. 2021; 12: 5939. Published online 2021 Oct 12. doi: 10.1038/s41467-021-26189-9
PMCID:
PMC9020517
AbstractArticlePDF–2.8M
15.
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari
PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412
PMCID:
PMC8513853
AbstractArticlePDF–4.1M
16.
Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes
Weijun Gui, Siqi Shen, Zhihao Zhuang
J Am Chem Soc. Author manuscript; available in PMC 2021 Nov 18.
Published in final edited form as: J Am Chem Soc. 2020 Nov 18; 142(46): 19493–19501. Published online 2020 Nov 3. doi: 10.1021/jacs.9b12426
PMCID:
PMC8462974
AbstractArticlePDF–975K
17.
OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING
Yunyun Guo, Fei Jiang, Lingli Kong, Haifeng Wu, Honghai Zhang, Xiaorong Chen, Jian Zhao, Baoshan Cai, Yanqi Li, Chunhong Ma, Fan Yi, Lei Zhang, Bingyu Liu, Yi Zheng, Lingqiang Zhang, Chengjiang Gao
Cell Mol Immunol. 2021 Aug; 18(8): 1945–1955. Published online 2020 Sep 2. doi: 10.1038/s41423-020-00531-5
PMCID:
PMC8322343
AbstractArticlePDF–3.8M
18.
N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
Yuanming Cheng, Wei Xie, Brian F Pickering, Karen L Chu, Angela M Savino, Xuejing Yang, Hanzhi Luo, Diu TT Nguyen, Shanlan Mo, Ersilia Barin, Anthony Velleca, Thomas Rohwetter, Dinshaw J Patel, Samie R Jaffrey, Michael G Kharas
Cancer Cell. Author manuscript; available in PMC 2022 Jul 12.
Published in final edited form as: Cancer Cell. 2021 Jul 12; 39(7): 958–972.e8. Published online 2021 May 27. doi: 10.1016/j.ccell.2021.04.017
PMCID:
PMC8282764
AbstractArticlePDF–3.4M
19.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
20.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M

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