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Select item 67426461.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 67403622.

Fas/Tumor Necrosis Factor Receptor Death Signaling Is Required for Axotomy-Induced Death of Motoneurons In Vivo

Gabriele Ugolini, Cédric Raoul, Anna Ferri, Christine Haenggeli, Yoichi Yamamoto, Danièle Salaün, Christopher E. Henderson, Ann C. Kato, Brigitte Pettmann, Anne-Odile Hueber

J Neurosci. 2003 Sep 17; 23(24): 8526–8531. doi: 10.1523/JNEUROSCI.23-24-08526.2003

PMCID:: PMC6740362

Abstract Article PDF–394K

Select item 67302743.

Tumor Necrosis Factor Receptor 1 and Its Signaling Intermediates Are Recruited to Lipid Rafts in the Traumatized Brain

George Lotocki, Ofelia F. Alonso, W. Dalton Dietrich, Robert W. Keane

J Neurosci. 2004 Dec 8; 24(49): 11010–11016. doi: 10.1523/JNEUROSCI.3823-04.2004

PMCID:: PMC6730274

Abstract Article PDF–369K

Select item 62982544.

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

Emmy Van Quickelberghe, Delphine De Sutter, Geert van Loo, Sven Eyckerman, Kris Gevaert

Sci Data. 2018; 5: 180289. Published online 2018 Dec 18. doi: 10.1038/sdata.2018.289

PMCID:: PMC6298254

Abstract Article PDF–1.4M

Select item 48207995.

Pretreatment with low-dose gadolinium chloride attenuates myocardial ischemia/reperfusion injury in rats

Min Chen, Yuan-yuan Zheng, Yun-tao Song, Jing-yi Xue, Zheng-yang Liang, Xin-xin Yan, Da-li Luo

Acta Pharmacol Sin. 2016 Apr; 37(4): 453–462. Published online 2016 Mar 7. doi: 10.1038/aps.2015.156

PMCID:: PMC4820799

Abstract Article PDF–2.1M

Select item 46520696.

Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy

Fang Wang, Hongbo Weng, Michael J. Quon, Jingwen Yu, Jian-Ying Wang, Anne-Odile Hueber, Peixin Yang

Am J Physiol Endocrinol Metab. 2015 Nov 15; 309(10): E861–E873. Published online 2015 Sep 29. doi: 10.1152/ajpendo.00215.2015

PMCID:: PMC4652069

Abstract Article

Select item 44775987.

Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl₄-induced hepatotoxicity in rats

Mohamed M. Hafez, Naif O. Al-Harbi, Ali Rashed Al-Hoshani, Khaled A. Al-hosaini, Shakir D. Al Shrari, Salim S. Al Rejaie, Mohamed M. Sayed-Ahmed, Othman A. Al-Shabanah

Biol Res. 2015; 48(1): 30. Published online 2015 Jun 11. doi: 10.1186/s40659-015-0022-y

PMCID:: PMC4477598

Abstract Article PDF–973K

Select item 42633718.

A Massively Parallel Pipeline to Clone DNA Variants and Examine Molecular Phenotypes of Human Disease Mutations

Xiaomu Wei, Jishnu Das, Robert Fragoza, Jin Liang, Francisco M. Bastos de Oliveira, Hao Ran Lee, Xiujuan Wang, Matthew Mort, Peter D. Stenson, David N. Cooper, Steven M. Lipkin, Marcus B. Smolka, Haiyuan Yu

PLoS Genet. 2014 Dec; 10(12): e1004819. Published online 2014 Dec 11. doi: 10.1371/journal.pgen.1004819

PMCID:: PMC4263371

Abstract Article PDF–7.6M

Select item 40025759.

Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats

Dun-quan Xu, Cao Gao, Wen Niu, Yan Li, Yan-xia Wang, Chang-jun Gao, Qian Ding, Li-nong Yao, Wei Chai, Zhi-chao Li

Acta Pharmacol Sin. 2013 Dec; 34(12): 1515–1525. Published online 2013 Oct 14. doi: 10.1038/aps.2013.96

PMCID:: PMC4002575

Abstract Article PDF–11M

Select item 336646310.

Survival function of the FADD-CASPASE-8-cFLIP_L complex

Christopher P. Dillon, Andrew Oberst, Ricardo Weinlich, Laura J. Janke, Tae-Bong Kang, Tehila Ben-Moshe, Tak W. Mak, David Wallach, Douglas R. Green

Cell Rep. Author manuscript; available in PMC 2012 Jun 4.

Published in final edited form as: Cell Rep. 2012 Apr 26; 1(5): 401–407. doi: 10.1016/j.celrep.2012.03.010

PMCID:: PMC3366463

Abstract Article PDF–3.0M

Select item 329149411.

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo

Rong-Hua Tao, Zuzana Berkova, Jillian F. Wise, Abdol-Hossein Rezaeian, Urszula Daniluk, Xue Ao, David H. Hawke, Judith E. Karp, Hui-Kuan Lin, Jeffrey J. Molldrem, Felipe Samaniego

Blood. 2011 Sep 15; 118(11): 3107–3118. Prepublished online 2011 Jul 29. doi: 10.1182/blood-2011-04-349670

PMCID:: PMC3291494

Abstract Article

Select item 322369512.

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

N Vanlangenakker, M J M Bertrand, P Bogaert, P Vandenabeele, T Vanden Berghe

Cell Death Dis. 2011 Nov; 2(11): e230. Published online 2011 Nov 17. doi: 10.1038/cddis.2011.111

PMCID:: PMC3223695

Abstract Article PDF–655K

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317656714.

Decreased Proliferation of Adult Hippocampal Stem Cells During Cocaine Withdrawal: Possible Role of the Cell Fate Regulator FADD

M Julia García-Fuster, Shelly B Flagel, S Taha Mahmood, Leah M Mayo, Robert C Thompson, Stanley J Watson, Huda Akil

Neuropsychopharmacology. 2011 Oct; 36(11): 2303–2317. Published online 2011 Jul 27. doi: 10.1038/npp.2011.119

PMCID:: PMC3176567

Abstract Article PDF–785K

Select item 317467415.

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

Jennifer V. Lu, Brian M. Weist, Bram J. van Raam, Brett S. Marro, Long V. Nguyen, Prathna Srinivas, Bryan D. Bell, Keith A. Luhrs, Thomas E. Lane, Guy S. Salvesen, Craig M. Walsh

Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37): 15312–15317. Published online 2011 Aug 29. doi: 10.1073/pnas.1102779108

PMCID:: PMC3174674

Abstract Article PDF–1008K

Select item 316327116.

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

Maria Feoktistova, Peter Geserick, Beate Kellert, Diana Panayotova Dimitrova, Claudia Langlais, Mike Hupe, Kelvin Cain, Marion MacFarlane, Georg Häcker, Martin Leverkus

Mol Cell. 2011 Aug 5; 43(3-6): 449–463. doi: 10.1016/j.molcel.2011.06.011

PMCID:: PMC3163271

Abstract Article

Select item 312221317.

TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8

Aminah Ikner, Avi Ashkenazi

J Biol Chem. 2011 Jun 17; 286(24): 21546–21554. Published online 2011 Apr 27. doi: 10.1074/jbc.M110.203745

PMCID:: PMC3122213

Abstract Article PDF–2.8M

Select item 299737418.

Whole-Exome-Sequencing-Based Discovery of Human FADD Deficiency

Alexandre Bolze, Minji Byun, David McDonald, Neil V. Morgan, Avinash Abhyankar, Lakshmanane Premkumar, Anne Puel, Chris M. Bacon, Frédéric Rieux-Laucat, Ki Pang, Alison Britland, Laurent Abel, Andrew Cant, Eamonn R. Maher, Stefan J. Riedl, Sophie Hambleton, Jean-Laurent Casanova

Am J Hum Genet. 2010 Dec 10; 87(6): 873–881. doi: 10.1016/j.ajhg.2010.10.028

PMCID:: PMC2997374

Abstract Article PDF–1.2M

Select item 298891219.

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

Liwei Wang, Jin Kuk Yang, Venkataraman Kabaleeswaran, Amanda J. Rice, Anthony C. Cruz, Ah Young Park, Qian Yin, Ermelinda Damko, Se Bok Jang, Stefan Raunser, Carol V. Robinson, Richard M. Siegel, Thomas Walz, Hao Wu

Nat Struct Mol Biol. Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: Nat Struct Mol Biol. 2010 Nov; 17(11): 1324–1329. Published online 2010 Oct 10. doi: 10.1038/nsmb.1920