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Select item 113102901.

LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress

Diana A. Quintero-Espinosa, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo

Neurochem Res. 2024; 49(9): 2440–2452. Published online 2024 Jun 7. doi: 10.1007/s11064-024-04141-9

PMCID:: PMC11310290

Abstract Article PDF–2.4M

Select item 111999552.

Modeling neurodegenerative and neurodevelopmental disorders in the Drosophila mushroom body

Aaron Stahl, Seth M. Tomchik

Learn Mem. 2024 May; 31(5): a053816. Published online 2024 May. doi: 10.1101/lm.053816.123

PMCID:: PMC11199955

Abstract Article PDF–937K

Select item 109681263.

Neuroprotective Effects of the Nutraceutical Dehydrozingerone and Its C₂-Symmetric Dimer in a Drosophila Model of Parkinson’s Disease

Maria Dolores Setzu, Ignazia Mocci, Davide Fabbri, Paola Carta, Patrizia Muroni, Andrea Diana, Maria Antonietta Dettori, Maria Antonietta Casu

Biomolecules. 2024 Mar; 14(3): 273. Published online 2024 Feb 24. doi: 10.3390/biom14030273

PMCID:: PMC10968126

Abstract Article PDF–5.8M

Select item 108800794.

Function and regulation of nitric oxide signaling in Drosophila

Sangyun Jeong

Mol Cells. 2024 Jan; 47(1): 100006. Published online 2023 Dec 20. doi: 10.1016/j.mocell.2023.12.004

PMCID:: PMC10880079

Abstract Article PDF–1.7M

Select item 106501925.

Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila

Jack Cheng, Bor-Tsang Wu, Hsin-Ping Liu, Wei-Yong Lin

Int J Mol Sci. 2023 Nov; 24(21): 15587. Published online 2023 Oct 25. doi: 10.3390/ijms242115587

PMCID:: PMC10650192

Abstract Article PDF–2.2M

Select item 104322046.

ArfGAP1 regulates the endosomal sorting of guidance receptors to promote directed collective cell migration in vivo

Alison Boutet, Carlos Zeledon, Gregory Emery

iScience. 2023 Aug 18; 26(8): 107467. Published online 2023 Jul 25. doi: 10.1016/j.isci.2023.107467

PMCID:: PMC10432204

Abstract Article PDF–3.1M

Select item 102915737.

A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia

Mari Suzuki, Hiroshi Kuromi, Mayumi Shindo, Nozomi Sakata, Naoko Niimi, Koji Fukui, Minoru Saitoe, Kazunori Sango

iScience. 2023 Jun 16; 26(6): 106997. Published online 2023 May 29. doi: 10.1016/j.isci.2023.106997

PMCID:: PMC10291573

Abstract Article PDF–5.4M

Select item 102327758.

Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies

Stefania Santarelli, Chiara Londero, Alessia Soldano, Carlotta Candelaresi, Leonardo Todeschini, Luisa Vernizzi, Paola Bellosta

Front Neurosci. 2023; 17: 1082047. Published online 2023 May 18. doi: 10.3389/fnins.2023.1082047

PMCID:: PMC10232775

Abstract Article PDF–2.4M

Select item 100380519.

The utility and caveat of split-GAL4s in the study of neurodegeneration

Luca Stickley, Rafael Koch, Emi Nagoshi

Fly (Austin) 2023; 17(1): 2192847. Published online 2023 Mar 23. doi: 10.1080/19336934.2023.2192847

PMCID:: PMC10038051

Abstract Article PDF–909K

Select item 967899710.

The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis

Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan

Cell Mol Life Sci. 2022; 79(12): 599. Published online 2022 Nov 21. doi: 10.1007/s00018-022-04574-x

PMCID:: PMC9678997

Abstract Article PDF–6.5M

Select item 967296611.

Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila

Tsuyoshi Inoshita, Jun-Yi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba-Fukushima, Nobutaka Hattori, Yuzuru Imai

iScience. 2022 Dec 22; 25(12): 105476. Published online 2022 Nov 2. doi: 10.1016/j.isci.2022.105476

PMCID:: PMC9672966

Abstract Article PDF–5.0M

Select item 963265812.

Exploring therapeutic potential of mitophagy modulators using Drosophila models of Parkinson’s disease

Jyotsna Asthana, Bhupendra V. Shravage

Front Aging Neurosci. 2022; 14: 986849. Published online 2022 Oct 19. doi: 10.3389/fnagi.2022.986849

PMCID:: PMC9632658

Abstract Article PDF–1.2M

Select item 931659813.

Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research

Valeria Olguín, Anyelo Durán, Macarena Las Heras, Juan Carlos Rubilar, Francisco A. Cubillos, Patricio Olguín, Andrés D. Klein

Int J Mol Sci. 2022 Jul; 23(14): 7570. Published online 2022 Jul 8. doi: 10.3390/ijms23147570

PMCID:: PMC9316598

Abstract Article PDF–1.1M

Select item 893100214.

Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor

Federico Miozzo, Eva P. Valencia-Alarcón, Luca Stickley, Michaëla Majcin Dorcikova, Francesco Petrelli, Damla Tas, Nicolas Loncle, Irina Nikonenko, Peter Bou Dib, Emi Nagoshi

Nat Commun. 2022; 13: 1426. Published online 2022 Mar 17. doi: 10.1038/s41467-022-29075-0

PMCID:: PMC8931002

Abstract Article PDF–6.9M

Select item 890994215.

Inter-Species Rescue of Mutant Phenotype—The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model

Alexandru Al. Ecovoiu, Attila Cristian Ratiu, Miruna Mihaela Micheu, Mariana Carmen Chifiriuc

Int J Mol Sci. 2022 Mar; 23(5): 2613. Published online 2022 Feb 27. doi: 10.3390/ijms23052613

PMCID:: PMC8909942

Abstract Article PDF–1.3M

Select item 883592016.

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease

Mari Suzuki, Kazunori Sango, Yoshitaka Nagai

Int J Mol Sci. 2022 Feb; 23(3): 1519. Published online 2022 Jan 28. doi: 10.3390/ijms23031519

PMCID:: PMC8835920

Abstract Article PDF–354K

Select item 860968317.

Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons

Alison Fellgett, C. Adam Middleton, Jack Munns, Chris Ugbode, David Jaciuch, Laurence G. Wilson, Sangeeta Chawla, Christopher J.H. Elliott

J Parkinsons Dis. 2021; 11(4): 1805–1820. Prepublished online 2021 Jul 3. Published online 2021 Oct 12. doi: 10.3233/JPD-202421

PMCID:: PMC8609683

Abstract Article PDF–2.1M

Select item 852602018.

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila

Jun-yi Zhu, Shabab B. Hannan, Nina M. Dräger, Natalia Vereshchagina, Ann-Christin Krahl, Yulong Fu, Christopher J.H. Elliott, Zhe Han, Thomas R. Jahn, Tobias M. Rasse

Autophagy. 2021; 17(10): 3160–3174. Published online 2021 Jan 25. doi: 10.1080/15548627.2020.1871211